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PMC9727330
Relative LDH production from treated cells compared to Triton 100-X treated cells and untreated cells (N.T.).
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PMC9822769
OCTs mediate the electrogenic and sodium-independent translocation of organic cations across the membrane in either direction, being the driving force of the electrochemical gradient and the inside-negative membrane potential .
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PMC11727306
Instead of decreasing the activity of cell ribosomal machinery and inhibiting protein synthesis as abrin did in Vero cells, the toxin does the exact opposite in the immune cells tested.
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PMC10291556
Data represents mean ± SD, n = 8; *p < 0.05, **p < 0.01, ***p < 0.001.
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PMC10587429
In addition, this model showed correlation of the tested immunotherapy regimen to its performance in the clinic.
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PMC11473750
predicated molecular weights of ectopically overexpressed Myc-RNF121 full-length and 4 Mutants with Myc-tag.
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PMC10582049
GO enrichment analysis showed that ADH1B CAFs participate in matrix deposition as well, but these CAFs display higher expression of DCN, LAMA2, and ELN and lower expression of different types of collagens in comparison to FAPACTA2 CAFs.
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PMC11656657
Notably, as seen for the RMS model, we observed a significant reduction of the CD4 + CAR + T-cells subset and an enrichment of CD8 + CAR + T-cells (Supplemental Fig. 11D–E).
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PMC10652261
Caspase 3 is a key protease that is activated during the early stages of apoptosis and, like other members of the caspase family, is synthesized as an inactive proenzyme that is processed in cells undergoing apoptosis by self-proteolysis or cleavage by another protease.
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PMC11470381
Duration and frequency of imaging for a time-lapse video depends on the nature of the events under examination.
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PMC11525028
The cell lines used in this study, including hFOB 1.19, G-292, U2OS, Zos, Zos-M, SaOS, HOS, 143B, SJSA-1 and HEK293T, were obtained from the First Affiliated Hospital of Sun Yat-sen University.
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PMC11525028
Percentage misincorporation was calculated.
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PMC11627060
This study aims to improve the anticancer efficacy of TQ-BSA NPs against the A549 lung cancer cell line.
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PMC11742290
Future studies need to define a Standard Operating Procedures for both mRNA and protein expression.
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PMC11206502
It was previously explained that excessive autophagy can serve as a mechanism of cell death by promoting apoptosis or autophagy cell death due to excessive cell degradation .
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PMC11706297
Lung cancer, which is generally divided into two main clinical types, small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC), is one of the most common and deadly cancers in the world.
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PMC9621239
The cells were centrifuged and resuspended in 8 mL of 3:1 methanol:acetic acid solution.
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PMC11513571
We also investigated the role of TSLP in B cell survival and antibody production.
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PMC10976516
Once this process is started, it must be synchronized with the OV life cycle inside the specific carrier cell type employed for delivery.
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PMC10530622
In order to assess the impact of AhR activation on CaOx nephrocalcinosis in normoxic conditions, Yang’s group (2020) used an animal model of mice intraperitoneally injected with glyoxylate to establish CaOx nephrocalcinosis, with or without a treatment with the AhR activator 6-formylindolo(3,2-b) carbazole (FICZ).
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PMC11533140
As shown in Table 3, 17e effectively inhibited proliferation in all cell lines as efficiently as BKM-120, while 17o and 17p had a slightly weaker activity than BKM-120, and 17m had weaker antiproliferative activity against A2780 and MCF7 and no inhibitory effects in U87MG and DU145 cells.
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PMC9429973
When looking at the general results, a statistically significant relationship was not found between the presence or absence of CD117 expression and OS (p: 0.853).
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PMC9429973
First line therapy was most commonly immune-chemotherapy, the most used regimens were R-CHOP (59.2%) and bendamustine-rituximab (24.8%).
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PMC9429973
Of evaluable pts at 3 mo post infusion, 43% (3/7) had minimal residual disease (MRD) at <10 sensitivity[JC(1], while 33% (2/6) were MRD negative at <10 by next-generation sequencing.
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PMC10421378
Effective adhesion allows probiotic cells to establish a foothold in the gastrointestinal tract, which is essential for exerting their beneficial effects .
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PMC9429973
All of them could undergo a second HSCT.
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PMC11185260
Gray box indicates the treatment period. *
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PMC11352666
Proteins were resolved on Tris-Glycine SDS-PAGE gels (Invitrogen, Thermo Fisher Scientific, Waltham, MA, USA) and transferred to nitrocellulose membranes.
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PMC9100622
It is interesting to mention that GGpp is generally more efficient than Fpp in rescuing the statin effect.
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PMC3681794
Drug-induced apoptosis was reduced in HOS and U2OS cells exposed to cisplatin, doxorubicin and etoposide and in 791T cells exposed to cisplatin and doxorubicin, suggesting reduced apoptosis as the underlying mechanism for hypoxia-induced drug resistance.
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PMC11628904
Treatment with saline showed promise when used as a washing agent in a small trial of paediatric burn patients.
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PMC11310713
Briefly, GTBs were transferred in a 6-well plate and then incubated with a solution of Calcein AM and ethidium homodimer-1 (LIVE/DEAD kit, Invitrogen) for 30 min in darkness.
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PMC4270159
The ηP was calculated using the formula on the spreadsheet accessed from Lakens and colleagues (Lakens, 2013).A204VarianceF (2, 6)ηPEffect size fPowerTotal sample size across all groups2%7273.61320.99958849.2563199.99%615%129.30870.9773266.56531699.99%628%37.11030.9252063.51710998.53%640%18.1840.8583842.46198185.32%6 These power calculations were performed with G*Power software, version 3.1.7 (Faul et al., 2007).
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PMC7039683
Left panels are stack views of the embryo, and right panels are surface plot for the embryos indicating most GFP signal is from the surface (periderm) of the embryos.
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PMC11116779
The autocorrelation functions were fitted by applying the Kalliope software (Anton Paar, Graz, Austria).
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PMC11049294
The limitations of the assay are that the sample preparation method is time consuming and laboratory intensive, and the assay can only measure an average enzymatic activity.
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PMC9429973
Methods: A total of 398 alloHCT recipients [median age: 43(17-71) years; male/female: 243/155] were included in this retrospective study.
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PMC9429973
The frequency of polymorphic alleles corresponded to 15.85% for the A1298C polymorphism and 4.87% for the C677T polymorphism.
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PMC11490153
+ low sensitivity (1–2), ++ mild sensitivity (2–3), +++ high sensitivity (3–6), ++++ indicates very high sensitivity (6< ) Table 5qPCR analysis of Bax and Bcl-2 expression in A-375 cells under normoxic and hypoxic conditionsSamplesBaxBcl-2Bax/Bcl-2SusceptibilityAlgNPs in normoxic1.030.991.03-AlgNPs in hypoxic1.070.961.11-C. citratus-AlgNP in normoxic1.031.450.71-C. citratus-AlgNP in hypoxic2.710.328.46++++citral-AlgNP in normoxic0.950.980.96-citral-AlgNP in hypoxic2.890.348.5++++C. citratus EO in normoxic1.041.130.92-C. citratus EO in hypoxic2.20.822.68++citral in normoxic1.230.861.43+citral in hypoxic2.060.633.26+++A Bax/Bcl-2 ratio < 1.00 indicates cancer-resistant cells, and a Bax/Bcl-2 > 1.00 indicates cancer-sensitive cells.
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PMC9429973
Recent studies demonstrated that, in unselected bone marrow (BM) samples, allele specific polymerase chain reaction (AS-qPCR) was superior in detecting CXCR4 compared to next generation sequencing, and digital PCR (dPCR) was more sensitive than AS-qPCR for MYD88 detection, highlighting the lack of a gold standard molecular method in WM diagnostics.
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PMC10040136
Immunofluorescence analyses were carried out on paraffin-embedded sections of surgical excision samples obtained from Nanjing Biobank.
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PMC11538390
Later blocking was done for an hour at RT on a rocker with a blocking buffer consisting of 5% goat serum (VWR, Catalog no. 101098-382), 3% BSA (VWR, Catalog no. 9048-46-8), and 0.1% Triton X-100.
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PMC7039683
Bar chart for the number of GPAEs with different two-motif combination. (
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PMC11394730
Therefore, in a manner linked to increased ROS and the consequent activation of the JNK pathway, necroptosis-related proteins such as receptor-interacting protein kinase-1 (RIP1) and mixed lineage kinase domain-like pseudo kinase (MLKL) were dramatically raised following emodin therapy .
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PMC11615828
The quantified swimming speed of wild‐type (black curve) and pHSP16/2::mCh‐CIBN‐Rab3‐SL2‐EMTB‐RFPnano‐Cry2 (green curve) transgenic worms is shown.
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PMC6461034
To identify phosphopeptides that are derived from a kinase activation segment, we use the Phomics toolbox (http://phomics.jensenlab.org; Munk et al, 2016).
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PMC11543885
True Positive Rate (TPR): Calculate the TPR, defined as the fraction of experimentally validated NLRP3-interacting proteins identified in the BioGRID or literature that are detected in your dataset.c.
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PMC11367146
From this study, it was observed that the induction of IL-1β in the SW982 cells increased IL-6, IL8, PGE2 and TNF-α levels significantly (p < 0.05) to 92.29 % (13.07 fold), 89.27 % (9.32 fold), 86.43 % (7.36 fold) and 97.75 % (44.48 fold) respectively, as compared with the untreated group.
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PMC7171147
On the other hand, FASN expression was reduced by COL11A1 knockdown in A2780cis cells (Fig. 4A).
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PMC9429973
These pts were treated with ARI0002h, 30 in the setting of the CARTBCMA-HCB-01 clinical trial (NCT04309981) and 3 as compassionate use.
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PMC9275501
At present, multifunctional mesoporous silica nanoparticles, PLGA nanoparticles, bovine serum albumin-coated superparamagnetic iron oxide nanoparticles, liposomes, and carrier-free NDCDS help to control proportional release.
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PMC9429973
Of the 904 evaluable subjects, 293 had MBL and 611 had CLL.
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PMC11394386
Moreover, an in silico meta-analysis indicated reduced PTEN expression levels, which were correlated with elevated expression of DNMT1, DNMT3A, and DNMT3B (Supplementary Figure S3C,D).
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PMC9100622
ChIP-seq were normalized according to the input DNA sample.
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PMC9545714
Upregulated ALOX 5 protein acts upon arachidonic acid to produce 5‐hydroperoxyeicosatetraenoic acid, which can then be converted to 5‐hydroxyeicosatetraenoic (5‐HETE) acid or to leukotriene A4 (LTA4).
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PMC7305184
150 µl of growth medium was added to obtain a high-enough volume for measurement.
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PMC3164356
Each chromosome preparation was amplified, barcoded and sequenced on an Illumina HiSeq(2000) (2 × 100 bp reads).
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PMC7570809
Different ongoing studies have evidenced that αvβ5 integrin regulates not only physiological processes but also a wide array of pathological events, suggesting the receptor as a valuable biomarker to specifically target for therapeutic/diagnostic purposes.
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PMC11628904
Methods used for quantification of imaging data are detailed within the appropriate section above.
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PMC2614416
DB-Resources of Mapping, for HepG2 (Panel A), and Normal Human Liver (Panel B), showing the databases where mapping found the Ontologies shown in Additional Files 4 and 5, respectively.
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PMC6889484
We verified that endogenous A3G and A3F expression in CD4 T cell lines 174XCEM (hereinafter referred to as CEM) and PM1 was similar to that in H9 T cells (Figure 2A); A3G and A3F expression in H9 cells was previously determined to be comparable to that in primary CD4 T cells.46, 47, 48 The CEM cells can be infected with CXCR4-tropic HIV-1 virions, while the PM1 cells can be infected with CXCR4-tropic as well as CCR5-tropic virions.
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PMC11544771
Additionally, the combined treatment greatly reduced the protein level of the anti-apoptotic protein survivin in both A549 and A427 cell lines (Figure 6C,D and Figure S4C,D).
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PMC11632064
Before experiments, compound stocks were further diluted in DMSO to obtain a final DMSO concentration of 0.1% (vol/vol) in culture media.
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PMC11629192
One month after the fourth OFA dose, a fifth dose was administered, resulting in mRS score reduction to 3 and CASE score reduction to 10, with a significant reduction in the percentage of CD19 B cells in peripheral blood lymphocytes.
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PMC11279397
Furthermore, osthol alone demonstrated antiviral activity against Porcine circovirus type 2 (PCV2), while its combination with Matrine resulted in better anti-PCV2 effects than either compound alone.
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PMC11615828
NIH3T3 fibroblasts co‐transfected with 5HT6‐mCh (a ciliary membrane marker; red), CFP‐FRB‐MAP4m (an axoneme marker; blue), and mNeon‐IFT88 or mNeon‐FKBP‐IFT88‐labeled (IFT machinery markers; green) were serum‐starved for 24 h to induce ciliogenesis.
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PMC11502443
A similar profile was observed for IP1 accumulation with ∼4-fold lower potency for tirzepatide than GIP(1-42) (Figure 1B; Table 1).
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PMC11777207
Quantification of epidermal thickness of lesional skin from IgG and 43H12 antibody–treated mice in micrometer. (
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PMC11790971
Image acquisition was controlled through a custom LabView (National Instruments) program.
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PMC6799808
To this end, A427 cells were treated with 0–2 mg/ml GLPT.
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PMC11725127
The observed rate constant for binding (kobs) of biotin–GA to USP2 was determined to be 0.023 min (D). (
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PMC11240052
Bioinformatics analysis suggested that SIRT-1 mRNA harbored a putative miR-211-5p binding site in its 3′-UTR.
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PMC11686380
Alexa Fluor 488-, 594-, or 647-labeled IgG (Life Technologies) was used as a secondary antibody.
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PMC9429973
Rapid reduction in ALC was observed in CLL patients (pending imaging assessment) during ramp-up and the first cycle of treatment at doses as low as 20mg.
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PMC11228511
In Zmpste24 and Lmnb1 SMCs, we also observed a very strong association between NM ruptures, nuclear blebs, and irregularities and gaps in the nuclear lamin meshworks.
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PMC8345486
The IC50 of compound 15 was 21 ± 1.5 μM, and it was approximately twice lower than that of compound 23 (48 ± 2.7, p < 0.01, Student’s t-test with Bonferroni correction).
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PMC11093197
Quantitative analysis of colony number (N = 3). (
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PMC7987994
Sole MEM with the corresponding concentration of FBS mixed with the suspension served as a control.
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PMC11321678
GABAergic neurons, including Purkinje cells, arise from multipotent precursor cells of the primary germinal epithelium in the roof of the fourth ventricular zone.
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PMC7342409
Flow cytometry was used to detect apoptosis in four quadrants: Q1-UL (necrotic cells and fragments), Q1-UR (late apoptotic and necrotic cells), Q1-LL (normal cells), and Q1-LR (early apoptotic cells, which could be detected by CCK8).
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PMC11267830
Moreover, we are the first to discover a splicing disorder in THOC1 (Fig. 6f).
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PMC5925824
In both models LY3300054 therapy strongly enhanced the alloreactive anti-tumor response (Fig. 5c-d).Fig.
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PMC9429973
Methods: In our lab, we employ cell culture systems and pre-clinical mouse models to elucidate pathophysiological mechanisms that underlie TET loss-of-function driven pathologies originating from B lymphocytes.
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PMC9424261
Cell lysates were incubated with the corresponding antibodies overnight at 4 °C, followed by incubation with protein A/G beads.
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PMC3019555
However, the signals that lead to recruitment of specific messages to P-bodies are not well understood.
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PMC11781181
One limitation is the lack of an SJS/TEN animal model, it is essential and interesting to study SJS/TEN-related keratinocyte lipid metabolism dysregulation in vivo after treatment with miR-375-3p inhibitor and FSP1 or FTH1 antagonists.
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PMC8753818
Then, plates were incubated for an additional 10 min and the absorbance was read at 545 and 630 nm reference wavelengths.
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PMC5839394
None toxic effect was observed for metal-free EPS.
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PMC3730428
As HDAC inhibitors have multiple effects in cells, we demonstrated that the effects of SAHA on apoptosis induced by AT-IAP/TNFα was due to FLIP downregulation using Ren MPM cell lines overexpressing FLIP(L) and FLIP(S) (Figure 7a).
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PMC11471176
The percentage of viable cells over the total number of viable cells added to dead cells was used to calculate cell viability (%), which was tested frequently to ensure they were healthy.
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PMC11171319
HR-HCMV strains were latent and/or replicated at low levels in chronically infected transformed cells and were reactivated following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) treatment , similar to KSHV and EBV reactivation under TPA .
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PMC11267036
To date, some drugs such as bortezomib, carfilzomib, daratumumab, and dexamethasone have been applied for MM treatment [6–8].
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PMC11627060
Morphological changes were assessed using inverted phase-contrast microscopy, along with DNA fragmentation tests and AO/EtBr staining after 24 h. The results indicate that BSA NPs can induce apoptosis in breast cancer cells, likely through the production of pro-apoptotic signaling molecules that stimulate cellular death by increasing ROS levels .
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PMC11506670
This was corroborated by the results of spheroid assays, which replicate specific aspects of 3D growth and enhance cell–cell interaction to provide a more relevant simulation of tumor physiology .
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PMC9429973
VSAA was combined with SAA for the analysis.
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PMC11290772
The morphology of ROBO1-NK cells remained unaltered, indicating that transfecting ROBO1-CAR did not induce permanent damage to the PBMC-derived NK cells (Figure 2A).
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PMC11576293
Additionally, the S-benzyl derivatives (14, 22, and 28) gave very high p values with the MolSoft and ChemDraw software compared to those obtained with the MOE program.
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PMC2196094
We detected 17 and 10 clones in 100,000 plaques for Pu-1 and GATA-1, respectively.
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PMC9429973
Mutations of note in the FL cohort were RUNX1 (33%), ASXL1 (33%), DNMT3A (7%), TET2 (40%) and TP53 (20%).
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PMC11697189
Kaplan-Meier curves of overall survival (OS) for ccRCC in three clusters. (
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