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PMC9429973
In the GBT021601-011 MAD phase, participants (n=10) were randomized 7:3 to 14 days of GBT021601 (3 days of loading doses followed by 11 days of once-daily maintenance doses) or placebo.
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PMC9318744
We noticed that the susceptibility of SARS-CoV-2 infection in 43.20 cells was dramatically reduced after several rounds of sequential culture.
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PMC11577421
Heparin also interacted favorably with the BSA coating on silica NPs.
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PMC11757131
Recent studies have shown that when valine metabolites are oxidized in the mitochondria, almost all metabolic products enter the tricarboxylic acid cycle for oxidative energy supply (10).
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PMC11477621
As shown in Figure 8b, the RMSF data suggested a flexibility ranging from 0.4 to 2.4 Å, indicating that the residues within the binding pocket are relatively stable.
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PMC11519788
Consistently, SPOP depletion in T24 cells with VEZF1 overexpression reversed the above effects significantly (p < 0.01).
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PMC11487720
Trafficking protein TRAPPC6A carries WWOX to relocate to the nucleus .
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PMC11349530
According to the recent study (22), tumor-derived PD-L1 does not directly protect tumor cells from cytotoxic T lymphocytes (CTL) cytotoxicity.
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PMC11705067
A natural follow-up issue is whether methylation of FDX1 and DLAT can be useful as prognostic predictors in patients with ccRCC.
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PMC11731161
p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 To evaluate whether inhibition of USP7 could enhance the sensitivity of MM cells to SEL, we conducted further experimental analysis.
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PMC9429973
This study will provide insights into determinants of treatment duration and its relationship with survival in real-life practice, which might help clinicians manage MM and AL amyloidosis.
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PMC11791264
Autophagy was quantified by counting GFP-LC3B puncta under a confocal microscope (Zeiss LSM710, Jena, Germany).
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PMC11644761
Furthermore, in neuronal-like cells differentiated from the retinoic acid-induced neuroblastoma cell line SH-SY5Y, forskolin exposure has been shown to induce tau hyperphosphorylation, increase cyclin expression levels, and promote the appearance of mitotic cells .
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PMC11739670
The structural analysis demonstrated the conservation of the structural positions of residues Q115 and D122 in MR1 and MHCI, important in contacting CD8 for classical MHCI.
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PMC9429973
Almost 5 to 10 percent of chronic myeloid leukemia cases demonstrate variant Philadelphia translocations.
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PMC10858941
B Images under confocal microscopy at 60x of p62 expression in U-251 MG.
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PMC11727907
GPx activity was assayed following the decomposition of H2O2 at 240 nm, using an assay solution containing 100 mM Tris-HCl (pH 7.4), 5 mM H2O2, and 5 mM GSH.
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PMC11291490
c The IFNγ titers were detected by ELISA.
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PMC10631132
Gating was performed using isotype controls following singlets and live/dead gating.
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PMC10547921
Mersana plans to initiate a phase I clinical trial of XMT-2056 later this year to investigate its therapeutic potential in a range of HER2-positive tumors, such as breast cancer, gastric cancer, and non-small cell lung cancer; Ono Pharmaceutical of Japan developed a non-nucleic acid STING agonist 95 as the payload, which was conjugated with the linker through the pyrazole ring in the structure of the drug.
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PMC10958426
Box plot of interaction weight of cytokine and adhesion signaling pairs in tumor tissue and normal tissue.
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PMC8068766
As expected, HepG2 and HepG2-2.2.15 cells were clustered in two distinct groups.
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PMC11380329
Scale bar: 50 μm Immunofluorescence with the proliferative marker, Ki67.
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PMC11720808
When we immunoprecipitated TRAF6 with rabbit anti-TRAF6, the result revealed that TLR4 band intensity in MG63 cells treated with SCU was dramatically weakened compared with that in the control group (Figure 3J).
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PMC7022782
Several authors reported the use of ICG to improve the intraoperative detection of neoplastic lesions and in sentinel lymph node mapping .
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PMC2193049
Second, analysis of proteasome- mediated degradation of synthetic peptide substrates in vitro revealed that the structural features of the digested products were compatible with those of peptides naturally associated with MHC class I molecules (30).
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PMC9592219
Anthracycline medications are the only available empirical drugs, which showed poor efficacy in clinical practice .
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PMC11790971
In passage 2, where the best classification performance was achieved using all cells, the lower quartile intensity of the redox ratio channel—representing the redox ratio threshold below which a quarter of pixels in the cell fall—was the top feature (Fig. 5a).
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PMC11518702
The knockout of HGAL did not affect SYK and GRB2 co-IP’s.
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PMC11687167
Huang et al. reported that PCSK9 expression is significantly increased during the occurrence of sepsis and can induce an inflammatory response through the activation of the TLR4/MyD88/NF-κB and NLRP3 pathways, which can lead to vascular endothelial dysfunction .
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PMC11610461
After beta-amyloid precursor protein is cleaved by γ-secretase, it releases Abeta, the accumulation of which in the brain is thought to be a major cause of Alzheimer’s disease (Mao et al., 2012; Wolfe, 2020).
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PMC7762347
We further studied the impact of cyanotoxins on the expression of genes implicated in the response to DNA damage, namely CDKN1A and GADD45A.
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PMC11627060
This discipline employs the unique physical and chemical characteristics of nanomaterials to design and develop innovative drug distribution platforms, which may transform cancer treatment and address other diseases.
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PMC7519871
The solutions were sterilized by filtering using DISMIC-25cs ADVANTEC filter (cellulose acetate, 0.20µm hydrophilic, pressure limitation: 0.51MPa).
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PMC11715644
To see epithelial monolayers, cell suspensions were prepared at 10 cells per mL and 10 μL volume (10 cells) droplets were used to grow monolayers in circular stencils of 3.7 mm diameter.
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PMC11351758
This result demonstrates that several neurodegenerative disorders could be potentiated due to complex defects or mitochondrial DNA mutations.
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PMC11155445
All derivatives showed negligible activity except L1 and L3 which exhibited moderate anticancer activity with IC50 = 83–90 μM against few cancer cells.
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PMC9429973
Our data suggest a multifaceted role of BAX and BCL2L12 circRNAs in B-cell CLL.
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PMC11541409
Type I TKIs occupy the conserved ATP-binding site and extend into different proximal regions.
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PMC11657744
Specifically, CEP83, SCLT1, and CEP164 are essential for ciliary assembly by facilitating proper basal body docking.
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PMC11786767
RO-3306 treatment enhanced intrachromosomal signals.
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PMC11740207
PGCs migrate from the posterior part of the embryo to the developing gonads (testes or ovaries), where they later differentiate into gametes.
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PMC11519567
two-sided, unpaired t test; n = 6 nuclei. ****
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PMC11576293
For C20H20N2O2SCl (M + H) 387.09285; found 387.09215.
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PMC11578343
We show that mz‐visco‐NPS can detect breast epithelial cells shifting toward a more compliant, less elastic phenotype when subject to actin cytoskeletal perturbation.
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PMC11365983
8Decreased Pdgfrα expression in the meninges of Foxc1 mutant embryos. (
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PMC9424261
When cells were pretreated with CA followed by erastin and RSL3, the ubiquitination of GSS increased more significantly (Fig. 5C).
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PMC9727330
The cell viability rate and cytotoxic concentration were monitored by using MTT colorimetric assay kit (Sigma-Aldrich, Germany).
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PMC11657744
Our study elucidates the distinct roles of centriole distal appendage proteins in ciliary assembly and disassembly, with a particular focus on CEP89 and FBF1.
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PMC11087301
The uncovering of miRNAs has subjoined an additional level of complication to the molecular networks modulating metastasis, EMT, as well as stemness .
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PMC9429973
Results: The mean CAS score was 2.42 (0 - 17).
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PMC11489275
2020–050-01).
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PMC11046454
We next tested the performance of Apt-CAR on primary human T cells (Figure 2A).
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PMC10452486
While characterizing the α/β T cell receptor molecules on the leukemia cells, a mAb A1.4 (IgG 1) recognizing B2m-free HCs of HLA-A, -B, and -C molecules was used to immunoprecipitate the HCs from the lysates of the leukemia cells.
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PMC11306019
Furthermore, future research should focus on examining the relationship between plasma concentrations of polyphenols in MM patients receiving BTZ/IXZ treatment and the influence of these concentrations on treatment outcomes.
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PMC11348300
It incorporates intuitive and common point-of-care methods such as palpation and capillary refill testing.
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PMC8303372
Each experiment was performed in sextuplicate and repeated four times and the cytotoxicity was calculated according to the following Equation :% cell mortality = [(ODcontrol − ODsample)/ODcontrol] × 100(1) Specimens were rated as slightly, moderately or severely cytotoxic when the toxic effects, relative to controls, were <30%, between 30% and 60%, or >60%, respectively .
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PMC5600151
The IC50 of TZ-DTX-dendrimer was 3.6-times higher than DTX-dendrimer, and no difference was observed between any of them or free drug in MDA-MB-123 .
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PMC11024707
Future studies are needed in this issue.
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PMC10094992
The instrument, for each gene tested, obtained graphical Cycle threshold (Ct) values automatically.
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PMC11001582
g, Quantification of MUNE determined in EDL muscle in WT, (GR)400 and (PR)400 mice at 12 months of age.
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PMC11472639
A limitation to our study may be the heterogeneity in our sample, whereby participants had a variable number of circulating clonal plasma cells, which in part explains a lack of a significant finding in clonal plasma cell mobilisation immediately following cycling exercise.
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PMC8193046
Our results indicate that these ‘under-represented substructures’ pose a high exploratory potential for the improvement of C@PA’s prediction capabilities and the discovery of novel pan-ABC transporter inhibitors, as their specific statistical evaluation as exerted in our previous report can easily be changed with a small number of additional compounds.
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PMC11306331
To do so, we analyzed single-cell expression of both 3xFUS and MBP as well as 3xFUS condensation in the dark and light (Fig. S4C).
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PMC11244823
On the amino acid level, the overall identity between gD1 and gD4 is 77% .
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PMC8584666
CD29 level was abundantly detected on the cell surface, while the co-localization of CD29 with FLAG-GPI-80 was not clearly observed (Figure 1a).
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PMC10495912
The simultaneous treatment of cells with concentrations of 37 and 75 µM of TQ and hydrogen peroxide caused the activity of this enzyme to increase significantly compared to the cells treated with hydrogen peroxide alone and equivalent doses of TQ (Figure 4-C).
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PMC6892818
This suggested that mCD40L-mediated apoptosis is caspase-dependent and apoptosis may entrain the ‘intrinsic’/mitochondrial pathway.
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PMC11306331
Data were fit to the generalized logistic function to calculate a decay rate.
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PMC11422150
In the present study, we found some results supporting the idea that anti-inflammation may lead to a good outcome induced by hAMSC injection.
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PMC10213179
The apparent KD of ATOP for hrEphA2 was observed to be within the picomolar range.
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PMC9429973
Gr 2 neurotoxicity occurred in 4 pts (27%).
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PMC11755467
Whether this tightly balanced and controlled battle can be exploited therapeutically remains to be further addressed.
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PMC11306331
A fusion protein consisting of three copies of the FUS IDR forms stable droplets when expressed in HEK293T cells.
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PMC9429973
Primary objective: safety of the anticipated BED, or the recommended phase 2 dose (RP2D).
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PMC6461034
To still include them in the global analysis, a separate ranking is based solely on the kinase‐centric side of the INKA score, i.e., C kin (equation (1)).As a more simplified visualization, INKA scores for the top 20 kinases are also plotted in a bar graph for each sample.
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PMC11666785
Often, the reconstructed super-resolved images suffer from noise, strong background and are prone to false detections that may impact quantitative imaging.
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PMC9429973
Figure 1) Image: Summary/Conclusion: Approximately 180 sites are planned in North and South America, Europe, Middle East, Australia and Asia.
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PMC11489351
After a final 3 × 2 min wash in PBS, cells were imaged using a Nikon Ti2 Eclipse confocal microscope equipped with a spinning disk microscope (CSU-X1, Yokogawa).
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PMC11543885
Data Filtering: Filter the MS/MS data set to remove the proteins that are potential contaminants, only identified by peptides or those that match to the reversed peptide sequences.
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PMC8345486
Although the C2′ derivative modified with ferra bis(dicarbollide) (compound 23) showed a 1.4–2-fold increase in cytotoxicity when compared to that of their Co-containing counterpart (Figure 2A,B and Figure 3A, compound 22, A2780 cells, p < 0.05; OVCAR-3 cells, p < 0.01; and SKOV-3 cells, p < 0.05), all C2′ derivatives displayed significantly higher cytotoxicity than their nido-7,8-dicarbaundecaborate counterpart (compound 25).
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PMC10968586
Incubation of human melanoma cell line A375 with 100 μM and 200 μM HT significantly diminished cell viability after 48 h. On the contrary, 48 h treatment of melanoma cell line MNT1 with 100 μM and 200 μM HT had no significant effect on cell viability.
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PMC9429973
However, rituximab and lenalidomide (R2) regimen was failed as front-line treatment in PVRL.
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PMC11637716
The affected amino acids, His30 and Asn867 (NP_078856.4), are evolutionarily highly or moderately conserved respectively.
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PMC10808409
D-optimal design of FA polymeric mixed micelles, and the composition of the 20 formulae.
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PMC6222635
In the positive drug group, three apoptosis-related genes, Bcl-2, NF-κB and p38, showed significant differences compared with the control group.
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PMC11711935
This study aimed to summarize recent findings on the effects of dermal fibroblasts on hyperpigmentation and hypopigmentation, enabling the discovery of new therapeutic targets.
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PMC11742670
Subsequently, they delved into recently developed methods for representing data using both sequence-based and graph-based approaches, in addition to discussing the latest DL-based techniques.
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PMC11739696
A dual-channel Flow Cytometer was used to differentiate between apoptotic and necrotic cells.
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PMC11568601
A TGT induced the apoptosis of 143B and MG-63 cells, as determined by a Hoechst staining assay.
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PMC9429973
The major limit of the study is the selection bias related to missing information in most centers about pregnancies and even more about miscarriages and medical abortions (none were registered).
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PMC9429973
Results: Here we reported that interventions aimed to modulate mitochondria recycling and metabolism can rejuvenate aged HSCs and thus preserving the lymphoid compartments and immune function.
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PMC11345828
For both doses, no significant change was observed in the median weight of the mice.
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PMC11615101
The confocal microscopy image shows TLR-4 expression (yellow) and nucleus (blue) in RAFLS. (
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PMC9031474
Despite that, these results should be interpreted carefully because the permeabilization of the MM and loss of MMP are part of several pro-apoptotic signaling cascades and are not restricted to detergent effects on the mitochondrial membrane, exclusively .
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PMC11225860
Ploidy analysis from the vehicle control 84.3% normalploid and 15.7% polyploid respectively (Fig. 7c).
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PMC8336407
This system detects NO2 in a variety of biological samples.
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PMC6684588
Patients with these and related disorders would likely benefit from therapeutic agents providing focal improvement in muscle function.
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PMC11388384
Furthermore, SCUBE1 acted as a catalyst to increase the transition rate between each SHH-Halo population and decrease the lifetime of each SHH-Halo population, without dramatically changing the net occupancy of each population (Fig. 5 D and E).
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PMC11612508
Figure 5C indicated the TEM image of magnetic NPs that confirmed that synthesized NPs are in under the 50-nm range of size.
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