Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9386809
224 mg (86% yield); white solid mp 202–204 °C; H NMR (400 MHz, DMSO-d6): δ 1.11 (t, 3H, J = 7.12 Hz, CH3), 2.27 (s, 3H, CH3), 4.00 (q, 2H, J = 7.0 Hz, CH2), 5.17 (d, 1H, J = 3.3 Hz, CH), 7.23–7.35 (m, 5H, Ar), 7.75 (br s, 1H, NH), 9.22 (s, 1H, NH).
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PMC11552389
It has been shown to enhance the activity of key signaling pathways involved in melanoma progression.
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PMC11612794
DNA was stained with DAPI.
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PMC11119602
The colony-like phenotype was formed for those cells that survived cisplatin treatment and their clonal progeny then grew in colony form.
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PMC11657695
Using the CCLE database, the expression of all genes encoding Kv1-type potassium channels was assessed in 66 tumour-derived cell lines (Fig. 2C and Figures S3A-S3G).
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PMC7823217
These techniques facilitate the development of constructs with varying spatial geometries with the added advantage of reproducibility.
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PMC11726848
Further study of the molecular mechanisms of cell response to different types of irradiations will potentially reveal ways to control the production of damage-associated molecular patterns and the activation of the immune system.
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PMC11055510
The number of clones in the mimics+ov-circMAN1A2 group was significantly higher than that in the mimics+ov-nc group (Fig. 4C).
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PMC11676674
Finally, a benzofuran (Icariside) and two glycolipids (mono- and di-galactosyldiacylglycerol, MGMG and DGMG) were also observed in the full spectra, although they were present in lower amounts compared to the most abundant classes of metabolites.
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PMC11317131
Data are shown as mean + s.d.
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PMC9429973
Median age was 73 years (61-91), 37.6% had secondary/therapy related AML, 56.3% received prior venetoclax/HMA and 18.1% had relapse after prior allogeneic HSCT.
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PMC9792775
Combined treatment index (Q) = Eab/[(Ea + Eb)–Ea × Eb], where Ea is the IR of tumor cells treated with LFU, Eb is the IR of tumor cells treated with PTX, and Eab is the IR of tumor cells treated with LFU plus PTX.
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PMC11461874
In fact, it has been shown that TRAF7 catalyzes different Lys-type ubiquitinations.
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PMC11607764
GAPDH was used for normalization (*P < 0.05, ****P < 0.0001).
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PMC11638255
In parallel, another study reported that T cell infiltration was accompanied by NK cell infiltration, suggesting a coordinated recruitment, and was associated with a favorable prognosis.
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PMC11687167
CHRD: most PCSK9 mutations occur in the M1 and M3 modules, while fewer PCSK9 genetic variants are observed in the hinge region and M2 module, but with greater structural flexibility PCSK9 regulates cholesterol metabolism by binding to LDLR through both extracellular and intracellular pathways.
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PMC11745600
In addition, NOD-scid mice exhibit a pronounced prevalence of thymic lymphoma, thereby complicating long-term transplantation experiments.
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PMC11206502
The primer sequences are given in Table 1.
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PMC11730311
Experiments were performed in singlicates.
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PMC11790971
The results from passage 0, passage 1, and passage 2 are shown in (a, d), (b, e), and (c, f), respectively.
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PMC10778532
In absence of expression of ZHX2, VHL-C162F cells significantly lose their healing ability.
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PMC2193049
Infected cells expressing the full length protein MAGE-31–314 were not efficiently recognized by MAGE-3271–279–specific CTL.
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PMC11686380
We first transiently expressed myc-tagged GAP43-E111K in COS7 cells and found that its expression level was similar to that of the wild type (WT) protein as expected (Fig. 2A).
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PMC6461034
Immediately sonicate in three cycles, e.g., 15 s on/1 min off at maximum amplitude when using a Branson high‐intensity cuphorn sonicator.
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PMC11476106
It contains multiple binding sites to cells, including integrins and other membrane receptors, such as uPAR and PAI-1 , and to ECM components (fibers and proteoglycans), creating temporary connections and facilitating cell adhesion and migration .
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PMC11694625
The liver and kidneys are the most critical detoxification and excretion organs, and most anti-cancer drugs produce various toxic effects, such as nephrotoxicity and hepatotoxicity.
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PMC11453018
Blocking was performed with 3% BSA for 1 h at room temperature.
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PMC11743316
Additionally, the administration of nanoparticles led to a decrease in systemic and nephrotoxicity, as seen by a reduction in the kidney's biodistribution of platinum.
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PMC11790599
Specifically, tyrosine kinase receptors and their ligands, including EGFR and its ligands epidermal growth factor (EGF), epiregulin (EPGN), amphiregulin (AREG), and heparin-binding EGF-like growth factor (HBEGF) were significantly induced by TSL in SK-BR-3 and ZR-75-1 cells (Figure 2D).
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PMC9429973
On the one hand, this will allow optimizing the antithrombotic prophylaxis regimen, on the other hand, it may be an additional indicator in determining the risk group.
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PMC11623887
They also found that FAM122A directly interacts with the C-terminal zinc finger domain of GATA1, a critical regulator of erythropoiesis, leading to a reduction in GATA1’s binding to its target gene promoters and a subsequent decrease in its transcriptional activity.
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PMC9429973
ASXL1 (p=0.002), EZH2 (p=0.003), and SETBP1 (p=0.019) mutations were more common among pts who developed hyperferritinemia.
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PMC10940855
All reactions were normalized using GAPDH.
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PMC8662250
Also, patients expressing high ACE‐2 density seem to be more susceptible to SARS‐CoV‐2 and to show worse clinical outcomes.
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PMC11409031
Furthermore, a clinical prognosis model was developed utilizing machine learning algorithms with data from the TCGA dataset and the GEO dataset (GSE140082).
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PMC11589157
Pseudomolecule No.Hap1Hap2Pseudomolecule No.Hap1Hap2Length (Mb)Length (Mb)Length (Mb)Length (Mb)Chr_01126.64119.14Chr_15113.70111.53Chr_02166.41166.20Chr_16107.81103.12Chr_03168.06159.32Chr_17103.74104.88Chr_04159.57158.65Chr_18104.97104.67Chr_05160.15156.86Chr_1996.8293.91Chr_06131.25126.96Chr_2088.2089.33Chr_07124.25122.55Chr_2187.7687.84Chr_08123.77121.18Chr_22140.79138.65Chr_09131.09131.91Chr_2342.5143.34Chr_10111.53112.79Chr_2437.2438.60Chr_11124.82124.40Chr_2532.4640.76Chr_12112.86112.83Chr_Y/X16.06141.9Chr_13111.60112.16Unassigned97.5430.86Chr_14105.33105.33Fig.
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PMC9429973
This examination revealed enrichment of microtubule bundles inside the nuclear indentations.
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PMC5673955
In control CD4 T cells reduction of telomere length was also observed, but it was not as rapid as in RrA‐treated cells.
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PMC11707577
and HSA‐TM were incubated, at a final concentration of 1 nm, with 500000 adherent A431 cells for 45 min.
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PMC11657744
Cells were transfected with Cep89 or Fbf1-specific siRNAs, subjected to serum starvation to induce ciliogenesis, and subsequently treated with serum for the indicated times to promote ciliary disassembly.
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PMC10698968
For the selective silver-staining of nucleoli, a confluent T150 flask of cells was trypsinized, pelleted, and then fixed overnight at 4°C in 10% neutral buffered formalin (Diapath S.p.
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PMC11767793
Both preparations were extensively characterized in terms of their size/size distribution, zeta potential, and mass ratio of PEI/Au, and their colloidal stability was tested in various physiological media, as well as a range of suspension temperatures and acidities.
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PMC11519583
To examine the role of Ror2 in IMAT accumulation in vivo, we injected the tibialis anterior (TA) muscles with Ctx or glycerol, which induces muscular injury without and with IMAT accumulation, respectively, after tamoxifen injection (Fig. 2d).
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PMC11739504
The immunoprecipitation results revealed that both Kat2b and α-tubulin existed in the cell lysate and that Kat2b interacted with α-tubulin endogenously (Fig. 2d).
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PMC10847511
Platinum agents (shown in the top panel) and PARP inhibitors (shown in the second panel) exhibiting a trend for positive difference (unadjusted P < 0.05) between the two groups are highlighted in red font, and those remained statistically significant (adjusted P < 0.05) after multiple testing correction are indicated in bold style.
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PMC11322866
Statistical significance was set at P<0.05.
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PMC9895440
The co-expression of PD-1, TIM3, and LAG3 and the impairment in degranulation correlated with the peptide concentration used for the repetitive stimulation (Supplementary Fig. 1d).
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PMC10387886
Of these, DUSPs are recognized as key regulators of MAPK proteins.
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PMC11612315
Unlike its influence on CAP-induced TRPV1 activation, exendin 9–39 did not block or potentiate proton-induced channel activity, even at a concentration approximately 30 times greater than its IC50 value for inhibiting CAP-induced TRPV1 activity, indicating mode-specific inhibition of exendin 9–39.
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PMC11476222
The efficiency of the method was evaluated based on its ability to resolve GD1 isomers (GD1a and GD1b), which served as a key analytical metric.
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PMC6222635
In this study, we thoroughly investigated the anti-tumor mechanism of the degraded polysaccharide fractions.
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PMC11574029
Cells on the upper side of the membrane were scraped off with a cotton swab, and the membrane was stained with crystal violet for about 30 min at room temperature.
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PMC11626627
For luciferase assays, cells were seeded in a 24-well plate and co-transfected with Lipofectamine 2000 (Invitrogen), the dual-luciferase reporter gene (wt or mut), and either the miR-204–3p mimic or NC in 786-O cells, following the manufacturer's instructions.
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PMC11696576
For CTG assays, luminescence was determined 10 min after reagent addition.
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PMC7504302
As a consequence, novel mechanisms such as chromosome rearrangements, gene fusions, and splicing factor alterations have been identified as inactivation mechanisms for recurrently mutated genes .
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PMC11754291
A combination of both effects is also possible, suggesting the need for further studies to elucidate this visible light-related stimulation in melanogenesis.
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PMC10237474
Over the past few decades, antibody and protein-based therapeutics have grown to represent a significant portion of the best-selling drugs in the pharmaceutical market .
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PMC11367146
After 40 ns, the fluctuation of the RMSD plot indicates that there must have been protein folding that has resulted in conformational and structural changes within the complex (Fig. 5C).Fig.
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PMC11534377
The resulting datasets were exported to Excel (Microsoft) for subsequent analysis.
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PMC3164356
Thus, we anticipate that further analyses and sequencing studies with other clonal populations and cell lines will be required.
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PMC11732635
EBV not only infects B cells but also T and NK cells.
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PMC11641630
After reaching a confluence monolayer, cells were infected at MOI 10 with BCG or M. brumae or left untreated.
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PMC11092382
Caprifoliaceae]), Pu Gong Ying (Taraxaci Herba—Taraxacum mongolicum Hand.
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PMC10940855
A and B, Mean fold change of CD138 cells in cocultures of U266 (A) and NCI-H929 (B) multiple myeloma (MM) cells with HAECs for 5 days.
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PMC11777207
In the absence of PD-L1, CD80 forms homodimers, which bind to CTLA4 in trans, leading to removal of CD80 via trans-endocytosis (6, 9, 10).
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PMC9599726
Supernatants were removed and caspase-3 active antibody was added to each tube at a concentration of 1/15 (diluted in BD Perm/Wash buffer 1x) for an incubation time of 1 h at room temperature.
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PMC10203589
Taken together, FGF18 plays an important role in promoting migration, proliferation, invasion, apoptosis and angiogenesis in HCC tissues and cells.
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PMC10452486
However, there is no report so far to document that the HLA variants present antigens.
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PMC9429973
Two of the three NGS/LC-MS cases were from a patient with kappa light chain MM.
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PMC11361748
These findings uncover a novel, keratin-dependent mechanism that amplifies neutrophil recruitment in skin under stress, with direct implications for inflammatory skin disorders.
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PMC9429973
The most common reason for discontinuation was adverse events (AEs) unrelated to clinical progression (35.8%) for C+R and radiologic progression (49.7%) for P+R. Similar to the initial disclosure, C+R reduced the risk of progression or death vs P+R by 47%, with median PFS of 22.3 mo (95% confidence interval [CI] 19.4, 30.7) for C+R and 13.8 mo (10.8, 17.5) for P+R (HR 0.53 [95% CI 0.41, 0.70]; p=0.000001).
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PMC11711871
These bioactive lipids, also called oxylipins, are potent endogenous mediators involved in the regulation of various biological processes.
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PMC11626627
Together, the results of Fig. 1 and Supplementary Fig. 1 indicate that TWIST1 plays a key role in the regulation of EMT in ccRCC as a downstream gene of the ERβ/circATP2B1/miR-204–3p axis.
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PMC9878562
Cumulative data of three independent experiments performed in triplicates (means ± SD, Turkey’s multiple comparisons test, ONE WAY ANOVA, ****p ≤ 0.0001). (
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PMC11635519
HEK293T cells stably expressing CCR2 and the reporter Gaussia Luciferase construct were trypsinized from subconfluent culture and seeded in a 96-well plate at a density of 5000 cells per well.
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PMC11359735
For experiments with P. falciparum, a 10% SDS-polyacrylamide gel was used.
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PMC11723947
3HP1α translates Treg-dependent suppressive signals at the chromatin level.a Differentially-expressed genes (DEG) between WT and HP1α-deficient T cells.
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PMC11173119
For chromosome banding, samples were stained with DAPI (4,6-diamino-2-phenylindole) solution (200 ng/mL, in 2xSSC) for 5 min, then rinsed in 2xSSC buffer and water.
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PMC8193046
Unfortunately, only a small fraction of the 49 existing ABC transporters can be considered as well-studied, in particular ABCB1 , , , , , , , ABCB11 , , , ABCC1 , , , , , , , and ABCG2 , , , .
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PMC7868205
Therefore, based on the IC50 value, this study determines that AgNPs synthesized using R. apiculata were more toxic towards HEK-293 cells in comparison to HeLa cells.
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PMC6102174
The 90% EtOH extract of this plant were first revealed with anti-HBV potency inhibiting HBsAg and HBeAg secretions with IC50 values of 0.44 and 0.92 mg/mL. Following investigation gave rise to two new alkaloids, hypserpanines A and B (138, 148) and 11 known compounds, phenolbetain (139), acutumine (140), acutumidine (141), dechloroacutumine (142), dauricumine (143), dauricumidine (144), pronuciferine (145), glaziovine (146), S-reticuline (147), magnoflorine (149) and laurifoline (150).
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PMC5941560
This deficiency causes Jurkat to express the Tn antigen, which is associated with cancer and other pathologies.
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PMC8524093
In some individuals, calcium deficiency might also happen, which could be related with the cases in which bone absorption occurs (Thiberville et al., 2013; Bedoui et al., 2018).
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PMC7570809
The ability to inhibit the generation of new capillary blood vessels by the RGDechi15D peptide was examined by an angiogenesis in vitro assay.
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PMC11758416
Note: It is important to regularly check on the cells and repeat the above steps as needed to keep the cells from becoming too confluent.
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PMC11392912
Thus, taken together, we presumed that cartilage degradation is possibly regulated by Clo-miR-14 due to its sequence similarity with has-miR-4693 and its stability in human plasma, suggesting a possible contribution to the regulation of pathways that culminate in reduced inflammation.
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PMC9429973
Accumulation of CD3+TCRab+CD4-CD8- double negative T-cells (DNT) in peripheral blood and tissue samples is a hallmark of the disease.
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PMC10723784
Furthermore, cannabinoids when used at a sublethal concentration in combination with carboplatin induced a selective synergistic effect in both carcinoma cell lines compared to non‐carcinoma cells.
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PMC11361748
Likewise, the role of additional cellular effectors of innate immune responses in skin, such as macrophages, Langerhans cells, and dendritic epidermal T-cells in modulating TAR needs be examined.
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PMC11705862
The presence of NFT and LB was scored according to Braak stages I-VI and the Aβ plaques were scored into O, A, B, C, where O = zero, A = some, B = moderate and C = many .
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PMC11343332
Aim: This study aimed to investigate the pro-apoptotic and anti-migrative effects of pycnogenol in a breast cancer cell line.
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PMC10812665
We explored how such a similarity-based target prediction may be refined.
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PMC11612508
The VASCO™ nanoparticle size analyzer, manufactured in France, is a specialized instrument designed to characterize nanoparticle suspensions and colloids, utilizing the principles of DLS.
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PMC9370419
Twenty-four hours, the medium was replaced with drug-diluted DMEM at final concentrations of 35 µM, 55 µM, and 75 µM for two days.
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PMC10522430
Varied concentrations of GACP extract (200 µg/mL and 400 µg/mL) were introduced, employing DMSO as a cosolvent.
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PMC9429973
Therefore, we started consolidation (total ARA-C 8g/m) + GO as inpatient.
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PMC9895440
On the day of the assay, cells were loaded for 45 min at 37 °C in a solution consisting of phenol free RPMI (base medium, supplemented with 1% PenStrep, 1 mM Pyruvate, 1% NEAA, 10 mM HEPES) with 0.04% PluronicF127 (Thermo Fisher) and 2 μM Calbryte520-AM (AAT Bioquest).
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PMC6892818
Bars show mean fold change of 4–5 technical replicates ± SEM.
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PMC11377827
P ≤ 0.0001, unpaired t-test. (
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PMC11769516
Mycotoxins reduce energy availability for neurons and impair brain function.
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