OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC7039683	To test this prediction, we partitioned the genome into 400 bp tiles, each overlapping the preceding one by 300 bp, and scored each tile with the classifier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10204952	However, there are evidences showing that SphK2 can induce cell apoptosis via different mechanisms, including inhibiting histone deacetylase (HDAC) 1 and 2 and interacting with B-cell lymphoma extra large (Bcl-xL) [10–12].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10777969	We named these compounds FCP23 and FCP26, respectively (Scheme 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "named", "these", "compounds", "FCP23", "and", "FCP26", ",", "re...
PMC9429973	The ISS 1, 2, and 3 were 209 (25.7%), 228 (28.1%) and 303 (37.2%), respectively, and 72 (8.9%) not available (NA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	X. Leleu, B. Gorsh, A. Bessou, P. Paka, J. De Nascimento, X. Colin, S. Landi, P. F. Wang Department of Hematology, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; GlaxoSmithKline, Upper Providence, PA, United States of America; IQVIA, Paris; GlaxoSmithKline, Rueil-Malmaison, France; GlaxoSmithKline, Research Triangle Park, NC, United States of America Background: While treatment options for multiple myeloma (MM) have expanded with the introduction of novel therapies, it remains unclear how this has translated into better patient outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	As an anti-influenza drug, RuSe played an antiviral role and also acted as a drug carrier to deliver selenium to the organism, regulate the selenium proteins GPx1 and TrxR1 in vivo, and play an antioxidant role in inhibiting ROS-mediated apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	Previously, upon training a gkmSVM classifier on melanocyte enhancers, the deltaSVM scores of SNPs within known melanocyte enhancers were found to correlate with the observed differences in reporter activity between t enhancer constructs tested in a melanocyte cell line (Lee et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: We found that UCK2 gene expression was higher in HTLV-1-infected T-cells than in normal T-cells using the gene expression datasets GSE55851 and GSE33615.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11095939	For stable knockdown of Nr1h3 and Rara, lentiviruses were generated according to our previous protocol (Cao et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11615743	Since D‐DNA and L‐DNA share the same base‐pairing property, we also confirmed the associative activation of HCR with D‐DNA probes (Sgc8‐DT1‐v1, TC01‐DT2‐v1, DC1‐v1, DH1‐v1, and DH2‐v1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8382973	HEC was added to the preparation as a gel matrix so that the preparation had a suitable viscosity and could be retained in the rectum and vagina.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Droplet-based bioprinting methods have been utilized to develop 3D bioprinted vascular constructs with enhanced resolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Droplet-based", "bioprinting", "methods", "have", "been", "utiliz...
PMC11467964	After that, we found that in the high‐risk group, the most mutated genes were TP53, MUC16, ATRX, and TTN, while in low‐risk group, TP53, ATRX, RB1, and TTN were the most ones (Figure 7D,E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748618	Notably, the variants identified through BIMBAM (rs72999655-A-G, rs7525622-G-A, and rs73004025-C-T), were the most significant variants associated within blocks 2, 3, and 4, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352746	Furthermore, 18% of the publications employed fluorescent microscopy in their neuronal studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "18", "%", "of", "the", "publications", "empl...
PMC8623816	Transmission electron microscope (TEM) images revealed that RsRV5 has isometric viral particles with a diameter of approximately 20 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transmission", "electro...
PMC9429973	Two weeks post vaccination anti-SARS-CoV-2 S-RBD titers were above the 75 percentile of the measuring area in 37% of CLL, 62% of aggressive NHL, 60% of indolent NHL and 93% of MM patients (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5311252	The results from the clonogenic assay therefore fully supported the results from the functional genomics screen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "from", "the", "clonogenic", "assay",...
PMC11715644	We found that for the first 24 hours after monolayers reached channel walls, 10A + RhoA cell monolayers maintained similar cell density differences between outside and inside both narrow and wide channels (Fig. 2A, C and Fig. S3A, C, ESI†).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	In further studies, we analyzed the activity of caspases 3/7, the key apoptosis executioner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "further", "studies", ",", "we", "analyzed", ...
PMC11490153	As tumors outgrow their blood vessels, oxygen levels drop from a normal range of 2–9% to hypoxic levels below 2% .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC11803149	Subsequently Ponceau Solution was decanted, and membrane was washed with distilled water until the background became clear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", "Ponceau", "Solution", "was",...
PMC11409031	The eight gene modules' distribution across various T cell subpopulations. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "eight", "gene", "modules", "'", "distribution", "across", "various", "T",...
PMC11228511	Scale bar, 2 µm.) (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "2", "µm", ".", ")", "(" ] } ]
PMC11705547	MHC-I: major histocompatibility complex class I, TCR: T cell receptors, PD-1: programmed death receptor 1, PD-L1: programed death ligand 1, CTLA-4: cytotoxic T lymphocyte-associated protein 4, CD80: cluster of differentiation 80.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	DAMPs from the extracellular matrix include biglycan, decorin, versican, heparan sulfate, hyaluronan fragments, tenascin C, fibronectin and fibrinogen .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5833712	Results are expressed as mean ± s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "expressed", "as", "mean", "±", "s.d", "." ] } ]
PMC10033453	To investigate possible explanations for the lack of tumor inhibition in WEHI 164, we tested whether exogenous murine IFNβ (mIFNβ) could protect WEHI 164 from VMG-induced cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Methods: We analyze 60 patients diagnosed with R/R AML at 4 hospitals belonging to ICO in Spain, treated with venetoclax (400mg/24h; initial daily dose of 100mg with a 3-day ramp-up to target dose of 400mg) in combination with hypomethylating agents (Azacitidine 75mg/m 7/28 days or Decitabine 20mg/m 5/28 days) or low-dose cytarabine (20mg/m 10/28 days) from May 2019 until December 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	While axi-cel remained superior to SOC with high (>median) or low CD19 expression level, the probability of an ongoing response increased with a higher CD19 H-score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	It was observed that the classification performance improved along the EM-ILR iterations, while the label modification ratio decreased throughout the processes (Fig. S5d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Age ≥65 years and high NLR were associated with a worse OS both in univariate and multivariate analysis, with a HR of 7.48 (CI 2.14–26.17) and of 6.57 (CI 1.70–25.48), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Transport experiments were performed using microporous polycarbonate membrane filters (0.4 µm pore size, 12 mm diameter; Transwell 3401; Costar, Corning, NY, USA), as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	After the formation of a δ-lactone ring by ring opening at the C7-C11 position, this type of compounds further undergoes C12-C14 esterification to form a γ-lactone ring (Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215722	The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11322866	Extracellular signal-regulated protein kinase (ERK1/2) is a mitogen-activated protein kinase with typical cascade signaling properties that plays a key role in signal transduction pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11787355	Such aberrant post-translational modification may impact CAR-T cell therapy efficacy, and increasing evidence is emerging suggesting TCR but not tonic CAR signaling cascades to be associated with favorable intratumoral T cell fate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11715644	The “outside” region was defined as the 450 to 550 μm square region immediately in front of the microchannel entrance, and the “inside” region as the 450 to 550 μm square region immediately inside of the channel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: In VIALE-A, 190/286 pts (66%) treated with Ven+Aza and 41/145 (28%) pts treated with PBO+Aza achieved CR/CRi; 93 (49%) and 10 (24%) pts with CR/CRi received G-CSF post-remission (median time to first post-remission G-CSF use [range], 36 d [2−483] and 35 d [4−127]), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	Therefore, we calculated the correlation of logP values for the whole set of compounds to relative P-gp inhibitory activity in order to determine its importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5443223	Following this, protein bands were detected using chemiluminescence liquid (Pierce; Thermo Fisher Scientific, Inc.), according to the manufacturer's instructions, and analyzed using ImageJ software (ImageJ 2x version 2.1.4.6, Bio-Rad Laboratories, Inc., Hercules, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240052	no. ab 119716) (Abcam, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "ab", "119716", ")", "(", "Abcam", ",", "USA", ")", "." ] } ]
PMC11357960	The results showed that there was no significant differences in the proportion of various lymphocyte subsets among five groups ( Figures 3E–H ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9341513	Positions of the IGH super-enhancers are shown as purple blocks above the map.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Positions", "of", "the", "IGH", "super-enhancers", "are", "shown", "as", ...
PMC11317131	Although IntePACE successfully improved PhiC31 integrase activity, we observed higher rates for wildtype Bxb1 integrase, which prompted us to perform IntePACE on Bxb1 integrase in an attempt to isolate hyperactive mutants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	Hi-C data was generated and processed with the FitHiC pipeline (39), which allows us to retrieve a list of highly confident interactions associated with a P-value, generating chromatin contacts maps that are quite comparable to the PCHi-C networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	We created CSV files containing the basic metadata of our ‘.idat’ files and used the R packages minfi and illuminaio to read our ‘.idat’ files as methylation arrays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154097	pcDNA3.1-YY1 transfection significantly increased YY1 level (P < 0.01) (Figure 5(a)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pcDNA3.1-YY1", "transfection", "significantly", "increased", ...
PMC9429973	Significant reduction in malaria events and related hospitalisations were associated with HU.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "reduction", "in", "malaria", "events", "and", "related", "hospitalisati...
PMC11585994	Following a 24-hour incubation with the cells, confocal microscopy was performed (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "a", "24-hour", "incubation", "with", "the...
PMC11761919	More than 80% bacteria were live after incubating in simulated gastric juice for 2 h, while unencapsulated bacteria were all inactivated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", ...
PMC10734950	The membranes were then transferred to blotting paper to remove any excess washer buffer and placed printed side up onto a plastic sheet lying on a flat surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9368503	DNA was quantified using a Qubit dsDNA HS assay kit, and STR profiles were then analysed via Eurofins cell line authentication service.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", ...
PMC11665555	To test this hypothesis, we evaluated OVOL1 subcellular localization in the parental and resistant cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "this", "hypothesis", ",", "we...
PMC11055510	In addition, they have a relatively normal cell morphology and phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "they", "have", "a", "relatively", "normal", "cell", ...
PMC10142392	The fibers can be electrospun directly onto the fabric.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fibers", "can", "be", "electrospun", "directly", "onto", "the", "fabric", "." ] } ]
PMC10907726	The results showed that DATS suppressed the protein levels of N-cad, Snail, MMP-2 and Vimentin, but increased the level of E-cad in OS cells (Fig. 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	A CDK1 inhibitor reduces Ki-67 phosphorylation, results in abnormal mitotic progression, and impairs microtubule organization and sister chromatin separation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "CDK1", "inhi...
PMC9874064	In order to investigate the ability of NP-Pt-USP1i to enhance DNA damage in vitro, we treated BEL-7404DPP cells with cisplatin, NP-Pt, and NP-Pt-USP1i for 48 h.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	Scale bars, 1 µm.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "1", "µm", ".", ")" ] } ]
PMC11502066	PTHR1 is a GPCR that is widely expressed in metastatic tissues and cells, playing a crucial role in the pathophysiology of osteosarcoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTHR1",...
PMC4355729	These results are in consistence with discoveries in hepatocellular and colon cancers1618, indicating that the reduction of PIK3R1 expression may acquired tumorigenicity in RCC, and thus supporting the view that PIK3R1 may function as a potential cancer suppressor, and that the downregulation of PIK3R1 may promote progression and metastasis of RCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	When these inhibitory histone modifications are relieved, the transcription factors can bind to the promoters of lytic genes and activate EBV lytic replication (Jung et al., 2007; Murata et al., 2012; Guo and Gewurz, 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4277423	To analyze potential off-target mutations, we built the human exon region reference as described by Mali et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "analyze", "potential", "off...
PMC11269933	Significant differences between groups were marked with “” for p< 0.05, “” for p<0.01, “” for p<0.001 and “” for p<0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10605143	It mainly regulates the expression of stress-inducible heat shock proteins (HSPs), which function as molecular chaperones assisting protein folding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "mainly...
PMC11679326	The β1,2-GlcNAc branch in hybrid glycans is subject to further elongation of the glycan structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "β1,2-GlcNAc", "branch", "in", "hybrid", "glycans", "...
PMC11711935	Riehl melanosis was first reported in 1917 to describe typical pigmented lesions on the face and neck, mainly occurring after episodes of contact dermatitis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11791478	Stock antibody solutions were diluted with PBS on the day of dosing to 1 mg/mL. Mice received a single intravenous dose of 10 mg/kg XB002 or vehicle (PBS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	To further establish a causative link between PARP1 expression and sensitivity to PARPi in DSRCT cells, we then evaluated the effects of silencing PARP1 on the sensitivity of JN1 and R cells to PARPi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	All participants completed a bout of cycling at an intensity corresponding to 15% above anaerobic threshold for 30-min with n = 1 SMM patient ceasing exercise at 16-min and 15-s due to volitional exhaustion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	Strategies that adjust MGMT activity might increase the efficacy of chemotherapy using alkylating agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strategies", "that", "adjust", "MGMT", "activity", "might", "increase"...
PMC11803918	Next, the thin film was hydrated with PBS buffer for 30 min at 56 °C to form the Ce6-loaded liposomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", ...
PMC11352666	All cell lines were DNA sequence verified by short tandem repeat (STR) analysis and tested negative for mycoplasma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", ...
PMC11462673	For 5-ethynyl-2-deoxyuridine Edu assays, the proliferation ability of cells was evaluated using a BeyoClick™ EdU Cell Proliferation Kit with Alexa Fluor 594 (Cat#: C0078S; Beyotime).The procedure was performed according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Real-time PCR to measure mRNA levels of Mecp2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR", "to", "measure", "mRNA", "levels", "of", "Mecp2", "." ] } ]
PMC11713609	Western blot analysis for the indicated proteins. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "for", "the", "indicated", "proteins", ".", "(" ] } ]
PMC11696659	B, percentage of telomeres of a sample with a telomere length under a given threshold (Short Tel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "percentage", ...
PMC11706491	An automatic first quality threshold was applied without a second filtering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "automatic", "first", "quality", "threshold", "was", "applied", "without", "a", ...
PMC11204465	This active form binds to DNA and albumin in the serum, forming adducts that ultimately cause DNA damage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "active", "form", "binds",...
PMC6114978	To assess this possibility, we evaluated expression of the Hippo kinases in an unbiased way through immunohistochemistry for MST1, MST2, LATS1, and LATS2 on the tissue microarray (Figure 1B and 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Assay media were prepared as follows, for 100 ml: 1 g RPM1640 (with glucose, without L-glutamine and sodium bicarbonate, #260-012 XK; Wisent inc.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	Preclinical study using in vivo mouse model to study the role of LncRNA-SERB/ERβ/ZEB1 axis in ccRCC VM formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Preclinical", "study", "using", "in", ...
PMC9429973	Methods: We initiated a multi-step content development process researching guidelines consented by the ASTCT, SITC, NCCN and EBMT as well as the prescribing information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585587	Apoptosis is a form of programmed cell death that removes harmful or damaged cells from the body to maintain stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "is", "a", ...
PMC8777939	Furthermore, the results indicated a significant decrease in the number of tumors and in the weight of tumor metastasis in mice treated with etravirine, paclitaxel, and the combination treatment compared with the control group (Figure 6f,g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Most common grade ≥3 TEAEs were febrile neutropenia (37.5%), anemia (29.2%; grade 3, 26.4%; grade 4, 2.8%), thrombocytopenia (29.2%), pneumonia (26.4%), and neutropenia (20.8%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912	Further, to validate the functional role of Clo-miR-14 in attenuating RA conditions, synovial fibroblast cells SW982 and RAFLS were treated with synthetic Clo-miR-14 with modified 2′-O-methylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11394227	Lipoic acid, for instance, reduces lipid peroxidation, removes ROS, and chelates iron and copper, thereby reducing cell death ; pyruvate has also been shown to remove H2O2 in cell media ; vitamin E is known for its ROS-clearing properties and ability to resist lipid peroxidation ; baicalein has been shown to reduce ROS levels and inhibit the activity of transcription factors involved in ER stress responses by interacting with BiP and CHOP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Caspase-3 activity was determined by the Caspase-3 Colorimetric Activity Assay Kit in ovarian cancer cell lines treated with 10 μg/mL of LMTK3BP #1 (P1) and #2 (P2) for 24 h. To determine binding affinity (Kd) for LMTK3BP, we utilized the Colorimetric Biotin Assay Kit to detect amino terminus biotin-labeled LMTK3BP #1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The overall response rate at day 28 of acute GVHD was 70% (38/54) with a complete response in 50% of patients (27/54).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	This is in accordance with our previous studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "in", "accordance", "with", "our", "previous", "studies", "." ] } ]
PMC9429973	More pts had CR on gilteritinib (16.4%) vs SC (10.2%; P=0.17690); CRc rates were 50.0% and 20.3% (P<0.00001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11560255	Following harvesting, the cells were rinsed with PBS, re-suspended in Annexin V binding buffer, and stained for 15 minutes at room temperature in the dark with 5 µl of Annexin V and 10 µl of PI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	Caki-1 and 786-0 Cells were treated with drugs and lysate was collected, PKC-ι was pulled down from 1000µg protein lysates.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	In Yersinia-infected macrophages, RIP1 is essential in the induction of apoptosis and pyroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Yersinia-infected", "macrophages", ",", "RIP1", "is", "essential...
PMC11604768	Dashed lines: 5% FDR threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dashed", "lines", ":", "5", "%", "FDR", "threshold", "." ] } ]
PMC10093184	With the exception of D-17 cells, we found no correlation between MET expression and the migratory or invasive potential of COS cells.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens"...
PMC9581083	Amongst M. canadensis -related flavonoids, hesperidin and linarin are abundant active substances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amongst", "M.", "canadensis", "-related", "flavonoids", ",", "hesperidin", ...
PMC9429973	Baseline demographics are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Baseline", "demographics", "are", "shown", "in", "Table", "1", "." ] } ]

PMC7039683

To test this prediction, we partitioned the genome into 400 bp tiles, each overlapping the preceding one by 300 bp, and scored each tile with the classifier.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10204952

However, there are evidences showing that SphK2 can induce cell apoptosis via different mechanisms, including inhibiting histone deacetylase (HDAC) 1 and 2 and interacting with B-cell lymphoma extra large (Bcl-xL) [10–12].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10777969

We named these compounds FCP23 and FCP26, respectively (Scheme 1).

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PMC9429973

The ISS 1, 2, and 3 were 209 (25.7%), 228 (28.1%) and 303 (37.2%), respectively, and 72 (8.9%) not available (NA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

X. Leleu, B. Gorsh, A. Bessou, P. Paka, J. De Nascimento, X. Colin, S. Landi, P. F. Wang Department of Hematology, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; GlaxoSmithKline, Upper Providence, PA, United States of America; IQVIA, Paris; GlaxoSmithKline, Rueil-Malmaison, France; GlaxoSmithKline, Research Triangle Park, NC, United States of America Background: While treatment options for multiple myeloma (MM) have expanded with the introduction of novel therapies, it remains unclear how this has translated into better patient outcomes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10747139

As an anti-influenza drug, RuSe played an antiviral role and also acted as a drug carrier to deliver selenium to the organism, regulate the selenium proteins GPx1 and TrxR1 in vivo, and play an antioxidant role in inhibiting ROS-mediated apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7039683

Previously, upon training a gkmSVM classifier on melanocyte enhancers, the deltaSVM scores of SNPs within known melanocyte enhancers were found to correlate with the observed differences in reporter activity between t enhancer constructs tested in a melanocyte cell line (Lee et al., 2015).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: We found that UCK2 gene expression was higher in HTLV-1-infected T-cells than in normal T-cells using the gene expression datasets GSE55851 and GSE33615.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11095939

For stable knockdown of Nr1h3 and Rara, lentiviruses were generated according to our previous protocol (Cao et al., 2022).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...

PMC11615743

Since D‐DNA and L‐DNA share the same base‐pairing property, we also confirmed the associative activation of HCR with D‐DNA probes (Sgc8‐DT1‐v1, TC01‐DT2‐v1, DC1‐v1, DH1‐v1, and DH2‐v1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8382973

HEC was added to the preparation as a gel matrix so that the preparation had a suitable viscosity and could be retained in the rectum and vagina.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8557138

Droplet-based bioprinting methods have been utilized to develop 3D bioprinted vascular constructs with enhanced resolution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Droplet-based", "bioprinting", "methods", "have", "been", "utiliz...

PMC11467964

After that, we found that in the high‐risk group, the most mutated genes were TP53, MUC16, ATRX, and TTN, while in low‐risk group, TP53, ATRX, RB1, and TTN were the most ones (Figure 7D,E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11748618

Notably, the variants identified through BIMBAM (rs72999655-A-G, rs7525622-G-A, and rs73004025-C-T), were the most significant variants associated within blocks 2, 3, and 4, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11352746

Furthermore, 18% of the publications employed fluorescent microscopy in their neuronal studies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "18", "%", "of", "the", "publications", "empl...

PMC8623816

Transmission electron microscope (TEM) images revealed that RsRV5 has isometric viral particles with a diameter of approximately 20 nm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transmission", "electro...

PMC9429973

Two weeks post vaccination anti-SARS-CoV-2 S-RBD titers were above the 75 percentile of the measuring area in 37% of CLL, 62% of aggressive NHL, 60% of indolent NHL and 93% of MM patients (Table 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5311252

The results from the clonogenic assay therefore fully supported the results from the functional genomics screen.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "from", "the", "clonogenic", "assay",...

PMC11715644

We found that for the first 24 hours after monolayers reached channel walls, 10A + RhoA cell monolayers maintained similar cell density differences between outside and inside both narrow and wide channels (Fig. 2A, C and Fig. S3A, C, ESI†).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767817

In further studies, we analyzed the activity of caspases 3/7, the key apoptosis executioner.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "further", "studies", ",", "we", "analyzed", ...

PMC11490153

As tumors outgrow their blood vessels, oxygen levels drop from a normal range of 2–9% to hypoxic levels below 2% .

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PMC11803149

Subsequently Ponceau Solution was decanted, and membrane was washed with distilled water until the background became clear.

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PMC11409031

The eight gene modules' distribution across various T cell subpopulations. (

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PMC11228511

Scale bar, 2 µm.) (

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PMC11705547

MHC-I: major histocompatibility complex class I, TCR: T cell receptors, PD-1: programmed death receptor 1, PD-L1: programed death ligand 1, CTLA-4: cytotoxic T lymphocyte-associated protein 4, CD80: cluster of differentiation 80.

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PMC11545737

DAMPs from the extracellular matrix include biglycan, decorin, versican, heparan sulfate, hyaluronan fragments, tenascin C, fibronectin and fibrinogen .

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PMC5833712

Results are expressed as mean ± s.d.

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PMC10033453

To investigate possible explanations for the lack of tumor inhibition in WEHI 164, we tested whether exogenous murine IFNβ (mIFNβ) could protect WEHI 164 from VMG-induced cell death.

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PMC9429973

Methods: We analyze 60 patients diagnosed with R/R AML at 4 hospitals belonging to ICO in Spain, treated with venetoclax (400mg/24h; initial daily dose of 100mg with a 3-day ramp-up to target dose of 400mg) in combination with hypomethylating agents (Azacitidine 75mg/m 7/28 days or Decitabine 20mg/m 5/28 days) or low-dose cytarabine (20mg/m 10/28 days) from May 2019 until December 2021.

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PMC9429973

While axi-cel remained superior to SOC with high (>median) or low CD19 expression level, the probability of an ongoing response increased with a higher CD19 H-score.

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PMC11790971

It was observed that the classification performance improved along the EM-ILR iterations, while the label modification ratio decreased throughout the processes (Fig. S5d).

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PMC9429973

Age ≥65 years and high NLR were associated with a worse OS both in univariate and multivariate analysis, with a HR of 7.48 (CI 2.14–26.17) and of 6.57 (CI 1.70–25.48), respectively.

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PMC8875242

Transport experiments were performed using microporous polycarbonate membrane filters (0.4 µm pore size, 12 mm diameter; Transwell 3401; Costar, Corning, NY, USA), as previously described .

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PMC10874773

After the formation of a δ-lactone ring by ring opening at the C7-C11 position, this type of compounds further undergoes C12-C14 esterification to form a γ-lactone ring (Fig. 5).

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PMC7215722

The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture.

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PMC11322866

Extracellular signal-regulated protein kinase (ERK1/2) is a mitogen-activated protein kinase with typical cascade signaling properties that plays a key role in signal transduction pathways.

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PMC11787355

Such aberrant post-translational modification may impact CAR-T cell therapy efficacy, and increasing evidence is emerging suggesting TCR but not tonic CAR signaling cascades to be associated with favorable intratumoral T cell fate.

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PMC11715644

The “outside” region was defined as the 450 to 550 μm square region immediately in front of the microchannel entrance, and the “inside” region as the 450 to 550 μm square region immediately inside of the channel.

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PMC9429973

Results: In VIALE-A, 190/286 pts (66%) treated with Ven+Aza and 41/145 (28%) pts treated with PBO+Aza achieved CR/CRi; 93 (49%) and 10 (24%) pts with CR/CRi received G-CSF post-remission (median time to first post-remission G-CSF use [range], 36 d [2−483] and 35 d [4−127]), respectively.

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PMC6160470

Therefore, we calculated the correlation of logP values for the whole set of compounds to relative P-gp inhibitory activity in order to determine its importance.

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PMC5443223

Following this, protein bands were detected using chemiluminescence liquid (Pierce; Thermo Fisher Scientific, Inc.), according to the manufacturer's instructions, and analyzed using ImageJ software (ImageJ 2x version 2.1.4.6, Bio-Rad Laboratories, Inc., Hercules, CA, USA).

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PMC11240052

no. ab 119716) (Abcam, USA).

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PMC11357960

The results showed that there was no significant differences in the proportion of various lymphocyte subsets among five groups ( Figures 3E–H ).

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PMC9341513

Positions of the IGH super-enhancers are shown as purple blocks above the map.

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PMC11317131

Although IntePACE successfully improved PhiC31 integrase activity, we observed higher rates for wildtype Bxb1 integrase, which prompted us to perform IntePACE on Bxb1 integrase in an attempt to isolate hyperactive mutants.

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PMC7192625

Hi-C data was generated and processed with the FitHiC pipeline (39), which allows us to retrieve a list of highly confident interactions associated with a P-value, generating chromatin contacts maps that are quite comparable to the PCHi-C networks.

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PMC9046263

We created CSV files containing the basic metadata of our ‘.idat’ files and used the R packages minfi and illuminaio to read our ‘.idat’ files as methylation arrays.

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PMC10154097

pcDNA3.1-YY1 transfection significantly increased YY1 level (P < 0.01) (Figure 5(a)).

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PMC9429973

Significant reduction in malaria events and related hospitalisations were associated with HU.

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PMC11585994

Following a 24-hour incubation with the cells, confocal microscopy was performed (Figure 2A).

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PMC11761919

More than 80% bacteria were live after incubating in simulated gastric juice for 2 h, while unencapsulated bacteria were all inactivated.

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PMC10734950

The membranes were then transferred to blotting paper to remove any excess washer buffer and placed printed side up onto a plastic sheet lying on a flat surface.

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PMC9368503

DNA was quantified using a Qubit dsDNA HS assay kit, and STR profiles were then analysed via Eurofins cell line authentication service.

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PMC11665555

To test this hypothesis, we evaluated OVOL1 subcellular localization in the parental and resistant cell lines.

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PMC11055510

In addition, they have a relatively normal cell morphology and phenotype.

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PMC10142392

The fibers can be electrospun directly onto the fabric.

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PMC10907726

The results showed that DATS suppressed the protein levels of N-cad, Snail, MMP-2 and Vimentin, but increased the level of E-cad in OS cells (Fig. 1D).

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PMC11786767

A CDK1 inhibitor reduces Ki-67 phosphorylation, results in abnormal mitotic progression, and impairs microtubule organization and sister chromatin separation.

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PMC9874064

In order to investigate the ability of NP-Pt-USP1i to enhance DNA damage in vitro, we treated BEL-7404DPP cells with cisplatin, NP-Pt, and NP-Pt-USP1i for 48 h.

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PMC11087766

Scale bars, 1 µm.)

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PMC11502066

PTHR1 is a GPCR that is widely expressed in metastatic tissues and cells, playing a crucial role in the pathophysiology of osteosarcoma .

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PMC4355729

These results are in consistence with discoveries in hepatocellular and colon cancers1618, indicating that the reduction of PIK3R1 expression may acquired tumorigenicity in RCC, and thus supporting the view that PIK3R1 may function as a potential cancer suppressor, and that the downregulation of PIK3R1 may promote progression and metastasis of RCC.

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PMC11655498

When these inhibitory histone modifications are relieved, the transcription factors can bind to the promoters of lytic genes and activate EBV lytic replication (Jung et al., 2007; Murata et al., 2012; Guo and Gewurz, 2022).

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PMC4277423

To analyze potential off-target mutations, we built the human exon region reference as described by Mali et al. .

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PMC11269933

Significant differences between groups were marked with “” for p< 0.05, “” for p<0.01, “” for p<0.001 and “” for p<0.0001.

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PMC10605143

It mainly regulates the expression of stress-inducible heat shock proteins (HSPs), which function as molecular chaperones assisting protein folding.

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PMC11679326

The β1,2-GlcNAc branch in hybrid glycans is subject to further elongation of the glycan structure.

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PMC11711935

Riehl melanosis was first reported in 1917 to describe typical pigmented lesions on the face and neck, mainly occurring after episodes of contact dermatitis.

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PMC11791478

Stock antibody solutions were diluted with PBS on the day of dosing to 1 mg/mL. Mice received a single intravenous dose of 10 mg/kg XB002 or vehicle (PBS).

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PMC11694066

To further establish a causative link between PARP1 expression and sensitivity to PARPi in DSRCT cells, we then evaluated the effects of silencing PARP1 on the sensitivity of JN1 and R cells to PARPi.

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PMC11472639

All participants completed a bout of cycling at an intensity corresponding to 15% above anaerobic threshold for 30-min with n = 1 SMM patient ceasing exercise at 16-min and 15-s due to volitional exhaustion.

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PMC11773391

Strategies that adjust MGMT activity might increase the efficacy of chemotherapy using alkylating agents .

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PMC11803918

Next, the thin film was hydrated with PBS buffer for 30 min at 56 °C to form the Ce6-loaded liposomes.

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PMC11352666

All cell lines were DNA sequence verified by short tandem repeat (STR) analysis and tested negative for mycoplasma.

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PMC11462673

For 5-ethynyl-2-deoxyuridine Edu assays, the proliferation ability of cells was evaluated using a BeyoClick™ EdU Cell Proliferation Kit with Alexa Fluor 594 (Cat#: C0078S; Beyotime).The procedure was performed according to the manufacturer’s instructions.

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PMC11095939

Real-time PCR to measure mRNA levels of Mecp2.

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PMC11713609

Western blot analysis for the indicated proteins. (

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PMC11696659

B, percentage of telomeres of a sample with a telomere length under a given threshold (Short Tel).

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PMC11706491

An automatic first quality threshold was applied without a second filtering.

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PMC11204465

This active form binds to DNA and albumin in the serum, forming adducts that ultimately cause DNA damage .

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PMC6114978

To assess this possibility, we evaluated expression of the Hippo kinases in an unbiased way through immunohistochemistry for MST1, MST2, LATS1, and LATS2 on the tissue microarray (Figure 1B and 1C).

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PMC11632064

Assay media were prepared as follows, for 100 ml: 1 g RPM1640 (with glucose, without L-glutamine and sodium bicarbonate, #260-012 XK; Wisent inc.),

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PMC11126803

Preclinical study using in vivo mouse model to study the role of LncRNA-SERB/ERβ/ZEB1 axis in ccRCC VM formation.

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PMC9429973

Methods: We initiated a multi-step content development process researching guidelines consented by the ASTCT, SITC, NCCN and EBMT as well as the prescribing information.

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PMC11585587

Apoptosis is a form of programmed cell death that removes harmful or damaged cells from the body to maintain stability.

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PMC8777939

Furthermore, the results indicated a significant decrease in the number of tumors and in the weight of tumor metastasis in mice treated with etravirine, paclitaxel, and the combination treatment compared with the control group (Figure 6f,g).

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PMC9429973

Most common grade ≥3 TEAEs were febrile neutropenia (37.5%), anemia (29.2%; grade 3, 26.4%; grade 4, 2.8%), thrombocytopenia (29.2%), pneumonia (26.4%), and neutropenia (20.8%).

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PMC11392912

Further, to validate the functional role of Clo-miR-14 in attenuating RA conditions, synovial fibroblast cells SW982 and RAFLS were treated with synthetic Clo-miR-14 with modified 2′-O-methylation .

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PMC11394227

Lipoic acid, for instance, reduces lipid peroxidation, removes ROS, and chelates iron and copper, thereby reducing cell death ; pyruvate has also been shown to remove H2O2 in cell media ; vitamin E is known for its ROS-clearing properties and ability to resist lipid peroxidation ; baicalein has been shown to reduce ROS levels and inhibit the activity of transcription factors involved in ER stress responses by interacting with BiP and CHOP .

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PMC11406030

Caspase-3 activity was determined by the Caspase-3 Colorimetric Activity Assay Kit in ovarian cancer cell lines treated with 10 μg/mL of LMTK3BP #1 (P1) and #2 (P2) for 24 h. To determine binding affinity (Kd) for LMTK3BP, we utilized the Colorimetric Biotin Assay Kit to detect amino terminus biotin-labeled LMTK3BP #1.

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PMC9429973

The overall response rate at day 28 of acute GVHD was 70% (38/54) with a complete response in 50% of patients (27/54).

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PMC10890055

This is in accordance with our previous studies .

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PMC9429973

More pts had CR on gilteritinib (16.4%) vs SC (10.2%; P=0.17690); CRc rates were 50.0% and 20.3% (P<0.00001).

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PMC11560255

Following harvesting, the cells were rinsed with PBS, re-suspended in Annexin V binding buffer, and stained for 15 minutes at room temperature in the dark with 5 µl of Annexin V and 10 µl of PI.

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PMC10823017

Caki-1 and 786-0 Cells were treated with drugs and lysate was collected, PKC-ι was pulled down from 1000µg protein lysates.

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PMC11545737

In Yersinia-infected macrophages, RIP1 is essential in the induction of apoptosis and pyroptosis.

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PMC11604768

Dashed lines: 5% FDR threshold.

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PMC10093184

With the exception of D-17 cells, we found no correlation between MET expression and the migratory or invasive potential of COS cells.

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PMC9581083

Amongst M. canadensis -related flavonoids, hesperidin and linarin are abundant active substances.

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PMC9429973

Baseline demographics are shown in Table 1.

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