PMCID string | Sentences string | ner list |
|---|---|---|
PMC11754436 | Identification of key functional molecules in OS is urgently required to develop effective preventive measures and reasonable treatment methods for OS. | [
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PMC3765139 | Furthermore, during a suggested metastatic transition, originally CD133- induced tumors can transform to CD133+ xenografts. | [
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PMC11720107 | A notable observation was that the strong decrease in CAT mRNA expression caused by the Ornak cultivar was accompanied by an increase in CAT protein expression. | [
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PMC4005030 | It is also a very common compound present in human diet, present in bran and grain brown rice (Oryza sativa L.) and onion (Allium cepa L.) , especially in the scales. | [
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PMC9429973 | 2021 Aug;84:110012. | [
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PMC11754094 | DNA sequences (10 kb) are amplified from genomic DNA isolated from CRISPR-treated and non-treated cells. | [
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PMC11478724 | RNA extraction electrophoresis gel (1%) from A549 with and without PMX-treated after DNase I treatment (a). | [
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PMC11763126 | Both culture media were supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin and cells were incubated at in a 5% CO2 environment. | [
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PMC10452486 | Kollnberger’s team assessed KIR binding to HLA-Ia variants using several approaches, which included (i) flow cytometric analysis of KIR-expressing cell lines stained with HLA-I Face-1; (ii) recombinant KIR Fc fusion proteins or KIR tetramers coated fluorescent multiplex beads; (iii) physical measurements of KIR binding to HLA-I variants; (iv) binding of KIR-expressing reporter cells to HLA-I variants or to HLA-I variant transfected cell lines; and (v) KIR inhibition of NK cytotoxicity and IFN-γ production by binding to HLA-I variants. | [
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PMC10452486 | We hope that our hypothesis may stimulate further studies on the multivarious HLA-I antibodies formed against novel HLA-I heterodimers in mismatched organ transplantation, which may play a role in transplant rejection. | [
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PMC10490530 | Reporter genes are also extensively used for performing non-invasive imaging procedures in various vertebrate, invertebrate, and plant model systems . | [
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PMC11746948 | Protein concentration was determined using the BCA Protein Assay Kit (Thermo Fisher Scientific, USA). | [
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PMC10530622 | Pyridoxine (VB6), a AGT cofactor, can partially rescue mistargeting by stabilizing the protein. | [
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PMC9429973 | The diagnosis of APL is based on morphological, cytogenetic and molecular study. | [
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PMC11345828 | The title compound (108 mg, 69% yield) was prepared following General Procedure F using compound 60 (150 mg, 0.19 mmol, 1.0 equiv) and (R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate (135 mg, 0.56 mmol, 3.0 equiv) followed by saponification using General Procedure G. LCMS Method 1: RT = 2.203 min, MS (ESI): mass calcd for C45H47Cl2N5O7, 839.3, m/z found 839.8 (M + H). | [
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PMC10440586 | The x-axis represents the time interval between the first and the second surgery. ( | [
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PMC11525028 | Mechanistically, NAT10 stabilizes ATF4 mRNA and inhibits ATF4 mRNA degradation by ac4C modification. | [
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PMC11129910 | Metaphase chromosomes from HMEC 5.6 RAB25 were prepared by using standard cytogenetic techniques. | [
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PMC9454178 | C Colony formation assays of GIST-T1 and GIST-882 cells after CDK7 knockdown. | [
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PMC11638288 | The study also employed Ig fusion proteins made from the D1 domain of NKp46, which allowed for the observation of specific, dose-dependent binding of NCR1 Ig and NKp46 Ig to F. nucleatum, indicating a direct interaction between NCR1 and NKp46 with F. nucleatum. | [
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PMC9841531 | Amongst the high-throughput screening-(HTS)- and organic synthesis-derived compounds, only a few structurally distinctive compound classes can be differentiated: (i) thieno[2,3-d]pyrimidin-2,4-diones, [e.g., AZD-3965 (3)], pteridine derivatives (e.g., compound 4(33)), pyrrolo[3,4-d]pyridazinones (e.g., compound 5(29)), coumarin derivatives [e.g., 7ACC2 (6)], the sulfonyldibenzene BAY-8002 (7), as well as cinnamic acid derivatives [e.g., hydroxy-4-cyanocinnamic acid (CHC); 8].Figure 1 shows the molecular structures of compounds 1–8. | [
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PMC9918897 | After in vitro cultivation, 10⁷ living HeLa cells (ATCC No.: CRM-CCL-2, BSL 2) were suspended in 100 microliters of physiological saline. | [
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PMC11637276 | Our data suggested that MAPK signalling regulates ECM endocytosis (S2 Table). | [
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PMC11617590 | PDAC with low Ser9 phosphorylation of GSK‐3β inflicts a negative prognosis owing to sustained tumor‐promoting signals . | [
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PMC11286266 | HEK293T cells (ATCC CRL-3216) were cultured in Dulbecco's Modified Eagle Medium (DMEM) cell media (Sigma) supplemented as above. | [
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PMC11687663 | The mobile phase consisted of 0.1% formic acid in water (A) and 0.1% formic acid in Acetonitrile HPLC grade (B) at a flow rate of 1.2 mL/min. | [
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PMC10761571 | Therefore, we aimed to design Fe3O4 NPs functionalized with glucose and conjugated with gingerol, as a therapeutic component. | [
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PMC9429973 | A 34.5 % of the patients were fully vaccinated. | [
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PMC6190245 | Comparison of the cytotoxic effect of different concentrations of Ferula gummosa and its radiosentisizing effects on HeLa cells. | [
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PMC11116779 | Each value represents the mean ± SD of six independent experiments. | [
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PMC11075223 | Ohwi . | [
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PMC11264242 | A further examination of the peak distance to transcription start site (TSS) revealed that FLAG-tagged SS18-SSX2 primarily occupies genomic regions close to the TSS (Figure 1A). | [
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PMC11803918 | Subsequently, cells were permeabilized with 0.2% Triton X-100 and blocked in 3% BSA in PBS for 1 h at room temperature. | [
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PMC11424574 | Using TNMplot software to screen the TCGA database, we observed that uPA expression was elevated in human osteosarcoma tissues compared to that of normal tissues (P = 1.13e) (Figure 3D). | [
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PMC11026382 | a Volcano plot examining the statistical significance of epistasis across all DHFR point mutations in the Q33S background. | [
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PMC11525028 | Osteosarcoma cell 143B stably expressing green fluorescent protein (GFP) were generated and validated for functional screening. | [
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PMC9261184 | The researchers boarded the ship on March 25, 2021, while the ship was anchored off the port of Corpus Christi, USA. | [
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PMC11348300 | In a similar way of how perfusion-based ICG imaging has gained prominence for intraoperative tissue assessment, imaging DF and quantifying PRESTO contrast is a promising method for assessing functional intra- an extracellular differences between cancerous and healthy cells. | [
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PMC11400680 | Specifically, points, boxes, and texts are termed as sparse prompts while masks are referred to as dense prompts. | [
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PMC11345828 | The combination of 26 and docetaxel (60 mg/kg + 10 mg/kg, q7d) resulted in a deepened response relative to either single agent treatment, with no sign of outgrowth after 21 days. | [
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PMC8973085 | ; IR (KBr, v, cm): 3446 (NH), 3336 (NH), 2225 (CN), 1661 (C=O), 1641 (C=O); H NMR (DMSO-d6): δ 2.36 (s, 3H, CH3), 2.54 (s, 3H, CH3), 4.15 (s, 2H, CH2), 7.11–7.97 (m, 12H, CH-Ar), 9.46 (bs, 1H, NH), 10.63 (bs, 1H, NH); MS m/z (%): 528 [M] (95). | [
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PMC10529414 | A549 is a differentiated-type adenocarcinoma cell line derived from lung tumor tissue of a 58-year-old Caucasian man . | [
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PMC9429973 | Given the minimal response rates at all dose levels, the phase II expansion portion of the trial was not conducted. | [
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PMC11766309 | A negative correlation was observed between the expression of YKT6 and the infiltration of numerous types of immune cells in ESCA, HNSC, STAD, THCA, and UCS. | [
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... |
PMC11723947 | Prior to adoptive transfer into NSG hosts, human Treg were first cultured in ImmunoCult-XF T Cell Expansion Medium (Stemcell) containing ImmunoCult Human CD3/CD28/CD2 T Cell Activator (Stemcell), 500 IU/mL rhIL-2 and 100 ng/mL Rapamycin (Sigma). | [
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PMC11640115 | These factors influence neutrophil counts and may be related to the weak effectiveness of the NLR compared to the imGPS in correctly predicting pembrolizumab efficacy. | [
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PMC8068766 | Se: Selenium-deficiency effect, HBV: HBV-integration effect, BCL: Between cell line, WCL: Within cell line, (E): Existing DEG, (S): Steiner node, HM: Heat map, OS: Oxidative stress, r: Reported. | [
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PMC11755519 | EVs can activate receptors or alter miRNA or RNA expression in neighboring tumor cells causing, for example, an increase in their migratory, invasive, or proliferation potential. | [
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PMC11607321 | Features ranked by their reconstruction quality are shown for the drug response (left) and the CRISPR-Cas9 (right) datasets. | [
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PMC9429973 | The ASCEND trial compared acalabrutinib with investigator’s choice chemotherapy, either idelalisib plus rituximab or bendamustine plus rituximab. | [
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PMC11252553 | The antioxidant activity of Taurine is believed to be mediated through various mechanisms, although the exact mechanisms are still under investigation. | [
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PMC11453018 | This oncogenic protein modulates immune-related gene expression, alters cytokine profiles to favor immunosuppression, interferes with effective antigen presentation by downregulating MHC class I molecules, and manipulates the tumor microenvironment to encourage the recruitment of immunosuppressive cells like M2 macrophages . | [
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PMC11609529 | Our study addresses this gap by showing the endogenous YM fusion’s expression, its interaction with the TEAD transcription factors, and its essential role in supporting cancer cell proliferation and survival. | [
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PMC9429973 | Aims: Here, we analyze the interplay between BH3 protein family members in PI resistant vs. sensitive cell lines aiming to decipher survival strategies of PI resistance. | [
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PMC11670407 | Mechanistically, GPX4 could be a downstream target of OTULIN, conferring cisplatin resistance to OS by blocking the mitochondrial apoptotic pathway but not ferroptosis. | [
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PMC8864075 | As our research provides direct evidence, TWIST1-targeted flavonoid may provide a new strategy to inhibit EMT progress. | [
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PMC11397654 | The body weight of the mice was monitored throughout the experiment and was determined to be constant, indicating that the nanoplatforms are safe and cause relatively insignificant initial side effects. | [
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... |
PMC11750161 | To construct point mutations in eel LH/CGR activating and inactivating mutants, we used cDNA encoding full-length eel LH/CGR-wt using an overlap extension PCR strategy to substitute specific amino acids, as described previously (Byambaragchaa et al., 2021b). | [
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PMC6114978 | To determine more directly whether promoter hypermethylation and histone deacetylation work in conjunction with one another to regulate expression of the Hippo kinases, we treated cells with 5 μM 5-azacytidine (AZA) for 4 days followed by treatment with 500 nM trichostatin A (inhibits class I, II, and IV histone deactylases (HDACs) by interacting with the Zn(II) in the catalytic site ) for 12 h (Figure 6A–6D). | [
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PMC11063646 | The pH of the optimized emulgel (ANG 12) was found to be 6.4 ± 0.5 indicating that the formulated emulgel is deemed safe for skin application. | [
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PMC5415764 | Using high-throughput or systems biology methods like metabonomics would hold excellent prospect for tumor treatment research in the future. | [
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PMC3164356 | Many of these genes are either cell adhesion molecules (CAMs), important for viral entry and vesicular trafficking, or plasma membrane proteins involved in viral recognition. | [
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PMC11087055 | Thus, the large-scale cell flow and midline morphogenesis in amniote gastrulation is not tightly coupled, which may be evolutionarily distinct from non-amniote gastrulation. | [
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PMC11519788 | Meanwhile, sphere formation assays indicated that U937 cells led to a significant increase in both the number and size of mCherry-labelled T24 spheres, whereas SPOP overexpression effectively mitigated this U937-induced enhancement (Figure 3B-C). | [
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PMC9429973 | Tocilizumab and corticosteroids were given to 92% and 86% of pts with both CRS and ICANS. | [
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PMC11354239 | The down-regulation of gene expression appeared to be the main transcriptional change detected in degranulating responder NK cells compared to non-responders. | [
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PMC9429973 | Median age was 57 years (range 20-92). | [
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PMC10329237 | A study reported that angiotensin II type 1 receptor blockers could postpone the damages induced by free radicals through increased SOD levels while decreasing MDA contents (13). | [
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... |
PMC11594074 | A large chemical library containing approximately 10,000 compounds from the ZINC15 clean subset, as well as 1500 FDA-approved drugs, was established. | [
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"tokens": [
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... |
PMC8414691 | In contrast, SRCAP and DOM-A depletion leads to specific categories of mitosis and cytokinesis alterations. | [
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PMC11679033 | Industrial hemp (C. sativa L. subsp. | [
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PMC9727330 | The number of surviving cells significantly decreased in response to NNDAsp treatment only in colon cancer cells. | [
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... |
PMC11597291 | The nCGO-PEG conjugates were characterized by Fourier transform infrared spectra (FTIR) obtained from 600 to 4000 cm using a DigiLab Excalibur series FTS 3000 spectrometer (Labexchange, Burladingen, Germany) equipped with an attenuated total reflectance (ATR) and a class II laser. | [
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... |
PMC9429973 | Patients without HR CA had a lower PFS and OS when they carried del(1p32) (del(1p32) vs. no del(1p32); PFS 25.6 vs. 34.8 months, P = 0.0004; OS 83.0 vs. 136.1 months, P = 0.0002). | [
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... |
PMC11481779 | Fig. 1FID score of the real and augmented data - example of chr8 8 600 000–10 600 000. | [
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... |
PMC9429973 | Interim analyses will be performed annually; an effectiveness interim analysis is scheduled at 20 months post-LPFV. | [
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... |
PMC11802929 | a Graphic relating the SARS-CoV-2 proteome to putative HLA A*02:01 restricted antigens (top row), to those SCT constructs that were expressed in usable yield (middle row), and those that captured antigen-specific CD8 T cells from COVID-19 participants (bottom row). | [
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... |
PMC8973725 | Unequivocal nuclear and cytoplasmic staining patterns of ZNF677 were considered positive. | [
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PMC10047551 | The DNA methylation of cg19724470 and cg(chr9:5450951) was not significantly correlated with PD-L1 mRNA expression, although there was a trend of inverse correlation between cg19724470 and PD-L1 mRNA expression (spearman r = −0.33, p = 0.0906) (Figure 5A). | [
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PMC10698968 | For passaging, aggregates were centrifuged and resuspended in 500 µl of fresh medium, then a single-cell suspension was obtained by pipetting the pellet with a 1 ml syringe with a 26G needle (BD Franklin Lakes). | [
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... |
PMC9596868 | Data represents the mean ± SEM of three or more independent experiments. | [
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PMC4277423 | In summary, we tested CCR5 gene disruption in HIV-1 susceptible cells using lentiviral vectors expressing Cas9 and sgRNAs CR1, CR2 or CR3. | [
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... |
PMC8193046 | The reference ABCB1 inhibitor 2 as well as the reference ABCG2 inhibitor 27 were purchased from Tocris Bioscience (Bristol, UK). | [
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... |
PMC11612508 | In this process, 1 g of natural flake graphite (45 µm, sourced from Asbury Graphite) was combined with 27 mL of a chilled H2SO4:HNO3 in a 2:1 ratio. | [
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... |
PMC11422497 | Cell counting kit-8 (CCK8) assay and (C) Annexin V-FITC/PI assay was performed to analyze the effect of circ_SMA4 on GISTs cell proliferation and apoptosis. | [
{
"tags": [
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... |
PMC11237030 | AQP5 expression on non-membrane and membrane fraction from CHO-K1 and CHO-K1/AQP5 cells (clone 16) assessed by western blot. | [
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... |
PMC11653533 | Distribution of Ficus species throughout the world. | [
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PMC10968586 | Acute promyelocytic leukemia is a form of acute leukemia characterized by a chromosomal rearrangement involving PML::RARA fusion , making this malignancy sensitive to differentiating agents inducing PML-RARA fusion protein degradation by targeting the RARA or the PML part (all-trans-retinoic acid and arsenic-trioxide, respectively) . | [
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PMC8922418 | The current PE system mainly includes PE1, PE2, PE3, and PE3b (Hsu et al., 2021). | [
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PMC11322866 | Targeting EZH2 has exhibited therapeutic effects in various haematological malignancies . | [
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PMC11591794 | The Hoechst staining solution was prepared by diluting the Hoechst stock solution 1:2000 in PBS. | [
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PMC9739791 | To test whether the prodrug 30 could release oxaliplatin after two-photon absorption, the solution of the Pt(IV) prodrug 30 was irradiated with 100 fs pulses (725 nm, 800 mW/cm, 1 h). | [
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PMC11650848 | We first designed a SNP pyroassay to assess polymorphism frequency at rs365052 in our cohort (Fig. 2, SNP Seq1). | [
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PMC11252553 | on the frequency of apoptosis induced by various doses of X-rays after 48 & 72 hours post-irradiation. | [
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PMC9275501 | Jiang et al. (2016) found that the antitumor activity of CUR combined with etoposide (ETP) was higher than that of CUR and ETP alone, and the dosage was reduced. | [
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PMC11774112 | All tumors that had been excised from the mice are shown, corresponding to the groups designated above in Panel D. (F) Results of H&E staining of different organs and tumors in nude mice. | [
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... |
PMC11045125 | The expression of LMP1 in ΔEBNA2 EBV-infected CB B cells grown on the CD40L/IL21 expressing feeder layer is consistent with the known ability of IL21 to induce LMP1 expression in the absence of EBNA2 . | [
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... |
PMC11769516 | It has been shown that dietary supplementation with oils can reduce the degree of tissue damage caused by mycotoxin exposure. | [
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PMC9143157 | These findings suggest the necessity of the further elaboration of nanomedicines for clinical application. | [
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PMC11422497 | Additionally, the analysis of the relationship between clinical factors and circRNAs needs to be supported by larger samples. | [
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"O",
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