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OTAR3088
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BioData-CellLine_annotated

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PMC9739791
First, the photoabsorber and the Pt(IV) prodrug could be used as a combination of two molecules.
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PMC11507371
Human melanoma biopsies show overexpressed antioxidant enzymes and elevated malondialdehyde levels, indicating a basal redox adaptation to elevated ROS levels .
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PMC11536589
Representative images were shown here and other images were represented in Supplementary Fig. 5B. (
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PMC9100622
In total, 187 compounds were identified as positive hits from the screening as inducing a significant decrease in Ewing cell growth at 24 and/or 72 h of treatment.
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PMC11752740
This pattern suggests that the combination of the drug and extract becomes increasingly effective over time.
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PMC7351993
Disturbances in cell metabolism often lead to various prevalent diseases such as cancer, inflammation, and cardiovascular disease, whereas microbial metabolism is of prominent significance in virtually all ecosystems including the natural environment and human body.
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PMC9429973
Results: Overall, 3 peptide-MHC multimers were recognized by CD8 T cells: (i) VTVADTAVYY (peptide A) and (ii) INLNPSLKRR (peptide B), both within the context of the A03*01 allele, and (iii) YSFTSYWINW (peptide C) within the context of the A24*02 allele.
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PMC11441402
Formazan crystals formed were dissolved by pipetting.
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PMC11412752
Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is a common food-borne pathogen that causes gastroenteritis and can lead to life-threatening systemic disease when it spreads to vital organs, such as the liver.
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PMC11266100
D-Luciferin (Promega, Madison, WI, United States) was added to the cells at a final concentration of 150 μg/mL. The luminescence of luciferase-pcDNA3 plasmid expressing firefly luciferase was evaluated using a Synergy two microplate reader and Gen5 software (BioTek, Shoreline, WA, United States).
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PMC11477621
Biological screening revealed that most of them exhibited nanomolar inhibitory activity against three HDAC isomers.
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PMC10006224
Cells in suspension were crosslinked with 1% formaldehyde added to the media for 15 min at RT.
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PMC11244823
The age of the horses ranged from 1–32 years, with a median age of 12 years.
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PMC9429973
Survival analysis did not allow us to conclude which of the endpoints have the greatest discriminative power in OS, so prospective studies with larger sampling will be necessary.
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PMC11641532
This method ensured that candidate genes were selected based on a broader understanding of the biological system rather than isolated pathways, providing a robust foundation for downstream validation.
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PMC10813895
We summarized the advantages and disadvantages associated with available human samples for implementing biological clocks that rely upon direct sampling of breast tissue (Figure 2).
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PMC11139449
Genomic primers were utilized in PCR to validate the integration of the PX460-1 vector at the targeted site.
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PMC11321678
Group 3 tumors account for ≈25–30% of MBs and have the worst prognosis.
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PMC11757131
Data are shown as mean ± standard error of mean; means not sharing the same letter are significantly different (p < 0.05).
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PMC8010066
The OD520 of extracted samples were multiplied to 17.072 (Dehbashi et al. 2020).
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PMC10810426
While knockdown of NUPs may have secondary effects that alter PIC nuclear entry, we did not see effects on either NIH3T3 or DC viability and NUP knockdown did not alter integration in NIH3T3 cells, suggesting that the requirement for nuclear trafficking in DCs is the direct result of the knockdown.
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PMC11442172
Created with BioRender.com.
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PMC5415764
The supernatant was removed for HPLC analysis.
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PMC10165258
Sequential combination treatment of EwS with etoposide applied 24 h before cisplatin resulted in amplified synergistic effect.
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PMC9599726
Our IHC results show that the TFRC was expressed in all human GIST tissues included in our cohort.
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PMC11703896
The media was centrifuged at 8000 rpm for 6 min and collected the cell free supernatant.
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PMC11469524
Differential expression analysis showed that α-IgM treatment had the largest effect with 8094 phosphosites (28% of detectable phosphosites) that were significantly different compared to untreated control (limma FDR≤5%, Fig 4C).
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PMC11643361
Transmission electron microscopy further confirmed the anti-mitochondrial effects, showing significant mitochondrial swelling, reinforcing the evidence of the ability of these complexes to induce mitochondrial disruption.
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PMC9436459
Fig. 7Structures of dehydroprenylflavone type MDAAs (Type D) Structures of dehydroprenylflavone type MDAAs (Type D) Among type D-I MDAAs 92–104, the diene moiety of six compounds (92–97) are located at C-8 of A ring and others (98–104) at C-6 of A ring.
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PMC9429973
The universal use of midazolam conscious sedation for BMAB under carefully controlled circumstances is strongly recommended.
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PMC8584666
Results with p values less than 0.05 were considered as statistically significant.
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PMC11470381
Coat glass-bottom confocal dishes (12 mm diameter) with 100 µL of ICAM-1 solution overnight at 4 °C.
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PMC8873393
Notably, a group of genes encoding proteins that are involved in the regulation of apoptotic signaling pathway were enriched in cluster 1 (cluster 1 in Fig. 3C, Table S3).
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PMC11541409
TKIs targeting the PI3K/AKT pathway, MAPK/ERK pathway, mTORC1 pathway, and cell cycle pathway have been reported in GISTs [68–72] (Fig. 3B).
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PMC8414691
RNAi knockdown was performed by transfecting HeLa cells with specific siRNAs (see the “Methods” section).
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PMC11674891
Additionally, H&E staining of lung tissues (Figure 6d) revealed a reduction in metastatic tumor regions in mice with GRPR-silenced cells.
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PMC11781181
Moreover, characteristics of ferroptosis, including the loss of glutathione (GSH) and induced lipid peroxidation, have also been reported in Alzheimer's and Parkinson's disease models 26-27.
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PMC11306331
Confocal microscopy was performed on a Nikon Eclipse Ti microscope equipped with a Yokogawa CSU-X1 spinning disk, Agilent 4 color laser line module (405/488/561/640 nm), fluorescence emission filters (470/40, 535/50, 570/25 and 710/75), an iXon DU897 EMCCD camera, and Mightex Polygon 400 digital micromirror device (DMD).
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PMC8973725
For example, ABCG1 and P4HB may serve as independent diagnostic and prognostic markers for ccRCC .
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PMC11412721
The p53 pathway thus underlies cancer sex-disparities through multiple mechanisms, which may notably include variations in p53 isoforms or Ackr4 expression.
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PMC11703896
The binding affinity of rapamycin on A549 cancer cell receptors such as ALK (PDB Id: 4JOA), EGFR (PDB Id: 1M14), FGFR (PDB Id: 4QQC), MET (PDB Id: 5UAB) and ROS1 (PDB Id: 5FTO) were determined by using molecular docking.
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PMC9429973
The rate of hospitalization due to COVID-19 progression was 19% (10/51), with an extremely low percentage of patients requiring ICU admission due to sever COVID-19 (2%,1/51).
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PMC11535726
Most species of Kirschsteiniothelia are saprobes occurring mainly in terrestrial and followed by freshwater habitats, with only a few taxa reported from environments, such as cork stoppers and as a pathogen that infects human beings (Hawksworth 1985; Boonmee et al. 2012; Su et al. 2016; Nishi et al. 2018; Rodríguez-Andrade et al. 2020; Sun et al. 2021; Xu et al. 2023; de Farias et al. 2024).
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PMC8751435
Moreover, fermentation or bioactive‐enrichment separation is possible refinement method to refine CME based on our findings, and it will advance clinic usage of CME as dietary therapy for cancer treatment.
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PMC11087055
Related to Figure 3, Figure 3—figure supplement 1, Figure 3—figure supplement 2, and Figure 3—source data 1.
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PMC11566417
After validation of the transfection technique and determination of the lethal dose of G418, a plasmid containing human EST2 (hTERT) under a CMV promoter, as well as a G418 resistance gene (NeoR/KanR), was used to transfect MDECs (Fig. 1a).
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PMC11609529
The changes in the activation or inhibition status of transcription regulators were plotted based on their Z scores.
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PMC9878562
No significant differences in mass were observed between tumors grown from wild type DLBCL, VAL-wt cells and DOHH2, VAL-ko and the respective mixtures of wild type and VAL-ko ( Figure 3A ).
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PMC8524093
The time between feeding with infected blood and the ability to transmit to vertebrate hosts, known as extrinsic incubation period (EIP), is a valuable parameter to estimate transmission rate and viral load during feeding.
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PMC11365427
Specifically, changes of VAPB protein were closely associated with the mentioned characteristics (Fig. 5B, Fig. S6A and S6B).
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PMC9429973
On karyotype, all mitoses still presented the Phi chromosome.
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PMC9429973
H. Witte, A. Kuenstner, J. Schwarting, V. Bernard, H. Merz, N. von Bubnoff, H. Busch, A. Feller, N. Gebauer Hematology and Oncology, German Armed Forces Hospital Ulm, Ulm; Medical Systems Biology Group, University of Luebeck; Hematology and Oncology, UKSH Campus Lübeck; Haematopathology, Haematopathology Luebeck, Luebeck, Germany Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggressive hematologic malignancy.
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PMC9516447
Fig. S2D).
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PMC11552389
A and B) The JASPAR software was used to predict putative sites of FOXN3 binding within the region upstream of the FSIP1 start codon. (
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PMC7215722
This is in line with previously published studies that report the alteration of cytokine production in the intestinal mucosa of pediatric IBD .
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PMC11731161
7Knockdown of USP7 enhances the sensitivity of MM to SEL in vivo.
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PMC11435360
We investigated the mechanisms by which inhibiting endogenous H2S production attenuates bladder tumor progression and enhances the anti-cancer effects of GEM using immunohistochemical (IHC) staining for markers of apoptosis (caspase-9 and poly [ADP-ribose] polymerase 1 (PARP-1)), neovascularization (vascular endothelial growth factor (VEGF)), proliferation (antigen Ki-67 (Ki67)), and immune-cell infiltration including macrophages (F4/80 and CD163) and T cells (CD8 and CD4) (Figure 4A).
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PMC9429973
However, the recurrences after therapies still occur due to the poor CAR-T persistence.
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PMC11730311
Contribution of amino acid positions in hαCGRP8-37N25K-C20DA-γGlu for antagonism against the hCGRP-R expressed in the CHO-K1 cell line.
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PMC11792090
Data are presented as means ± SD from at least three donors.
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PMC11632064
Functional gene classification of differentially expressed transcripts in these cells revealed the enrichment of diverse pathways linked to extracellular matrix remodeling, signaling, and metabolism (Fig 3C and D).
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PMC11720107
However, it should be noted that these results are inconclusive because the authors tested entirely different garlic varieties without conducting such detailed chromatographic analyses.
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PMC8735881
HIV −1SubtypeTropismMean % infection ± SDGPI-FluIgG03GPI-3BNC117GPI-N6GPI-PGT126GPI-PGT128GPI-35O22GPI-10E8Replication-competent virus JR-CSFBCCR598 ± 244 ± 350 ± 60075 ± 100RHPA.c/2635BCCR597 ± 458 ± 757 ± 506 ± 181 ± 40THRO.c/2626BCCR595 ± 587 ± 776 ± 190 ± 974 ± 1387 ± 20CH077.t/2627BCCR597 ± 550 ± 830 ± 13 ± 119 ± 169 ± 40NL4-3BCXCR491 ± 3102 ± 4100 ± 2014 ± 170 ± 40LAI.2BCXCR492 ± 779 ± 877 ± 5116 ± 155 ± 2089.6BR5X4104 ± 699 ± 354 ± 5016 ± 187 ± 10MJ4CCCR5101 ± 479 ± 668 ± 40071 ± 50"Global Panel" pseudovirus 398-F1_F6_20ACCR5123 ± 4128 ± 1158 ± 60091 ± 120TRO.11BCCR5104 ± 296 ± 1153 ± 293 ± 784 ± 694 ± 30X2278_C2_B6BCCR5122 ± 582 ± 1233 ± 349 ± 8928 ± 20CE1176_A3CCCR5111 ± 4101 ± 762 ± 80087 ± 80CE703010217_B6CCCR5109 ± 494 ± 575 ± 14 ± 11101 ± 10HIV_25710-2.43CCCR5113 ± 4131 ± 1849 ± 500112 ± 80X1632-S2-B10GCCR5110 ± 2104 ± 471 ± 9103 ± 280 ± 6104 ± 50246_F3_C10_2A/CCCR5110 ± 3107 ± 1438 ± 667 ± 10285 ± 10CNE8A/ECCR5121 ± 4127 ± 855 ± 457 ± 62107 ± 90CNE55A/ECCR5119 ± 2112 ± 659 ± 2156 ± 3139 ± 17103 ± 111CH119.10B/CCCR5109 ± 3117 ± 374 ± 150 ± 70108 ± 60BJOX002000.03B/CCCR5108 ± 1110 ± 1259 ± 915 ± 301040VSV-GNANA100 ± 3113 ± 7103 ± 4112 ± 589 ± 3106 ± 897 ± 5Env -mediated cell fusion 398-F1_F6_20ACCR5110 ± 558 ± 251 ± 42 ± 03 ± 160 ± 1016 ± 392RW020ACCR5109 ± 857 ± 453 ± 414 ± 119 ± 450 ± 96 ± 192UG037.8ACCR5104 ± 354 ± 950 ± 81 ± 02 ± 048 ± 811 ± 1NL4-3BCXCR4112 ± 855 ± 547 ± 137 ± 358 ± 251 ± 119 ± 1SF162BCCR5102 ± 759 ± 247 ± 341 ± 136 ± 344 ± 73 ± 1R3ABCCR5107 ± 1251 ± 755 ± 72 ± 016 ± 250 ± 1117 ± 2CNE11B'R5X4110 ± 857 ± 551 ± 41 ± 02 ± 045 ± 921 ± 4ZM53M.PB12CCCR5101 ± 955 ± 650 ± 151 ± 965 ± 444 ± 1112 ± 3HIV_25710-2.43CCCR5101 ± 653 ± 646 ± 20052 ± 837 ± 4GX11.13A/ECCR599 ± 750 ± 441 ± 013 ± 216 ± 150 ± 511 ± 1CNE8A/ECCR5103 ± 659 ± 752 ± 446 ± 651 ± 649 ± 1140 ± 9CNE55A/ECCR5106 ± 451 ± 1246 ± 557 ± 1271 ± 747 ± 1220 ± 3CH70.1B/CR5X4107 ± 680 ± 854 ± 842 ± 22 ± 057 ± 824 ± 7CH119.10B/CCCR5110 ± 779 ± 445 ± 135 ± 818 ± 450 ± 54 ± 1BJOX002000.03B/CCCR5111 ± 876 ± 967 ± 247 ± 742 ± 363 ± 828 ± 7*The assay was performed in triplicate and repeated three times.
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PMC9635307
However, our results also indicate that the expression of CEACAM1 increases during B cell development from pro-B cells to immature B cells, suggesting that this expression may be required more in matured B cells.
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PMC11185260
AURKA is a direct downstream target of SMARCB1-mediated repression in malignant rhabdoid tumor cells,45 and loss of SMARCB1 leads to aberrant expression of AURKA, which results in a weakened mitotic checkpoint, ultimately allowing ATRT to proliferate uncontrollably.
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PMC10237474
Compared to CHO-K1 and HEK293 expressed proteins, they consistently migrated faster, suggesting less glycan modification.
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PMC11723947
e, g, h Floating bar charts represent the mean of the biological replicates as well as the minimum and maximum values.
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PMC6650823
The latter hypothesis has been soundly addressed by the group of Ciulli, with a novel PROTAC that targets a POI–E3 ligase pair considered unPROTACable: BRD9, an active bromodomain which is involved in MYC transcription and proliferation of leukemic cells and the von Hippel–Lindau (VHL) E3 ligase.
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PMC11740573
All strains used in the study came from the collection of the Chair of Microbiology Jagiellonian University Medical College and were isolated from the genital tract of women suffering from AV.
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PMC11470999
Knockdown of CIP2A reduces the inhibitory activity of PF on melanoma cells migration.
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PMC11291490
Therefore, the identification of modifications for DNA vaccines that enhance MHC II presentation and stimulate CD4 T cell responses is of fundamental importance in optimizing vaccine-induced immunity against a diverse spectrum of microbial pathogens.
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PMC11534035
However, the paradox of PAI1’s function, described in the literature and supported by our own findings, is that cancer patients with high levels of PAI1 circulating systemically have been correlated with poorer prognosis (11,37).
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PMC9261184
For further details on the voyage, please see Supporting Information Table S2.
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PMC9325715
In the fingerprint region, two additional bands 1472 cm (almost undetectable) and 1451 cmof δas(CH3) and δ(CH2)vibrations can be distinguished.
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PMC11792090
Data are presented as means ± SD.
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PMC11286266
Amino acid sequence homology between residues 349 and 670 of human (hs), hamster (cg), and mouse (mo) ATF6α indicating the transmembrane domain (TMD) and the cleavage sites for S1P and S2P proteases.
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PMC8041314
At these concentration ranges, compound-related assay interferences (e.g., solubility problems, solvent effects, short-term cell toxicity, fluorescence quenching, or unspecific binding) are much more likely to have occurred.
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PMC11463018
10.
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PMC10747139
Moreover, complexes 23, 24, and 26 increased the intracellular ROS levels, which were likely responsible for the antitumor action.
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PMC11640476
After a 1.5 h (h) incubation, metabolized resazurin WS was transferred to a 96-well plate for fluorescence intensity (FI) detection (#MSSBNFX40, Millipore, Burlington, MA, USA).
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PMC8409415
CD70‐ADC was cytotoxic to A2780cisR, SKOV3, and SKOV3cisR cells, with IC50 values ranging from 0.104 to 0.341 nmol/L. In A2780cisR and SKOV3cisR xenograft models, tumor growth in CD70‐ADC treated mice was significantly inhibited compared to that in the control‐ADC treated mice (A2780cisR: 32.0 vs 1639.0 mm, P < .01; SKOV3cisR: 232.2 vs 584.9 mm, P < .01).
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PMC9635307
These results suggest that CEACAM1 may suppress BCR signaling-induced B cell activation.
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PMC11541241
We also discuss the potential of combining these strategies with traditional agricultural practices to enhance their efficacy and sustainability.
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PMC11611077
Left panels, bright field (BF) images; right panels, prestin-labeled images.
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PMC8735881
Because GPI anchoring in nature is a typical posttranslational modification process and many GPI-linked proteins are directed to lipid rafts where host the HIV receptors and serve as gateways for HIV entry and budding, we prefer anchoring an HIV entry inhibitor such as antibody or peptide to the cell membrane through a GPI anchor as a technical platform.
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PMC11678368
Energy calculations indicate that the isomer based on the cis conformers is energetically more stable, with an energy difference (Δ) of approximately 4.66 kcal/mol for the Pd(II) complex (Table S1 in the Supplementary Materials).
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PMC9429973
Bioinformatic analysis was used to predict transcription factor (TF) binding to SNP sequences.
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PMC11271278
HiChIP data were visualized using the R package gTrack (URL: https://github.com/mskilab/gTrack) or RCircos.
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PMC11513011
The tumor volume change rate was calculated, with the tumor volume before drug administration in each group set as 1 (Fig. 5).
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PMC8526701
H WT and PUMA-KO GIST-882 or GIST-T1 cells were treated with the combination of 100 nM GSK602 and 50 nM imatinib for 24 h. Caspase 3 level was analyzed by western blotting.
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PMC11791264
G, Western blot for SETD7 in SKOV3 cells infected with pCDH-SETD7 or control vector (pCDH).
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PMC11539788
RNF19A mRNA expression was analysed in various cancers using the TIMER database. (
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PMC11565047
For the diagrams and heatmaps (A, B, D and E), NES, p-values and false discovery rates (FDR, q-values) are indicated.
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PMC11785489
To be considered part of the same expanded clone, TCRs had to match exactly for each of these TCR components, and be sampled from the same individual.
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PMC9100622
Genes down-regulated upon EGR2-KD (280 genes) demonstrated a very significant enrichment in genes involved in the cholesterol/steroid synthesis pathway (Figure 1B and Figure S1A).
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PMC11190538
Therefore, this work investigates the production of locally crude phycocyanin by a novel technique and verifies its antioxidant, anti-inflammatory, anti-tumor, and anti-HCoV-229E activities.
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PMC11786600
The PED0 group demonstrated efficacy levels similar to gauze, likely due to its reduced water vapor transmission properties.
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PMC9429973
Mean number of total treatment days was 181.3 and 153.0 for the induction and post-remission phases, respectively.
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PMC9268620
Both damnacanthal and nordamnacanthal were cytotoxic towards breast carcinoma MCF-7 .
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PMC11413393
It remains unclear whether this decreased expression is occurring via effects on RBPs, or other mechanisms such as transcriptional regulation via the H4R3me2a histone mark.
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