Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11679326
Glycosylation is a ubiquitous and the most structurally diverse post-translational modification of proteins.
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PMC11075223
Moreover, the toxicity of the ingredients of Cimicifugae Rhizoma in vitro studies have been demonstrated on various tumor cells.
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PMC11033180
Group comparisons were executed by first assessing normal distribution and then applying appropriate statistical tests: the t-test or one-way ANOVA for parametric distribution, and the Mann-Whitney test or Kruskal–Wallis test supplemented by Dunn’s post-hoc test for nonparametric distribution.
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PMC9429973
Due to its cytostatic properties, HU is frequently used for treatment of myeloproliferative neoplasms, ovarian cancer, and sickle cell anemia.
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PMC9429973
Date of the first ITP registration marked start date of follow-up, and comparators were assigned the same start date.
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PMC10317042
To confirm the transcriptional control activity of SOX10 toward EWSR1::ATF1, we conducted CUT&RUN-seq and a reporter assay.
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PMC11471176
Both clinical and basic science implications of these findings are paramount.
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PMC9429973
Tocilizumab and corticosteroids were used for CRS management in 4 (80%) and 2 (40%) pts at DL2, respectively.
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PMC11680562
The PXFCu6 gel can decrease the probability of aerobic vaginitis and urinary tract infections (UTIs), which are frequent complications associated with altered vaginal pH and bacterial imbalances, by preventing the proliferation of E. coli .
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PMC11792740
However, when T cells become depleted, they lose their ability to regulate tumor growth, leading to tumor progression and recurrence.
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PMC11683240
Figure 8Effect of different preincubation schemes of α1AT on PT-intoxication and binding of PT to cells.
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PMC3765139
In contrast with the general thinking that CD133+ CSCs may represent only a minimal part of the total tumor cell population, CD133 was expressed on high percentages of D10 cells and very small percentages of Me39, RE, Me59, and Na8 cells.
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PMC9429973
Remarkably, MLL-AF9 AML consists of two subgroups, one with high oncogenic MECOM expression and dismal outcome; the other with a unique gene expression profile lacking MECOM expression and a favourable outcome.
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PMC11244823
Both, older and more recent studies have shown that current vaccines are not able to significantly reduce EHV-1-viraemia, which is a prerequisite for the development of abortion and EHM .
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PMC11519077
One of the main cytokines responsible for triggering and maintaining intestinal inflammation in IBD is IL-12 .
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PMC10213199
The RPT gene family is an ATP-dependent part of the 26 S proteasome , which acts as a proteolytic cascade downstream component of the 26 S proteasome in the ubiquitin-proteasome pathway .
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PMC11767582
for C18H20N3O3 [M+H]: 326.1499, found: 326.1502.
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PMC11457557
A brief list of detected chromosome regions for DKD is illustrated in (Table 1).Table 1Linkage analysis of DKDDiabetic ComplicationChromosome RegionPopulationReferencesDiabetic Kidney Disease3q24Pima Indians2q14.17q21.1,7q21.3 10p15.3 14q23.1 15q26.3Caucasian and African Americans18q, 18q22.3–23TurkishAfrican AmericansDiabetic retinopathyChr 3Chr 9Chr 1Pima Indian cohort3q11-q1212p13.2-p12MexicanDiabetic cardiovascular complications19p13.23p12.1-3q13.3111p15.4-11p11.319p13.2-19q13.42CaucasiansCaucasiansHispanicAfrican Americans Linkage analysis of DKD 2q14.1 7q21.1,7q21.3 10p15.3 14q23.1 15q26.3 Turkish African Americans Chr 3 Chr 9 Chr 1 3q11-q12 12p13.2-p12 19p13.2 3p12.1-3q13.31 11p15.4-11p11.3 19p13.2-19q13.42 Caucasians Caucasians Hispanic African Americans The gene to be examined is chosen based on an understanding of its contribution towards DKD pathophysiology, such as those involving blood pressure management, proteinuria severity, insulin resistance, lipid metabolism, or other pathways implicated in the progression of DKD.
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PMC11791432
Protein was extracted and analyzed via previously-reported methods .
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PMC5673060
Briefly, A204 cells were initially grown in media containing 500 nM of pazopanib or dasatinib and the drug dose increased when the cells proliferated to near confluency alongside minimal visible cell death.
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PMC11767582
for C17H17BrN3O3 [MH]: 390.0448, found: 390.0432.
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PMC9429973
Mitapivat, through its unique mechanism of action, may represent a novel therapeutic approach for this condition.
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PMC11747885
Compounds were defined as hits if the inhibition was above 70%.
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PMC11240448
Cell line labeling, both normal vs cancer, and luminal vs basal breast cancer, were taken from the original publication .
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PMC10482220
For crosslinking, proteins were dialyzed against 50 mM triethanolamine, pH 7.9, mixed at 37°C with 0.05% of glutaraldehyde in the same buffer, and the reactions were stopped with 4× Laemmli loading buffer.
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PMC11680049
This once again indicates that hyperaccumulation of polyphenols, in response to the presence of lighting, in callus tissue may be an indirect cause of inhibition of the growth of Sequoia callus culture .
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PMC9429973
Anemia-related complications, including transfusions, contribute significantly to PNH-associated costs of care, thus highlighting the need to understand Hb level changes and healthcare resource utilization (HCRU) in patients with PNH.
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PMC5916734
SDS-PAGE analysis (Fig. 5) showed that most FIX molecules were eluted from the Capto Q sorbent after Ca had been added to the low-salt eluent, indicating that these FIX molecules have a properly formed Gla domain whose structural rearrangement upon chelation of Ca ions causes elution of Gla proteins from the anion exchanger.
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PMC10631132
Illustration drawn by Hannah and Alexander Blümke using Affinity Designer 2.1.1 Schematic outline of the differentiation process and the comparison between embryoid body-based (EB) and monolayer-based (MB) differentiation.
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PMC9622879
In this case, the local buying and selling prices in this time slot will be 38[12pt] $$&P_(t) = P_(t) $$(t)=Pmid(t)39[12pt] $$&P_(t) = (t) _^E_^(t) + P_(t) |E_(t)|}^E_^(t)}. $$(t)=PLB(t)∑i=1NEi,Combuy(t)+αPMG(t)|ECom(t)|∑i=1NEi,Comsell(t).
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PMC11754094
Collectively, the screening results indicate that large deletions are primarily generated by TMEJ following the end resection pathway.
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PMC9429973
Summary/Conclusion: FTX-6058 is an investigational, potential first-in-class oral HbF inducer.
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PMC11694066
To further investigate the presence of ongoing replication stress, we evaluated the levels of RPA2 phosphorylation (pRPA2) and found increased pRPA2 levels upon exposure to PARPi, ATRi, and their combination.
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PMC10094992
Conversely, NR6 treatment induced the expression of CDKN2A (coding for the cell cycle regulator p16) and IL6 suggestive of a secretory senescent phenotype (Figure 2H).
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PMC11588008
Cells were harvested and digested by pancreatic enzymes.
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PMC5839394
Total Ag was determined by Inductively Coupled Plasma Atomic Emission Spectrometry, ICP-AES (Optima 3100, Perkin Elmer) .
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PMC11539788
The resulting samples were immediately frozen and stored in liquid nitrogen after being washed with cold PBS.
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PMC11725127
ns: no significance.
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PMC9895440
n = 6 intergenic and n = 4 Snx9 KO.
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PMC11656380
This could potentially unveil novel nonapoptotic cell death mechanisms and new molecular targets for cancer therapies beyond CSL proteins associated with NOTCH1 signaling.
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PMC9250505
p < 0.05, **p < 0.01, ***p < 0.001.
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PMC11488203
Moreover, another seven transmembrane-spanning receptor CXCR7 (= atypical chemokine receptor-3 (ACKR3)) represents affinity to SDF-1 binding suggesting that both, CXCR4 and CXCR7 can relay intracellular signals following stimulation by SDF-1.
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PMC6617630
Progress is being made in the targeting of the regulation of MYC activity by BET inhibitors in the MYC-expressing murine lymphoma or DLBCL cell lines [22–24].
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PMC9532503
Moreover, the process of glycoengineering is in itself very tedious, and demands expensive resources.
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PMC10993311
PPI networks have been studied in chronic diseases such as obesity (Chen et al., 2017; Chen et al., 2021) and in gestational diabetes mellitus (Zhu et al., 2020) but have not yet been described in maternal EGWG.
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PMC11672602
NC – Control animals, DC – positive control, DT-D – 100 mg/kg DEAE-Dextran treated, DT-PTX – 30 mg/kg paclitaxel treated, DT-B – β-interferon treated, NT-D100 – normal treated with 100 mg/kg DEAE-Dextran, NT-PTX – normal treated with 30 mg/kg paclitaxel and NT-B – normal treated with β-interferon.
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PMC11594806
CD73 is also found in Tregs and is highly expressed in anergic CD4+ T cells .
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PMC9712534
Intriguingly, some of these TOP2B-controlled long genes are linked to autism.
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PMC9014716
The results of qRT-PCR analysis showed that miR-224-5p was highly expressed in human HepG2 cells treated with PS-T, consistent with the results of the miRNA microarray (Figure 5J).
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PMC11785489
However, only amino acid sequences were made publicly available for the TCRα chain for Dataset 1.
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PMC11594806
In cultured renal tubular epithelial cells, CDDP-induced AMPK activation over time is associated with p53 phosphorylation.
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PMC10391797
In summary, CD123 and CLL-1 are promising targets for AML CAR-T cell therapy.
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PMC10362265
However, they can only vaguely describe the conformational dynamics of the complexes, representing a single snapshot of a plethora of possible conformations.
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PMC10669966
The median follow-up time for survival in the series was 4.7 years (the range was from 0.3 to 20.3).
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PMC6160470
In spite of being membrane-active compounds, our results point to a clear interaction between crown ethers and P-gp.
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PMC11655536
E Caspase3/7 activity positive cells of RPMI-8226 and U266 when treatment with HA for 48 h at 10 μM. F BCECF-AM probe detected the pHi of RPMI-8226 (left) and U266 (right) after treatment with HA at 10 μM for 48 h. G The effect of HA on pHi in primary MM patient cells treated with HA for 48 h.Data are presented as the mean ± SD of at least three independent experiments, and comparisons were evaluated by two-tailed Student’s t test. *
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PMC11543885
Mixed well before used.
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PMC11697703
The coverslips were then mounted using Fluoroshield with DAPI (Sigma) and imaged on a Zeiss AxioImager microscope.
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PMC10999934
Patient cases without a platinum-free interval (PFI) were excluded, along with those lacking RNA-seq data despite having a PFI.
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PMC9739791
Platinum-based antitumor drugs are a part of almost 50% of all clinically used chemotherapy regimens .
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PMC11023271
The upstream primer for human RIPK4 is 5’-CAGAAGAAGCCGTTTGCAGAT-3’ and downstream primer is 5’-GAGGCGTATCAGGTGGCTG-3’.
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PMC11502443
At the E354Q GIP receptor, GIP(1-42), GIP(1-30)NH2 and tirzepatide all stimulated concentration-dependent signaling for all pathways measured (Figures 2A–E).
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PMC8270637
In addition, CTLA-4 also regulates the differentiation of T cells (13, 14).
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PMC9325715
During reversible metal reduction, the formation of superoxide occurs, which belongs to the so-called “reactive oxygen species" (ROS).
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PMC7762347
After 24 h no significant elevation in DSBs formation was determined at any concentration applied (Figure 3a), while after 72 h CYN at 0.5 µg/mL and the CYN/MCLR mixture (0.5 µg/mL/1 µg/mL) (Figure 3b) induced a statistically significant increase in the formation of DSBs.
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PMC11772585
Metabolic adaptation toward aerobic glycolysis, known as the Warburg effect, is a defining characteristic of cancer.
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PMC11291490
Scale bars, 20 μm.
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PMC11637276
In phosphoproteomic studies, knocking down PPP2R1A has been used to inhibit the whole PP2A phosphatase complex in HeLa cells .
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PMC8409415
CD70 expression gradually increased in A2780 mock cells starting at 1 h of cisplatin exposure, whereas no significant change in CD70 expression was observed in A2780‐NF‐κB‐p65‐silenced cells.
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PMC11594641
For A375 cells, the loss of Rab27A did not inhibit the cell invasion capability.
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PMC9429973
European Leukemia Net (ELN) risk was 23% favorable, 37% intermediate, and 40% adverse.
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PMC7185206
Healthy human PBMCs from unique donors were treated with supernatant from wild type versus PD-L1-knockout 786–0 cells over 4 h. PBMCs were then isolated and added to calcein-labeled 786–0 PD-L1 knockout cells at a 10:1 ratio and cell survival was visualized by microscopy and quantified at 0, 1, and 2 h (f-g).
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PMC10887351
Since β3-AR expression has been observed also on microenvironmental cells’ surface, the investigation of the β3-ARs levels in the microenvironment could be considered a valuable marker of “stromal malignancy”, in the meaning of an indicator of the active role of stromal cells in disease progression.
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PMC9878562
CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
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PMC11507371
Consequently, it was established that Keap1′s role extends beyond mere cytoplasmic Nrf2 sequestration, revealing its function as a post-induction repressor of Nrf2.
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PMC10605143
However, the number of migrating cells (Boyden assay) increased (Figure 6c), and these cells also formed more dispersed spheroids in Matrigel (Figure 6d), indicating the progression of cancer cell phenotype toward a more invasive one.
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PMC9429973
In patients with HOTR, ASA dosing was changed to twice daily with a dose from 50 mg step by step up to 150 mg till AOTR was reached.
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PMC11656380
Hemolytic activity was measured using red blood cells in mice to investigate this possibility.
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PMC11621493
PE and PC subspecies are labeled according to their acyl-chain composition.
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PMC11591794
When the GA application and DOX application were compared, it was shown that the viability in the HeLa cell line decreased more in the DOX group.
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PMC10870498
KIF23, kinesin family member 23; ATC, anaplastic thyroid cancer; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; THCA, thyroid carcinoma To further explore the biological functions of KIF23 in ATC progression, we transfected si-KIF23#1/2 into 8505C and BCPAP cells.
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PMC9429973
Methods: We performed a retrospective, observational study at a blood diseases hospital in China for patients who received ≥ 72 h of CAZ-AVI for bloodstream infections due to carbapenem-resistant Enterobacteriacea and Pseudomonas aeruginosa between November 2018 and June 2021.
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PMC7154001
In dogs and humans, similar 14 metabolites were detected in both genders.64 These results suggest that the metabolites generated from the parent anticancer drugs/candidate compounds may vary depending on the expression levels of the responsible metabolizing enzymes in each gender.
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PMC11775197
Dysregulation of lipid metabolism is one of the important pathways for cancer formation and progression, and it is a key factor in the acquisition of energy supply by cancer cells to regulate the tumor environment .
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PMC8753818
Moreover, it seems that Bub1, Scc1/Rad 21, BubR1, INCENP and CENP-C are contributed to M phase progression [27–30].
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PMC11476004
Certain traits, such as overweight, obesity, or reduced immunity, make dogs more susceptible to cancer.
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PMC11747885
The synthesized derivatives did not significantly inhibit its activity, suggesting a selective inhibition of Rlig1.
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PMC11739504
Scale bar: 2 μm.
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PMC11594806
In gastric cancer, metformin reduces ATP production and activates AMPK phosphorylation at Thr172, which increases the expression of mitophagy markers such as Parkin and PINK1.
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PMC11377827
HeLa cells were seeded on FCS precoated coverslips in 24-well plates at 5 × 10 density.
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PMC9429973
Two dose-limiting toxicities occurred at 7mg, including diarrhea and grade 2 peripheral neuropathy.
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PMC9429973
Exclusion criteria included RI caused by other reasons than tubular nephropathy, such as renal amyloidosis, light chain deposition disease, etc.
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PMC11247842
As an udder disease, mastitis can affect the production of dairy cows in many ways, including milk yield, milk composition, and milk properties [1–3].
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PMC11024707
A recent study comparing mi-RNAs between individuals with autism, those with developmental delay, and neurotypical individuals revealed that mi-RNA-125a expression was significantly increased .
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PMC8041314
To determine IC50 values, in-depth concentration-effect curves have been generated by plotting the slopes against several logarithmic concentrations of the tested compounds.
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PMC11755467
We therefore focused on the hsa-miR-132-3p pro-HIV-1 Enoxacin interrelation in CEM-SS cells only for the further investigations.
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PMC9429973
FL accounts for 35 percent of NHLs and has an estimated incidence of 3.18 cases per 1,00,000 people in the United States.
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PMC11201245
aCGH: following the Agilent protocol, 1 μg of isolated DNA from a tumor and an equivalent amount of reference Agilent female DNA (Agilent, Santa Clara, CA, USA) were used for aCGH.
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PMC11687167
Prodomain: most of the GOF and LOF mutations of PCSK9 are occurred in this region.
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PMC11247842
We also used --gene-settings adap-permp to enable adaptive permutation with a maximum of 1,000,000 permutations and a stopping criterion of 10.
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