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OTAR3088
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PMC11757131
Data are shown as mean ± SEM.
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PMC11687167
DESCARTES2.
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PMC6600592
The selectivity index (SI) was determined as the ratio of CC50 to IC50 which a major pharmaceutical parameter of estimates possible future clinical application.
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PMC10968586
According to another report, 100 μM HT reduced DNA synthesis in HL-60 cells, with promotion of cell differentiation, cell accumulation in G0/G1 phase, and apoptosis of S phase cells .
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PMC9516447
Recent studies also suggest that phosphorylation of eIF4E and 4E-BP1 regulates translation of stress or oncogenic proteins .
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PMC7812570
A dual-split-protein (DSP)-based cell–cell fusion assay was described previously.
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PMC9712534
In this viewpoint, we sought to examine whether the impact of H58Y may be reflected in the TOP2B dynamics.
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PMC11754784
By comparing the diffusion kinetics and the DNA reacton or target binding kinetics, it is clear that the diffusion rate is several orders of magnitude faster than reaction rates (Fig. 2h).
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PMC11730000
CHO-K1 cells were subjected to different dosages of EGCG, RA, and their combination for 24 h. The results exhibited a statistically significant protective effect of both EGCG and RA against DOX-induced cytotoxicity.
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PMC11224020
Data were analyzed by ordinary one-way ANOVA; ****P < 0.0001; **P = 0.0043.
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PMC8140214
Effect of D-glucose and/ or quercetin on CAT activity in HepG2 cells after 48 (A) and 72 (B) hr treatment.
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PMC10747139
The virulence of the progeny virus in the H1N1 group was 3.09·10/0.1 mL, whereas that in the H1N1+60 group was 1.04·10/0.1 mL. The virulence of the progeny virus of the treatment group was significantly reduced.
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PMC11248911
The input files for equilibration and production are then downloaded and the desired changes were made which include number of steps of MD run, frequency of saving of trajectories and calculation of energy, etc.
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PMC11754291
Keratinocytes, as the primary producers of α-MSH, outnumbered fibroblasts by a ratio of approximately 12–13, reaching 7 to 8 million cells per T75 flask after 7 days of culture.
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PMC11779993
The total phenolic content was evaluated using the Folin–Ciocalteu assay.
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PMC8922418
The strategy of targeting CXCR4 to treat HIV-1 has only been conducted in CD4 T cells.
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PMC11320834
One solution to this problem may be pegylation, which significantly improves liposome stability during long-term storage without any negative impact on the delivery of the therapeutic .
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PMC11718817
Within this framework, M1 macrophages were found to kill cancer cells and M2 macrophages to promote cancer .
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PMC9429973
Journal editors (JEs) are selected due to their expertise in a field, publication record, and history of collaboration with a scientific journal.
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PMC8753818
For cell viability assay the medium from each well was entirely removed and replaced with 100 µL of fresh serum-free culture medium containing 5 mg/mL MTT solution.
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PMC11768927
Immune checkpoints such as PD-1, PD-L1, and CTLA-4 are critical regulators of T-cell activity, functioning to maintain immune homeostasis and prevent autoimmunity.
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PMC11739504
Immunocytochemistry data confirmed that the fluorescence intensity of Smo (green) was decreased in Kat2b silenced cell.
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PMC9429973
In vivo treatment of mice with FL3 after TCL1 adoptive transfer leads to a significant delay in CLL progression and an increased survival (E-F), demonstrating the relevance and possible impact of this molecule.
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PMC11777207
These different interactions between costimulatory and coinhibitory molecules between APCs and T cells emphasize the intricate mechanisms that control T cell activation and deactivation.
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PMC11243198
This automated 384-well C3H10T1/2 assay with fluorescence readout was adapted from our previous 96-well colorimetric version .
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PMC11682224
Data are expressed as mean ± standard deviation; N = 3; **P < 0.01.
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PMC11615828
The enlarged mean speed trajectories of VAMP2‐positive vesicles are shown.
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PMC11774112
Viability of A375 and NIH3T3 cells treated with different concentrations of Blank-PHRD for 72 h. Dose-dependent cell viability of A375 cells treated with DTIC, PHRD-DTIC (B), miRNA 34a, or PHRD-miRNA 34a (C) and DTIC + miRNA 34a or Co-PHRD (D) for 72 h. MTT was used to assess cell viability.
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PMC10048572
To assess the significance, a two-tailed Fisher’s test was used.
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PMC10165258
A sigmoidal fit is performed over these data to determine the IC50 value (indicated with a vertical bar in the middle of the sigmoid).
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PMC9219615
Four contiguous images, taken in 2 × 2 montages, were captured via GE InCell Analyzer 2000 with a 10x objective from the two fluorescent channels corresponding to Hoechst and PI emission.
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PMC11623887
This increase in GATA-1 expression coincided with a decrease in c-myb expression levels.
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PMC11045125
Our results here suggest that cytokine therapies such as IL21 (which enhances JAK kinase-mediated STAT3 activity) may be useful for reactivating LMP1 expression in human BLs, particularly when combined with epigenetic modifiers such as HDAC inhibitors and/or DNA methylation inhibitors.
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PMC11612794
3xFLAG-CENP-T or 3xFLAG-CENP-T was expressed in AID-based CENP-T conditional knockdown CENP-C cells in which wild-type CENP-T protein was degraded by IAA addition.
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PMC10452486
In HLA- B-derived HCs, C is highly prevalent and may contribute to S-S bonding between the HCs.
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PMC10849234
Two-tailed T-tests between comparisons of interest are also shown.
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PMC11754432
Primer (Biomers.net, Ulm, Germany) sequences are available in Table S2.
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PMC11638288
This complex targets two activation receptors, NKp46 and CD16, on NK cells as well as tumor antigens on cancer cells.
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PMC10914904
All vtRNAs are expressed by RNA polymerase III [57–59].
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PMC11740207
Research into CSCs suggests that these resistant cell types could be crucial for developing therapies to prevent cancer relapse by targeting dormant cancer cells.
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PMC9844987
For a full version of the plot see Figure 2—figure supplement 3A. (
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PMC11509278
Cholesterol is a metabolite associated with multiple biological functions that play complex roles in supporting cancer progression and suppressing immune responses.
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PMC11392912
Biotinylated primary antibody was added to each well and incubated for 90 min at 37°C, washed after incubation, added HRP conjugated secondary antibody, and incubated for 40 min.
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PMC11604768
Dark gray data points: negative control promoters.
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PMC11791203
Tocopherol and epoxylathyrol, identified from the ethyl acetate extract of Anamirta cocculus, demonstrated strong binding affinities with key proteins, including Caspase-3, Caspase-8, Caspase-9, and P53[. The presence of additional residues in the most favoured region of the Ramachandran plot may enhance the ligand’s binding affinity, as described by Oruganty et al.. These findings suggest that cyclododecanol, along with other bioactive compounds in the extract, hold promise as a potential anticancer agent and warrants further exploration for its therapeutic applications in cancer treatment.
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PMC11401350
Data are summarized in the histogram (mean (SD), INFγ n = 6, Granzyme n = 6, Perforin n = 3; multiple student t-test; *p < 0.05, ***p < 0.001, ****p < 0.0001).
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PMC11545868
Major isoflavone glucosides include genistin, daidzein, and glycitin .
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PMC11655536
All plasmid vectors used in this study are listed in Supplemental Table 2.
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PMC10729469
12–0031-81, Invitrogen, Waltham, MA), APC-H7-anti-CD4 (cat.
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PMC8623816
TEM observation revealed that the virus particles purified from strain D122 were isometric with an approximate diameter of 20 nm (Figure 4a), comparable to the Rhizoctonia solani dsRNA virus 3 (RsRV3) previously reported in our laboratory .
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PMC11727062
Co-treatment with brusatol and UVA led to diminished expression of CyclinD1, CyclinE2, CDK4, and CDK6, culminating in G1 phase cell cycle arrest.
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PMC11585565
The fluorescent signals were visualized using Z-stack optical sectioning by Zeiss Apotome 3 (Zeiss).
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PMC11489175
By using the zinc ion, MP hydrolyzes a water molecule producing the hydroxide ion allowing the hydrolysis of the isopeptide bond between substrate and ubiquitin 18.
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PMC9429973
Randomization was stratified by CXCR4 mutational status by Sanger sequencing and lines of prior therapy (0, 1-3, or >3).
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PMC10965680
In addition, population structure was assessed using ADMIXTURE v1.3.0 with the default setting (Zhang et al., 2019).
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PMC9429973
The ENROL project, which includes rare anemias, dendritic cell leukemia and von Villebrand’s disease pilots, aims to collect exhaustive and therefore epidemiological data for RHDs.
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PMC11754436
because of the insufficient clinical sample size, the present study did not include investigations of clinical cases.
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PMC9545474
It is of interest to observe how the addition of a phosphine ligand can dramatically alter or not the anticancer properties of these complexes.
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PMC9429973
Aims: This study aims to compare efficacy and safety of first-line PON versus imatinib with reduced-intensity chemotherapy in patients with newly diagnosed Ph+ or BCR::ABL1–positive ALL (p190/p210 transcript type).
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PMC11723947
Mice carrying a conditional ready Hp1a (Hp1a) allele were crossed with CMV-cre transgenic mice to excise the floxed sequence.
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PMC11365427
DR5, also known as TRAIL-R2 or KILLER, is a death receptor in the tumor necrosis factor receptor superfamily that can induce cell apoptosis when bound to its ligand TRAIL.
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PMC10055960
The resistance displayed by malignancies toward platinum(II) metallodrugs, coupled with the inherent lack of specificity of platinum-containing compounds has become prevalent in recent times .
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PMC11388384
Therefore, the diffusion behavior of individual molecules revealed by TIRF microscopy should be sufficient to explain the difference in the effective diffusion rate that contributes to SCUBE-mediated gradient expansion.
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PMC10988555
Nevertheless, we cannot exclude the hypothesis that Co(III) can be reduced to Co(II) or even to Co(I) even before internalization within cells (e.g., what happens of Fe(III) to Fe(II) and Cu(II) to Cu(I) which can then be internalized by the respective plasma membrane transporters.
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PMC11777207
Glutamic acid 57 depicted in blue within durvalumab depicts the interacting residue with PD-L1 (52).
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PMC6222726
B. excelsa (synonyms: Bullockia sphaerocarpa and Elaphrium excelsum) is commonly known as tecomajaca, or copal santo, pom (in the Maya language) and tecomahaca in the Náhuatl language .
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PMC9429973
Other key eligibility criteria included bilirubin ≤1.5x upper limit of normal (ULN), AST/ALT ≤2.5x ULN, creatinine ≤1.5x ULN, QTc ≤500 msec, and ECOG 0-2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136
Kaplan–Meier survival curves were used to determine survival analysis, and the differences in survival curves were evaluated using the log-rank test.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11695623
Differential expression of DCUN1D5 protein in cancer and adjacent tissues of lung adenocarcinoma patients. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differential", "expression", "of", "DCUN1D5", "protein", "in", ...
PMC9985266
In conclusion, these results confirm that IL-27 attenuates PF by activating autophagy via inhibition of the ERK/p38 signaling pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", ...
PMC11544122
SNX9.13.10 (9-2)], SNX18 [cat.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SNX9.13.10", "(", "9", "-", "2", ")", "]", ",", "SNX18", "[", "cat", "." ...
PMC10198699
The answer is ‘no’.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "answer", "is", "‘", "no", "’", "." ] } ]
PMC11075223
Caffeic acid, FA and IFA displayed positive correlations (the correlation coefficient values were 0.51, 0.50, and 0.51, respectively) with antioxidant levels by anti-lipidperoxidation, OH scavenging, Cu-chelating and Fe reducing assays .
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PMC10578720
Liver stiffness assessment based on shear-wave elastography.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Liver", "stiffness", "assessment", "based", "on", "shear-wave", "elastography", "." ] } ]
PMC11172027
Resultant fluorescence was measured by using excitation and emission wavelengths of 495 and 519 nm, respectively.
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PMC6892818
Normal and malignant cells expressed CD40 which could be up-regulated by TNF-α/IFN-γ.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "and", "malignant", "cells", "expressed", "CD40", "which", "could", "be...
PMC8609870
Cushman et al. found the correlation between GRIA1 SNPs and cattle infertility .
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PMC9429973
Complications, such as pneumonia and bacteriaemia, developed in 32%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Complications", ",", "such", "as", "pneumonia", "and", "bacteriaemia", ",", "dev...
PMC9429973
Subsequently, we evaluated their potential role as non-invasive disease biomarkers in MF.
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PMC10818573
B95-8 cellular DNA (50 ng/μL) was used as the reaction template.
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PMC11411131
Krab-Sec 2 did not suppress pCT-Luc activity in Cos-7 cells.
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PMC11476264
Concomitantly, in a wound-healing migration assay (Figure 4E) and transwell invasion assay (Figure 4F), the migratory and invasive abilities of the cells were weakened.
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PMC11258145
In frozen liposome suspensions, curcumin enhances water penetration.
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PMC8343815
At a similar concentration, it was observed that AuNRs could induce a higher level of cell death compared to AuNPs (P<0.05).
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PMC11089031
p <0.05 indicated a statistically significant difference in OS.
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PMC11730311
Arteries were exposed to progressively increasing concentrations of hαCGRP in the presence or absence of 10 nM, 30 nM, 100 nM and 300 nM (a) hαCGRP8-37N25K-C20DA-γGlu or (b) hαCGRP8-37A36S, N25K-C20DA-γGlu following a stable contraction induced by 200 nM U4619. (
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PMC11461833
The upregulated (A) or downregulated (B) DEGs in HA-progerin-expressing HEK293 cells overexpressing STXBP5 (relative to those overexpressing the empty vector) were identified through KEGG analysis.
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PMC10329074
Clone formation ability of ACHN cells was investigated via clone formation assay. (
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PMC11279397
The biological activities of germacron are attributed to its ketone and non-conjugated double bonds .
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PMC9429973
The median age at diagnosis was 72 years (interquartile range [IQR] 65-81) and 4386 (61%) were males.
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PMC9429973
Results: Thirty-two (54.2%) patients with HC under palliative care (non-Hodgkin lymphoma=10, acute myeloid leukemia=9, myelodisplastic syndrome=7, multiple myeloma/plasma cell leukemia=6) and 27 (45.8%) controls (metastatic lung cancer=6, metastatic breast cancer=1, dementia=3, mental retardation=1, other=16) were retrospectively included in the period between January 2019 and January 2022.
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PMC11545868
A study by Farzaneh Behelgardi, M. et al. showed that VEG4, a representative antagonist, interferes with VEGF/VEGFR interaction, inactivating the PI3K/AKT/XIAP pathway and downregulating the caspase pathway to inhibit apoptosis .
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PMC11206251
MTT was diluted with phosphate-buffered saline (PBS) to a 5 mg·mL solution.
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PMC11412721
Asynchronous MEFs were exposed to 0–10 Gy γ-irradiation, then after 24 hr cells were labeled with BrdU for 1 hr and analyzed by FACS.
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PMC9429973
These two groups were matched in age, sex and body mass index.
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PMC3730428
Recombinant GST-FADD was expressed in BL21 bacteria and purified.
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PMC9429973
Results: Of the 1097 patients, 730 patients had a positive D-dimer with the Tina-quant D-Dimer Gen. 2, and 775 patients had a positive D-dimer with the STA-Liatest D-Di Plus; cut-off for both tests was ≥ 0.5 µg/mL FEU.
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PMC11758416
You may also reduce the number of T cells and L cells, although we do not advise using less than 5,000 L cells per assay well.
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PMC11680578
Significantly, there was a rise in the protein levels of PPAR-γ in combined treatment as opposed to individual treatments with RGZ and PTX.
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PMC11622247
Herein we introduce a fluorogenic probe technology in which energy transfer between two or more dyes persists in both the unbound and bound states.
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