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PMC11585565
This graphic summarizes the key findings of this study, illustrating that the missense variants c.1474G > T, c.1475G > A, and c.1484 C > T in CNNM4, which correspond to p.(Gly492Cys), p.(Gly492Asp), and p.(Thr495Ile), respectively, in the CBS domain of the CNNM4 protein, result in significantly increased mRNA and protein decay rates compared with the wild type.
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PMC11397654
In 2020, they further demonstrated that 44 induced the degradation of the AXL receptor tyrosine kinase in Panc-1 cells via clathrin-mediated endocytosis .
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PMC9817179
To quantify the surface roughness of a cell nucleus image, the standard deviation of fluorescence intensities in the nucleus were compared before and after fixation (Figure 8).
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PMC11476264
The modulation of cisplatin resistance by the miR-324-5pFBXO11 axis is observed in lung cancer .
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PMC11380454
In accordance with the ethical committee guidelines, mice whose tumor volume reached 2000 mm were sacrificed.
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PMC9220170
Experiments on recording the level of cytosolic Ca in cells loaded with a Fura-2AM fluorescent calcium probe.
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PMC6889484
NL4-3 replication peaked on day 7 in cultures that had 0% or 10% CEM/D128K cells and peaked on days 7–9, 9–12, and 12–14 in cultures that had 25%, 50%, and 75% CEM/D128K cells, respectively.
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PMC11592837
Statistical significance of differences between pairs was assessed by Student’s t-test with a 95% confidence interval.
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PMC11319300
An alternative approach is to use modelling schemes to predict interactions based on other types of epigenomic linear data (Buckle et al., 2018).
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PMC11604830
This research was funded by Associazione Italiana per la Ricerca sul Cancro (AIRC, IG‐22041) and by the University of Torino (Ricerca Locale 2021).
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PMC11775197
Despite the increase in awareness of CRC and the continuous improvement of medical treatment nowadays, the challenge of CRC still needs to be conquered.
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PMC11754094
Desired DNA fragments from the digested pAX198 were isolated through a 1% agarose gel and subsequently purified using the Expin Gel SV kit (GeneAll).
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PMC10454535
Of the three MM cell lines tested (RPMI 8226, U266, and NCI-H929), RES derivatives overall exhibited the greatest cytotoxicity in RPMI 8226 cells.
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PMC9429973
Methods: A multi-center, global, observational, retrospective chart review study was conducted at 6 study sites (4 European, 2 US) to identify and collect data from AdvSM patients who received BAT.
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PMC11686380
This cold anesthesia method blocks nerve conduction and reduces pain.
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PMC11756514
For the MGL-expressing HEK293-cells, we observed a highly significant (P<0.0001) specificity for GalNAc-BSA ( Figure 1D ).
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PMC9693627
Such regulation in baker’s yeast is carried out via translational activators—special proteins which bind predominantly 5′-UTRs of mRNAs and increase its affinity to mitochondrial ribosome.
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PMC9429973
Aims: Compare overall survival of guadecitabine to that of TC consisting of low-dose cytarabine (LDAC), intensive chemotherapy (IC), or best supportive care (BSC).
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PMC11201989
To confirm that PD-L1 is an intrinsic component of the Golgi complex, we examined the fate of PD-L1 upon treatment with nocodazole.
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PMC11271278
In the lung squamous cell carcinoma cell line NCIH2170, we identified a cluster of trans enhancer hijacking genes from chromosomes 8 and 17 (Fig. 5A).
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PMC11739504
Representative figures of Kat2b localization in NIH/3T3 cells by serum starvation time (0 h, 6 h, 12 h, and 24 h).
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PMC11724582
We hypothesized that the YAP/TAZ molecular pathway is associated with CAFs to promote drug resistance in NSCLC.
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PMC11321678
There has been no clinical determination of the molecular subgroup of any of the samples.
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PMC11615743
The sensitivity was calculated as the ratio of Q2/(Q2 + Q3).
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PMC9780037
These systems exploit specific features of cyt c, such as its binding to an aptamer or the electrical currents generated from electron transfer originating in its heme. (
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PMC7802142
n ≥ 3; *P < 0.05, ***P < 0.001 versus the 293-NVgroups (c) or PBS groups (d) by One-way ANOVA According to previous reports, miR-100 repress multiple β-catenin negative regulators and increase β-catenin signaling.
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PMC9429973
This analysis includes data from patients with CP-CML in PACE and from the 45-mg starting dose cohort in OPTIC.
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PMC11745823
Studies have shown that RIT1 mutations are also common in acute myeloid leukaemia, which can enhance leukaemia cell survival and proliferation, further exacerbating the disease .
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PMC3995603
The ranges of LOD and LOQ were 38.40–126.49 ng/mL and 128.00–421.62 ng/mL, respectively.
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PMC11707577
The same experiments were carried out with i) a 1D‐TNP, missing of the EGFR recognition moiety, using the wild‐type M13 phage as a template, that is, M13(TNP) and ii) 3D‐TNPs (Figure S8, Supporting Information).
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PMC9429973
Pacritinib 200 mg BID may represent a full-dose therapeutic option for patients with myelofibrosis, including those with thrombocytopenia.
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PMC11676670
The OVAR79 line shows significant expression of NANOG, a key pluripotency factor .
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PMC7553912
The full-length blots are presented in Supplementary Fig. S7.
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PMC10743717
It indicates that the pathogenesis is most likely not due to the mediation of Aβ neurotoxicity by 17β-HSD10.
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PMC8711270
The most recent HEK-produced recombinant protein therapeutic, NUWIQ®, was produced in HEK293F cells.
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PMC11637276
Scale bar, 20 μm. (
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PMC11612626
H, Rank order of genes of the top 20 MHC-I–restricted peptides upregulated in cells treated with compound A. Red stars indicate peptide that has undergone posttranslational methionine oxidation.
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PMC9014716
OXA was purchased from Hangzhou Sanofi-Aventis Minsheng Pharmaceuticals Co., Ltd. (Hangzhou, China) and prepared in accordance with the manufacturer’s instructions.
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PMC11499381
Quantification of mVenus intensity in live and fixed cells.
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PMC9429973
Results: Our results showed a decreased metabolic activity induced by all the epigenetic modulators in a time- and dose-dependent manner.
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PMC11653168
In some systems, STAT3 is rapidly turned over, while in others, the phosphorylation status may be sustained for longer periods.
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PMC10547921
In contrast, structural modifications to approved or well-studied payloads can identify novel payloads more quickly.
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PMC11545868
Another important regulator of cancer cells in angiogenesis, which is a hallmark of many cancers, is VEGF, which also induces cell death through the terminal caspase pathway.
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PMC11705547
Thus, the combination of FASN inhibitors and cisplatin can synergistically inhibit tumor growth and metastasis, and improve patient prognosis.
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PMC9429973
Aims: We aimed to analyze the potentiality of Next Generation Sequencing (NGS) in the identification of KMT2A-PTD, a technique that is being implemented in many laboratories and could be a good strategy to detect this marker.
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PMC11461874
These coding sequences were inserted into pSG5 (Agilent #216201) with 6xMyc-tag (MEQKLISEEDL each).
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PMC11413393
PRMT1 inhibition leads to loss of aDMA post-translational modifications on RBPs involved in RNA processing, resulting in the accumulation of R-loops.
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PMC11506670
To assess the impact of the novel NRAS G48C, Q43K, and E37K mutations on the proliferative capacity of HCT116 and NIH3T3 cells, the CellTiter 96 AQueous One Solution Cell Proliferation Assay was carried out.
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PMC9429973
Per 100-patient years, exposure-adjusted TE-AOEs were 15.8 events at 0 to <1 year in PACE and 7.6 events at 0 to <1 year in OPTIC.
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PMC11731614
n = 3 biological replicates for each group.
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PMC9429973
MYC abnormalities play a critical role in the disease progression.
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PMC9596868
Samples were quantified as described in the protocol and plotted as RTA.
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PMC11047729
It has multiple purposes and can be used in treating diabetes, asthma, arthritis, cancer, and cardiovascular disease .
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PMC11711063
Authentication of cell lines was performed by deep sequencing before the study.
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PMC11665584
Notably, products of the genes S100a9, Il1b, and Tgfb1 were predicted to engage receptors transcribed from genes like Alcam, Il1r1, and Itgb8 in dendritic cells, dermal fibroblasts, and dermal adjacent keratinocyte subpopulations.
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PMC9429973
It is characterized by severe thrombocytopenia with complete absence or severe reduction of megakaryocytes in the bone marrow, with otherwise normal hematopoiesis.
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PMC9920575
HeLa and HaCaT cells were incubated with the S. chinantlense extract at the IC50 value or cisplatin for 24 h. Then, 1 × 10 cells were washed twice with PBS and incubated in lysis buffer for 1 h at room temperature with gentle shaking.
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PMC11650848
cDNA sequence of ZFP57 gene with individual exons marked in different colours Alternative promoter variant of the imprinted gene regulator ZFP57 is regulated by DNA methylation.
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PMC11461874
List of identified E3 ligases that contain substrate recognition domains HEK293T cells were transiently transfected with DBP expression plasmids together with expression vectors for myc-TRAF7 (WT; a or ΔRING; b) and GFP.
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PMC11629192
The NMDAR antibody testing in cerebrospinal fluid (CSF) and serum samples was conducted using a cell-based assay method, as previously described in our earlier publication .
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PMC9429973
Only in patient 13, in SPTA1 the low expression allele α-LELY was detected, located in trans to a missense variant.
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PMC10891340
Duck fibroblasts were infected with 1 MOI of DPV for 1 h, followed treating CCCP of 5, 10, 15, and 20 μM. The result showed that the fluorescent spots were significantly attenuated under 15 and 20 μM of the drug treatment (Figure 1A).
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PMC11607638
p = .0013, ****p < .0001. (
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PMC9429973
J. N. Allan, A. P. Skarbnik, N. Emechebe, H. Alhasani, B. S. Manzoor Weill Cornell Medicine University Medical Center, New York; Novant Health, Charlotte; AbbVie, North Chicago, United States of America Background: Treatment with fixed-duration venetoclax regimens are approved in first-line (1L) and relapsed/refractory (RR) settings for patients with chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL).
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PMC11766309
For immune-inhibitory genes, the expression of YKT6 was positively correlated with the expression of OV, UVM, BLCA, and DLBC.
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PMC11640115
The significance of associated parameters was assessed using the Cox proportional hazards regression model.
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PMC11621493
Next, we investigated whether PLA2G4D exhibits phospholipid:MAG(PMAT) and PDAT activities.
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PMC7757104
The culture medium containing 300 µg/ml geneticin was changed every 2 days until clones stably expressing the OPNc isoform were selected, which lasted 15 days.
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PMC11409031
M2a macrophages boost the endocytosis process, M2b macrophages have the ability to generate both inflammatory and anti-inflammatory cytokines, M2c macrophages are experts in phagocytosing apoptotic cells, and M2d macrophages play a role in angiogenesis and tumor advancement [, , ].
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PMC11761919
As shown in Fig. 6C, the clinical symptoms scores indicated that FAdV-4/GS01 was obviously virulent from 3 to 7 dpi, peaking at 5 dpi.
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PMC8270637
It is mainly expressed on the surface of activated CD4+, CD8+ T lymphocytes, and B lymphocytes.
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PMC10551595
Optical densities were measured at 492 nm using a Stat fax‐2100 microplate reader (Awareness Technology, Inc.).
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PMC11675244
Wnt proteins are synthesized in the endoplasmic reticulum of the secreting cell and function as paracrine or autocrine glycoproteins promoting cell growth.
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PMC11087301
EMT process has been shown to generate cells-enriched stem cell and CSC behaviors to introduce networks of signaling pathways that are more favorably used in the cellular products of an EMT.
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PMC11092382
This article aims to summarize the pharmacology, pharmacokinetics, and toxicity of sophocarpine, evaluate its potential pharmacological effects in various diseases, and propose the necessity for further research and evaluation to promote its clinical application.
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PMC11693599
To verify the CD109 secretion pattern of pOCs, the protein levels of CD109 and exosome markers in total CM, ΔEV_CM, and EV fractions were measured by western blotting.
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PMC11462673
The interconnection of master transcription factors and the core transcriptional regulatory circuitry is crucial for maintaining cell identity and status.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "interconnection", "of...
PMC11478724
Caspase 3 and 7 activities in A549 cells increased significantly when exposed to PMX at the IC50 dose compared to the control group.
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PMC11763111
Through the integration of multiple innovative strategies, including the disruption of CD38, TCR, HLA-I, and HLA-II, and the overexpression of LLT1, we established a UCAR-T cell platform with significantly reduced immunogenicity and enhanced allogeneic persistence.
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PMC9429973
Summary/Conclusion: As a result, the PTM sites of cereblon are clearly functionally significant.
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PMC5330095
These findings suggest that CBD could be further developed and used therapeutically against HCV.
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PMC5854676
TEM and SEM results confirm symmetric and asymmetric forms of the nanostructures in both an individual and agglomerated manner for the different nanomaterials.
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PMC9429973
This analysis evaluated MOMENTUM pts with baseline (BL) platelet counts (PLT) ≤150 x 10/L on key symptom, anemia, and spleen volume endpoints at 24 weeks (wks).
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PMC9960565
The monodentate G0.5COO(Pt(NH3)2Cl)8 and G2.5COO(Pt(NH3)2Cl)32 metallodendrimers, as well as the bidentate G2.5COO(Pt(NH3)2)16 metallodendrimer, were even more active towards the cisplatin-resistant cell line (A2780cisR cells) than the correspondent cisplatin-sensitive one (A2780 cells).
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PMC11476837
In the case of ML-385, we observed doxorubicin-induced apoptosis only in HL-60/DR cells pre-incubated with ML-385 at 50 µM and then incubated with doxorubicin at 100 nM (p < 0.001) (Figure 5).
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PMC11587606
Target proteins were isolated by using specific antibodies (PKCζ, improtin β1 or normal IgG) linked on magnetic beads (catalog #B23202, Bimake, Texas, USA), then subjected to Western blot analysis.
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PMC4270159
Prepare the gel for sample loading—insert the gel in the gel box with 1× running buffer and ensure there is no leak.i.
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PMC9429973
PFS and OS outcomes were comparable in the subgroup of patients with cHL.
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PMC9429973
Although validation with larger studies is required, initial MRD testing after two cycles of Hyper-CVAD induction (i.e. after day 42) promotes appropriate resource utilization and ensures no loss in the prognostic power of early MRD monitoring in adult B-ALL.
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PMC3019555
The latter is an important control, as we have previously shown that p53 protein utilizes microtubules for its nuclear targeting; however, in contrast to HIF-1α, microtubule disruption had no effect on p53 protein expression (Giannakakou et al., 2000, 2002).
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PMC11694625
Finally, the product was filtered, washed with water and then dried, which was named 4,6-dihydrazinyl pyrimidine (2a), yield ca.
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PMC11629143
Targeted epigenetic editing is a desirable alternative, which can be achieved using CRISPR technology.
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PMC11615101
However, we did not observe any changes in ALDOA mRNA levels (Figure 4F).
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PMC6643347
The p24 level was measured using certified commercial test systems manufactured by Bio-Rad (USA) and Vector-Best (Russia).
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PMC6771295
In addition, SIRT1 has been shown to play a role in mTOR, AKT, and ER beta signaling in mesothelioma (29, 30).
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PMC11310713
During the 90-day in vitro culture, the GTBs exhibited an “alive” state, consistent with the duration applied in the in vivo experiment (Fig. 2C and D).
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PMC10759659
This domain is involved in multiple cellular processes, such as DNA replication, DNA damage repair, tumour metabolism and transcription .
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PMC9927933
The lysates were incubated with nickel–nitrilotriacetic acid (Ni-NTA) beads (QIAGEN) for pulling down, followed by IB using indicated antibodies.
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PMC11770199
Tumor sizes were measured from 6 d after implantation and recorded every other day.
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PMC8358006
In China, esophageal squamous cell carcinomas (ESCCs) are the predominant histological subtype of esophageal cancer and fourth leading cause of cancer death.
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