OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10490530	NF-κB and p53 signaling are well-characterized and elucidated in cancer biology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NF-κB", "and", "p53", "signaling", "are", "well-characterized", "and", "elucidated", "in", ...
PMC11519583	Notably, the analysis of single-cell RNA sequencing data obtained from the Tabula Muris (https://tabula-muris.ds.czbiohub.org/) database revealed that Wnt11 was highly expressed in MPs (Fig. 4a, b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	In the human placental trophoblastic choriocarcinoma BeWo cell line, VPA also increase SLC7A11 expression .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "human", "placental", "trophoblastic", ...
PMC9351137	By contrast, the ISWI remodeler was not found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "contrast", ",", "the", "ISWI", "remodeler", "was", "not", "found", "." ] } ]
PMC11768281	This process is initiated when the T-cell receptor (TCR) binds to the major histocompatibility complex (MHC) on APCs, coupled with TLR engagement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CFU-F cultures were obtained according to the standard method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CFU-F", "cultures", "were", "obtained", "according", "to", "the", "standard", "method", "." ] } ]
PMC9429973	Most frequent complication was febrile neutropenia (46%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "frequent", "complication", "was", "febrile", "neutropenia", "(", "46", "%", ")", "...
PMC6771295	Effect of silencing of SIRT5 on SIRT1 and on SIRT3 protein levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "silencing", "of", "SIRT5", "on", "SIRT1", "and", "on", "SI...
PMC9429973	The bone marrow is infiltrated by malignant plasma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bone", "marrow", "is", "infiltrated", "by", "malignant", "plasma", "cells", "." ] } ]
PMC7189327	Moreover, the CytoNCA (http://apps.cytoscape.org/apps/cytonca), a cytoscape plugin, was used to analyze topological characteristics of PPI nodes using the without weight parameter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10907726	Overactivation of autophagy has been shown to induce tumor cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overactivation", "of", "autophagy", "has", "been", "shown", "to", "induce", "tumor", ...
PMC11422150	NO is an essential biological messenger.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NO", "is", "an", "essential", "biological", "messenger", "." ] } ]
PMC11371747	Although d-LV may be taken up into cells via the normal folate transport systems albeit at a lower efficiency than l-LV, and is not metabolized or less efficiently than l-LV, it has been reported to interfere with the pharmacokinetics of l-LV (Sirotnak et al., 1979; Zittoun et al., 1993) and may have some antitumor effect by itself (Carlsson et al., 1995).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Twin” cells appear to express more pigmentations that the surrounding cells (black arrows).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twin", "”", "cells", "appear", "to", "express", ...
PMC9429973	CMV disease was not significantly different between the 2 periods: 0% vs 3.2% [0.9-8.4] at 14 weeks, 1.5% [0.1-7.2] vs 4.3% [1.4-9.9] at 24 weeks, and 3.3% [0.6-10.3] vs 4.3% [1.4-9.9] at 1 year post allo-HCT, p = 0.69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6650823	Highlighted by Arduino A. Mangoni A significant number of patients suffer from coronary events despite being on maximal treatment with cardioprotective drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Highlighted", ...
PMC11775197	Additionally, it stimulates lipogenesis, facilitates wound healing, and enhances resistance to adverse environmental conditions [19–22].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "it", ...
PMC11759751	The tumor load of NSG mice in the last group of Chidamide + CD19 CAR T group was effectively controlled after CD19 CAR T cell therapy, and no mice died within 21 days after CD19 CAR T cell therapy (Fig. 6B, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Data are presented as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]
PMC11587606	The expression of related proteins in MCF10A/RH acini with CRT0066854 (4 µM) stimulation on the day 4 and cultured for another 6 days in 3D cultures. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	It should be noted that the results of registration studies often do not correspond with the data from real-life observations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "should", "be", "...
PMC11525293	Next, we assessed whether ΔNp63α downregualtion is sufficient to reduce pseudo-SARS-CoV-2 infectivity by employing the stable shp63#3/shp63#4 transfected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "ass...
PMC11471176	Table 2ACE2 levels expressed in absorbance or optical density (OD) for all breast cancer cell lines and following 2 and 24 h of exposure to various concentrations of carnosine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	IMPα3: MERS-CoV NLS crystallized in 0.2 M magnesium chloride, 0.1 M Tris pH 8.0, 20% w/v PEG 6000 with plate-shaped crystals forming within 14 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11490153	In another study, citral was identified as the most effective inhibitor of ALDH1A3 in MDA-MB-231, MDA-MB-468, and SKBR3 breast cancer cells out of twelve drugs tested .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O"...
PMC11483468	However, GST-TAT-LPTS39 protein did not influence the growth of telomerase-negative osteosarcoma cell Saos-2 (Figure 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "GST-TAT-LPTS39", "p...
PMC11012313	Of these proteins listed above, EBV utilizes EBV latency proteins found in each of these latency programs to enhance B cell metabolism and/or HIF-1α production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10919056	The GRPS was associated with immune cell infiltration, the TME, the TMB, and sensitivity to chemotherapy drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GRPS", "was", "...
PMC9429973	Dose was reduced due to safety reasons in 11pt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dose", "was", "reduced", "due", "to", "safety", "reasons", "in", "11pt", "." ] } ]
PMC11412721	The detailed phenotyping, presented here, yielded surprising information on lymphomagenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detailed", "phenotyping", ",", "presented", "here", ",", "yielded", "surp...
PMC11761919	The Fiber2 protein level in E. faecalis treated with 1% PINs was larger than that treated with 0.5% PINs, and 1% inulin (v/m).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11116779	Senescent cells exhibit distinct characteristics beyond proliferation arrest, including enlarged cellular morphology, the presence of SA-β-Gal, and the secretion of a diverse array of cytokines, chemokines, proteases, and growth factors constituting the SASP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964635	The results suggest that molecules may be effective against kinase targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "suggest", "that", "molecules", "may", "be", "effective", "against", ...
PMC11483468	The cells were incubated for 7 days at 37 ℃ in 5% CO2 and saturated humidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "incubated", "for", ...
PMC11422150	After initial denaturation at 95°C for 1 min, a two-step cycle procedure was conducted (denaturation at 95°C for 15 s, annealing and extension at 60°C for 15 s, and data collection at 72°C for 35 s) for 40 cycles using a 7500 Sequence Detector and 7500 software ver.2.0.6 (Applied Biosystems, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Several factors were significantly associated with DIC score ≥ 4, including diabetes (p=0.038), FLT3 and NPM1 mutations (p=0.024 and p=0.017, respectively), elevated serum LDH (p<0.001) and a leukocyte count above 50x10/L (p=0.002).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This indicate that BMP2 may modify the TGF-β signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicate", "that", "BMP2", "may", "modify", "the", "TGF-β", "signaling", "pathway", ...
PMC9429973	Following the safety lead-in, approximately 80 patients will be randomized 1:1 to receive tamibarotene/ven/aza or ven/aza.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "safety", "lead-in", ",", ...
PMC10452486	The formation of Face-3 and Face-4 may serve a preventative function against possible ill effects of binding of such antibodies to exposed epitopes on Face-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11438317	LYP contains an electropositive surface surrounding the catalytic pocket that would explain why acidic residues are preferred .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LYP", "contains", "an", "electropositive", "surfa...
PMC9429973	None of the patients experienced serious adverse events requiring blinatumomab discontinuation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "None", "of", "the", "patients", "experienced", "serious", "adverse", "events", "requiring",...
PMC11676169	Procedures involving animals and their care conformed with institutional guidelines and were authorized by local (OPBA) and national (Italian Ministry of Health) animal ethical committees.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661	The pharmacokinetic profile of NOV202 was investigated after intravenous and oral administration in male C57Bl/6 mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "pharmacokinetic", "profile", "of", "NOV202",...
PMC11774112	Viability of A375 and NIH3T3 cells treated with different concentrations of Blank-PHRD for 72 h. Dose-dependent cell viability of A375 cells treated with DTIC, PHRD-DTIC (B), miRNA 34a, or PHRD-miRNA 34a (C) and DTIC + miRNA 34a or Co-PHRD (D) for 72 h. MTT was used to assess cell viability.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...
PMC9429973	Although 7/11 tested patients developed an acquired von Willebrand syndrome, there were no major bleeding complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "7/11", "tested", "patients", "develop...
PMC6835428	Due to the potent antitumor activity of PTX alone, addition of DFP-10825 only resulted in a modest augmentation of antitumor activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", ...
PMC11725127	G, H) Levels of KRAS in MM.1S (G) and RPMI 8226 (H) cells treated with 1 μmol/L GA for 24 h in the presence or absence of MG132 (20 μmol/L), which was added 6 h before the cells were harvested. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	Carfilzomib (K) was started with 20mg/m at d 1 of cycle 1, and was continued with 27mg/m for the first 2 cycles (d 1 + 2, 8 + 9, 15 + 16 schedule); followed by K administration at 57mg/m once weekly for a 28 d cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593713	When the cells reached a confluency of 80%, they were ready to be inoculated with viral test suspension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "cells", ...
PMC11599565	Multikaryocyte formation (D-F) was a frequent event in SKOV3 cells treated with cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Multikaryocyte", "formation", "(", "D-F", ")", "was", ...
PMC11026382	Metabolites are in gray or black italic text.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolites", "are", "in", "gray", "or", "black", "italic", "text", "." ] } ]
PMC11585587	The result showed RA was combined with MAPK1 through 6 hydrogen bonds, and the affinity is -12.85 kcal/mol, which suggests vigorous docking activity (Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	E, F The protein levels of PCNA in tumor tissues were detected by IHC and western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "F", "The", "protein", ...
PMC11400680	Similarly, SAM also works on each bounding box and generates separate masks for each prompt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "SAM", "also", "works", "on", "...
PMC8973725	Previous studies have demonstrated that DNA methylation alterations participate in tumorigenesis and are significantly correlated with the clinicopathological features of ccRCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", ...
PMC11271800	As far as GIST patients are concerned, the poor efficacy exerted by ICIs in clinical trials and the lack of significant synergism between ICIs and tyrosine kinase inhibitors (TKIs) may be why their clinical application has not yet been realized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	Following the boiling phase, the filtrate extracted from G. applanatum underwent centrifugation at 4300 rpm for 5 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "boiling", "ph...
PMC11438317	Then, cells were fixed and stained with specific antibodies for SLP76 and LYP, as indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "cells", "were", "fixed", "and"...
PMC11739484	These MMPs are known to degrade various components of the ECM, including collagen, laminin, and fibronectin, thereby facilitating tumor cell invasion and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cumulative incidence of MMR (<0.1%) by 12 and 24 mos were 75% (95% CI 66-84%) and 92% (95% CI 86-97%), respectively; MR4.5 by 24 and 48 mos were 48% (95% CI 38-60%) and 76% (95% CI 64-90%), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11736898	Proliferation of normal and keloid-derived keratinocytes treated with vitamin D. Normal keratinocytes (NK, white bars; n = 3 strains) and keloid keratinocytes (KK, black bars; n = 4 strains) were cultured in the presence of vehicle or active vitamin D (0–100 nM) for 24 h, and proliferation was measured using an MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Statistical analysis was performed using t-test (Holm-Sidak) and 2way ANOVA (Tukey’s multiple comparisons test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", ...
PMC11461833	The orange arrowheads indicate progerin and Lamin A bands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "orange", "arrowheads", "indicate", "progerin", "and", "Lamin", "A", "bands", "." ] } ]
PMC11632064	ES, enrichment score; NES, normalized enrichment score; NOM p, nominal P value; FDR q, false-discovery rate q value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11467964	BMRG subtypes and clinicopathological and biological characteristics of two distinct subtypes of samples divided by consistent clustering. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BMRG", "subtypes", "and", "clinicopathologic...
PMC10092581	The samples were treated with highly pure nitric acid (1 mL; Ag≤0.01 μg kg, Au≤0.02 μg kg, Au≤0.005 μg kg, Trace‐SELECT Ultra, Sigma Chemical Co.) and transferred into a microwave Teflon vessel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291697	No mRNA expression changes of both neighbouring genes, ZEB2 and ARHGAP15 (Supplementary Fig. S1b), which are contained in the same Topologically Associating Domain (TAD), were observed in the proband’s LCL (as confirmed by RNA-seq).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10212663	DSS, disease‐free survival; KRAS‐mt, Kirsten rat sarcoma viral oncogene homolog‐mutant type; OS, overall survival; PFS, progression‐free survival; RANKL, receptor activator of nuclear factorκB ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	However, the same treatments did not affect chromosomal DNA or nuclear Ki-67 protein (Fig. 1B and C), supporting the specific effect of methanol and acetone in removing lipids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	To increase cytosolic Ca concentrations, cells were treated with thapsigargin/calcimycin A23187 (5 μM each) or DMSO for 15 min before fixation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11352746	Because the cell does not require staining for the components of the cell to be seen, this method is termed non-invasive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "t...
PMC9424261	In HERPUD1-sg1 liver cancer cells, the content of GSH in the same treatment group was significantly higher than that in WT liver cancer cells (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	We used bioinformatics analysis, cell culture and molecular biology experiments in order to confirm that CLP36 expression in lymphoma cells correlates with disease prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11682525	Hypoxia equips cells with the ability to adapt to their external microenvironment, reducing oxidative stress, enhancing proliferation and differentiation, maintaining stemness, and improving motility, all of which are advantageous in the context of cell therapy following transplantation ( 8 - 10 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912	Total miRNAs were isolated from the clear supernatant using miRNeasy (Qiagen, U.S.A.) isolation kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "miRNAs", "were", "isolated", "from", ...
PMC11740207	The first HL-60 leukopoiesis model was proposed in 1988, identifying LSLCs at the top of the hierarchical development of this cell line (Birnie, 1988), which appears to support subsequent mathematical models of hematopoietic senescence (Marciniak-Czochra et al., 2009; Stiehl et al., 2014).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	Mitochondria have several modes of mtDNA replication that differ significantly from the nuclear mode of replication, including the strand displacement mode (SDM), ribonucleotide-embedded lagging strand replication, and coupled leading and lagging strand synthesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545474	After removal of the media, cells were washed with PBS and loaded with DCFH2‐DA dye (20 μM, in basal RPMI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10969097	Group 1 was given a dosage of 2 mg/kg of cisplatin every three days through an injection in their abdomen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Group", "1", "was", "g...
PMC11766332	This duplicated region contains nine genes, including the LFNG gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "duplicated", "region", "contains", "nine", "genes", ",", "including", "the", ...
PMC11267830	For trypsin digestion, proteins were precipitated with TCA, centrifuged, washed with acetone, and dried.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "trypsin", "digestion", ",", "pr...
PMC11727145	To the best of our knowledge, no studies have previously examined the specific impact of these components on DED culture systems, confirming the novelty of our model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	This network is under the tight regulation of various protein families, including Rab small GTPases, SNARE proteins, Golgins, different coat proteins, and others. , , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739670	TCR α‐ and β‐chain encoding DNA was PCR amplified from cDNA prepared from peptide‐specific T‐cell lines and cloned into bacterial expression vectors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCR", "α‐", ...
PMC11297139	g Left: spheroid invasion assay conducted on four cell lines over 2 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Left", ":", "spheroid", "invasion", "assay", "conducted", "...
PMC11683240	However, our findings revealed that α1AT also inhibits proteolytically activated forms of both diphtheria toxin (nicked DT) and the B-component of anthrax toxin, PA63.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9318744	Other viral proteins, like the membrane (M), envelope (E), and nucleocapsid (N) proteins, may also contribute to virus entry and attenuate replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	FACS analysis was performed on a FACScan LSR II (Becton Dickinson, Mountain View, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FACS", "analysis", "was", "performed", ...
PMC7762347	Etoposide (30 and 1 µg/mL) was applied as a positive control for MTS and flow cytometry analyses, respectively, while B(a)P (30 µg/mL) was used for gene expression analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Using the null distributions, P‐values are calculated for each of the original INKA scores associated with kinases for a given sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the...
PMC11441402	One limiting factor of the automated cell imaging system is the time required to image a plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "limiting", "factor", "of", "the", "a...
PMC10551595	CCRF‐CEM cells were seeded in 96‐well plates and incubated with 5 and/or 10 μM GinA for 72 h. Subsequently, cells were stained with (A) dual acridine orange/ethidium bromide (AO/EtBr) or (B, C) Annexin‐V‐PI. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Evidence is limited on the use of granulocyte colony-stimulating factor (G-CSF) and impact on outcomes in this pt population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Evidence", "is", ...
PMC11055323	Outside and inside groups indicate the distribution of random pixels’ fluorescence intensity normalized by Z score from outside and inside of SS18 (a) or SS18-SSX (b) condensates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In parallel, allogenic Vγ9Vδ2 T cells functions against cell lines and primary ALL blasts were evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "parallel", ",", "allogenic", "Vγ9Vδ2", ...
PMC10671321	In both clones, the levels of AChR subunits coding mRNA were significantly increased, whereas MuSK and rapsyn mRNAs levels were not different from controls (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Abbreviations: FC fold change, PanCK pancytokeratin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abbreviations", ":", "FC", "fold", "change", ",", "PanCK", "pancytokeratin", "." ] } ]
PMC11461833	Scale bars, 50m. (D) The Lamin B1 expression level was measured woth anti-Lamin B1 antibody, and a graph was generated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11683240	The transfer of proteins from the gels onto nitrocellulose membranes was performed by semi-dry Western blotting and controlled by staining the membranes with Ponceau-S-staining (AppliChem GmbH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11464982	A bacterial reverse mutation test (Ames test) was performed according to the Organisation for Economic Co‐operation and Development (OECD) Test Guideline 471 (OECD, 1997a) and following Good Laboratory Practice (GLP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10490530

NF-κB and p53 signaling are well-characterized and elucidated in cancer biology.

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PMC11519583

Notably, the analysis of single-cell RNA sequencing data obtained from the Tabula Muris (https://tabula-muris.ds.czbiohub.org/) database revealed that Wnt11 was highly expressed in MPs (Fig. 4a, b).

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PMC11025866

In the human placental trophoblastic choriocarcinoma BeWo cell line, VPA also increase SLC7A11 expression .

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "human", "placental", "trophoblastic", ...

PMC9351137

By contrast, the ISWI remodeler was not found.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "contrast", ",", "the", "ISWI", "remodeler", "was", "not", "found", "." ] } ]

PMC11768281

This process is initiated when the T-cell receptor (TCR) binds to the major histocompatibility complex (MHC) on APCs, coupled with TLR engagement.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

CFU-F cultures were obtained according to the standard method.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CFU-F", "cultures", "were", "obtained", "according", "to", "the", "standard", "method", "." ] } ]

PMC9429973

Most frequent complication was febrile neutropenia (46%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "frequent", "complication", "was", "febrile", "neutropenia", "(", "46", "%", ")", "...

PMC6771295

Effect of silencing of SIRT5 on SIRT1 and on SIRT3 protein levels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "silencing", "of", "SIRT5", "on", "SIRT1", "and", "on", "SI...

PMC9429973

The bone marrow is infiltrated by malignant plasma cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bone", "marrow", "is", "infiltrated", "by", "malignant", "plasma", "cells", "." ] } ]

PMC7189327

Moreover, the CytoNCA (http://apps.cytoscape.org/apps/cytonca), a cytoscape plugin, was used to analyze topological characteristics of PPI nodes using the without weight parameter.

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PMC10907726

Overactivation of autophagy has been shown to induce tumor cell death .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overactivation", "of", "autophagy", "has", "been", "shown", "to", "induce", "tumor", ...

PMC11422150

NO is an essential biological messenger.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NO", "is", "an", "essential", "biological", "messenger", "." ] } ]

PMC11371747

Although d-LV may be taken up into cells via the normal folate transport systems albeit at a lower efficiency than l-LV, and is not metabolized or less efficiently than l-LV, it has been reported to interfere with the pharmacokinetics of l-LV (Sirotnak et al., 1979; Zittoun et al., 1993) and may have some antitumor effect by itself (Carlsson et al., 1995).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

Twin” cells appear to express more pigmentations that the surrounding cells (black arrows).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twin", "”", "cells", "appear", "to", "express", ...

PMC9429973

CMV disease was not significantly different between the 2 periods: 0% vs 3.2% [0.9-8.4] at 14 weeks, 1.5% [0.1-7.2] vs 4.3% [1.4-9.9] at 24 weeks, and 3.3% [0.6-10.3] vs 4.3% [1.4-9.9] at 1 year post allo-HCT, p = 0.69.

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PMC6650823

Highlighted by Arduino A. Mangoni A significant number of patients suffer from coronary events despite being on maximal treatment with cardioprotective drugs.

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PMC11775197

Additionally, it stimulates lipogenesis, facilitates wound healing, and enhances resistance to adverse environmental conditions [19–22].

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PMC11759751

The tumor load of NSG mice in the last group of Chidamide + CD19 CAR T group was effectively controlled after CD19 CAR T cell therapy, and no mice died within 21 days after CD19 CAR T cell therapy (Fig. 6B, C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11525028

Data are presented as the mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]

PMC11587606

The expression of related proteins in MCF10A/RH acini with CRT0066854 (4 µM) stimulation on the day 4 and cultured for another 6 days in 3D cultures. (

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PMC9429973

It should be noted that the results of registration studies often do not correspond with the data from real-life observations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "should", "be", "...

PMC11525293

Next, we assessed whether ΔNp63α downregualtion is sufficient to reduce pseudo-SARS-CoV-2 infectivity by employing the stable shp63#3/shp63#4 transfected cells.

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PMC11471176

Table 2ACE2 levels expressed in absorbance or optical density (OD) for all breast cancer cell lines and following 2 and 24 h of exposure to various concentrations of carnosine.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8956657

IMPα3: MERS-CoV NLS crystallized in 0.2 M magnesium chloride, 0.1 M Tris pH 8.0, 20% w/v PEG 6000 with plate-shaped crystals forming within 14 days.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11490153

In another study, citral was identified as the most effective inhibitor of ALDH1A3 in MDA-MB-231, MDA-MB-468, and SKBR3 breast cancer cells out of twelve drugs tested .

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PMC11483468

However, GST-TAT-LPTS39 protein did not influence the growth of telomerase-negative osteosarcoma cell Saos-2 (Figure 3C).

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PMC11012313

Of these proteins listed above, EBV utilizes EBV latency proteins found in each of these latency programs to enhance B cell metabolism and/or HIF-1α production.

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PMC10919056

The GRPS was associated with immune cell infiltration, the TME, the TMB, and sensitivity to chemotherapy drugs.

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PMC9429973

Dose was reduced due to safety reasons in 11pt.

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PMC11412721

The detailed phenotyping, presented here, yielded surprising information on lymphomagenesis.

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PMC11761919

The Fiber2 protein level in E. faecalis treated with 1% PINs was larger than that treated with 0.5% PINs, and 1% inulin (v/m).

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PMC11116779

Senescent cells exhibit distinct characteristics beyond proliferation arrest, including enlarged cellular morphology, the presence of SA-β-Gal, and the secretion of a diverse array of cytokines, chemokines, proteases, and growth factors constituting the SASP.

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PMC9964635

The results suggest that molecules may be effective against kinase targets.

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PMC11483468

The cells were incubated for 7 days at 37 ℃ in 5% CO2 and saturated humidity.

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PMC11422150

After initial denaturation at 95°C for 1 min, a two-step cycle procedure was conducted (denaturation at 95°C for 15 s, annealing and extension at 60°C for 15 s, and data collection at 72°C for 35 s) for 40 cycles using a 7500 Sequence Detector and 7500 software ver.2.0.6 (Applied Biosystems, CA).

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PMC9429973

Several factors were significantly associated with DIC score ≥ 4, including diabetes (p=0.038), FLT3 and NPM1 mutations (p=0.024 and p=0.017, respectively), elevated serum LDH (p<0.001) and a leukocyte count above 50x10/L (p=0.002).

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PMC9429973

This indicate that BMP2 may modify the TGF-β signaling pathway.

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PMC9429973

Following the safety lead-in, approximately 80 patients will be randomized 1:1 to receive tamibarotene/ven/aza or ven/aza.

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PMC10452486

The formation of Face-3 and Face-4 may serve a preventative function against possible ill effects of binding of such antibodies to exposed epitopes on Face-2.

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PMC11438317

LYP contains an electropositive surface surrounding the catalytic pocket that would explain why acidic residues are preferred .

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PMC9429973

None of the patients experienced serious adverse events requiring blinatumomab discontinuation.

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PMC11676169

Procedures involving animals and their care conformed with institutional guidelines and were authorized by local (OPBA) and national (Italian Ministry of Health) animal ethical committees.

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PMC5417661

The pharmacokinetic profile of NOV202 was investigated after intravenous and oral administration in male C57Bl/6 mice.

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PMC11774112

Viability of A375 and NIH3T3 cells treated with different concentrations of Blank-PHRD for 72 h. Dose-dependent cell viability of A375 cells treated with DTIC, PHRD-DTIC (B), miRNA 34a, or PHRD-miRNA 34a (C) and DTIC + miRNA 34a or Co-PHRD (D) for 72 h. MTT was used to assess cell viability.

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PMC9429973

Although 7/11 tested patients developed an acquired von Willebrand syndrome, there were no major bleeding complications.

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PMC6835428

Due to the potent antitumor activity of PTX alone, addition of DFP-10825 only resulted in a modest augmentation of antitumor activity.

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PMC11725127

G, H) Levels of KRAS in MM.1S (G) and RPMI 8226 (H) cells treated with 1 μmol/L GA for 24 h in the presence or absence of MG132 (20 μmol/L), which was added 6 h before the cells were harvested. (

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PMC9429973

Carfilzomib (K) was started with 20mg/m at d 1 of cycle 1, and was continued with 27mg/m for the first 2 cycles (d 1 + 2, 8 + 9, 15 + 16 schedule); followed by K administration at 57mg/m once weekly for a 28 d cycle.

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PMC11593713

When the cells reached a confluency of 80%, they were ready to be inoculated with viral test suspension.

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PMC11599565

Multikaryocyte formation (D-F) was a frequent event in SKOV3 cells treated with cisplatin.

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PMC11026382

Metabolites are in gray or black italic text.

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PMC11585587

The result showed RA was combined with MAPK1 through 6 hydrogen bonds, and the affinity is -12.85 kcal/mol, which suggests vigorous docking activity (Fig. 8).

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PMC11772585

E, F The protein levels of PCNA in tumor tissues were detected by IHC and western blot.

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PMC11400680

Similarly, SAM also works on each bounding box and generates separate masks for each prompt.

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PMC8973725

Previous studies have demonstrated that DNA methylation alterations participate in tumorigenesis and are significantly correlated with the clinicopathological features of ccRCC .

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PMC11271800

As far as GIST patients are concerned, the poor efficacy exerted by ICIs in clinical trials and the lack of significant synergism between ICIs and tyrosine kinase inhibitors (TKIs) may be why their clinical application has not yet been realized.

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PMC10522430

Following the boiling phase, the filtrate extracted from G. applanatum underwent centrifugation at 4300 rpm for 5 minutes.

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PMC11438317

Then, cells were fixed and stained with specific antibodies for SLP76 and LYP, as indicated.

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PMC11739484

These MMPs are known to degrade various components of the ECM, including collagen, laminin, and fibronectin, thereby facilitating tumor cell invasion and metastasis.

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PMC9429973

Cumulative incidence of MMR (<0.1%) by 12 and 24 mos were 75% (95% CI 66-84%) and 92% (95% CI 86-97%), respectively; MR4.5 by 24 and 48 mos were 48% (95% CI 38-60%) and 76% (95% CI 64-90%), respectively.

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PMC11736898

Proliferation of normal and keloid-derived keratinocytes treated with vitamin D. Normal keratinocytes (NK, white bars; n = 3 strains) and keloid keratinocytes (KK, black bars; n = 4 strains) were cultured in the presence of vehicle or active vitamin D (0–100 nM) for 24 h, and proliferation was measured using an MTT assay.

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PMC9429973

Statistical analysis was performed using t-test (Holm-Sidak) and 2way ANOVA (Tukey’s multiple comparisons test).

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PMC11461833

The orange arrowheads indicate progerin and Lamin A bands.

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PMC11632064

ES, enrichment score; NES, normalized enrichment score; NOM p, nominal P value; FDR q, false-discovery rate q value.

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PMC11467964

BMRG subtypes and clinicopathological and biological characteristics of two distinct subtypes of samples divided by consistent clustering. (

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PMC10092581

The samples were treated with highly pure nitric acid (1 mL; Ag≤0.01 μg kg, Au≤0.02 μg kg, Au≤0.005 μg kg, Trace‐SELECT Ultra, Sigma Chemical Co.) and transferred into a microwave Teflon vessel.

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PMC11291697

No mRNA expression changes of both neighbouring genes, ZEB2 and ARHGAP15 (Supplementary Fig. S1b), which are contained in the same Topologically Associating Domain (TAD), were observed in the proband’s LCL (as confirmed by RNA-seq).

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PMC10212663

DSS, disease‐free survival; KRAS‐mt, Kirsten rat sarcoma viral oncogene homolog‐mutant type; OS, overall survival; PFS, progression‐free survival; RANKL, receptor activator of nuclear factorκB ligand.

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PMC11786767

However, the same treatments did not affect chromosomal DNA or nuclear Ki-67 protein (Fig. 1B and C), supporting the specific effect of methanol and acetone in removing lipids.

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PMC11621493

To increase cytosolic Ca concentrations, cells were treated with thapsigargin/calcimycin A23187 (5 μM each) or DMSO for 15 min before fixation.

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PMC11352746

Because the cell does not require staining for the components of the cell to be seen, this method is termed non-invasive.

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PMC9424261

In HERPUD1-sg1 liver cancer cells, the content of GSH in the same treatment group was significantly higher than that in WT liver cancer cells (Fig. 4A).

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PMC11674146

We used bioinformatics analysis, cell culture and molecular biology experiments in order to confirm that CLP36 expression in lymphoma cells correlates with disease prognosis.

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PMC11682525

Hypoxia equips cells with the ability to adapt to their external microenvironment, reducing oxidative stress, enhancing proliferation and differentiation, maintaining stemness, and improving motility, all of which are advantageous in the context of cell therapy following transplantation ( 8 - 10 ).

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PMC11392912

Total miRNAs were isolated from the clear supernatant using miRNeasy (Qiagen, U.S.A.) isolation kit.

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PMC11740207

The first HL-60 leukopoiesis model was proposed in 1988, identifying LSLCs at the top of the hierarchical development of this cell line (Birnie, 1988), which appears to support subsequent mathematical models of hematopoietic senescence (Marciniak-Czochra et al., 2009; Stiehl et al., 2014).

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PMC11594588

Mitochondria have several modes of mtDNA replication that differ significantly from the nuclear mode of replication, including the strand displacement mode (SDM), ribonucleotide-embedded lagging strand replication, and coupled leading and lagging strand synthesis .

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PMC9545474

After removal of the media, cells were washed with PBS and loaded with DCFH2‐DA dye (20 μM, in basal RPMI).

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PMC10969097

Group 1 was given a dosage of 2 mg/kg of cisplatin every three days through an injection in their abdomen.

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PMC11766332

This duplicated region contains nine genes, including the LFNG gene.

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PMC11267830

For trypsin digestion, proteins were precipitated with TCA, centrifuged, washed with acetone, and dried.

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PMC11727145

To the best of our knowledge, no studies have previously examined the specific impact of these components on DED culture systems, confirming the novelty of our model.

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PMC11615828

This network is under the tight regulation of various protein families, including Rab small GTPases, SNARE proteins, Golgins, different coat proteins, and others. , , ,

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PMC11739670

TCR α‐ and β‐chain encoding DNA was PCR amplified from cDNA prepared from peptide‐specific T‐cell lines and cloned into bacterial expression vectors.

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PMC11297139

g Left: spheroid invasion assay conducted on four cell lines over 2 days.

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PMC11683240

However, our findings revealed that α1AT also inhibits proteolytically activated forms of both diphtheria toxin (nicked DT) and the B-component of anthrax toxin, PA63.

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PMC9318744

Other viral proteins, like the membrane (M), envelope (E), and nucleocapsid (N) proteins, may also contribute to virus entry and attenuate replication.

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PMC10538569

FACS analysis was performed on a FACScan LSR II (Becton Dickinson, Mountain View, CA).

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PMC7762347

Etoposide (30 and 1 µg/mL) was applied as a positive control for MTS and flow cytometry analyses, respectively, while B(a)P (30 µg/mL) was used for gene expression analyses.

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PMC6461034

Using the null distributions, P‐values are calculated for each of the original INKA scores associated with kinases for a given sample.

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PMC11441402

One limiting factor of the automated cell imaging system is the time required to image a plate.

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PMC10551595

CCRF‐CEM cells were seeded in 96‐well plates and incubated with 5 and/or 10 μM GinA for 72 h. Subsequently, cells were stained with (A) dual acridine orange/ethidium bromide (AO/EtBr) or (B, C) Annexin‐V‐PI. (

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PMC9429973

Evidence is limited on the use of granulocyte colony-stimulating factor (G-CSF) and impact on outcomes in this pt population.

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PMC11055323

Outside and inside groups indicate the distribution of random pixels’ fluorescence intensity normalized by Z score from outside and inside of SS18 (a) or SS18-SSX (b) condensates.

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PMC9429973

In parallel, allogenic Vγ9Vδ2 T cells functions against cell lines and primary ALL blasts were evaluated.

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PMC10671321

In both clones, the levels of AChR subunits coding mRNA were significantly increased, whereas MuSK and rapsyn mRNAs levels were not different from controls (Figure 6C).

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PMC11638255

Abbreviations: FC fold change, PanCK pancytokeratin.

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PMC11461833

Scale bars, 50m. (D) The Lamin B1 expression level was measured woth anti-Lamin B1 antibody, and a graph was generated. (

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PMC11683240

The transfer of proteins from the gels onto nitrocellulose membranes was performed by semi-dry Western blotting and controlled by staining the membranes with Ponceau-S-staining (AppliChem GmbH).

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PMC11464982

A bacterial reverse mutation test (Ames test) was performed according to the Organisation for Economic Co‐operation and Development (OECD) Test Guideline 471 (OECD, 1997a) and following Good Laboratory Practice (GLP).

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