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PMC9429973
Lenalidomide combined with rituximab (R) has shown complimentary clinical activity and is a tolerable regimen in both untreated and relapsed or refractory (R/R) patients with iNHL (RELEVANCE: N Engl J Med 2018;379:934 and AUGMENT: J Clin Oncol.
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PMC9776316
A 1 mL volume of cells at a concentration of 1 × 10/mL was seeded onto the microscope cover glass in 12-well cell culture plates overnight.
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PMC9429973
At BNS diagnosis, BM involvement with LPL ranged from 0-95%.
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PMC11173119
The study was approved by the Ethics Committee of the Institute of Molecular Biology NAS RA (IRB 00004079, Protocol N3 from 23.08.2021).
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PMC11786767
PicoGreen, an ultrasensitive green-fluorescent nucleic acid dye for double-stranded DNA, was used to outline nuclear chromosomal DNA.
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PMC11574271
C Validation of candidate genes positively correlated with RON expression in 5637-shRON, 5637-NC, J82-oeRON, and J82-NC groups was conducted using qRT-PCR.
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PMC9429973
Protein profiling of the patient’s CLL cells collected at 5 time-points before, during and after the combination regimen showed that B-cell signaling was reduced by the treatment, but again significantly increased when the therapy was stopped.
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PMC10203589
For example, in terms of steroid hormone regulation, progesterone induces the nuclear transcription factor heart and neural crest derivative expressed transcript 2 (HAND2) in endometrial stromal cells, leading to the reduction of FGF18 production in endometrial stromal cells.
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PMC11499381
The mVenus halves used in the present study were as described by Kodama et al. mVenus was preferred over eYFP due to its reduced self-assembly, higher fluorescent yield, and its ability to mature at 37°C .
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PMC10551595
A Lamarckian genetic algorithm was applied for docking calculations.
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PMC9920575
All the experiments were carried out under these same culture conditions.
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PMC9429973
CK2 is a S/T kinase overexpressed in several solid and blood tumors.
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PMC10958426
We inferred cell-cell communication signatures and communication strengths by using cellchat v1.4.0 .
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PMC11674146
In addition, lymphoma cell proliferation, apoptosis, and effects on PI3K/AKT/CREB pathway activity were observed by knocking down CLP36.
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PMC9952933
This effect occurred in supernatants of all cell lines and all media used.
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PMC9596868
p ≤ 0.05; **p ≤ 0.01).Fig 5 Effect of quercetin and MST-312 on expression of DNA damage response proteins and telomerase activity. (
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PMC9429973
C.-H. Lee, C.-L. Ho Hematology and Oncology, Tri-Service General Hospital, Neihu Dist, Taiwan Background: In recent 10 years, there were many studies explored the treatment efficacy of refractory/relapse multiple myeloma (R/R MM).
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PMC11224020
c, Top, representative images of untreated control cPLA2 DCs and cPLA2 DCs treated with 2.5 µg ml PGE2 for 30 min in the presence or absence of BI605906 (30 µM) before confinement.
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PMC11640247
C,E) Quantification of the distribution of GFP-positive neurons in distinct regions of the cerebral cortex (bin 1–3) at P0 (C) and P7 (E).
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PMC6337547
and Salvia miltiorrhiza Bunge .
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PMC11682224
The results of the wound healing experiment showed that at 48 h, the healing rate was significantly increased in the CHD1L-OE group relative to the NC group, while it was significantly decreased in the CHD1L-KD group.
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PMC8567602
We observed no histologic difference between hSS2-induced tumors with wild-type Smarcb1 or heterozygous inactivation of Smarcb1 (Supplementary Fig. S1H), but homozygous ablation of Smarcb1 accompanying fusion expression initiated by TATCre generated distinct histology that included the same EpS features (Fig. 1G and H).
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PMC10976516
Although this is a significant improvement over the expected intravenous delivery of "naked" VSV, where just 0.001% of virions reach the tumor, there is still potential for improvement.
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PMC9509578
The resultant intracellular ROS decreases the expression of membrane efflux proteins and anti-apoptotic Bcl-2 family proteins .
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PMC10858941
Then, we compared the effects of NNC and bafilomycin-C (Baf; 50 nM, 8 h), that inhibits the lysosomal v-ATPase and blocks autophagic flux.
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PMC11786704
To validate the structural stability of PC capsules, we examined their release profiles under varying pH conditions (Fig. 1J).
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PMC11790971
Feature engineering was then conducted to clean the cell profiles and select the most informative set of features for each passage.
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PMC9429973
Overall survival was 67% at median follow-up (Figure 1).
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PMC4005030
Protocatechuic acid methyl ester isolated from fraction of the bark of Machilus thunbergii Sieb.
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PMC11541409
Less common mutations in exon 13/14 (located in TKD N lobe, TKD1) and 17 (located in TKD C lobe, TKD2), enhance ATP binding and/or increase kinase activation velocity, resulting in varying degrees of resistance to imatinib .
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PMC10329074
ns: no significance.
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PMC10958426
CNVs in each cell were identified by CNVkit-0.9.6 .
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PMC11703896
According to Swetha et al. (2022), compounds with lower RMSF values and binding affinities are often more stable, which aligns with our observations for rapamycin with these receptors.
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PMC11680391
The first author also retrieved information from the National Danish Cattle Database regarding herd BTSCC.
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PMC11672142
Chemical shifts were recorded in units of parts per million (ppm, δ) relative to the peak of the internal solvent standard.
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PMC9429973
Out of the later intervention group of patients, none achieved normal ferritin levels after an observation period of 12 months.
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PMC11244823
Among other possible factors (e.g. solubility, toxicity), this circumstance could be attributed to the different folding of gD_160 (Fig 9).
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PMC10713411
Moreover, the efficacy of this predictive model was further tested in KIRC-testing and E-MTAB-1980 datasets (Figure 3E, 3F).
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PMC9429973
Image: Summary/Conclusion: ALICE data confirms that the combination of iada with azacitidine gives robust, fast and durable responses in unfit, previously untreated, AML patients.
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PMC10890307
Moreover, no change was observed in the cell death as measured by the subG0 peak.
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PMC11218145
Measurements were carried out at 72 h after the treatment.
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PMC7553912
Frozen sections were incubated with the solution for 30 min (min).
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PMC10482220
For this purpose, proteins were metabolically labeled with [32P] orthophosphate, immunopurified with anti-G3BP antibody, and subjected to phosphotryptic mapping.
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PMC11756937
In addition to comparing the two reprogramming methods, we have examined the effect of different source materials on the success of reprogramming.
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PMC10940855
n = 6–7/group.
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PMC11785489
Both types of information may be crucial to the immune response in autoimmunity, cancer, and infection.
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PMC5600151
PPI dendrimers also have abundant primary amines that assist complexing nucleic acid molecules on their surfaces.
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PMC11534035
In the knockdown experiments this step was skipped.
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PMC11791203
These variations in fluorescence corresponded to different stages of apoptosis.
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PMC7757104
ACRP ovarian cancer cells resistant to CDDP, as well as their parental cell line A2780, were used.
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PMC11045125
The expression of these proteins is normally highest in the pro-B and/or pre-B cell differentiation states, although RAG1, RAG2 and IL7R are also reported to be turned on in GC B cells undergoing light chain receptor revision .
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PMC11731161
After indicated time periods, the cell lysates were harvested and subjected to immunoblotting analysis of XPO1 protein levels.
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PMC10728200
The calibration plot showed good consistency between predicted and observed values, as the deviation correction line closely matched the ideal curve (45-degree line) (Fig. 7F).
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PMC11803149
Red and blue colored dots represent upregulated and downregulated genes in cells with Epas1-Crispr, respectively.
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PMC4659567
No 3I5Braza signals were found in the appropriate proton spectra.
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PMC10094712
According to the real-time PCR results shown in Figure 4C, we can confidently speak about a significant increase in the mRNA of the endogenous selenoprotein SELENOM by more than 3–5 times compared with the control when treating human glioblastoma cells with 50, 100, and 200 μg of recombinant hSELENOM.
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PMC11612626
Importantly, the immunoproteasome-specific inhibitors blocked the effect of compound A on immunoproteasome-specific catalytic activity.
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PMC9429973
Methods: We analyzed by quantitative PCR the expression of 89 selected miRNAs.
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PMC11472569
The “Warburg effect”, a hallmark of cancer metabolism, is associated with the biogenesis of oncosomes.
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PMC11128598
The anticancer effect of CQ has been mainly attributed to its ability to inhibit autophagy (6, 10, 11, 13, 18, 22), which serves as a resistance mechanism against chemotherapy (23).
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PMC11790971
For each feature, the associated imaging modality, feature category, and median profiles of the four cell lines are illustrated.
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PMC11684269
LXR target gene encodes Srebp-1, thereby suppressing Th17 differentiation.
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PMC11659734
No induction of micronuclei was observed after short treatment with BPE both in the absence and presence of metabolic activation.
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PMC11718031
We observed that the basal media IS CHO-CD G17.4, IS CHO-CD-17.7, and CD-FortiCHO yielded higher viable cell counts.
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PMC11590870
As a negative control, CCD18-Co cells were grown under the same conditions but without any stimulus.
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PMC9429973
The median age was 38 years [range 22-72] and there was a female preponderance (2.6).
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PMC8973085
Structures of derivatives (5a–5h) were confirmed using both the elemental analysis plus spectral data.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Structures", "of", "derivatives", "(", "5a–5h", ")", ...
PMC6190245
Cell viability was assessed 66 hr after radiation by MTT test (Hosseini et al., 2017 ▶).
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PMC9429973
In vivo efficacy was evaluated in NSG mice bearing THP-1 AML tumors.
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PMC10957991
In spheroid samples nuclear fragments (blue arrow) are located evenly in the center, while in TRPV4-depleted sample nuclear fragmentation is more random and spheres vary morphologically, with some cellular protrusions (red arrowheads).
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PMC11566417
For the neutrophils assays, CM was generated in RPMI (Corning) + 2% FBS, and in phenol red-free, FBS-free DMEM (Thermo Fisher) for the mass spectrometric analyses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160
The lack of Griffithsin-mediated enhancement of trans-infectivity on 3t3 cells led us to believe that the enhanced trans-infectivity observed in Section 3.3 with Raji cells (Figure 4D) was likely due to unforeseen signaling changes or interactions in the Raji cell line.
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PMC11756937
Ct values were adjusted to the endogenous housekeeping gene GAPDH.
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PMC9424261
RNA was reverse transcribed into cDNA using a kit from Vazyme (R323-01, Nanjing, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "reverse", ...
PMC11607321
MOSA performed better compared to a similar systematic supervised analysis designed to predict each CRISPR-Cas9 gene dependency either using core-omics (e.g., genomics, transcriptomics), only genomic, or only functionally related genes (mean feature best Pearson’s r = 0.25).Fig.
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PMC10547921
Using smaller molecular payloads is also a way to reduce the risk of immunogenicity.
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PMC11013014
C NMR (101 MHz, CDCl3); δ (ppm): 195.3, 167.2, 160.9, 154.3, 152.6, 150.1, 144.3, 134.3, 131.5, 131.3, 128.8, 128.7, 127.2, 122.7, 117.4, 111.9, 110.9, 108.9, 68.2, 64.1, 38.3, 23.3, 12.3.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Major adverse reactions: bone marrow suppression, granulocytopia with fever and septicemia were the major adverse reactions after chemotherapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Major", "adverse", "reaction...
PMC9429973
Descriptive analyses were performed on all questionnaire responses, and a mixed model for repeated measures was performed on the PRO endpoints at Weeks 12 and 24.
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PMC7762347
After 72 h, CYN alone (0.25 μg/mL) and CYN (0.5 μg/mL) in combination with MCLR (1 μg/mL), arrested cells in G0/G1 phase, while CYN at 0.5 μg/mL showed the same trend, but did not statistically significantly differ from the solvent control.
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PMC11576293
Yield 63%; m. p. 198–201°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.1 (overlap d.d.,
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PMC11045125
Here we show that an EBNA2-deleted EBV mutant (ΔEBNA2 EBV) cooperates with Myc over-expression to form BL-like lymphomas that lack LMP1 expression in NSG mice.
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PMC10976516
Rao et al.AdE3-SCCA1 derived from Ad E3.
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PMC11201245
Hereditary mutations in the breast cancer genes BRCA1 and BRCA2 are the cause in one in ten cases, and if there is a known familial history, regular screening can facilitate earlier diagnosis .
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PMC9581083
Interestingly, high levels of NO, IL-6 and TNF-α expression in a mouse model of pneumonia were effectively lowered after treatment with polyphenol-rich extract from M. officinalis bark, which also provided long-term protection against reinfection (Lin et al., 2007; Zhang et al., 2017; Jeong et al., 2021).
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PMC7053076
Therefore, the combination of anticancer drugs with NF-κB and ABC transporter inhibitors can be considered an efficient approach to sensitize cancer cells to chemotherapy.
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PMC10994876
This enhanced expression of c-MYC is associated with its ability to regulate diverse biological activities.
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PMC11435360
Statistical significance was accepted at p < 0.05.
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PMC9429973
We will better characterise the impacts of a host of NRAS mutations within AML using over-expression and knockout cell lines, and assess drug sensitivity and subsequent pathway re-wiring.
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PMC11730305
Cell cycle arrest and subsequent apoptosis are the most common outcomes in response to exposure to cytotoxic compounds.
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PMC8584319
Its physiological and pathological significance is true because of its multifunctional mechanism.
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PMC11727145
However, we utilized HaCaT cells in this study, which do not require these components for proliferation.
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PMC11525028
In the present study, we detected the presence of ac4C modifications in mRNA using acRIP-seq, and ac4C modification was found to be located in the coding sequence of ATF4 mRNA.
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PMC11585254
The CT of CXCR5 has 14 Ser/Thr amino acid residues that fall into three discernable clusters, which we have labeled Prox, Med, and Dis, based on their distance from predicted transmembrane domain 7 (Fig. 2A).
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PMC9739791
The singlet oxygen quantum yield for the Pt(IV) prodrug 27 and the free ligand 27L was determined as 0.29 and 0.18, respectively.
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PMC9429973
It is used in the treatment of various of haematologic conditions.
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PMC11727907
Specifically, IGF-1 addition causes a decrease in oxidative phosphorylation, both in terms of oxygen consumption and ATP synthesis, within the first 4 h of treatment.
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PMC9118379
These rigorous examinations can serve to reveal low-confidence variant events from the shotgun proteomics experiment.
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PMC9429973
A. Meloni, L. Pistoia, N. Martini, D. Visceglie, P. M. G. Sanna, M. Murgia, A. Barone, P. Giovangrossi, G. Alberini, V. Positano, F. Cademartiri Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, Pisa; Servizio di Immunoematologia e Medicina Trasfusionale, A.S.L. di Bari, Ospedale “Di Venere”, Bari; Servizio trasfusionale Aziendale, Azienda Ospedaliero-Universitaria di Sassari, Sassari; Centro Provinciale per le Microcitemie, Ospedale San Martino di Oristano, Oristano; Unità Operativa di Pediatria e Oncoematologia Dipartimento Materno-Infantile, Azienda Ospedaliero-Universitaria di Parma, Parma; Servizio di Immunoematologia e Medicina Trasfusionale, Ospedale S. M. Goretti, Latina; U.O.C. INFOTEL Translational BioInformatics and eHealth, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy Background: Altough T2* cardiovascular magnetic resonance (CMR) represents the non-invasive gold standard for myocardial iron overload (MIO) assessment, native myocardial T1 mapping was demonstrated more sensitive in presence of small amounts of iron.
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PMC11473750
Since either a mono-allelic RNF121 loss-of-function mutation or RNF121 deletion delayed or ablated tumour formation in homozygous TH-MYCN mice, we assessed RNF121 gene copy number variation (CNV) and expression in databases of bulk mRNA and somatic DNA analyses of human neuroblastoma primary tumour tissues.
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