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PMC11387401
Overall, we did, however, identify a number of strong HIV-1 protein–non-coding RNA interactions.
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PMC9429973
Methods: Hence, we performed a time series single-cell sequencing experiment on sorted HSPCs (Lin cKit), 3, 24 and 72 hours after injection of mice with the pro-inflammatory cytokine IFNa to investigate the acute inflammation response of bone marrow hematopoietic stem and progenitor cells (HSPCs) in time.
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PMC10812665
For all compounds, the concentration triggering neurite degeneration correlated with the onset of gene expression changes.
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PMC11774747
Each method impacts the final VST product’s characteristics, balancing the trade-offs between efficiency, specificity, and scalability to optimize therapeutic efficacy against viral infections and malignancies.
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PMC11727062
In summary, medicinal monomers derived from hot nature herbs demonstrate potential anti-melanoma activities through diverse mechanisms, including the inhibition of melanoma cell proliferation, the induction of melanoma cell apoptosis, and the modulation of the tumor microenvironment.
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PMC11694625
Compounds 3a–3d are symmetric and the results of H NMR were consistent with their structures.
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PMC7305184
This control allowed us to evaluate if pulse treatment has influenced cells to develop adaptive resistance over time.
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PMC11352666
The interaction between MRX-2843 and navitoclax in A673 cells was synergistic when higher concentrations of both drugs (400 nM MRX-2843 and 1000 nM navitoxlax) were combined (Supplemental Figure S3).
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PMC7504302
Using low-pass whole genome sequencing (LP-WGS) on a set of 21 MPM cases with matched normal samples, Hylebos et al. identified novel copy number gains in the oncogenes such as CD79B (CD79b molecule, chr location: 17q23) and MDM4 (MDM4 regulator of p53, chr location 1q32) .
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PMC10568263
N-Methyl pyrrolidone (C5H9NO) was from Carlo Erba reagents.
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PMC11739484
Despite the reduced proliferation and clonogenic potential, si-MMP7-A375 cells exhibited accelerated wound closure compared to control cells (Fig. 10G,H).
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PMC11755519
Mass spectrometry analysis confirmed that ErbB2, integrin α2, ErbB3, and FAK proteins are downregulated in EVs isolated from CRK-silenced UM-UC-3 cells.
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PMC9454852
After 8 days, colonies were fixed with 3.7% paraformaldehyde (PFA) for 15 min and stained with 0.5% crystal violet for 10 min for colony visualization.
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PMC6650823
According to this computer-based virtual screening, the authors selected 44 (for AmpC) and 549 (for the D4 dopamine receptor) candidate ligands/drugs which were chemically produced and experimentally tested for binding to their molecular targets.
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PMC11699178
Studies indicate that HIF-1α is connected to tumor development by promoting the expression of Vascular endothelial growth factor B (VEGF-B) and angiogenesis .
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PMC11344246
In contrast, the cell lines have adapted to standard media and do not require Wnt supplementation.
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PMC11773391
This result was not consistent with the previous literature .
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PMC11095939
Then, the cells were resuspended in ChIP buffer and the chromatin was sonicated on ice (30 s on/30 s off) to obtain soluble sheared chromatin (average DNA length of 150–450 bp).
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PMC9429973
Thrombin generation and D-dimer were analyzed.
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PMC11711347
Molecular Docking Studies The 3D structure of the Ni(II) complex reveals interactions with the active site residues ARG394, LEU387, ALA350, and PHE404 (Figure 2; Table 1).
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PMC11190538
Molecular weight of C-phycocyanin.
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PMC11469524
This finding is important as it demonstrates the existence of a signaling network core for the activated BCR in BL cells.
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PMC11802929
Created in BioRender.
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PMC9429973
Summary/Conclusion: Our study demonstrates a satisfactory immune response of adult SCD patients, primarily after the second vaccination dose.
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PMC9105697
Every patient-specific breakpoint was covered with a 360 bp stretch of three 120 bp lockdown probes, 180 bp on chromosome X and 180 bp on chromosome 18.
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PMC6901583
Furthermore, this CCL2 upregulation causes recruitment of macrophages into the tumor leading to tumor growth.
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PMC11792090
Twenty-four hours later, the activated T cells were transduced with the CAR lentivirus to generate CAR-T cells.
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PMC11119602
When observed using inverted phase contrast microscopy, the residual cisplatin-resistant cells (HepG2/cr) differed in their morphology and growth features compared to HepG2 parental cells (Figure 1A–C).
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PMC11656048
Among the identified ferroptosis pathways, the xCT/GPX4 axis is the predominant negative regulatory system.
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PMC10850553
The square in the demagnified image corresponds to the area shown in the magnified images.
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PMC10654497
The significance of each gene in the comparison and control groups was evaluated using the t-test function in R software.
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PMC11301242
Genes with names colored red signify higher expression in ecDNA amplification sample, while those colored blue indicate lower expression.
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PMC6461034
The network includes two clusters with highly connected activated kinases, MAPK1/3 and SRC, respectively.
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PMC7215832
At pH 7.4, MTX uptake in CEM/MTX was 93-fold lower than in parental CCRF-CEM cells, but at pH 5.5, this was only 2.2-fold (Table 1).
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PMC11806818
Reprinted with permission from Table 4Single-mode aptamer biosensors based on nanozymes for other protein tumor biomarkers detectionCancer typeBiomarkerAptamerNanozymeSubstrateDetection MethodElectrodeLinear RangeLODSensitivityRecovery(RSD)Assay TimeRef.−HER2HER2Mn3O4Pd@PtHQ/H2O2DPVGE0.1 − 100 ng/mL0.08 ng/mL−−− Ovarian CancerCA125Aptamer 2.26Aptamer 2.43AuDAB//H2O2ALFA−7.5 − 200 U/mL5.21 U/mL−86.5 − 114.8%− CA125CeO2TMB/H2O2Colorimetry−1.0 − 10.0 U/mL0.43 mU/mL−95.4–104.0%(< 6.7%)− HCCGP73GP73RGO-CMCS-Hemin/Pt@PdTMB/H2O2Colorimetry−10.0–110.0 ng/mL4.7 ng/mL−98.2–107.0%(1.90–5.44%)120 min GP73H-rGO-Mn3O4TMB/H2O2SWVSPE0.01–100.0 ng/mL0.0071 ng/mL2.441 µA/µM/cm98.66–121.11%− GPC3GPC3H-R-Pt@PdTMB/H2O2Colorimetry−10–300 ng/mL5.06 ng/mL−105.94–116.33%(0.93– 3.08%)− GPC3H-rGO-PdAgNO3/ H2O2DPVSPE0.01–10.0 µg/mL10.0–100.0 µg/mL3.30 ng/mL1.535 µAµM cm103.78–106.52%(1.89–8.81%)30 min −VEGF165VEGF165(MnCo)Fe2O44-CN/H2O2PECFTO1 × 10−1 × 10 pg/mL0.1 fg/mL−100.9–101.7%(2.12–2.15%)60 min Single-mode aptamer biosensors based on nanozymes for other protein tumor biomarkers detection Mn3O4 Pd@Pt Aptamer 2.26 Aptamer 2.43 95.4–104.0% (< 6.7%) 98.2–107.0% (1.90–5.44%) 105.94–116.33% (0.93– 3.08%) 0.01–10.0 µg/mL 10.0–100.0 µg/mL 103.78–106.52% (1.89–8.81%) 100.9–101.7% (2.12–2.15%) Single-mode sensing strategies are relatively simple, low-cost, and more direct for data collection and analysis of a single signal, which can usually achieve faster response speeds.
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PMC11706491
Overall, our novel cell cycle reporter system provides a powerful tool for studying cell cycle dynamics at the single-cell level.
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PMC8584666
However, treatment with a high dose of reducing reagent causes a reducing environment in the intracellular space.
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PMC7351993
This is the only process that can convert CO2 into organic compounds with high energy content and can, hence, provide a source for sustainable liquid transportation fuel.
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PMC10852540
The value obtained from the control group applied to the vehicle mine was determined as the comparative viability rate based on 100% viability.
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PMC6892818
In parallel, the ‘quality’ of the signal may determine whether CD40L–CD40 interactions are pro-apoptotic; mCD40L causes apoptosis, while soluble agonists are mainly growth-inhibitory.
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PMC9429973
81 patients with acute leukemia in first complete remission were considered to have low-risk disease.
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PMC9429973
Group 2: 34 samples, shelf life from 6 to 10 months.
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PMC10728535
The MeSH terms searched for the current study included “Ovarian neoplasms, Carcinoma/Ovarian Epithelial” and “Drug resistance, Recurrence” and “Cisplatin.”
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PMC10957991
The membranes were washed with 0.1% Tween-PBS and incubated with secondary HRP- conjugated antibody (Anti-Mouse/Anti Rabbit IgG, CST) for 1 h at room temperature, after which the membranes were washed with 0.1% Tween-PBS.
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PMC10376064
The determined absorbance values were plotted against the logarithmic concentrations of DMF, subsequently applying non-linear regression using Prism (v8.4.0, GraphPad Software, San Diego, CA, USA).
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PMC9784246
The molecular docking simulation was performed through flexible ligand-fixed receptor docking using Triangle Matcher placement, forcefield refinement with London dG as scoring, and rescoring algorithm.
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PMC10849234
However, no study has directly compared the two lines as models for degranulation including their release of different types of mobilizable organelles.
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PMC9429973
Only 3% of treatment-emergent adverse events (AEs) of interest occurred since the primary report.
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PMC9429973
At time of data lock, 831 cases had information on initial therapy.
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PMC11699042
i Left, collective variability in drug response of all A-673, HeLa, and MCF-7 cell line strains depicted as the standard error of ED, each compound is shown as a black circle, one-sided Wilcoxon signed-rank test.
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PMC11785489
For 37 twin members (16%), we observed clonal expansion within a single transcriptional cluster (resolution 0.5, Figure 1A), and we used this cluster to annotate the TCR twin member.
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PMC11752740
The significant reduction in MDR1 and MRP1 gene expression indicates a marked decrease in the cells’ ability to expel drugs, which could potentially lower chemoresistance and improve treatment efficacy .
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PMC11307990
In this study, we constructed DNA nanotapes based on 6HB-DON nanostructures for SUN adsorption and delivery, achieving long retention and RTK inhibition on the cell membrane, thereby increasing drug efficacy on renal clear carcinoma cells.
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PMC10674574
Therefore, the selection of the Caco-2 cell line for permeability studies depends on the researcher’s preference.
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PMC9429973
SAEs (1 pt each) during the 4-wk follow-up were Gr3 acute chest syndrome + Gr3 VOC, Gr3 non-cardiac chest pain and Gr3 syncope (all unrelated).
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PMC7039683
These included two SNPs with p-values reaching formal genome-wide significance (5E-8): rs11170344, the lead SNP in our re-analysis; and rs3741442, which was identified in a recent GWAS in a Chinese orofacial cleft population. (
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PMC9429973
Results: Only 4 (10%) out of 42 employees had a positive PCR test result while having COVID-19 symptoms, the rest - during routine screening.
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PMC10965315
The LD50 (median lethal dose) is a measure of the toxicity of a substance and is defined as the dose required to cause the death of 50% of the test population (usually laboratory animals) within a specified time period.
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PMC11615101
Among those many key enzymes, Fructose-bisphosphate aldolase A, ATP synthase subunit beta, L-lactate dehydrogenase A, L-lactate dehydrogenase, and Pyruvate kinase were found to be associated with glucose metabolism.53 The GO and KEGG in-silico pathway enrichment was performed with identified interacted proteins.
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PMC11754784
Through kinetic analysis, we improve the computing speed and signal intensity of DNP by optimizing the rate-limiting step.
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PMC11779960
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC11700247
This enhancement is tied to the restructuring and heightened activation of infiltrating T cells.
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PMC10006224
In cells with full NIPBL but reduced CTCF levels, STAG1 is upregulated (Supplementary Fig. 3b) and cohesin-STAG1 preferentially occupies remaining CTCF-bound positions (Supplementary Fig. 5b).
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PMC11802929
These were calculated by Scanpy.tl.score to represent the average expression of the given set of genes.
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PMC7039683
While some combinations were present more frequently than others, genes associated with zGPAEs with the most frequent three-motif-combination and those associated with the least frequent three-motif combination both were highly enriched for with the GO term ‘EVL (6–8 hr)'.
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PMC11699465
Relative CD274 mRNA level in TMEM199 knock out cells with different oligos (∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001).
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PMC10747160
Regardless, the presence of both the M and E proteins on the surface of the coronaviral virion could provide a significant number of accessible high-mannose glycans for virus recognition, capture, and trans-infection .
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PMC11407042
Note: Wipe the vial with 70% EtOH before opening it to prevent contamination.
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PMC10452486
The structure of HLA-II illustrates that a dimerization of two HCs can provide structural stability and a stable site for binding.
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PMC11228511
In blebs with very low levels of lamin B1, the progerin meshwork was irregular with large openings (Fig. 5C).
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PMC10969097
Treatment began with stem cell mobilising chemotherapy and continued until the end of aplasia after high-dose chemotherapy, totalling around seven weeks.
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PMC9429973
Understanding the mechanism of action of KER-050 in the context of PLT production is important to ascertain its potential clinical benefits.
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PMC11656657
To prepare CM2, freshly isolated PBMC (4 × 10/cm) were cultures for three days in the OS conditioned medium (CM1).
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PMC11787355
In addition, it contributes to angiogenesis and tumor radioresistance.
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PMC11747885
The cell viability was normalized to the DMSO controls with or without menadione.
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PMC11412752
Although the cGAS-STING pathway has been extensively studied for its role in promoting the antiviral innate immune response, its function in bacterial infections remains debatable.
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PMC11519583
All mice were maintained under a 12-/12-h light/dark cycle.
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PMC11739504
Thus, the results indicate that Kat2b is required for the appropriate initiation of ciliary formation.
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PMC11371627
Routine myositis screening revealed positive anti-PM-Scl100 antibodies which can be associated with overlapping polymyositis, scleroderma (Reichlin et al., 1984; Mahler M et al., 2005) or other autoimmune diseases (Lackner et al., 2020) and had triggered muscle biopsy for exclusion of myositis prior to the genetic diagnostic work-up.
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PMC10858941
On the left, confocal microscopy images of control devices and NNC treatment.
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PMC11499381
Each point is an independent experiment; lines indicate mean ± s.e.m. *
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PMC9429973
Results: From January 2000 to December 2020, 284 children were treated with the EORTC 58951 protocol.
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PMC11549612
By regulating Fe-S cluster assembly, BOLA proteins ensure proper mitochondrial function and energy production.
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PMC9429973
The expression level of RRAD has significant diagnostic value for the diagnosis of MM.4.
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PMC11755467
Moreover, the relative expression changes of hsa-miR-132-3p, but no other exemplary miRNA such as hsa-miR-223 or hsa-miR-23a mirror the anti-HIV-1 effect of Enoxacin (neither nalidixic acid or DMSO treatment) at the time points (day 4 and 7 p.i.)
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PMC9429973
Results: In the adult cohort, for every 10 mmHg increase in Point of Sickling (PoS, the pO2 tension where RBCs start to sickle, reflecting sickling tendency) the likelihood of >1 acute complication increased; the adjusted odds ratio (aOR) was 3.00 (p=0.015).
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PMC10729469
Briefly, Tresp cells were labeling with carboxyfluorescein succinimidyl ester (CFSE) (Cat.
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PMC11361748
This property represents a short-lived, transient adaptation that entails the K17-dependent regulation of PKCα activation and release of classic neutrophil chemokines.
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PMC11286266
This suggests a special role of CRT in the regulation of ATF6α, at least in CHO-K1 cells.
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PMC9964654
To sum up, BCMs prepared with Me-PEG-b-PCL chains, loaded and non-loaded with gold bisdithiolate complexes ([Au(cdc)2]), were successfully synthesized.
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PMC9429973
Cytogenetics was diploid in 77 pts (64%), abnormal in 34 (28%), and unavailable in 9 pts (7.5%).
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PMC11743975
We found that cells treated with Opto-MitoA and niclosamide had a significant decrease in ROS production compared to cells treated with niclosamide after blue light illumination, indicating that the drug has the potential to rescue mitochondrial function (Supplementary Figure S4).
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PMC11794568
Fig. 5Predicted pathways related to CRIP1 influence on mitochondrial biogenesis in melanoma.
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PMC10605143
BT-549 cells (2 × 10/well) were seeded in 96-well plates.
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PMC9429973
All patients have been examined with routine laboratory tests, immunochemical analysis of serum proteins and urine, cytologic examination of bone marrow smears, histologic and immunohistochemical examinations of bone marrow trephines and bone plasmacytomas biopsy specimens, instrumental examinations (CT, MRI).
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PMC10728200
A GIST-T1 cells were subcutaneously transplanted into the dorsolateral side of nude mice.
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PMC9429973
Image: Summary/Conclusion: RI-CHOP could be one of the promising choice for DE-DLBCL patients with fair physical condition,and could achieve high ORR and CRR.
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PMC11127909
We found that overexpression of EFHD1 in 143B and 143BR cells significantly reduced the apoptosis rate compared with that of the vector group.
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PMC11766332
A computational pathway enrichment analysis was carried out to study the potential biological involvement of ASD-miRNAs on glycosylation processes using DIANA-miRPath v3.0 web server based on KEGG (Kyoto Encyclopedia of Genes and Genomes) gene annotation database.
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PMC9275501
First, the optimal ratio of natural active ingredients and chemotherapy drugs is the primary issue.
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