Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
ITP was suspected, and secondary causes were ruled out.
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PMC11544122
Data were normalized to endocytosis in parental cells.
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PMC11363012
However, while SA and ABH have cells that specialize in secologanin (2) accumulation, in LBE, secologanin (2) nearly always colocalizes with flavonoids.
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PMC11638255
A Percoll gradient was prepared using 90% Percoll solution (Percoll [Merck, USA; #P4937-100ML] in 10× PBS (No Ca/Mg) to form bottom (~55% Percoll solution), middle (~68%) and top (~81%) layers in 1 × PBS (No Ca/Mg).
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PMC11394227
Calculation of cell line unit productivity: The suspension cell antibody production rate (qmAb, pg/cell/day) was calculated by the following formula:qmAb=mmAbICA mmAb is the total mass of mAb in the culture supernatant measured by ELISA and ICA (integral cell area) is the overall cell area.
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PMC11721587
S2 cells with endogenous Fu depleted by Fu double-stranded RNA (dsRNA) were transfected with Ci, Sufu, RNA interference (RNAi)–insensitive (Ins) WT or mutant CC-Fu carrying K33R, S482A, or AAV mutations (Fig. 1A), and a ptc-luciferase (ptc-Luc) reporter gene.
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PMC11564322
The primary antibodies specific against human GAPDH (dilution 1:4000, cat.
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PMC11803149
Flow cytometry analysis of Zombie NIR staining in B16-OVA cells (gated on CD8−: gating strategy is shown in Supplementary Figure S4F ) co-cultured with OT-I T cells for 3 days.
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PMC10969097
Doğan et al. were the only researchers to describe collection.
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PMC9429973
The predescribed SLC4A1 variant Band 3 Bicêtre I was detected twice, a nonsense variant in ANK1 and one in SPTB once.
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PMC9429973
A booster dose of the SARS-CoV-2 vaccine proved beneficial also in previously seronegative patients.
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PMC6337547
It could be regarded as a new possible resource of natural phenolic antioxidants .
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PMC4685341
Antibody-dependent cellular cytotoxicity (ADCC) is one important mode of action for therapeutic mAbs in the field of oncology.
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PMC6799808
Having observed that treatment with GLPT for 72 h is able to induce concentration-dependent cell death in A549 and A427 cells (Fig. 1e), we reasoned that GLPT might also induce apoptosis in lung cancer cells.
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PMC9429973
BTKis were given mainly as second-line (86%) and as monotherapy (93%).
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PMC10538569
stands for P values = or < 0.001.
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PMC5673955
Inhibition of telomerase in cancer cells leads to telomere attrition, lifespan limitation the of these cells, senescence, and apoptosis 8, 9, 10.
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PMC11746948
Tumor volume indicated by fluorescence intensity.
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PMC2196094
The characteristics of the clones, encoding the five different serine proteases isolated from the RBL-1 cDNA library, and some of the biochemical properties of these proteases are listed below.
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PMC11306331
A Mean pixel intensity and enrichment (max/mean) in the FusionRed (3xFUS) channel of the nucleus of NIH3T3 cells stably expressing 3xFUS-iLID and MBP-SspB. Points are colored for cells with visible condensate formation (purple) and no resolvable condensates (gray).
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PMC10253973
Various treatments for cancer are currently available, such as chemotherapy, which blocks the activity of rapidly-proliferating cells.
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PMC11301927
Therefore, we aimed to investigate the differences in gut microbiome composition between Latino and non-Latino patients with mRCC.
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PMC11129910
Chromosomal abnormalities of chromosome 1p/q are highly associated with multiple myeloma conditions .
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PMC11785489
To identify “TCR twins” in Dataset 1, we counted the number of individuals observed for each TCR clonotype.
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PMC9429973
All ICT regimens included Rituximab.
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PMC8164677
It enters cells uniquely through a distinctive mode involving multiple pathways and effecting several genetic and epigenetic drivers.
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PMC9872547
Moreover, E6 and E7 genes’ expression increases in the full-thickness epithelial lesion in cervical cancer (17-19).
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PMC9429973
Median time from allo-SCT to neutrophil (>0.5G/L) and platelet (>20G/L) recovery was significantly delayed in the PT-Cy group (neutrophil: 19 vs 17 days, p=0.049; platelets: day 26 vs 10, p<0.001).
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PMC11519583
The proportion of MPs (k) and Ki-67-positive MPs (l) in TA muscles from control or Ror2 cKO mice, injected with either Ctx or glycerol, was monitored by flow cytometric analysis (Ctx-injected control: n = 9 (k) and n = 3 (h), Ctx- injected Ror2 cKO: n = 11 (k) and n = 4 (l), glycerol-injected control: n = 8 (k) and n = 3 (l), glycerol-injected Ror2 cKO: n = 10 (k) and n = 4 (l)).
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PMC9966931
Significant results were considered for p-values less than 0.05.
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PMC11173119
The list of primers used is shown in Table 2.
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PMC11055323
For quantitative PCR, cDNAs were synthesized with ReverTra Ace (Toyobo) and oligo-dT (Takara), and then analysed by qPCR with ChamQ SYBR qPCR Master Mix (Vazyme).
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PMC10723784
In separate experiments, attempts were made to investigate if the cytotoxicity induced by cannabinoids can be overcome by withdrawing the drug.
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PMC11539788
mTOR is a central signalling hub that integrates multiple intracellular and environmental signals in eukaryotic cells.
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PMC9429973
A first-in-class, CD123-directed therapy, tagraxofusp (TAG, SL-401) is the only approved treatment for patients with BPDCN.
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PMC9429973
In the single activities, ~50% of participants stated they would modify treatment plans and ~80% were committed to those changes.
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PMC11495567
NCI-H23 cells (2.0 × 10) in serum-free media were plated in T-25 and left to attach overnight.
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PMC5941560
The Jurkat cell line’s inability to properly synthesize O-glycans, due to deficient core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) activity, was first noticed in 1990 .
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PMC11638255
The resulting conditioned media was collected immediately after neutrophils were ready for incubation.
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PMC11711127
Thus, while ignorance can inhibit CAR T cell activation, it may also serve a protective function by reducing exhaustion in the context of tonic signalling, ultimately enhancing therapeutic efficacy.
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PMC11657695
G YAP protein expression in A-673 and SK-ES-1 lines treated with κ-Conotoxin during 72 h with the normalized and relative quantification (N = 3).
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PMC11078693
Fill the tube with 50 mL of 1× PBS.c.
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PMC9429973
The mean(SD) age was 41.4 (15.0) years, 425 (80.3%) were women and 252 (47.6%) patients had blood group O. In total, 318 patients had BUC, the reaiming patients hat PFD(n=122, 23.7%), VWD (n=51, 9.9%), mild clotting factor deficiencies (CFD, n=18, 3.5%) and 4 had an other bleeding disorder (0.8%).
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PMC9874064
The results shown in this paper demonstrate a future precise cancer therapy with DNA damaging agents of cisplatin with USP1i to overcome cisplatin resistance in clinic.
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PMC11711663
In contrast, the Wald test produced a chi-square value of 35.5 (p = 1e-06), and the score test resulted in a chi-square value of 37.1 (p = 6e-07), all indicating the model’s overall significance.
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PMC11680578
Thus, through modifications in mitochondrial metabolism and membrane potential, cancer cells can become more susceptible to treatment methods that aim at disrupting other vital functions such as cell cycle progression and initiation of cell death.
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PMC11659921
F–H) Molecular docking of TNFSF11 with angiogenesis‐related drugs.
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PMC11787651
In cancer, EMT has been associated with the increased aggressiveness and metastasis of tumor cells.
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PMC10968586
In HT-29 and WiDr colorectal cancer cell lines, combination of 10 μM HT and monoclonal anti-epidermal growth factor receptor (EGFR) antibody cetuximab reduced cell growth, both in the presence and in the absence of epidermal growth factor (EGF) stimulation, inducing G1/S and G2/M phase cell cycle arrest .
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PMC11681005
We also found that the TM4SF1‐positive cancer subpopulation (TPCS) drives ITH diversification in BLCA via integrative single‐cell atlas analysis.
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PMC11719944
It is known that the use of PD-1 antagonist monoclonal antibodies is a therapeutic alternative in various neoplasia that has presented favorable effects in different clinical phases .
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PMC11371627
Abbreviations: Cys, cysteine; MRI, Magnetic resonance imaging; F, front; H/E, hematoxylin eosin staining; R, righthand side; RBCs, red blood cells; STIR, Short Tau Inversion Recovery sequence.
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PMC11204465
One new compound, aspertoxin acetate (34), was isolated from secondary metabolites of Aspergillus flavus .
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PMC11342785
The central design feature of synMAPs is the pairing of TPPP’s native MT-binding activity with other orthogonal, condensate-forming IDR sequences that are unrelated to MT biology.
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PMC11787381
Agreement number: A1301337.
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PMC11126803
Forty 5-week-old athymic BALB/c-nu female mice were divided into four groups for injection with luciferase-labeled cells under the renal capsule.
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PMC11482552
Notwithstanding these validation criteria, only a limited number of studies have focused on evaluating the importance of sample adequacy assessment in molecular HPV-based primary testing in cervical cancer screening .
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PMC10212663
Moreover, nearly 60% of patients with non‐KRAS mutations are still without targeted drugs.
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PMC9878278
We further confirmed that the exposure of SC to these molecules also did not affect IFN-β levels (Figures 5C,D).
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PMC10114490
p < 0.05; **p < 0.01; ***p < 0.005.
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PMC11301242
Comparative distribution of amplicons in hematological malignancies and normal blood cells.
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PMC11656048
Mitochondria are the “energy pumps” of cellular metabolic activities, and mitochondrial damage and morphological changes are usually the early events of cell death (Koenig et al., 2023).
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PMC11394227
To cope with the increased protein processing and the UPR, the ER increases its load capacity by increasing its capacity.
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PMC11726848
This difference is determined by the higher degree of DNA damage in HDR irradiation due to a more pronounced contribution of rapid radiation damage, as well as the late initiation of adaptation mechanisms.
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PMC11539788
The following primary antibodies were used: anti-RNF19A (1:200; Cat: NBP1-87989; Novus Biologicals), anti-ILK (1:100; Cat: sc-20019; Santa Cruz Biotechnology), anti-Ki-67 (1:200; Cat: #9027; Cell Signaling Technology), anti-p-AKT (1:200; Cat: #4060; Cell Signaling Technology), and anti-p-mTOR (1:200; Cat: #2976; Cell Signaling Technology).
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PMC11453853
We used Rank Ordering of Super Enhancer (ROSE) analysis on these PR/ER binding sites to predict which are likely super enhancer elements capable of coordinating the regulation of multi-gene subsets.
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PMC11388384
Our results revealed surprising mechanisms that evolution can leverage to shape morphogen gradients in a tissue- or species-specific manner.
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PMC9878278
No: sc-271024), IRF3 and phospho-IRF3 (Cell Signaling Cat.
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PMC11653533
Another study observed that unrefined extracts of stem bark of F. auriculata showed significant alpha-amylase activity.
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PMC11782508
The absorbance of the dissolved formazan was measured at 560 nm using a microplate reader.
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PMC11317131
These results demonstrate that IntePACE is capable of generating novel integrase mutants with improved genomic insertion efficiency.
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PMC10809689
The trend of glutamate concentration after treatment with galectin-9 in the HL-60 cell line was decreasing in comparison to the PMA and control group but with no significant difference. (
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PMC8526701
The assessment of the IC50 (half inhibitory concentration) of GSK602 along with the combinational index (CI) of imatinib and GSK602 was performed after 48 h. CompuSyn software was used for the calculation of CI based on the equation of Chou-Talalay CI, which indicated the antagonistic effect.
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PMC9429973
Especially the incidence of diffuse large B-cell lymphoma (DLBCL) as one aggressive subtype increases and up to 40% of patients relapse or do not attain complete remission.
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PMC10728535
To better illustrate the key DEGs that contributed to OC drug resistance, heatmap graph was pictured using pheatmap and viridis packages in R. The R statistical computer program was used to perform all statistical analyses.
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PMC9429973
Results: Male to female ratio was 2.2, median age was 55 years (29-79 years)， with preponderance of lambda light chains (89.4%).
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PMC5810978
The medium in the petri dish or wells became cloudy at several hours post BoNoV inoculation.
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PMC10820104
Cell viability was assessed using the PrestoBlue HS Cell Viability Assay (#P50201, Invitrogen, Waltham, MA, USA) in 96-well plates (cat.
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PMC9429973
Cytokine release syndrome (CRS) was graded per Lee 2014 criteria.
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PMC11033180
C, C′, D, and D′) Triple immunolabeling for Sema5A (green), Hu (red), and S100β (marker of glial cells, blue) in the myenteric plexus of rat distal colon. (
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PMC11506827
Notably, the GEF treatment alone decreased MuD expression but increased Bax expression (Figure 5A).
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PMC8358006
b Genomic snapshot of H3K27me3, H3K4me3, H3K4me1, H3K27ac, and RNA-seq in NE2, KYSE450, and KYSE510 at the TBX20 loci.
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PMC11295144
The enlarged images are 10 × zoom in. (
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PMC9429973
Assessing treatment responses, 53% (38/76) of patients achieved a complete remission (CR) or a complete remission with incomplete recovery (CRi).
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PMC9429973
Detailed results after 1 and 2 years of observation are summarized in Table 1.
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PMC11711066
Additionally, AS‐IV has been reported to promote nitric oxide production and vasodilation.
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PMC11707832
However, autoimmunity arises when enzyme abnormalities cause overlapping glycosylation patterns between host and pathogen.
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PMC11470999
Consequently, a single degrader molecule can catalytically degrade numerous pathogenic proteins, achieving high efficacy at low doses.
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PMC9429973
Pts received TAG intravenous infusions, at 12 mcg/kg once daily on days 1–5 (up to day 10 allowed) of a 21-day cycle.
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PMC11665555
Calculated ATP-linked respiration was also greater in 5637GR than either parental or GR-OXCT1KO lines.
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PMC11295144
To record functional current GABAAR responses, drugs were applied to cells using a Y-tube delivery system (Mortensen and Smart, 2007).
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PMC11549612
DrugBank is a comprehensive bioinformatics database providing information on drugs, their targets, and interactions.
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PMC9429973
Aims: In a prospectively enrolled cohort of adult subjects undergoing mRNA or adenovirus vector vaccination, we wanted to longitudinally evaluate the changes in levels of hemostatic biomarkers (i.e. activation of blood coagulation and perturbance of endothelium and fibrinolysis), together with the serological response, and occurrence of manifest thrombotic complications.
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PMC11802855
STAT3 is a key transcription factor involved in the initiation and progression of MM .
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PMC10798140
Compounds 3c, 3d, and 3e, on the other hand, exhibited numerous larger substitutions at the same location.
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PMC11574271
We further observed that the effect of RON inhibition can be reversed through MMP12 overexpression (Fig. S1E, F).
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PMC11739484
Fig. 8This presents the correlation, immunological and drug sensitivity analysis of MMP7, MMP11, and MMP14 genes in skin cutaneous melanoma (SKCM) samples, utilizing the TISIDB and Gene Set Cancer Analysis (GSCA) database.
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PMC11026382
Given their structural location near the folate binding pocket, it is possible that some of these negatively epistatic mutations reduce affinity (and increase Km) for dihydrofolate substrate.
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PMC8973725
Overexpression of ZNF677 induced 786–0 cell apoptosis.
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PMC7642379
Figure 1Comparisons of genomic and transcriptomic profiles of HEK293 cells showed taxonomic divergence between parental HEK293 and progeny cell lines. (
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