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PMC9429973
Methods: Adults who had R/R CD20 DLBCL and had failed or were ineligible for ASCT were enrolled.
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PMC9878562
Similarly, VAL-ACKR3-ΔC, which express comparable CXCR4 levels on the surface ( Figure S1Ei ) did not perform CXCL12-dependent migration ( Figure S1Eii ).
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PMC11694346
Detecting biothiols like glutathione (GSH), homocysteine (Hcy), and cysteine (Cys) is key to understanding their roles in health and disease.
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PMC9429973
Earlier we demonstrated the domination of E. coli in gram-negative systemic infections in immunocompromised oncohematological patients. [
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PMC8567602
These experiments demonstrated that in synovial sarcoma cells, SMARCB1 protein is present and co-IPs with a PBAF subunit (Fig. 4A).
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PMC11594074
Finally, 50 µL of stop solution was added to each well, and the absorbance was read on a microplate reader at 450 nm.
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PMC11767817
Luminescence was measured using a Tecan microplate reader (Infinite M Plex, Männedorf, Switzerland).
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PMC8956657
The gel was then stained using Coomassie stain and destained in 10% ethanol and 10% glacial acetic acid.
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PMC11761919
In this study, phthalate inulin nanoparticles (PINs) were chemically modified and characterized.
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PMC11155445
A series of iminothiazolidinone (26a–j) was evaluated as an inhibitor for carbonic anhydrase II enzyme.
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PMC9429973
D. Krauchanka, S. Arcady, M. Viktor Hematology; RRC RM&HE, Gomel, Belarus Background: An important stage in the management of patients with CLL is the prediction of the course of the disease in order to assess the need for an earlier onset of therapy and the use of alternative therapy on an individual basis, depending on the detectable prognostic markers.
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PMC9429973
Methods: Individuals with primary or secondary ITP completed the survey.
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PMC9429973
72.3% male, median age 63 yrs (34.3% >65yo) and 40.9% Binet C. IGHV were available for 256 (93.4%) pts - 48.2% IGHV unmutated (≥98% homology to germline), 45.3% IGHV mutated and 9.1% Subset 2.
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PMC10734950
By permeating living cells with an intact membrane, the substrate is able to be cleaved.
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PMC7612475
However, because it is known that the HR and fork protection functions of BRCA2 are separable, our data would suggest that the fork protection defect in the SF3B1 cells lies within the BRCA2-dependent pathway but upstream of Rad51 loading.
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PMC11734514
Quantitative data of band intensity was measured with ImageJ ver.
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PMC11607321
The conditionals layer in MOSA contains both binary, e.g., mutations and tissue of origin, and continuous, e.g., cancer cell line growth rates and doubling times from independent studies, features.
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PMC11757131
In PMECs, fatty acids not only serve as essential nutrients to maintain normal cellular physiological functions but also become an important energy source for cell proliferation through β-oxidation (22).
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PMC10243817
According to the presence or absence of nasal polyps (NPs), CRS is classified into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) (14–16, 18).
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PMC11754784
a Flow cytometry analysis of the segregation effect of DNP3 in shielding the interference of erythrocyte.
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PMC11618052
The GI50 values of compounds 8h (R1 = p-tolyl, R2 = Me) and 8j (R1 = m-tolyl, R2 = Cl) were 25 nM and 29 nM, respectively.
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PMC11739504
Graphs on right side showed relative western blotting band intensity of acetylated-α-tubulin normalized α-tubulin and acetylated-α-tubulin normalized Kat2b. (
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PMC11748335
Fig. 5Short LOCKs are related to poised promoters.
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PMC11687167
A similar effect was observed on RA patients, where PCSK9 was positively correlated with the proportion of Th17 cells and the increase in the Th17/Treg ratio .
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PMC10142392
Similarly, star, comb, and brush copolymers have unique structural features that make these types of polymers suitable for drug delivery applications.
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PMC9429973
For treatment, 4 patients received VTD (Bortezomib, Thalidomide, and Dexamethasone), 2 received VAD (Vincristine, Adriamycin, and Dexamethasone), 2 were on Thalidomide Dexamethasone, and one patient received Revlemid Dexamethasone.
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PMC11789597
Both 6‐MP and daidzin inhibited MM growth and enhanced bortezomib‐induced inhibition of MM growth in vivo (Figure 7F,G; Figure S9E, Supporting Information).
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PMC9429973
Four pts died (disease progression, n=2; transformation to diffuse large B-cell lymphoma after stopping treatment, n=1; adverse event [AE], n=1 [septic shock unrelated to treatment]); median OS was not reached.
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PMC9118379
Moreover, of the 98 variant events derived from the 320 PSMs, 47 variant events were confirmed by consecutive fragment ions in MS/MS spectra (Figure 7D).
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PMC9370419
Next, 2 µL of each sample was diluted with ddH2O to a final volume of 10 µL and used for RT-PCR amplification using the Diagnostic Kit for Hepatitis B virus DNA (Sansure Biotech).
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PMC8469018
Milli-Q water (18.2 MΩ·cm) was prepared using Direct-Q 3 UV System, systems deliver both RO (Type 3) and ultrapure (Type 1) water directly from tap (Millipore, Bedford, MA, USA).
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PMC9429973
In acute leukemias, patients with increased γδ T cells reconstitution after allogenic stem cell transplantation had better outcomes.
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PMC11045125
Similar to previous results using primary human tonsil GC B cells , CB B cells infected with the Myc-expressing vectors alone did not result in long term lines, presumably due to Myc-induced apoptosis.
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PMC11772449
PFD has a wide range of anti-fibrosis effects.
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PMC11470999
Immunoprecipitation and immunoblot assays analyses revealed a strong interaction between CIP2A and VHL (Figure 6E).
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PMC11750165
J2ICD, intracellular domain of zebrafish Jagged2.
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PMC10734950
The cells were treated with 2X CC50 (5.78 μM) of F8 and DMSO as vehicle control for 4 h. The cells were then harvested in 15 ml conical tubes, pelleted, and transferred to 1.5 ml tubes.
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PMC10631132
Resorption pits are also visible in both groups (white dashed lines in A, E).
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PMC8494202
Indeed, silencing TTK can inhibit the proliferation, invasion, and radiation resistance of glioma cells and other malignant behaviors .
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PMC11752767
Multi-mechanisms are attributable to this hurdle, including the heterogeneity of antigens or lack of specific antigens, highly suppressive TME, difficulties penetrating solid tumors’ physical barrier, and the lack of chemokines to attract CAR-T cells .
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PMC9429973
The treatment protocol includes: a course of induction (Cytarabine 200mg/m2/day associated with Daunorubicine (DNR) 60 mg/m2/day or Novantrone 12mg/m2/day).
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PMC11438317
D, PBL cells were left untreated or stimulated with PHA for 72 h to induce the expression of LYP.
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PMC11587541
The novel findings from this study provide valuable insights into the potential impact of telomere attrition on the progression of SMA and lay the foundation for future research in this domain.
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PMC11711663
By integrating multiple prognostic factors into a graphical representation, the nomogram allows healthcare professionals to easily assess individual patient outcomes and make informed decisions regarding treatment strategies.
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PMC11319300
The purple arcs denote interactions between fragments.
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PMC11477621
Both compounds 5i and 5l possessing a 5-fluoro and 5-cyano indole cap group, respectively, showed even stronger HDAC inhibition potency than SAHA.
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PMC11347429
The Manhattan plot showed the strongest cis-eQTLs on chromosome 6 ( Figure 8 ) at the location of the HLA cluster.
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PMC11502327
The nano particle synthesis with plant extract as the end agent and reducing agent can not only help to reduce the preparation cost, and improve the operability and scalability of NNDDS, but also make it safer and more environmentally friendly.
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PMC11736898
By causing the degradation of hormonally active vitamin D, CYP24A1 limits vitamin D’s biological activities .
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PMC9596868
CI values were calculated according to the classic isobologram equation (see materials and methods).
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PMC11483468
Cells were treated with PBS or GST-TAT-LPTS39 protein for 6 weeks.
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PMC4485786
Accordingly, A204 sarcomas showed neither the cross-striation that characterizes myocytes nor expression of desmin prior to transplantation (not shown).
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PMC11753435
Specifically, the predicted interface TM (ipTM) score is a verified metric within AlphaFold2-Multimer that proxies as a potential interface binding affinity of the peptide-protein complex, thus serving as a quantitative assessment of generation quality (32, 33).
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PMC11143482
Another study was performed by inoculating numerous types of OS cell lines in nude mice including HOS-143B .
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PMC11594806
However, AMPK can also act as a tumor promoter by allowing tumor cells to adapt metabolically.
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PMC11593084
As shown in Figure 2C, PMab-117-mG2a exhibited a low reactivity to 293FT.
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PMC11754432
Mean pixel intensity of filipin staining at the plasma membrane and total per cell (D), Mander’s M1 and M2 co-localisation analysis of MemGlow 488 (E) or Calnexin (F) and filipin, data are mean per cell per biological replicate (N = 6).
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PMC11471176
However, the formidable challenge posed by the rapid degradation of this natural dipeptide has spurred multiple research groups to propose innovative drug delivery solutions .
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PMC9096373
The difference in the ratio of apoptosis levels among groups was calculated using Eq. .
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PMC10994876
Moreover, there is evidence supporting the involvement of YAP in regulating BAX, which is a transcriptional target of p73.
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PMC11468365
A normalization layer is applied after concatenation to maintain the integrity of the combined cell line and drug features.
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PMC11767725
Sebum in PCOS-associated acne is enriched in squalene and saturated fatty acids, which serve as substrates for C. acnes metabolism.
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PMC9429973
Twenty four patients (36%) were treated with HyperCVAD protocol; OS was 22% and EFS at 2 years was 16 %, with median follow up of 8.8 months (8.7- 17.1).There were no significant differences in OS and EFS between the groups compared.
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PMC11400680
This is because of the utilization of low confidence scores (<0.3) and the absence of non-maximum suppression in the prompt generator.
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PMC11763533
To measure the spectra, 90 µL of the cell solution was mixed with 10 µL of 10 mM D-luciferin.
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PMC10419319
This suggests that isoalantolactone inhibits glycolysis and enhances the efficacy of cisplatin by promoting apoptotic cell death in cisplatin-resistant OC cells.
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PMC11301242
Differential expression of NHEJ genes in paired AML patients, pre-treatment (with circular amplification) versus post-treatment (without circular amplification). (
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PMC11451829
A subconjunctival injection of fibroblasts (NIH3T3) and extracellular matrix was administered to 22 New Zealand rabbits.
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PMC9429973
Overall, our centre experience shows that SAT is an effective and safe treatment in MM in the new drugs era.
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PMC9429973
By the time this abstract is written, among the pts intended to treat (34), 27 have had at least 1 bone marrow evaluation after cycle 1 and are therefore evaluable for efficacy.
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PMC11781181
Lipids were separated using a 1.8 µm C18 column (Agilent).
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PMC10055960
H NMR (300 MHz, DMSO-d6): δ (ppm) = 9.01 (br s, 6H, H1a), 7.72 (br s, 6H, H2a), 3.89 (br s, 6H, H3a), 2.85 (br s, 12H, H4a, H5a), 1.76 (s, 36H, H6a).
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PMC11106977
The N-terminal catalytic domain (N-cat) and C-terminal catalytic domain (C-cat) are the two catalytic structural domains (blue), and the intervening domain (Int-D) (green) is of unknown function.
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PMC11381192
Likewise, C2 subtype showed reduced immune and stromal cell abundance, higher tumour purity, and lower expression of immune checkpoints (Figure 6G–I).
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PMC11763764
These results provide evidence that SORL1 can regulate EGF1 and FGF1 signaling in ovarian cancer possibly through its interaction with EGFR and FGFR4.
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PMC7917457
The VP concentration and IUs were determined from a freshly made batch of VALO-D102 and after 1, 4, 6, and 9 months of storage at −20°C or <−60°C.
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PMC11502066
Myricetin was able to downregulate CXCR4 expression also in mouse models, restricting the lung and bone metastasis in PC-3 cells-implanted mice .
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PMC11055510
The effect of the sh-circMAN1A2 group was completely opposite to that of the ov-circMAN1A2 group (Fig. 9D).
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PMC4395774
A similar protocol was followed for the P14.prf LSK reconstitutions.
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PMC11543853
Data are displayed as mean values normalized to the housekeeping gene (GAPDH, B2M) and time point of 1 h post-infection.
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PMC8864075
penicillin-streptomycin (PS; Gibco, 15140-122).
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PMC11218145
Kaplan-Meier survival curves showed increased OS for TB treated group vs. vehicle control group (log-rank (Mantel-Cox) test, χ1 = 7.117; P = 0.0076) [Fig. 6], although the tumour growth apparently did not change in either group as evaluated by BLI.
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PMC11750696
The activation of ATF4 in T cells, especially under high oxidative stress or amino acid limitation, is partially driven by GCN2 (15), which initiates the UPR by phosphorylating eIF2 in response to cellular stressors like proteasome inhibition and nutrient scarcity (41).
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PMC3931643
The construct was electroporated in a FBS free media and cells were allowed to recover in complete IMDM media for 2 hrs followed by inhibitor treatment for 16 hrs.
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PMC9503669
Subsequent X-ray crystallography of a Nef:SH3 domain protein complex revealed that in addition to the PxxPxR motif, SH3 domain binding also requires a hydrophobic pocket in the Nef core region that engages the RT-loop of the SH3 domain .
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PMC9429973
Risk of VTE was estimated using Cox proportional hazards model with CLL/SLL status as a time-dependent variable.
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PMC11805741
The extract exhibited significant cytotoxicity against MDA-MB-231 cells with an IC50 of 1200 µg.
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PMC11462673
Fig. 2Altered LDB1 expression affects the proliferation of T-ALL cells.
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PMC10965315
It involves creating a wound or scratch in a cell monolayer and then monitoring the ability of the cells to migrate and close the wound overtime (Cory, 2011).
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PMC9874064
DNA damage response pathways, particularly TLS and ICL repair, may have contributed to this resistance.
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PMC11748363
A R substitution in position 2 was not favorable whether the substituent was lipophilic (R = 2‐Cl or 2‐CF3) or more hydrophilic (R = 2‐OMe).
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PMC11536589
The simultaneous use of inhibitors targeting RAS/MEK and mTORC1/2 leads to long-lasting and effective suppression of PDAC tumour growth, and it also overcomes the development of resistance to the individual drugs (Brown et al. 2020).
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PMC11377827
However, HIF-α deubiquitination does not generally overcome the dominant action of VHL when oxygen is present, and has mostly been observed by overexpression of the DUB, re-oxygenation experiments, or in VHL-deficient kidney cancer cells (Hong et al, 2020).
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PMC11754432
For lipid peroxidation experiments cells were incubated with 10 μM BODIPY 581/591 C11 (ThermoFisher Scientific) in media for 30 min at 37 °C, in addition 10 μM ML351 was added for the inhibitor experiment.
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PMC9545474
xenograft models: The compounds were prepared fresh on the days of treatment as described above and administered i. p. to mice on days 0–4 in a volume of 0.1 mL per 10 g of body weight.
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PMC11204465
Figure 6) Three new compounds, including sterigmatocystin (31), 5-methoxysterigmatocystin (32) and O-acetates (33), were isolated from a mutant strain of Aspergillus versicolor .
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PMC11047729
VPA can be used in AML treatment, where it acts as a histone deacetylase inhibitor and triggers cytotoxicity toward tumors in AML blasts .
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PMC9429973
We have published a low incidence of IE caused by viridans streptococci in neutropenic patients.
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PMC11659734
In this aspect, validation and standardisation of NAMs are needed to reach regulatory readiness level and development of OECD Test Guidelines.
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PMC11476106
However, small clusters increased their density with time.
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