Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Patients were also distributed in two different groups according to whether they received intensive chemotherapy treatment.
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PMC9429973
In addition, we accidentally noticed in some patients after BMT a significant admixture of donor DNA in the samples isolated from the buccal epithelium.
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PMC11705484
Immunohistochemistry (IHC) analysis of TRMT61A and NF‐κB protein expression in BLCA tissues (upper panel scale bar: 50 µm; lower panel scale bar: 20 µm). (
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PMC11593084
PMab-117-mG2a also elicited more potent ADCC against endogenous PDPN expressing tumor PC-10 (42.1% cytotoxicity; p < 0.01) and LN319 (23.9% cytotoxicity; p < 0.01) cells.
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PMC11467800
When challenged by an environmental insult the cancer cell is in a search of alterations in the expression of genes required to change its epigenetic landscape. ,
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PMC11699042
WGS of A-673 wild type derived from BioProject PRJNA610192 (ref. ).
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PMC9429973
In ADC-exposed and CAR-T-exposed pts, the ORR was 38% (95% CI, 15–65) and 45% (95% CI, 17–77), respectively.
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PMC11409031
A, B) Differential expression analysis of hub genes between normal and OV samples.
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PMC9429973
Results: The median age was 39 years (25-66), men - 25 (55.6%), women - 20 (44.4%).
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PMC7841189
FTC133 cells (1 × 10 cells/0.1 ml) transduced with sh-LTBP2 or mock were injected subcutaneously into the flank of nude mice. (
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PMC11172027
The cells were then washed twice with DPBS 1X and incubated in a fresh medium with 10% WST-1 reagent for 2 h. The absorbance was measured at 450 nm (690 nm was used as a reference wavelength and subtracted) in a spectrophotometric reader (Spectra Max Pro 384; Molecular Devices; San Jose, CA, USA).
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PMC11127909
CATR can fix ANTs in the c-state, which can induce mPTP opening, whereas BKA locks ANTs in the m-state, which inhibits the opening of mPTP .
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PMC11534377
PIM1 exhibited a fold change (FC) of −3.5123045 (log FC = −1.8124179) with a corrected p-value of 1.18E-04, while BCL3 showed a FC of −3.5693064 (log FC = −1.8356438) with a corrected p-value of 5.13E-05.
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PMC9429973
Fresh blood or bone marrow samples from patients with AML were purified and sorted for CD34 or CD117, these samples were profiled by RNA-seq an ATAC-seq.
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PMC7305184
In each experiment generation efficiency of permeabilization of control samples (CTRL, ) was compared to samples exposed to PEF treatment/electric pulses (EP, ) in the same experiment.
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PMC11798926
Given that SynDIG4 co-localizes with GluA1 in early and recycling endosomes in cultured hippocampal neurons, we sought to identify the sorting signals that target SynDIG4 to endosomes to further elucidate the role of SynDIG4 in GluA1 trafficking.
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PMC9429973
Methods: We treated AML cell lines, patient AML blasts, and CD34+ cells from healthy donors with JIB-04, venetoclax, or the combination for 72 hours.
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PMC7338939
All bars indicate mean ± SD in at least four independent tests.
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PMC11742431
However, it did not affect A375 cells (Figure 4E).
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PMC9429973
After 3 cycles, his blood counts improved (Fig 1) and correction of thrombocytopenia (PLT 282 x10/L) allowed treatment of the SM component by avapritinib via Compassionate Access Programme and he started avapritinib 200mg daily.
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PMC11541241
TOR contains the N‐terminal clusters of huntingtins, elongation factor 3, a subunit of protein phosphatase 2A and TOR1 (HEAT) repeats, followed by a FRAP, ATM, and TRRAP (FAT) domain; the FKBP12–rapamycin binding (FRB) domain; the catalytic kinase domain; and the C‐terminal FATC domain. (
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PMC11098378
All crystals used for data sets in this study were grown from the same batch of purified protein, but the crystallization condition for data set 1 was 2.0 M sodium, potassium phosphate whereas for data sets 2 and 3 the major precipitants were polyethylene glycols.
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PMC11139449
PCR analysis showed 60% positive single-cell clones and sequencing confirmed homozygous CASP8AP2 gene silencing.
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PMC8316344
We found that TRIB2 knockout had no effects to increase labile iron level when TFRC was deleted in Bel-7404 cells both in basal condition and following treating with RSL3 and erastin (Fig. 4D, E).
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PMC11786600
Immunofluorescence microscopy images of MMP9 expression. (
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PMC8270637
ChIP assay was used to detect the binding of NFATc1 to the promoter region of the PD-1 gene. (
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PMC11240448
In contrast, core networks of basal BC were heterogeneous and segregated into roughly four major subclasses with distinct oncogenic and BC subtype drivers.
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PMC11252033
Then, complimentary to FTMap studies, we applied FTSite to find likely ligand-binding sites.
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PMC10728535
These profiles included 16 samples that were sensitive and 7 samples that were resistant to cisplatin.
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PMC11766350
Following centrifugation at 300× g, 5 min, 20 °C, cells were resuspended in 100 µL 4% formaldehyde and incubated at room temperature for 15 min.
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PMC11045125
Akata BL line and the BL5 LCL line serve as positive and negative controls for protein expression.
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PMC11087055
PIV is a standard technique used in the Fluid Physics and Engineering community to quantitatively measure and characterize fluid flows in different systems.
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PMC11406030
NO, a labile nitrosylating species, increases S-nitrosylation of caspase-3, which inhibits apoptosis and, thus, increases survival.
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PMC9429973
Subsequent treatment included three-factor prothrombin complex concentrate (PCC), starting in the 1990s.
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PMC9398137
Thus, MCL1 inhibitors alone might represent an effective treatment strategy in Burkitt lymphoma and in substantial part of DLBCL using a simple biomarker—BCL2 expression by standard IHC.
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PMC10812665
Ber (204 changed metabolites) showed similar effects as MPP and rotenone.
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PMC11335267
For Alx3, we used a specific antibody directed against the N-terminal region (1:4000 dilution) .
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PMC9919300
No. 330231 PAHS-157ZC, Qiagen).
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PMC9966931
Statistically significant differences between treatments were observed amongst the various concentrations assayed.
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PMC10882807
Our study concluded that overexpression of hsa_circ_0005397 promoted progression and metastasis of HCC through EIF4A3.
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PMC11762280
p-MLKL phosphorylated MLKL.
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PMC11640555
Phase I/II clinical trials are ongoing on CK2 inhibitors, particularly Silmitasertib (CX4945), whose activity is directed at various solid tumors, and in the context of CNS tumors, it has only been examined in patients with neuroblastoma and medulloblastoma .
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PMC11655498
Additionally, Alphafold3 can be harnessed to predict the structures of lesser-known EBV gene products, providing valuable insights into their functions and interactions with the host.
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PMC11291490
Subsequently, ducks from each group were challenged with 10 TCID50 TMUV CQW1 strain per duck via intramuscular injection at 5 w after the third immunization.
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PMC11779960
Alpha-beta clonotype thresholding was performed using Cell Ranger-derived clonotypes.
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PMC11350568
To provide further empirical support for the superior target protein degradation capability of the AptG-1-TfR1 TMPDS, preincubation with AptG-1, AptG-2, and Sgc8c∼lib was followed by evaluating the membrane-associated PTK7 protein content through the fluorescence signal of Cy5-Sgc8c.
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PMC11594641
Overall, these results indicate that Rab27A does not directly control the number of sEVs secreted by A375, DMBC12, and SkMel28 cells, regardless of the basal mRNA and protein levels.
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PMC11078693
Air-dry the cover glasses in a cell culture hood 12–15 h. Note: The coated and labeled cover glasses can be stored for at least a few weeks at 4°C in a closed container.
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PMC6461034
Continue with three‐dish batches until all dishes with the same cells have been processed.
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PMC10522430
Ultimately, this process leads to the elimination of cancer cells and the suppression of tumor growth.
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PMC6771295
The effect of SIRT1 silencing on LC3 and Beclin-1 protein levels. (
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PMC9065483
While EGFR inhibition by gefitinib did not impact STAT1, it was interestingly able to rescue the otherwise decreased levels of STAT2 phosphorylation caused by vanadate/virus infection (Figures 3A, 3B, and S10).
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PMC9577200
Additionally, the 43-kDa chitosan revealed higher effects than the 67-kDa chitosan vs. G– bacteria than G+ bacteria.
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PMC11696576
Ashcroft, F. (2024) https://BioRender.com/r27a486.
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PMC6835762
Weiss et al. reported that a low substitution of lauric, stearic or behenic acid decreased nanoparticle size relative to unmodified PGA, suggesting interactions of fatty acid chains in the particle core enhanced the packing of particles (Table 1).
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PMC6160470
For achieving the best inhibitory activity, crown ethers need to have optimal lipophilicity and structural features to enter the membrane and interact with P-gp.
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PMC9429973
G. Greenfield, M. F. McMullin, K. Mills PGJCCR; CME, Queen’s University Belfast; PGJCCR, Queen’s Universtiy Belfast, Belfast, United Kingdom Background: Dysregulation of normal epigenetic processes is increasingly recognised as a feature of myeloid malignancy generally and implicated in the pathogenesis of MPN.
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PMC11736898
Keratinocytes were cultured in keratinocyte growth medium with 0 or 100 nM vitamin D, combined with 0 or 10 μM ketoconazole or 0 or 100 nM VID400, and cells were harvested for analysis 24 h later.
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PMC11615828
Scale bars of kymographs, 20 µm.
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PMC11661040
The hFOB1.19 cells were maintained in DMEM/F12 medium with 0.3 mg/mL G418 from Servicebio Technology (Wuhan, China), and the other cells were cultured in DMEM (Servicebio Technology, Wuhan, China).
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PMC7153288
When cultured in the PY medium, this strain shows a cytotoxic effect on the A549 cell line.
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PMC11763126
A IP combined with mass spectrometry revealed that usp5 binds to YTHDF2.
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PMC11680982
P < 0.05; **P < 0.01; ***P < 0.001; n = 3.
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PMC11763126
Synthetic CBDP1 was compared with a Scr peptide in colony formation and CCK-8 assays, demonstrating a dose-dependent inhibitory effect on ccRCC cells proliferation (Fig. 2B-C).
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PMC11025866
These findings should facilitate the formulation of hypotheses for unraveling the mechanisms of action of VPA and VPM in the nervous system.
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PMC11574271
A Immunohistochemical staining was performed to assess RON protein expression in bladder cancer (n = 93) and adjacent normal tissues (n = 26).
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PMC9848491
A formula was used to calculate a risk score for each patient, and patients were divided into high-risk and low-risk groups according to the median risk score.
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PMC11765243
Our data showed a significant role for p110α in T lymphocyte differentiation in the thymus, particularly in the CD4CD8 DP T cells, CD4 SP T cells, and CD4 SP Treg populations, whereas differences in T cell differentiation, homeostasis, and function in the periphery were mainly observed in CD4 T cells, the Tfh, and Treg populations.
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PMC11449273
Histograms were then constructed based on the mean ± SD values. *
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PMC9429973
Previous studies have associated enhanced complement activation with increased disease severity.
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PMC9646302
These findings support the notion that LAPTM5 regulates ccRCC growth through the RAC1 signaling pathway.
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PMC11298021
In contrast, the miR-3182 mimic group only exhibited decreased expression levels of mTOR and S6KB1 compared to non-transfected Jurkat cells (***P<0.001) (Fig. 7B).
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PMC10047551
To examine whether a CpG site located near cg19724470 also displays an association with PD-L1 expression, we included a methylation analysis of an as-yet unannotated CpG site located 15 bases downstream of cg19724470 in the genomic position chr9:5,450,951 (hereafter abbreviated as cg(chr9:5450951)).
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PMC10568263
These results demonstrate the good selectivity, reproducibility, and stability of the HSP70 immunosensor.
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PMC9429973
Methods: Retrospective cohort study that included patients who underwent LT from 2015 to 2017 at the Instituto Nacional de Nutricion (INCMNSZ), excluding those with HH.
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PMC9954564
The binding of HLA-G to its receptors, LILRB1 and LILRB2, induces the downregulation of innate and adaptive immunity, thus modulating the activity of NK cells, antigen-presenting cells, and T and B lymphocytes .
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PMC11632064
Treated cells proliferated as control cells at 72 h and over a 6-d period (Fig 3A).
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PMC5916734
Southern blot analysis using a probe targeting the regions of plasmid DNA corresponding to the domain of plasmid replication initiation and the sequence of the bla gene found two restriction fragments: a heavy fragment (~3700 bps) approximately corresponding to the calculated cassette integration at the site of its linearization by PvuI restrictase and a short fragment (~800 bps) putatively corresponding to cassette integration involving DNA deletion near the PvuI site.
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PMC11750696
In addition, following TCR activation, there is a notable increase in the phosphorylation of eIF2α and the upregulation of ATF4 in Th2 cells, which in turn affects the expression of downstream genes such as GADD34, CHOP, GRP78, and HERP (48).
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PMC9429973
No patient has yet discontinued therapy.
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PMC8557138
The tumor ECM comprises of diverse components including proteoglycans such as syndecan, glypican, versican, aggrecan; polysaccharides such as hyaluronic acid; proteins such as collagen, fibulin, laminin, fibrillin, fibronectin, periostin, thrombospondin, and integrin (Nallanthighal et al. 2019).
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PMC3734024
Splenocytes from naïve mice were stained for surface expression of FasL and the cellular composition of FasL and FasL subsets was examined by flow cytometry. (
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PMC11627133
The binding affinities between the bifunctional aptamers and SpyRho (or GFP) were determined by measuring the fluorescence change while titrating the aptamers to SpyRho (or GFP).
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PMC5673060
One sample t-tests were performed on SILAC log2 ratios to determine significantly different regulated phosphosites; where the null hypothesis was that the phosphopeptide abundances were unchanged and the log2 SILAC ratio was equal to 0.
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PMC11781181
The clinical characteristics of the SJS/TEN patients are listed in Table S1.
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PMC11783017
Zhou Sha: Writing – original draft, Validation, Methodology, Formal analysis.
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PMC10213199
We further investigated 19 genes in the HL 60 cell line using KEGG pathway and GO functional enrichment analyses.
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PMC3019555
Using the miRBase Targets database (Sanger Institute), we identified nine miRNAs predicted to target the 3′ UTR of human HIF-1α.
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PMC5173112
Isolated ALDH cells from the 786-O and A-704 cell lines (1,000 cells/dish) were cultured in serum-free medium including 10 ng/mL epidermal growth factor (EGF) (Thermo Fisher Scientific) and 20 ng/mL basic fibroblast growth factor (bFGF) (Thermo Fisher Scientific) in ultra-low-attachment 6-well plates (Corning Inc., Corning, NY, USA) for 1 week.
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PMC11319300
Abbreviation sE–Strong Enhancer, P/E−promoter/enhancer (where one replicate had an enhancer state and the other had a promoter state).
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PMC11727062
They can be classified into several groups, including protopanaxadiol group saponins (PPD saponins), protopanaxatriol saponins (PPT saponins), and oleanane-type saponins.
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PMC10656496
Treatment with panobinostat and then trametinib successfully eliminates both cell lines at 24 days.
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PMC11240448
In contrast, MRA infers causal connections, feedback loops, and their strengths, but requires as many perturbations as the number of network modules while being sensible to noise .
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PMC4112127
Copy numbers of each PCR product were corrected by the concentration of DNA in the input sample, prior to bisulfite treatment.
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PMC9429973
Aims: We aimed to assess clinical characteristics, treatment choices, and survival of these patients.
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PMC11391695
The formula used to represent all data is mean ± standard deviation.
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PMC11789597
The mRNA and protein expression of CAV1 were significantly knocked down by shRNAs (Figure 1C–E).
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PMC11209164
64-0712), then treated with TNF (Sigma-Aldrich, Oakville, ON, Canada) or TPF.
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PMC4277423
More recently, Ye et al. combined TALENs or sgRNA-Cas9 with piggyBac technology to generate CCR5Δ32 deletion mutant in induced pluripotent stem cells (iPSCs).
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PMC9429973
Therefore, we consider that it should be included as a first line treatment at the same level as the classic alternatives, especially in cases where the esthetic consequences of the treatment are particularly relevant.
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