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OTAR3088
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BioData-CellLine_annotated

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PMC11543935
To improve the image quality and avoid artifacts, the Bio-Phantom should be cultured as one hydrogel containing a healthy tissue and a tumor site, which could be realized with a spheroid.
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PMC10761571
Furthermore, the effects of Fe3O4@Glucose-Gingerol nanoparticles on the expression of the CASP8, BAX, and BCL2 genes and the activity of Caspase 3 were characterized.
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PMC11770746
The order of rates of reduction by ascorbate was cisPt(Pac)(OH) ≫ cisPt(OAc)2 > oxali(OAc)2.
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PMC11477621
Firstly, we synthesized hydroxamic acid-based SAHA-like targeting products 3a–e comprising aliphatic linkers of various lengths (Scheme 1).
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PMC11694625
The melting point of 3d is about 271 °C.
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PMC9429973
Median age at enrollment was 64 years (range, 41–81) and 20.5% pts were ≥75 years.
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PMC9964654
Regarding the thin-film hydration solvent used, a higher loading was obtained using H2O compared to PBS.
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PMC11337594
After the matrix gel had completely solidified, 0.1 mL of serum-free, cell density 5 × 10 cells/well cell suspension was added to the upper chamber of the Transwell (3422#, Corning, NY, USA).
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PMC8711270
The OneBac rAAV production systems were developed to improve the scalability of the production system by reducing the number of required recombinant baculoviruses for production from three to one.
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PMC6889484
Feng Gao and Beatrice Hahn; catalog #3284).
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PMC8316344
Data were analyzed by one-way ANOVA and expressed as mean ± SD from three independent experiments.
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PMC10578720
In contrast, long-term or high doses of lipopolysaccharide exposure can induce the feedback suppression of TLR signaling, causing macrophages to subsequently transform into immunosuppressive phenotype, a status of inflammation inhibition.
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PMC9412887
Liu et al. constructed a nanoemulsion delivery system (SSB NMs) to synergistically load selenocysteine (SeC) and TGF-β inhibitors to realize an amplified immunotherapeutic effect.
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PMC11760643
Next, the ability of the anti‐P2X7 mAb to mediate CDC was assessed using a flow cytometric cell death assay with human RPMI 8226 cells, known to express endogenous cell surface P2X7 .
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PMC8839885
Moreover, the presence of 2HE2 in direct co-culture condition partially restored platinum sensitivity to OC as evident by increased levels of cPARP (Figure 3B).
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PMC10926885
According to the target protein's molecular weight, the primary antibody was added and incubated overnight, followed by the addition of the secondary antibody and a 2‐h wait at room temperature before the photographs were taken.
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PMC11583690
When compared with free DTX, at low concentration (5 μg/mL of DTX), BPMO@DTX was associated with lower cell viability and this difference became more pronounced at higher concentrations.
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PMC8873393
After irradiation, cells were grown in fresh medium for various time periods.
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PMC9429973
Complete remission was achieved by day 30 after 1 induction and no change in the outcome was reported, even though an altered maturational phenotype persisted with complete absent CD33 expression, during and after treatment, suggesting a very rare polymorphism of CD33 receptor that mimicked MRD positivity.
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PMC9429973
Results: Three of five patients responded to daratumumab plus chemotherapy and were in second complete remission (CR2) and underwent stem cell transplantation (SCT).
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PMC11366496
p < 0.05, **p < 0.01 and ***p < 0.001.
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PMC9429973
Agonists to thrombopoietin receptors (TPO-RAs) have been shown to produce sustained platelet responses in ITP.
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PMC11615743
However, the ease of inactivation caused by degradation or nonspecific binding to nucleic acids and proteins in complex environments greatly limits their practical application in the biomedical field.
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PMC11680562
The viscosity of the gel formulations showed a noticeable increase, which may be ascribed to changes in the amount of xanthan gum in the PXFCu gels.
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PMC9509578
Yang et al. reported that sitravatinib interferes with the tumor microenvironment and immune-checkpoint blockade (PD-1) in many cancer models .
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PMC6771295
Error bars represent standard error of means of three or more independent experiments.
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PMC11700247
The continued relevance of RT in this context is well supported by various real-world evidence data sets, underscoring its utility in optimizing patient condition for subsequent CAR T-cell treatment.
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PMC10978090
This unexpected kinetics differed from the one previously described, in which negative functional assay was achieved more quickly.
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PMC10297204
Ethanol is often used in medical fields, costs less, and is convenient.
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PMC11087055
Blue, clockwise; red, counter-clockwise rotation.
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PMC11532793
Figure 3B shows the operating characteristics of each DTE method in terms of false discoveries versus number of transcripts with transcripts ranked by p-value.
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PMC11700523
Oxidative stress by IS may be responsible for MR transactivation through MR protein levels elevation in CKD.
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PMC11737091
Therefore, the correlation between DBF4 expression and immune modulators was analysed.
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PMC9429973
We also investigated whether DA-EPOCH-R induction influences the immune system to have an impact on the response.
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PMC11352746
The six remaining publications used cancer cell lines to study neurotoxicity and neuroinflammation in different neurological diseases , whereas the immortalized cell line was used for cellular differentiation .
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PMC9516401
The standard curve was drawn for gallic acid (y = 0.0008x + 0.0223, R2 = 0.982) and the extract's phenolic compound content was calculated as milligram of gallic acid equivalent (Hooshmand et al., 2021 ▶).
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PMC3813807
Moreover, the bioinformatics prediction and experimental results indicated that miR-373 is able to target TNFAIP1.
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PMC8956657
F Fluorescence polarization measuring the binding interaction of IMPα2 with the crystallized mutants (n = 3 biologically independent experiments).
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PMC11534035
This connection serves as further evidence that PAI1 is involved in the cascade of GPER1 and affected by estrogen signaling (15,16).
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PMC10588957
Allicin is an allyl organic sulphide compound that can be extracted from garlic bulbs.
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PMC11656048
Currently, the treatment of OS mainly adopts a comprehensive treatment based on surgery, combined with radiotherapy, chemotherapy as well as targeted therapy and other treatments (Wakamatsu et al., 2019).
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PMC11621565
The CI values registered for each sample provide information about cell number, proliferation rate, size/shape, and attachment quality.
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PMC10522430
In this study, GACP demonstrated the ability to decrease levels of TNF-α, IL-6, IL-2, IL-12, and IFN-γ.
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PMC9164404
E Representative drug release profile of Abplatin under various conditions Characterization of Abplatin.
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PMC11588008
01 vs PM + MSC group. (
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PMC11536589
The CCK8 experiment was conducted using different concentrations of MRTX1133 (ranging from 0 to 10 µM) and PKF-118-310 (ranging from 0 to 500 nM) in MRTX1133-resistant PDAC cells.
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PMC9429973
Summary/Conclusion: Nivolumab 40 mg therapy is comparable to the standard dose of 3 mg/kg in terms of overall response rate as well as survival in patients with r/r cHL.
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PMC8973725
All histopathological parameters were evaluated according to 8 tumor node metastasis classification (TNM) classification of the International Union Against Cancer (UICC).
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PMC10957991
Colocalization analysed with Image J and indicated with the white color on the left side panel.
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PMC11682172
The selection procedure of relevant proteins was based on significant expressional difference before and after T lymphocyte or CM contact and functional properties related to cell migration and/or cell locomotion.
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PMC11593713
Luo et al. found that infection in cancer patients was associated with its severe clinical course, with 62% of patients requiring hospitalization and 25% of cases ending in death.
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PMC11394227
Monoclonal antibodies (mAbs) possess a complex structure and function compared to other recombinant proteins produced in CHO cells .
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PMC9429973
H. De Boussac, A. Machura, A. Steer, A. Kassambara, M. Gely, D. Chemlal, C. Gourzones, G. Requirand, N. Robert, L. Vincent, C. Herbaux, A. Bruyer, J. Moreaux Diag2Tec; UMR 9002 CNRS-UM; Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology; CHU Montpellier; Institute of Human Genetics, UMR 9002 CNRS-UM, Montpellier, France Background: Characterized by an abnormal clonal proliferation of malignant plasma cells, Multiple myeloma (MM) is the second most common hematological malignancy.
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PMC10898159
KIT extracellular segment contains five immunoglobulin-like structural domains (D1-D5), D1-D2-D3 are stem cell factor (SCF) binding regions, and D4-D5 are important units for KIT dimer formation.
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PMC11756514
Error bars are depicted as mean ± standard deviation (sd) in all bar graphs.
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PMC11348300
It is defined as follows:CBR=Stumor-Shealthytissuestd(healthytissue), where denotes the mean value of the ROI over the tumor, represents the mean value of the ROI over the healthy tissue, and corresponds to the SD of the ROI over the healthy tissue.
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PMC6771295
Representative Western blot is shown.
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PMC7709199
The glycan stubs do not need further enzymatic processing, and we show that for heavily glycosylated fragments of human colony-stimulating factor 1 receptor (CSF-1R), murine IL-12B and human Down syndrome cell-adhesion molecule (DSCAM) the NG modifications facilitate the production of diffraction-quality crystals.
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PMC9429973
However, for relapsed/refractory patients, novel treatment options (mainly immunotherapy-based) targeting B cell-specific antigens are already used in clinics and further optimized in preclinical models.
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PMC11739504
The measured results were calculated as a ratio of the number of transfected cells and showed in a graph.
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PMC8777939
One week after injection, the mice were randomized into four groups (n = 5 mice per group), including the control group (saline 0.9%), etravirine group (100 mg/kg three times a week by i.p.
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PMC9429973
Group 1: 83 samples, shelf life from 1 to 5.9 months.
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PMC11001582
NS denotes P > 0.05.
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PMC10165258
This was done by co-encapsulating etoposide with the Cascade blue dye (6 μM, fluorescent in the blue channel, Thermofisher) and cisplatin with the CF647 dye (1 μM fluorescent in the far red channel, Biotium).
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PMC10055960
A low temperature NMR could not be attained to investigate the nature of the signals due to the observed precipitation of complex 8 from the solution and fusion temperature of DMSO.
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PMC7185206
They also predict treatment resistance in breast, colorectal, hepatocellular, and lung cancers.
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PMC9065483
Our findings introduce previously unappreciated considerations and opportunities for the advancement oncolytic virotherapy regimens.
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PMC10729469
Electroporation of the plasmid encoding TCRAβ generated antigen-specific Tregs that transiently expressed the Aβ-specific TCR.
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PMC9429973
A. Segura Diaz, R. Stuckey, Y. Florido Ortega, M. Sobas, A. Álvarez Larrán, F. Ferrer-Marín, M. Pérez Encinas, G. Carreño, M. Fox, B. Tazón Vega, B. Cuevas, J. López Rodriguez, N. Farías Sánchez, C. Bilbao Sieyro, M. Gómez Casares H.U.Dr.
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PMC11743414
FHL1 is highly expressed in AML, and knockdown of FHL1 can increase the sensitivity of AML cells to cytarabine and daunorubicin.
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PMC9398137
Diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma are aggressive types of B-NHL, both requiring intensive treatment upon diagnosis.
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PMC9429973
Overall findings on regional prevalence indicated that sub-Saharan and North-East Africa, India and the Middle East are global SCD “hotspots”.
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PMC11012012
Potential anti-tumor effects of anti-SLAMF antibodies against B-CLPD have been tested both in vitro and in vivo.
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PMC11359735
Gametocyte cultures and mosquito infections were performed as previously described (38), maintaining P. falciparum NF54 blood stage cultures in 4% human erythrocytes in RPMI-1640 culture medium (2 mM L-glutamine, 50 mg/L hypoxanthine, 25 mM HEPES, 0.22% NaHCO3, and 10% v/v human serum) at 37 °C in a candle jar made of glass desiccators.
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PMC10808409
This study aims to incorporate ferulic acid into polymeric mixed micelles made of Pluronics and TPGS, in an attempt to enhance its solubility and stability, and to investigate its potential anti- cancer activity via miRNA-221/TP53INP1 axis-mediated autophagy on Caco-2 cancer cell line.
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PMC10387886
In our study, it was shown that significant phosphorylation of ERK1/2 and p38 MAPK occurred after TGFβ1 treatment.
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PMC11502066
In human mammary epithelial cells MCF-10A, the flavonol quercetin (Figure 1) and its major circulating metabolite quercetin-3-O-glucuronide could behave as antagonists for α2C-AR subtype, inhibiting the binding of [H]-NA to this receptor, and leading to the prevention of NA-induced phosphorylation of histone H2AX (γ-H2AX) and premutagenic apurinic sites in DNA in the presence of 4-hydroxyestradiol (4-OHE2).
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PMC5941560
An even greater reduction in the number of database matches was seen in the long structural variant database comparisons (Fig. 4).
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PMC8978939
Differences in mRNA fibronectin expression for P138R and L163R pVHL variants with similar disrupted deposition patterns. (
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PMC11453346
Due to its association with breast cancer, we further examined the PDI Anterior gradient protein 2 (AGR2) as H6PD interacting partner.
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PMC7759933
Altogether, the results suggest that the expression of gene markers related to the proliferation and division of cells decreased over time.
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PMC3734024
Somewhat unexpectedly, we found essentially equivalent amounts of FasL protein (on a per cell basis) in all B cells stimulated with CD40L, regardless of the addition of cytokines (Figure 8B).
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PMC11786704
For example, VX-702, a selective p38 MAPK inhibitor, has shown significant efficacy in treating sepsis-associated acute kidney injury by downregulating inflammatory factors in macrophages, thereby reducing the severity of the condition .
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PMC11607638
These data together suggest that activation of the Gq protein‐coupled (i.e., calcium‐mobilizing) sulfakinin receptor inhibits blood meal intake in female A. aegypti mosquitoes and could serve as a strategic node for the future control of A. aegypti mosquito reproduction/population and disease transmission.bovine serum albumin charge coupled device cholecystokinin cholecystokinin 1 receptor 4',6‐diamidino‐2‐phenylindole diethylpyrocarbonate Dulbecco's modified Eagle's medium double stranded RNA concentration at which 50% of maximum effect can be obtained fetal bovine serum green fluorescent protein Gq protein‐coupled receptor 4‐(2‐hydroxyethyl)‐1‐piperazine‐ethane‐sulfonic acid minimum essential medium quantitative real‐time PCR RNA interference ribosomal protein S17 research resource identifier standard error of means sulfakinin sulfakinin 1 sulfakinin 2 sulfakinin receptor The dengue, Zika, yellow fever, and chikungunya virus vector, the mosquito Aedes aegypti, is now present in expanding areas of the world.
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PMC11252553
Blood samples were collected from volunteers who provided informed consent.
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PMC11502327
This pathophysiological feature of tumors has selectivity and retention of macromolecular substances, in such cases, passive targeting came into being.
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PMC11055323
SS, SS18-SSX1.
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PMC11694066
By mediating PARP1 trapping onto DNA, PARPi are known to increase reliance upon the ATR/CHK1 pathway because of increased stalled replication forks and resultant replication stress (33).
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PMC11320834
In this experimental model, a liposomal formulation increased topotecan activity and decreased the IC50 value by half (IC50 10.59 μM) (Fig. 2BI).
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PMC9429973
Methods: After informed consent, elranatamab was given subcutaneously weekly or every 2 weeks (Q2W) at doses from 80 to 1000µg/kg.
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PMC9429973
Medications included single antiplatelet in 114 patients, dual antiplatelets in 31 patients, single antiplatelet and anticoagulant in 23 patients, and anticoagulant in 74 patients.
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PMC8358006
Methylation BigWig file was generated by iBSTools v1.3.0.
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PMC9429973
2 of the patients who died received anti-SARS-CoV-2 monoclonal antibodies which did not seem to improve the condition.
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PMC11337594
However, this phenomenon was not observed in HepG2 cells (Fig. 1C).
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PMC11703992
Here, for a given SNP, the probability that the SNP is linked to GCA is assigned as p1, the probability that the SNP is linked to a significant eQTL is p2, and the probability that the SNP is both linked to GCA and eQTL is denoted as p12.
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PMC7342409
ERK and KIT expression and regulation levels were detected by Western blotting.
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PMC11740508
E Foci numbers from Tala + Deci treatment plotted to directly compare M231 BRCA variants.
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PMC9596868
Points below the isoeffect line indicate synergism and those above the line indicate antagonism. (
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PMC11766309
Assessment of the expression levels of YKT6 in various tumor stages. (
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PMC11461025
Although researchers have documented the apoptotic effect of isoginkgetin on many mammalian cancer cell lines, to our knowledge, there is no evidence using a mammalian melanoma cell line which motivated our study using the A375 cell line.
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