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OTAR3088
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BioData-CellLine_annotated

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PMC11650848
Our data support the existence of mQTLs at this locus and through examination of mother–child pairs could also exclude an imprinting effect at this locus, since G/G homozygotic mothers showed near 100% methylation rather than the 50% expected if the region was imprinted.
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PMC5810978
The supernatants were further centrifuged at 10,000 × g at 4°C for 3 min and filtered through 0.2 μm-pore size filters.
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PMC7759933
New knowledge on the characteristics of the 3D cell model is of great importance for its further development and application in the safety assessment of chemicals, food products, and complex mixtures.
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PMC8557138
These tumor PDOs when cultured adjacent to the vascular network showed profound angiogenic response for as long as 22 days.
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PMC10940855
n = 6/group.
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PMC10538569
One surprising finding in this study is that GPI-scFv X5 not only effectively blocks HIV-1 cell-cell infection of CD4 cell lines or human primary CD4 T cells in trans from either iDC or mDC-captured HIV-1, but it also blocks HIV-1 infection of the iDCs ( Figures 3 , 5 ).
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PMC11643491
As a control, spherical and ellipsoidal particles without drug were prepared by the same process.
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PMC11730311
Seven C-terminal fragments were identified from hαCGRP8-37N25K-C20DA-γGlu.
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PMC9429973
However, this is little data of CPX-351 in a real-world setting.
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PMC11740399
C, D, and E) Qualitative and quantitative results of Western blot revealed that T24 cells and 5637 cells treated with 3025@ML showed downregulation of PKM2 protein levels and induced apoptosis. (
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PMC11763126
A IHC analysis showing YTHDF2 expression in ccRCC.
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PMC10551595
Animal Studies: N/A.
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PMC3765139
In contrast, the CD105- fraction in Me39, WM115, Na8, and HBL cell lines even dominated in terms of clonogenic capacity, but not significantly.
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PMC11697189
The data obtained from the Cancer Genome Atlas (TCGA) were applied to determine the differential expression of HSPs in normal tissues and ccRCC.
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PMC11388384
In cultured SHH sender cells, SCUBE family proteins promote SHH release from SHH-producing cells into the culture media by interacting with the cholesterol moiety (13, 14, 32).
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PMC7351993
Compared to conventional Raman microscopy with manual pipetting (which is highly labor-intensive and time-consuming), the RIACS shortens the duration of the entire detection-to-isolation process by a few orders of magnitude (i.e., from years to days, from days to minutes), helping researchers significantly accelerate their discovery-making workflow.
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PMC11352877
For the scratch assay, the tested cells were seeded in a 6-well plate (5 × 10 cells/well), and at circa 90% confluence, the cell monolayer was scraped off.
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PMC8662250
Cell culture medium, fluorescein isothiocyanate (FITC)–dextran, size 4 kDa, and 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyltetrazolium bromide (MTT) were purchased from Sigma–Aldrich (St. Louis, Missouri).
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PMC11271278
Source data for the (H) are provided as a Source Data file.
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PMC11506827
Statistical significance was assessed using Student’s t-test, with p < 0.05, p < 0.01, or p < 0.001 considered significant.
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PMC11060216
In osteosarcoma, overexpression of S100A6 has been proven to inhibit the differentiation of mesenchymal stem cells into osteoblasts, thus promoting tumorigenesis.
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PMC9429973
Further validation and ChIP sequencing will provide novel direct target genes of STAT3β which could serve as prognostic or therapeutic molecules.
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PMC11352746
BrainBits animal protocol #32-08-013 was approved by the Southern Illinois University School of Medicine Laboratory Animal Care and Use Committee on 18 May 2011.
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PMC11591038
Several compounds may also exert beneficial effects through the inhibition of the HIF-1 pathway.
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PMC8922418
The most direct and effective gene therapy method is to remove the integrated provirus DNA from the host genome by CRISPR/SpCas9 targeting.
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PMC8270637
The dephosphorylation of the NFAT family is specifically mediated by CaN. We also found that TGF-β1 did not increase the expression of CaN. However, the CaN inhibitor CsA blocked the increased transportation of NFATc1 to the nucleus and enhanced the expression of PD-1 and CTLA-4 induced by TGF-β1 in T cells.
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PMC11789597
Targeting CAV1 enhances NK cell‐mediated cytotoxicity and improves daratumumab efficiency.
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PMC11739504
Scale bar: 100 μm. (
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PMC8557138
Additive manufacturing (layer by layer deposition), selective removal of materials for the formation of tubular voids connected to perfusion networks, and use of sacrificial materials are some of the 3D fabrication techniques explored (Grebenyuk and Ranga 2019; Xie et al. 2020).
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PMC11401350
At week 12 of engraftment, 20 engrafted NSG mice were injected at day 4 and day 1 before vector injection with IL-15 (200 ng) and IL-7 (200 ng).
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PMC9275501
Amphiphilic SN38 prodrug polymeric micelles (PSN38) and encapsulated the hydrophobic esterase-responsive prodrug of TPL, TPL-naphthalene sulfonamide (TPL-nsa), were synthesized to form PSN38@TPL-nsa nanoparticles.
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PMC11472639
indicates a significant difference from pre-exercise at p < 0.05.
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PMC11638255
Representative image obtained from one independent experiment.
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PMC4839679
Genes involved in cell adhesion serve as tumor suppressor and maybe involved in inhibiting cell migration.
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PMC11098378
Statistical significance was determined with unpaired student’s t-test.
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PMC9429973
30-day mortality was 42.4%.
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PMC11802929
Mean values +/- SEM are utilized for violin plots.
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PMC11367146
Cells were seeded in 6 well plates at a density of 2 × 10 cells/well until it attained 80 % confluence as a monolayer.
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PMC6379402
Bars in blue indicate reduced cell viability in cancer that is statistically different from the control (MWU p value ≤ 5%), bars in red indicate increased cell viability in cancer that is statistically different from the control, and bars in white indicate cell viability changes in cancer cell lines that were not statistically significant Next, tabfigwe find that 32 of our 63 prioritized genes (50.8%) have potential clinical relevance as biomarkers of cancer, by assessing if the expression value of a prioritized gene (from TCGA projects; The Cancer Genome Atlas, http://cancergenome.nih.gov/abouttcga) can be used to stratify cancer patients into two subgroups having different survivals (Kaplan–Meier survival curve analysis, detailed in Methods, section Gene expression based analysis).
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PMC11365427
QC samples were evenly inserted in every ten samples to monitor the instrumentation and method stability.
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PMC10073922
The effects of NDRG2 overexpression on the migration and invasion of A549 cells using transwell assay.
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PMC9429973
Secondary endpoints included overall survival (OS), cumulative incidence of chronic GvHD, and adverse events.
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PMC7504302
The increasing incidence of MPM highlights the need for finding effective treatments.
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PMC9429973
Aims: To characterize the demographics, clinical characteristics, treatment patterns, and outcomes in pts with LBCL receiving 2L therapy with or without HDCT/HSCT in the real-world setting.
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PMC10204952
This experiment was carried out in triplicate and cells treated with methanol were used as the vehicle control.
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PMC9429973
Data also suggest that, in AI with adequate iron stores, ALK2 inhibition potentially acts by liberating iron from the recycling pathway.
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PMC7185206
High doses of pembrolizumab reduced CD8 + T cell apoptosis in each matched donor.
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PMC7351993
The transmitted pulses are collimated by another objective lens and filtered by a short-pass optical filter.
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PMC11772449
The data of p38α (A, B), p38β (C, D), p38γ (E, F) and p38δ (G, H) in the Ualcan database website were analyzed.
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PMC11774747
However, beginning in the 2010s, there has been a notable increase in the number of clinical trials.
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PMC11792090
The phenotypes of CAR-T cells were analyzed using antibodies from BioLegend, including APC anti-human CD3 Antibody (317317), PE anti-human HLA-A,B,C Antibody (311405), FITC anti-human HLA-DR Antibody (327005), APC anti-human CD47 Antibody (323123), PE anti-human CD4 Antibody (300507), APC anti-human CD8 Antibody (344721), APC anti-human CD69 Antibody (310909), APC anti-human CD45 Antibody (304011), APC anti-human CD45RO Antibody (304210), PE anti-human CD62L Antibody (304805), PE anti-human CD223 (LAG-3) Antibody (369205).
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PMC11206502
Silencing of the P53 mutant decreases cell viability .
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PMC9429973
Prediction of individual treatment responses based on clinically actionable biomarkers is needed to overcome these challenges.
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PMC8336407
unit of measurement = percentage)t: tert-Butyl hydroperoxide (t-BHP) E: Pyrus biossieriana Buhse leaves extractt 100 (t-BHP, concentration: 100 µM), t 150 (t-BHP, concentration: 150 µM), t 200 (t-BHP, concentration: 200 µM)Table 2The effect of pyrus biossieriana buhse leaf extract and t-BHP treatment on nitrite production in HepG2 cell lineControl28.20 ± 1.15p valuet10055 ± 0.97p valuet15056 ± 1.16p valueE1.531 ± 3.330.090t15056 ± 1.160.573t20070 ± 5.40< 0.001E2.031.80 ± 1.10.020E1.531 ± 3.33< 0.001E1.531 ± 3.33< 0.001E2.548.30 ± 1.90< 0.001E2.031.80 ± 1.1< 0.001E2.031.80 ± 1.1< 0.001t10055 ± 0.97< 0.001E2.548.30 ± 1.90< 0.001E2.548.30 ± 1.90< 0.001t15056 ± 1.16< 0.001t100 + E1.540 ± 2.63< 0.001t150 + E1.541 ± 0.
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PMC10994876
In the final phase, we examined the impact of YAP5SA overexpression on the overall and specific productivity of EPO.
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PMC10335954
A Relative RNA levels were determined by qPCR, when ΔCt ≤ 12, the expression of TRIP13 was abundant.
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PMC3681794
increased p-glycoprotein ) or drug targets (eg.
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PMC11144200
All protocols were approved by the Hainan Medical University’s animal ethics committee.
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PMC11367146
After removing the disconnected nodes, generated network was exported to Cytoscape 3.9.1 software included 71 nodes and 348 edges as shown in Fig. 2B.
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PMC9429973
In 6 patients (9.4%) interim imaging conditioned a treatment modification (premature discontinuation of therapy, increase/decrease in the number of ICT cycles or ICT dose attenuation).
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PMC9429973
In contrast to controls with constant increase of local tissue oxygenation (StO2: +11.2 ± 7.0%, p<0.001) for the entire 90 minutes driven by increased oxygen supply (O2h: +11.7 ± 7.3 µM/s, p<0.001) and microvascular perfusion (th: 7.6 ± 8.7%, p<0.005), patients with CTX showed significant reduced th and dh (p<0.05 each) only, but no increase of StO2 with PSC.
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PMC5916734
However, unlike VKORC1, soluble PACE/furin secreted by some cells into the culture medium ensured propeptide cleavage in all the secreted FIX molecules.
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PMC11477621
H NMR (400 MHz, CDCl3) δ 7.95–7.92 (m, 1H), 7.45–7.30 (overlap, 2H), 7.20 (d, J = 3.2 Hz, 1H), 6.55 (dd, J = 3.2, 0.8 Hz, 1H), 4.15–4.06 (overlap, 4H), 2.25 (t, J = 7.4 Hz, 2H), 1.83 (p, J = 7.2 Hz, 2H), 1.59 (p, J = 7.5 Hz, 2H), 1.37–1.27 (overlap, 4H), 1.23 (t, J = 7.1 Hz, 3H).
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PMC11676670
Immunocytochemical analysis confirmed wild-type p53 expression in the original clinical ascites sample.
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PMC10669128
Many transgenic mouse models have also been generated to study gastrointestinal stromal tumors.
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PMC9429973
Compared to patients with normal VitD levels, patients with deficient vitamin levels showed significantly higher LV end-diastolic volume index (87.61±19.19 ml/m2 vs 79.17±14.27 ml/m2; P=0.003) and LV mass index (63.39±13.55 g/m2 vs 57.45±12.90 g/m2; P=0.006).
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PMC11422497
The in vivo mice xenograft tumor model, as depicted in Fig. 8A, was established to delve deeper into the oncogenic role of circ_SMA4 in GISTs.
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PMC9429973
In PACE, proactive dose reductions were mandated in ≈2 years from initiation of first patient (in 2013) as arterial occlusive events (AOEs) emerged as notable adverse events (AEs).
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PMC9024365
We conclude that the cluster size of both SD4 and AMPAR puncta is significantly increased only when co-localized in COS cells, indicating a bi-directional interaction mechanism.
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PMC11656380
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is as the tumor suppressor gene for its negative regulation of the phosphatidylinositol 3-kinase (PI3K) pathway.
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PMC11277157
The expected impact of DJ-1 on cancer is tightly connected to its role in apoptosis, cell proliferation, and metastasis.
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PMC9429973
Results: Our patient cohort were 45.1% female with median age 67 years.
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PMC9693627
We found that the absence of PTCD2 in mitochondria of HeLa cells leads to significantly lower oxygen consumption rates in the presence and absence of uncoupler reagent compared to wild-type cells.
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PMC11727062
Furthermore, research has identified that deer plasma, an extract derived from the blood of cervids, in combination with cisplatin, exhibits synergistic anti-tumor effects in a melanoma mouse model.
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PMC11317131
Specifically, a 36-h variant evolved from P2 (L1-10) increased by 10.9-fold and a 184 hour variant from P3 (L1-13) reached 5.0% efficiency at the ROSA26 target sequence (up from 2.3% from the P3 starting variant) (Figure 3E).
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PMC10114490
Values depicted correspond to the average of three different diHLC-T clones with WT and PiZZ genotype.
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PMC11471176
Carnosine was prepared by dissolving different concentrations with different solvents.
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PMC11411131
The full-length TrxR1-GFP did not show a fluorescence signal, whereas the truncated version did.
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PMC11548041
Epithelial cell adhesion molecule (EpCAM) is an attractive candidate for aptamer-targeted therapeutics.
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PMC11457557
According to research, they lower PTEN expression by acting as significant autophagy regulators and TIF via stimulation of the Akt/mammalian target of the rapamycin (mTOR) signaling pathway .
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PMC11506670
Similar to the canonical NRAS mutant Q61K, Q43K and E37K did not show a significant difference in the migration rate when compared to the wild-type and vector-only controls (Figure 4a,b).
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PMC11483468
In cell derived xenograft (CDX) experiments, the liver cancer cell line BEL-7404 were injected (2×10 cells per site) subcutaneously into the right flank of mice.
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PMC7602170
MRI is only suggested for those GIST patients with a liver-related problem (e.g., potential hepatic resection) or contraindications to CT .
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PMC11680562
Moreover, the intriguing existence of few phytochemicals on the metal NPs' surface offers excellent potential for enhanced interactions with a wide range of organic compounds, including drugs, biomolecules, lipids and polymers .
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PMC9621239
Numbers of genotyped clones with genotypes B, C and D were counted and compared between tumour and non-tumour tissues.
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PMC8584666
These observations suggested that GPI-80 expression or secreted GPI-80 contributes to an inflammatory tumor microenvironment.
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PMC7757104
In a number of experimental models, tOPN expression levels were upregulated in response to drug treatment (11,13,15).
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PMC11538390
a Browser view of the human genome, GRCh37/hg19, focused on the rs570516915 variant.
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PMC11290772
Characters of ROBO1-NK cells. (
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PMC9429973
We chose the final model that yielded the largest AUC or the smallest AIC.
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PMC11451940
Cisplatin showed a typical increase in cytotoxicity with increasing time, showing IC50 from 15.4 μM (24 h), through 6.5 μM (48 h) to 3.7 μM (72 h).
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PMC11747949
However, we did not detect the change in a fraction of CD11bCCR2 cells (Figure 3G).
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PMC2196094
The nucleotide sequence is deposited in GenBank under the accession number U67915.)
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PMC11781181
FSP1 and FTH1cDNA was synthesized by Huzhou Hippobiotec Co., Ltd. Small interfering RNAs (siRNAs) against FSP1, NCOA4, and FTH1 were purchased from Huzhou Hippobiotec Co., Ltd. The sequences are listed in Table S3.
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PMC9503685
Multiple series of ceragenins have been prepared to determine the structural features that combine to provide antibacterial activity.
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PMC11765879
The extraction process of ZSC leaves was performed by the maceration technique .
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PMC11718109
Quantification of clear empty vesicles in iNeurons and DA neurons are shown in dot plot (G) and frequency histogram (H).
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PMC11224020
DCs were obtained following a protocol adapted by the Ricciardi-Castagnoli and Amigorena labs.
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PMC11643361
The unpredictable nature of scorpionate activity requires reimagining the possibilities of ligand design, transforming the yet unpredictable and often elusive and serendipitous activity of scorpionates into systematic approaches for future work.
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PMC11474209
No.Analytical methodSensorSampleLoD valueInferenceReference1Electrochemical impedance spectroscopy (EIS)Advantage - Utilizes advanced signal processing techniques and can investigate relaxations over a broad frequency spectrum.
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