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OTAR3088
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BioData-CellLine_annotated

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PMC9583612
Moreover, while emission attribution of measurements from aerial technologies is an ongoing field of research, comparing operational data with snapshot measurements can help with root-cause analysis.
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PMC11476264
ZEB1, also known as TCF8 or δEF1, is a key transcriptional regulator of EMT .
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PMC11777207
Last, these data suggest that clinically available PD-L1 antibodies elicit unique and specific effects based on the residues they interact with and suggest the importance of dosing and clinical outcomes with these different antibodies.
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PMC9429973
Fluorescence in-situ hybridization (FISH) analysis was performed centrally on CD138-purified plasma cells.
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PMC11694625
55.5%.
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PMC11621493
In conclusion, our observations suggest that PLA2G4D exhibits hydrolase and transacylase activity using both phospholipids and acylglycerols as substrates.
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PMC11486946
Our method observed changes in EGFR mobility and clustering instead of focusing on a specific process of the signaling, allowing it to detect changes in multiple processes dependent on the ligand.
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PMC9429973
S. Yazji, S. Hamburger, Y. Wang, S. Yavrom, A. Pietrofeso, R. Bliss, J. B. Breitmeyer, M. Dreyling, M. Wang Oncternal Therapeutics, Inc., San Diego, CA; Veristat, LLC, Southborough, MA, United States of America; University of Munich, Munich, Bavaria, Germany; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America Background: Zilovertamab (ZILO) is a humanized monoclonal antibody that inhibits the tumor promoting activity of ROR1 and has demonstrated additive/synergistic activity with anti-cancer agents including ibrutinib (Ibr).
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PMC11477621
Moreover, hydrophobic contacts were observed with His132, Phe141, His170, Phe198, and Leu265, during the entire MD simulation process.
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PMC8097906
Only the treatment with 50 μg/ml lupeol revealed a significant anti-migratory effect on RH-30 cells (Fig. 6g).
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PMC11697703
Bioinformatic target analyses consistently predicted that both miR-193b and miR-365 target the signaling molecule MapK8 (Figure 2A).
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PMC8992508
In fact, the most BCRP active compounds 60 and 61 are the most lipophilic.
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PMC11774251
To further explore the roles of these key targets, we conducted GO enrichment analysis using the DAVID database.
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PMC10421378
These compounds may include short-chain fatty acids , antimicrobial peptides , or metabolites, which can exert beneficial effects on the intestinal epithelium, immune system, or overall gut health.
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PMC11701801
For each sample, the mRNA level of target genes was normalized to that of GAPDH.
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PMC11539788
qRT‒PCR analysis of RNF19A mRNA expression in T24 and 5637 cells stably overexpressing RNF19A. (
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PMC11665584
Withdrawal of either atRA or its precursor, vitamin A, potentiates HFSC migration to the wound bed but prevents HF neogenesis in the healed skin.
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PMC11786767
Biotin-DHPE was distributed throughout cells and covered the entire chromosomes.
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PMC11787355
D170, P. (2025) https://BioRender.com/p23d083 (h).
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PMC11361748
The Click-iT Plus TUNEL Assay for in situ apoptosis detection with Alexa Fluor 488 (Invitrogen #C10617) was used as recommended by the manufacturer.
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PMC5311252
Samples were diluted in 4 × Laemmli Sample buffer (Bio-Rad, 1610747) with 1:10 β-mercaptoethanol.
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PMC11612794
The side chains of key residues of CENP-T for binding to Mis12C are shown with labels.(C) Schematic representation of the CENP-T aa 161–216 structure.
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PMC11126803
Next, the promoter with ERE#2 WT or with the ERE#2 mutant ZEB1 was cloned into the pGL3 luciferase reporter plasmid.
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PMC9429973
The total person-years for pts randomized to luspatercept at risk of progressing to HR-MDS/AML was 401.7 y vs 190.9 y for placebo.
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PMC11489351
A and B, Notch1 signaling pathway genes with transcripts that are upregulated (magenta) or downregulated (cyan) at low pHi (EIPA) (A) or high pHi (NH4Cl) (B) compared to control MCF10A (Metacore pathway analysis; see Methods).
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PMC10033453
Area under tumor growth curves was compared by one-way ANOVA with Holm-Šídák correction for type I error. (
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PMC8193813
Its t95 was measured as 32.3 ± 3.8s with a noise level of 0.015 ppm.
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PMC11537649
Each group was set up with 3 compound wells and each experiment was repeated 3 times.
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PMC9429973
All patients had a frailty score ≥2 and 13 (24 %) had a 3 or 4 frailty score.
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PMC9429973
Clinical analyses of the whole cohort confirmed the independent prognostic value of IGLV3-21.
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PMC9429973
Written informed consent will be obtained upon enrollment.
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PMC9429973
The current first-line therapy strategies such as HLH-94 or HLH-2004 regimens are largely extrapolated from paediatric HLH; however, the prognosis of adult HLH is worse than that of children.
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PMC9503541
OPLS-DA scores plot showed separation of the active and inactive classes and overlapping of the individual elements within each group.
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PMC11306331
Source data provided as a Source Data file.
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PMC9429973
The search strings were established by logical association of appropriate words and MESH terms.
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PMC11740573
The results of this preliminary study confirm that calcitriol treatment influences cytokine-mediated immune response during infection and indicate that it can be effective in enhancing antibiotic activity.
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PMC11679892
Total oxidant and total antioxidant levels were measured from the cells in the study group with the help of the commercial kit provided (TAS and TOS, Rel Assay, Gaziantep, Turkey.
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PMC11345828
LCMS Method 1: RT = 2.178, 2.218 min, MS (ESI): mass calcd for C41H43Cl2N5O5, 755.3, m/z found, 755.90 (M + H).
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PMC8740518
Quality control (QC) samples were prepared by pooling an aliquot of 30 µL from each sample.
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PMC11574271
Stable cell lines were then generated either with RON knockdown (5637-shRON) or RON overexpression (J82-oeRON), together with their corresponding control cell lines including 5636-NC and J82-NC (Fig. 1F).
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PMC11736898
In keloid keratinocytes, the increase in CYP24A1 expression in ketoconazole + vitamin D treated cells versus vitamin D treatment alone was only 1.5-fold and was not statistically significant.
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PMC11629192
Both mRS and CASE scores decreased to 0 after the final dose of OFA, with a significant reduction in the percentage of CD19 B cells in peripheral blood lymphocytes.
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PMC11789597
CAV1 inhibition in MM cells enhances natural killer cell‐mediated cytotoxicity through increasing CXCL10, SLAMF7, and CD112.
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PMC11640555
Control group (GBM): the animal received only oral administration of saline solution (n = 18); GBM + CX-4945 (50 mg/kg): the animal with GBM received administration of CX-4945 at a dose of 50 mg/kg for two weeks (n = 18); GBM + CX-4945 (100 mg/kg): the animal with GBM received administration of CX-4945 at a dose of 100 mg/kg for two weeks (n = 18).
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PMC9429973
Hypoxia inducible factor (HIF) is central to mediating the cellular response to hypoxia.
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PMC11468365
The second model used the attention model only where the outputs are fed to the prediction network directly.
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PMC11638255
Anti-GD2 immunotherapy has improved the survival of patients with high-risk neuroblastoma with efficacy likely hampered by the immunosuppressive tumor microenvironment.
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PMC11727062
This polarization leads to the secretion of a variety of antitumor factors by M1-type macrophages, such as TNF-α, IL-1β, CXCL9, and CXCL10, which play an antitumor role (He et al. 2021; Zhang et al. 2021).
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PMC11802929
’s are assigned to each single cell by matching SNP analysis from whole genome with scRNAseq data.
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PMC9429973
This phase 2 study needs confirmation in a larger cohort.
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PMC11697065
This analysis revealed many adaptive changes in the transcriptome and proteome of cells selected for high and low productivity.
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PMC9429973
In patient 2, variants affecting IDH2 (92%), RUNX1 (43%), and DNMT3A (49%) genes were detected by at diagnosis.
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PMC11638255
Here, we report that copper chelation therapy induces a marked increase in the infiltration of pro-inflammatory neutrophils and reprograms the neuroblastoma tumor microenvironment to reinvigorate anti-tumor immunity.
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PMC11638288
Effective defense against cytomegalovirus infection requires the involvement of T cells and NK cells .
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PMC11548041
Docking and molecular dynamics simulations of several seed DNA sequences that bind to EpCAM were performed to identify structural motifs and key sites of binding to the EpCAM extracellular domain (EpEX) monomer.
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PMC6190245
Two groups of HeLa cells were treated with various concentrations of F. gummosa for 24 hr (A), 48 hr (B), and 72 hr (C) and one of two groups was exposed to 2 Gy γ-rays.
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PMC11627398
P<0.05, **P<0.01, ***P<0.001.
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PMC11604768
f Example cell line-specific promoters responsive to treatment with 10% FBS.
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PMC11650848
We decided to examine possible spliced variants of ZFP57 using RNA-Seq in human placenta from publicly available data.
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PMC9429973
Median prior therapies were 5 (3–10) with 24(92%) patients having received ≥4 prior therapies.
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PMC11635087
Nuclei and cell membranes were stained with DAPI (Nacalai tesque) and FM1-43 Dye (Invitrogen), respectively.
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PMC3813807
Moreover, this putative miRNA response element (MRE) was highly conserved in vertebrates (Fig. 2A).
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PMC11001582
PCR amplification across the 400 codon-optimized repeats showed that DPR length is stable across at least five generations (Extended Data Fig. 1e).
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PMC6133382
Plates were incubated with a 1:3,000 dilution of AlexaFluor 488 conjugated goat-anti-human polyclonal antibody, and binding is reported as RFUs.
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PMC8358176
The housekeeping genes β-actin and glyceraldehyde 3-phosphate dehydrogenase was utilized for normalization.
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PMC9429973
However, too few cases 1.3 Autos: a marked decrease in activity from March-May, the biggest drop in April (-42%), but a moderate total decrease (-7%) 1.4 Non-malignant diseases (47% auto and 53% allo-HCT): a marked total decrease, higher in allo-HCT (-19.7%) than in auto-HCT (-5.6%) 2.- HCT activity in children 2.1 Global (allo & auto): a discrete increase in the activity in nearly all months, with a 5.2% total increase.
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PMC11593031
To prove that the enlargements of centromere-near sub-band A1 (which is homologous among all murine chromosomes—see Figure S1) are centromeric DNA amplifications, a corresponding microdissection-derived probe has been used in Neuro-2A.
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PMC6617630
We then evaluated the effect of SAHA and I-BET on cell survival and observed that SAHA or BETi used alone had only a modest decline in cell survival for the WT-MYC cells; the combination had no further change in cell survival in any of the MYC rearrangement DLBCL cell lines tested (Fig. 7d–f).Fig.
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PMC9429973
Ruxolitinib will be administered twice daily for all 21 days of the cycle.
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PMC11363012
Hierarchical clustering analysis (HCA) was applied to the untargeted data sets in order to identify relationships between cells and metabolites, particularly the co-occurrence of different compounds in the same cell.
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PMC9429973
High EVcargo is associated with high sFLC lambda, IgA immunoparesis and shorter time in response.
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PMC11013014
The binding affinity values for 2 and 3 are −7.4 kcal/mol and −7.3 kcal/mol, respectively (Table 5 and Table 6).
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PMC7022782
Biological interaction in vitro between NPs and cells was studied at the light microscope on semithin sections stained with toluidine blue.
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PMC11653533
Again, 100 μg/ml, 50 μg/ml, and 25 μg/ml ethanol extracts of F. benghalensis leaves have shown antiplasmodial activity against Plasmodium falciparum which causes malaria, however, the zone of inhibition value was 82, 39 and 25 %, where the IC50 value was 52 μg/ml (Simonsen et al., 2001).
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PMC11723947
Analyses were carried out using FlowJo software.
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PMC11657695
B Normalized and relative EWS::FLI1 and KCNA2 gene expressions in A673/TR/shEF cell line after doxycycline treatment (1 µg/mL) (N = 5, left and middle panel).
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PMC3019555
Noc was then removed, and cells were incubated in drug-free media for the indicated times.
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PMC9429973
55(82%) pts had a documented toxicity.
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PMC10165258
The color of plotted dots indicate the measured spheroid radius in micrometers.
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PMC11731161
Briefly, MM cells under various treatment conditions were additionally treated with CHX (200 μg /mL) for the indicated times.
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PMC11750712
CAR T cells (orange) are identified by coexpression of both Q/BenD10 and anti-CD3.
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PMC11656657
Specifically, we aimed at evaluating whether GD2 expression could be influenced by cell confluency.
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PMC9429973
In particular, GRHPR (p=0.035) and SGK1 (p=0.039) mutations identified only on the liquid biopsy, and MYC mutations identified only on the LN biopsy (p=0.021) were associated with a shorter PFS.
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PMC11805741
The IC50 values, or the concentration of a chemical that inhibits 50% of the growth of cells relative to the untreated control cultures, were calculated using the percentages of cell viability.
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PMC11746942
To establish a causal relationship between STAT3 activation and the antiproliferative effects of TY, we expressed a constitutively active STAT3 mutant (STAT3C) in keratinocytes.
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PMC11730305
The zeta potential of Co3O4@Glu-Ellagic acid NPs was − 5.43 mV. (b) DLS analysis.
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PMC11291490
These results collectively demonstrate the successful construction of TMUV prM-E-based DNA vaccines, incorporating or not with the biological adjuvant dusCD40L.Fig.
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PMC11683240
Disease manifestations are predominantly caused by pertussis toxin (PT), a pivotal virulence factor classified as an ADP-ribosylating AB-type protein toxin.
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PMC10956161
All assays were performed at least three times.
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PMC9429973
The PFS and OS curves are shown in Figure 1.
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PMC11271278
This method ranks genes by 1) their enhancer contact value defined as the number of interacting enhancers and 2) their interaction intensity as defined by the number of HiChIP paired-end tags (PETs).
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PMC11682224
The inhibition of PI3K/AKT pathway glycolysis in esophageal squamous cell carcinoma cells by downregulation of CHD1L increases the cytotoxicity of cisplatin.
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PMC8864075
The cell lysates were collected and the protein concentration was detected by Pierce™ BCA Protein Assay Kit.
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PMC11317131
We used a fluorescent protein-based assay to show that selected mutants outperformed their unevolved starting variants in human cells.
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PMC11655536
Moreover, immunofluorescence staining showed significant enhancement of nuclear translocation of TFE3 in HA-treated RPMI-8226 and U266 cells (Fig. 4C).
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PMC10092581
IC50 values were calculated by a four‐parameter logistic model 4‐PL (P<0.05).
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PMC11727062
The underlying mechanism is hypothesized to involve CHOP-dependent apoptotic pathways (Wang et al. 2023).
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PMC11768927
Another investigation focused on the therapeutic potential of VSVrp30, a VSV variant isolated through serial passaging on glioblastoma cells, for the treatment of systemic cancer metastasis.
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PMC6461034
The limited patient material was available precluded replicate analysis, so results reported here are preliminary.
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PMC11216402
In the Epi-like upregulated group, KLF5 and HNF4A along with GATA4 and GATA6 have been shown to promote GC (Chia et al. 2015).
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