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OTAR3088
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BioData-CellLine_annotated

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PMC11731614
https://www.integratedproteomics.com/) using ProLuCID (Eng et al., 1994, Xu, 2015), DTASelect2 (Cociorva, 2007, Tabb et al., 2002), Census and Quantitative Analysis.
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PMC9429973
Aims: Evaluate the efficacy of the PET3 adapted treatment in patients with classical Hodgkin’s lymphoma (HL) in Ann Arbor stages I-IV.
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PMC11803149
p <0.01.
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PMC7433824
Peptidyl‐prolyl cis‐trans isomerase enzymes (PPIases) regulate cis‐trans isomerization in peptide bonds and thus, controls the folding of proteins.
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PMC11672142
The ultraviolet–visible (UV–vis) spectrum of the compound at pH 7.4 (50:50 DMSO:H2O) shows a LMCT absorbance at 450 nm (ε = 3200 M cm based on compound concentration) (Figure 1B).
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PMC9429973
Proteomic analysis of WU-NK-101 was performed using tandem-mass spectrometry.
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PMC11335267
The existence of reduced sympathetic innervation in the gastrocnemius muscle of Alx3-deficient mice is indicated by reduced noradrenaline content as well as by decreased levels of tyrosine hydroxylase and VMAT2, two proteins present in sympathetic nerve endings.
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PMC9429973
Co-culture experiments were performed with the CD155 models and T-cells isolated from healthy donors for 48 hours and studied T-cell cytotoxicity by analyzing the remaining MM cells with flow cytometry.
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PMC11650848
The Functional OR Genomic Element Database (FORGEdb) was included in the LDmatrix software and calculates a score out of 10 for how likely a genetic variant is to be a regulatory variant.
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PMC8557138
Pre-vascularized organoids produced in vitro, when transplanted on the chicken chorioallantoic membrane, connected to host circulation (Wörsdörfer et al. 2019).Challenges in developing appropriate vascular 3D model systemsAlbeit, diseases related to aberrant vasculature are broadly classified into excessive and insufficient angiogenesis, paracrine interactions, and the key mediators to modulate pathological angiogenesis are highly heterogeneous and thus specific to diseases.
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PMC11785489
We observed empirical p values <0.001 for both training and held-out testing data for the first four canonical variates (CVs) (Figure 2C).
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PMC11599565
SKOV3 cell populations cultured in 2D Neuropan neuronal induction medium form typical iPSC-like colonies which generate cells which are morphologically clearly different from the parental SKOV3 cell population (G-I).
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PMC8753818
3luciferase expression assay; Graph is representative of three separate production experiments during 24, 72 and 120 h after transfection, and error bars represent the standard deviation (p < 0.05).
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PMC9429973
Methods: The proband was referred to our specialized consultation to explore an isolated increase in HbA2 (3.8 and 4.1% on 2 different controls) found at hemoglobin studies, in the context of a medically assisted procreation (MAP).
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PMC11787381
The mean concentration of BBT-loaded liposomes was 0.9 ± 0.1 mg/mL. Blank liposomes in the in situ-forming gel were used as vehicle for in vivo evaluation.
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PMC8777939
Wortmannin, which is a PI3K inhibitor and AGT7 knockdown blocks autophagosome formation.
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PMC11623887
The results showed expression of GATA1 in the group cotransfected with GATA1 and PHI0, and GATA1 only transfected group and no expression in mock and PHI0 groups.
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PMC11656657
Here, for the first time, we show that also in GD2 sarcoma cells, such as in OS cell line (HOS) and in ARMS cell lines (RH4.
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PMC10669128
PD3D therefore could be a valuable tool to facilitate translational studies toward individualized subtype-specific radiotherapy in STS patients .
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PMC11727638
Therefore, investigating CD19 and CD20 expression on lymphoma-derived cells in 3D cultures can provide important knowledge for developing drugs targeting these biomarkers.
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PMC10530622
Activation of TRPV1 led to the increase of intracellular calcium, which induced PKC-α subunit activation and, consequently, upregulation of Nox4 and ROS formation (superoxide and H2O2).
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PMC9000591
In the DPPH assay, the strongest extract was SE, with an IC50 value of 0.20 mg/mL The IC50 values of the remaining extracts including SM, SH, SB, and SW were 0.79, 0.82, 2.43, and 15.20 mg/mL, respectively.
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PMC11661040
The confirmation of this was further supported by the results from clinical patient IHC analysis (Fig. 1D, E).
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PMC9429973
At data-cutoff, the median number of cycles started by patients was 3.6 (range 1-8) and the median duration of exposure was 16 (range 3-28) weeks.
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PMC9841531
Strikingly, this lactate becomes imported by MCT1 and converted into pyruvate feeding the tricarboxylic acid (TCA) cycle and, thus, aerobic energy production.
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PMC6102174
Eight xanthones exhibited significant activity inhibiting HBV DNA replication with IC50 values from 0.01 to 0.13 mM. Especially, mangiferin and isoorientin could inhibit HBV DNA replication with IC50 values of 0.01 (SI > 145.2) and 0.02 (SI > 177.0) mM, respectively.
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PMC10887351
However, given the late discovery, β3-ARs’ role in humans is still controversial.
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PMC11525293
Actin was used as the loading control; one representative experiment is shown.
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PMC7961460
Although the highly deregulated expression of proteins by cancer cells is a well-known mechanism, the c10orf118 is not yet described in terms of its potential effect on tumour development.
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PMC6835428
Among these, the vascular endothelial growth factors (VEGFs) and their tyrosine kinase receptors (VEGFR-1/Ftl-1, VEGFR-2, VEGFR-3/Ftl-4) have often been considered (Table 3).
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PMC10470467
The human ES cell line (A673) and human bone marrow stroma cell line (HS5) were obtained from the America Type Culture Collection (ATCC, United States).
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PMC9504875
Subsequently, to investigate the effects of N protein on type I IFN induction, amounts of type I IFN in the culture supernatant were measured by SEAP assay.
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PMC11423992
Consequently, it elicits robust T-cell activation characterized by the release of cytotoxic molecules, cytokines, and chemokines, as well as induction of T-cell proliferation .
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PMC10988808
Ultimately, the development of CCDC25-targeted therapies could offer a promising addition to the current treatment landscape for ccRCC, especially for patients with advanced disease stages.
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PMC11588085
We examined the expression profiles of JPX and FTX, which positively regulate XIST.
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PMC10170482
Importantly, when stress-fiber formation was increased, there was a concomitant elevation of TRIM21 localization on F-actin.
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PMC11704135
µg/ml)Compounds1012Viability (%)Inhibition (%)Viability (%)Inhibition (%)500.017.85 ± 1.3982.1535.79 ± 2.3764.21250.038.71 ± 2.0561.2980.62 ± 1.4619.38125.064.56 ± 1.4235.4498.96 ± 0.421.0462.588.07 ± 0.6911.93100031.2598.12 ± 0.441.88100015.6100010007.8100010003.9100010002.0100010001.0100010000.010001000IC50 (µg/ml)195.40 ± 6.93420.75 ± 17.28Fig.
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PMC11761919
The effects of inulin and PINs on the growth of recombinant E. faecalis were evaluated by measuring OD600 values at different time points.
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PMC11708541
The enhancement of conduction along demyelinated axons was attributed to the blockage of axonal Kv channels, which accounted for positive effects.
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PMC11342785
These metrics allow us to take a systematic approach to experimentally define how bundling dynamics of a synMAP circuit are quantitatively affected by either 1) the strength of the TPPP MT binding component or 2) the strength of the droplet-forming IDR component (Fig. 6, A and E).Figure 6Microtubule interaction strength and IDR potency provide a two-level control scheme for tuning inducible synMAP bundling circuits in cells.
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PMC10452486
A causal factor for the emergence of cell surface expression of Face-2 is inflammatory stress, since T-cell activation occurs under the influence of proinflammatory cytokines.
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PMC11538390
In zebrafish, Grhl3 acts downstream of Irf6 in periderm differentiation.
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PMC9878562
However, cells in the mixture appeared to migrate with an intermediate velocity being faster than VAL-ko cells alone, but slower than VAL-wt cells ( Figure 4B ).
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PMC11740207
Once healing is complete, MET restores the epithelial characteristics of these cells.
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PMC10812665
Data analysis and visualization were conducted using the R software version 4.1.1.
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PMC9684669
Although numerous structural derivatives with a relatively low toxicity profile, such as fexofenadine (58), have been developed, their activity and target for MDR cancer treatment have yet to be investigated.
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PMC9509578
Besides surfactants, other nanoformulations such as liposomes, polymeric nanoparticles, metallic nanoparticles, nanoemulsions, and inorganic nanoparticles have been designed with the ability to bypass drug efflux transporters and deliver chemotherapeutic drugs to MDR cancer cells [75–80].
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PMC9429973
Of these, 79 (57%) were high or high-intermediate risk in the IPI.
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PMC10873328
In order to determine which hypoxia factor contributed to their expression, HIF-1α and HIF-2α were overexpressed separately.
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PMC11532793
The new tools, together with reductions in short read sequencing costs, now make it practical to perform differential expression analyses of RNA-seq data at scale at the transcript level.
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PMC9429973
Compared to other cohorts of patients with SCD, these patients are ethnically more heterogeneous and more frequently treated with hydroxyurea (HU) .
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PMC11623887
B19 virus (B19V) is a single-strand DNA virus that has specific tropism to erythroid progenitor cells (EPCs).
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PMC11694625
4,6-Bis(2-((E)-quinolin-2-ylmethylene)hydrazinyl)pyrimidine (3a).Quinoline-2-formaldehyde (2.1 mmol, 330 mg) and 2a (1 mmol, 140 mg) were added to 20 mL ethanol solvent at room temperature.
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PMC9429973
Incorporating Ibrutinib based therapy in management of CLL is a reasonable strategy in reducing the risk of RT.
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PMC10999934
High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and aggressive histological subtype of epithelial ovarian cancer.
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PMC10253553
We asked whether the decrease in 786-0 cell viability in response to Torin 2 was correlated with an increase in apoptosis.
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PMC11247842
In Denmark, Sweden and Finland, clinical mastitis was recorded as 0 = no disease or 1 = disease occurred.
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PMC9429973
PCR validation of high level expression of hsa_circ_0001599 The PCR results showed that the mean expression level of hsa_circ_0001599 in the aGVHD group was more than twice that of the control group. (
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PMC8584319
Although HepG2 cells are known to be sensitive to MEK inhibitors , we used MEK inhibitor concentrations that did not significantly affect cell viability while ERK activity was rapidly inhibited (Figure 4b).
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PMC11307990
The absorbances of 6HB-DONs and DNA nanotape-SUN were measured by full wavelength scanning using a UV spectrophotometer (Cary300, Agilent).
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PMC4360730
The reagents and conditions applied to the biological input (i.e. treatment; e.g. 20-hydroxyecdysone—CHEBI:16587 and estradiol—CHEBI:23965 in Figure 1).
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PMC11700340
The most potent binding occurred through conventional hydrogen bonds with the ASP:54 amino acid residues at a distance of 2.93 Å. The docking scores for linagliptin were comparable to those of the reference drug geldanamycin, indicating a strong interaction between linagliptin and Hsp90.
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PMC8481254
GFP images were obtained using a small animal in vivo imaging system, and the tumor volume was calculated using software.
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PMC4277423
Another important finding is that we did not detect off-target mutations in 12 loci that contain one nucleotide mismatch to the 3′ 13 nucleotide seed regions and PAM (NGG) of CR2 or CR3 in cells co-transduced with lentiviral vectors expressing Cas9 and CR2 or CR3 using T7 endonuclease I assay even at 84 days post transduction (Fig. 4), indicating that likely co-transducing cells with lentiviral vectors expressing Cas9 and CR2 or CR3 does not induce mutations at potential off-target sites that are highly homologous to CR2 or CR3 in HIV-1 susceptible human CD4 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11760643
As such the anti‐P2X7 mAb favourably mediated CDC of leukocytes that displayed relatively high cell surface P2X7, specifically monocytes, DCs, NK T cells, myeloid‐derived suppressor cells (MDSCs), and T helper (Th17) cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711127
Finally, some mechanisms of T cell resistance to activation are just emerging as promising future targets for immunotherapy, such as the challenge of reversing T cell senescence to achieve immune system rejuvenation and more effective vaccine responses or cancer immunotherapies.
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PMC11782508
A single isolate was selected for identification.
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PMC11438317
Cell nuclei were counterstained with 1 μg/ml of the DNA binding dye DAPI added with the secondary antibody.
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PMC10033453
Clinical relevance has been shown in human Ewing sarcoma, where a high frequency of T cells and activated natural killer (NK) cells correlated with prolonged overall survival.
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PMC11721587
Myc-Gli2/Flag-Gli2 were made by adding 6× Myc/3× Flag tag to the N-/C-terminal end of mouse Gli2 coding sequence.
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PMC11317131
Site-specific recombination involves the exchange of DNA strands between short, specific DNA sequences recognized by site-specific recombinases (SSRs) (18).
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PMC8750422
GPR87 overexpression markedly increased the expression of the mesenchymal cell marker, N-cadherin and the EMT-inducing transcription factor, ZEB-1 (Figure 2a,b and Figure S2a).
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PMC10957991
Furthermore, loss of TRPV4 was reflected to alterations in the signaling pathways upstream of actomyosin assembly and cellular forces exerted by the epithelial layers.
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PMC9429973
Results: From January 2013 to November 2018, 114 patients were screened, and 107 patients that fulfilled the inclusion criteria were enrolled into the trial and randomized to receive R-DHAP or BR-DHAP (54 patients in R-DHAP, 53 in BR-DHAP).
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PMC9429973
Among those positive, 37 also had a BMB+, whereas 151 patients had a BMB+ with a PET/CT-.
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PMC11736898
No significant differences in migration were observed in keloid keratinocytes; however, this may be due to larger standard deviations, as migration rates were more variable among the different keloid keratinocyte donor strains than among the normal strains (Figure 6b).
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PMC11509278
Among the negative ion metabolites (Figure 3C,D), lipids and lipid-like molecules accounted for 40.51%, and organic acids and their derivatives accounted for 20.25%.
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PMC11747467
The top 10 hallmark pathways were finally identified and ranked by the normalized enrichment score (NES) ( Figure 4A ).
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PMC10729469
Data presented as mean ± SEM for 5–6 mice per group.
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PMC11502443
Interestingly, no significant difference in Emax was observed for either cAMP accumulation or CREB phosphorylation, suggesting that lower Emax is not universal and receptor expression is unlikely to be a factor.
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PMC11087301
It has been shown that MET along with EMT are necessary for immortalized oral epithelial cells to keep epithelial features of stem cells .
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PMC11643491
PLGA (1% w/v) and 6-coumarin (5 μg/mL) fluorophore probe were dissolved in DCM.
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PMC11564322
The extracellular matrix (ECM) is currently considered to be an important factor influencing the migration and progression of cancer cells .
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PMC11750696
However, the precise mechanisms by which ER stress and the UPR regulate T cell-mediated immunity remain incompletely understood.
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PMC9429973
For this analysis, adults (≥18 years [yrs]) with classifiable PKLR genotype data were grouped into 3 cohorts: missense/missense (M/M); missense/non-missense (M/NM); non-missense/non-missense (NM/NM).
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PMC11643491
At submicron scales, the scales relevant to our study, uptake mechanisms are mainly “phagocytic-like” mechanisms, which are mainly affected by cell deformability.
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PMC11301242
The study of extrachromosomal DNA (ecDNA), an element existing beyond classical chromosomes, contributes to creating a more comprehensive map of the cancer genome.
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PMC9599726
Multidimensional scaling (MDS) plots showed that, except for VP-treated GIST882 cells, CA3-treated GIST882 and GIST48 cells and VP-treated GIST48 cells were not well separated from control cells.
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PMC9429973
MRD was analyzed in 29 pts total; 24 of 29 were MRD-negative at mo 1, and 15 of 19 with available data were MRD-negative at mo 6.
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PMC10772747
The PPI network was constructed using common target proteins with a minimum required interaction score of 0.400.
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PMC11594806
Methotrexate is a well-established analog of the B vitamin folic acid.
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PMC9429973
Aims: Here, we report the French experience of CAR-T toxicity, we specifically addressed the modifiable risk factors for toxicity and we assessed management toxicity in real-world population.
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PMC10094712
The soluble protein fraction was filtered through a 0.45 μM filter to remove cell debris and applied to Poly–Prep Chromatography Columns (Bio–Rad, Hercules, CA, USA) containing nickel agarose.
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PMC11258145
Values represent the mean ± SD of three independent experiments.
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PMC11521786
No cell viability reduction was observed in the PC3 tumor cell line (see Supplementary Figure S5 ), which lacks HER3 expression, suggesting that viability reduction is dependent on HER3 targeting and, hence, specific.
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PMC11680982
These findings collectively lay a robust experimental foundation, substantiating the clinical viability of a novel regimen comprising medium-dose neratinib, CDK4/6 inhibitor combined with endocrine therapy, offering an important avenue for optimizing treatment in HR/HER2-low breast cancer.
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PMC9429973
Real-word data is lacking.
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PMC9583612
Recent field studies of methane emissions have demonstrated that tanks are one of the largest sources of methane emissions from upstream O&G facilities.
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PMC3995603
Chlorogenic acid and isochlorogenic acid A were the major components in A. capillaris extract (Table 2).
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PMC11802855
E HE staining was employed to identify the presence of lung, liver, kidney, and subcutaneous tumor colonization in mice from the CXCL7-OE group and NC group.
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