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PMC11424574
Depletion of MTA2 suppresses oral cancer cell metastasis via the p-cofilin-1/LC3-II pathway .
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PMC9275501
Cancer is a major public health problem worldwide (Siegel et al., 2021).
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PMC6684588
n = 8–10). ***
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PMC9878562
The inhibition of CXCR4/CXCL12 signaling in VAL-ko was not observed when chemotaxis was stimulated via the CXCL13/CXCR5 axis, indicating a selective interference of ACKR3 in the CXCR4 signaling pathway.
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PMC10523483
Since the causes for chemoresistance are diverse and usually mixed, these results may also relate to the effect of H1.2 in promoting tumor growth; thus, investigation in vast cell lines and in chemoresistance mouse models is warranted.
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PMC10734950
Thiophene is a heteroaromatic compound comprising of a five membered ring, with a sulfur atom located at the first position.
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PMC11496728
Effect of Apaf1 knockout on apoptosis. (
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PMC9429973
Results: 24 pts were classified as having PMF (10 in the pre-fibrotic and 14 in the overt fibrotic stage) and 25 as having SMF (15 had PPV- and 10 PET-MF).
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PMC11588008
One in 250 women will suffer POI before the age of 35, and one in 100 women will become sick before the age of 40 , which can cause disorders in the endocrine system and increase the risks of osteoporosis and cardiovascular diseases in women.
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PMC9429973
Image: Summary/Conclusion: Our data indicate that the incidence of SARS-CoV-2 infection is not significantly reduced in fully vaccinated MGUS patients (even after three doses), likely also because of the higher diffusion capacity of the recently recognized Omicron viral variants.
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PMC7305184
Other myocardial ablation therapies like radiofrequency or cryo-ablation may result in damaging untargeted tissue (e.g. phrenic nerve and esophagus).
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PMC10454535
Cells treated with the combination PIN/BTZ showed even greater apoptotic effects.
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PMC9429973
Esomeprazole was well tolerated, reported adverse events were mild and none of the patients withdrew from the study due to side effects.
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PMC9429973
A paired samples t-test was conducted for significance testing on overall average number of correct responses and for confidence rating, and a McNemar’s test was conducted at the question or learning objective level (5% significance level, P <.05).
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PMC11703992
48 h after transfection, the Jurkat cells were collected into tubes and centrifuged.
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PMC11401350
p-values are indicated in the figure legends.
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PMC11337594
Transwell experiments demonstrated that the invasive capacity of A375 cells was diminished with the elevation of TER concentration (Figure S1B).
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PMC11468365
This drug molecular graph comprises nodes that represent atoms and edges that denote chemical bonds.
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PMC11371747
Thymidine will also efficiently protect against antifolates including TS inhibitors such as RTX and PMX (Smith et al., 1995; Van der Wilt et al., 2001).
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PMC11766309
Furthermore, ImmuCellAI, the UCSC Xena platform, and the ESTIMATE algorithm were subsequently utilized to explore the potential relationship between YKT6 expression, the tumor microenvironment, and tumor immune infiltration.
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PMC11782780
Even while BC stem cells (BCSCs) only make up a small portion of the tumor population, they have a profound impact on tumor initiation, recurrence, metastasis, and treatment resistance.
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PMC11476004
The study was approved by the Polish Local Ethics Committee, Warsaw, Poland (Number: 51/2015) and by the Polish Laboratory Animal Science Association (Numbers 3235/2015; 4466/2017).
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PMC11787355
Therefore, we evaluated whether PTPRZ1-enriched subsets of malignant cells were preferentially targeted by PTPRZ1-TCR-T. Individual patient tumor organoids (IPTO) maintain tumor multicellular characteristics and are thereby suitable to study PTPRZ1-TCR-T-mediated alterations in a realistic multicellular-orchestrated microenvironment (Fig. 6a).
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PMC4816271
Absolute identity of all constructs were sequenced by capillary sequencing (Beckman, UK).
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PMC9429973
All data were collected through the French DESCAR-T registry.
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PMC11676670
Our results show that OVAR79 cells exhibit an epithelial phenotype, including some features related to stemness as well as a more aggressive phenotype.
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PMC10577955
Moreover, by adjusting the multimolecular targets of natural products that are involved in angiogenesis, metastasis, and multidrug resistance, natural products could be applied as potentially effective drugs in the prevention of lung cancer.
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PMC11786767
Second, the enrichment of nuclear lipids at the chromosomal periphery is negatively correlated with total protein and phosphorylation levels of Ki-67 during mitosis.
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PMC11593713
Viral infection significantly increased TOS values when compared to the MCR-5 cells from the control group (Figure 2a).
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PMC11683240
During the coronavirus disease 2019 pandemic, intervention measures enacted to mitigate the spread of Coronavirus disease 2019 had secondary effects on other infectious diseases, such as pertussis.
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PMC11711871
Since polyunsaturated fatty acid (PUFA) metabolites are known to be involved in vasodilation and/or vasoconstriction, we first quantified the abundance of the sEH protein in thoracic aortas from 10-week-old wild-type and GR rats fed a NSD or HSD (Fig. 2H, upper panel).
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PMC5916734
Measuring furin activity Furin activity was determined using a peptide substrate with a detachable 7-amino-4-methylcoumarin moiety Pyr-Arg-Thr-Lys-Arg-AMC (344935, Merck Millipore, USA) according to the procedure described in .
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PMC9429973
Remarkably, we identified Procr (CD201) as a specific cell surface marker for this lymphoid to myeloid transition, allowing us to distinguish, sort and track the switch from CD201 lymphoid-bias HSCs (present in PBS control) towards CD201 myeloid-bias HSCs (present upon LPS stimulation).
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PMC11765988
It may be possible that SLRs, due to various stimuli, such as drugs, or due to microenvironment changes, as seen in malignancies, present as the most ‘limited’ form of the sarcoidosis spectrum .
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PMC11066331
Numbers 1–5 indicate replicates measured on different days.
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PMC6102174
Of the total 170 species, 79 species and 10 variants are present in China.
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PMC9429973
Summary/Conclusion: The incidence of infection in patients with multiple myeloma is about 21.6%.
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PMC11574029
Images were captured using a high-definition digital camera.
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PMC10203589
Although the literature provides a more systematic framework for the cancer characteristics of CRC, the understanding of its effective therapeutic advances remains much less well understood (58).
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PMC11803210
Expression was filtered by average TPM (transcript per million) ≥ 10 .
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PMC4485648
We found that SFN reduces migration of hypoxic chemosensitive and chemoresistant A2780 cell lines (Fig. 6A, C, E and G).
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PMC11240448
All reconstructed networks are provided in the SI file cSTAR_networks.zip.
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PMC10761218
Withania somnifera is an important herb that belongs to the Solanaceae family.
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PMC11700247
B-C) A20 tumor growth from irradiated and abscopal tumor (n = 17-21). (
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PMC9429973
We believe, however, this should not discourage the investigator to use such a device.
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PMC11001582
n = 6 control and 6 C9orf72 iPS cell lines.
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PMC11536589
In our study, we have discovered the binding element of β-catenin/TCF4 complex in the promoter region of MGST1.
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PMC11093197
The genomic region on chromosome 12p that encodes for KDM5A is frequently amplified in patients with breast cancer.
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PMC11697065
Cited1 is involved in apoptosis and cell differentiation, Itga3 functions as a cell receptor that is involved in cell adhesion, C1qtnf1 is involved in negative regulation of platelet aggregation and a related family member was reported to be downregulated in later growth phases in CHO clones .
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PMC11628904
Samples were cryopreserved with Tissue‐Tek compound (Sakura Finetek USA, Torrance).
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PMC11680562
The 5-Fu and CuO NPs were added 0.1% of the total weight of the gel.
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PMC9429973
C. Barros Lima, S. Marini, A. Ribeiro, D. Luís, M. Pereira, R. Ferreira, E. Cortesão Hematology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Background: Azacitidine + Venetoclax (Aza/Ven) is indicated for the treatment of Acute Myeloid Leukemia (AML) in patients not fit for intensive regimens.
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PMC11576293
Also, correlating values of RMo with that of Co were significantly high in all proportions of the MeOH/H2O mobile phase (r ≈ −0.9915).
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PMC9429973
For patients out of remission and primary patients with AML the survival rate was 38.0±6.5% and 33.7±8.7%, respectively.
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PMC11672617
The present study demonstrates that the synthesized ionic compounds and hybrid molecules based on lithocholic acid induce the release of cytochrome c into the cytoplasm, thereby initiating mitochondrial apoptosis.
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PMC11271278
In total, 20 metaphase spreads of high quality were collected from seven separate images, all indicating the presence of MYC-ERBB2 chimeric ecDNAs in high abundance.
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PMC11394730
Moreover, Pre-treatment with 300 µM QUE significantly down-regulated the phosphorylation of Akt, PDK1, Bcl-2-associated death promoter (BAD), and the amount of tumor necrosis factor receptor 1 (TNFR1).
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PMC11024707
After the centrifugation process, tubes were carefully removed without shaking and lids were gently opened.
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PMC11678130
As far as we are aware, the enhanced antineoplastic activity of the QUE + 5-FU combination in CM cells has not been previously demonstrated.
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PMC11490153
The absorption frequency of the characteristic band at 1092 and 1094 cm in C. citratus-AlgNPs and citral-AlgNPs, respectively, showed a significant increase compared with AlgNPs (1080 cm), which confirmed ionic crosslinking in alginate nanoparticles containing C. citratus EO and citral.
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PMC6222635
In recent years, several studies on the structure of polysaccharides as well as the bio-activities of Dendrobium species have been reported .
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PMC11543853
Additionally to HRV2, echovirus 18 was selected for the wiskostatin inhibition studies because it propagated in cos7 cells most efficiently of the analyzed viruses.
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PMC11301242
The size of amplicons was compared between ecDNA, BFB, complex non-cyclic, and linear types.
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PMC11640555
Of relevance is the use of the casein kinase 2 (CK2) inhibitor.
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PMC11708541
AMR refers to the potential of microorganisms to flourish in the middle of drugs designed to kill them.
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PMC3203927
Three main categories or microenvironment factors (MEFs) or “three-dimensions” from the literature include: 1) chemical or biochemical composition, 2) spatial (geometric 3D) and temporal dimensions, and 3) force and substrate physical properties –. However, there is still a lack of a quantifiable entity which can establish if the cellular response in a 3D culture is actually physiologically relevant and in vivo-like or just different from 2D.
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PMC11224020
Data were analyzed by one-way Mann–Whitney test; ****P < 0.0001.
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PMC9429973
Methods: The ongoing Phase 1b open-label study investigating FTX-6058 is a multiple cohort trial that is being conducted in adults with SCD +/- hydroxyurea.
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PMC11767725
These pathways disrupt insulin signaling, alter macrophage polarization, and impair endothelial function, creating a feedback loop that perpetuates metabolic and cardiovascular risks.
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PMC9429973
Patients in spectrum 0 exhibited no acquired molecular and karyotypic abnormalities.
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PMC10040136
4TGF-β2 secreted by MSC may have induced drug resistance in GIST cells.
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PMC10174970
We have provided a strategy for choosing the appropriate PAAD cell line, and compared the genetic similarity between PAAD cell lines and human tumor tissue.
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PMC11615218
Moreover, another study recently revealed that the ICOS and OX40 tandem costimulatory domain resulted in less differentiated memory CAR-T cells and superior tumor control compared with CD28 and 4-1BB CAR-T cells in preclinical models .
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PMC10040136
MSC are a heterogeneous population of multipotent adult cells found in many tissues.
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PMC11487720
We reported the inhibition of UV/cold shock-mediated BCD in COS7 cells by transiently overexpressing TRAF2(113–312) of the zinc finger domain and the full-length of TRAF2 (14).
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PMC11779993
As shown in Table 3, SPEE exhibited antioxidant capacity by quenching the ABTS radical and scavenging the DPPH radical at values of 102.23 ± 2.26 μmol Trolox/g extract and 67.24 ± 0.87 μmol Trolox/g extract, respectively.
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PMC10975211
This portion of the protein is responsible for specifying the direct interaction with nucleic acids , inhibiting the cellular processes of the bacteria by binding to DNA and RNA .
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PMC11088135
These results indicated that lncRNA NUTM2A-AS1 and miR-376a-3p are aberrantly expressed in glioma cell lines.
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PMC11472639
It is well established that a sufficiently intensive bout of exercise in healthy individuals induces leukocytosis in blood, comprising lymphocytes – such as NK-cells and B-cells – and monocytes (Campbell and Turner, 2018).
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PMC11765678
In contrast to ER, RSL3 was more effective in sensitizing NCI/ADR-RES cells to ADR (Figure 2C).
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PMC11700247
∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.
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PMC10926885
DNA methylation may either promote or prevent tumour development.
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PMC5941560
Binned copy number alterations as fractions of the genome The structural variant calls from each tool were compared and merged with specific considerations made for each category of variant and each detection tool (see “Methods” section).
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PMC5034105
in 8/15 cell lines (Figures 4A and 4B).
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PMC11762280
C Representative images of H&E, TUNEL, MPO, MMP9, F4/80 staining in Krt14-Gsdmd mice and Krt14-Gsdmd mice after exposure or non-exposure to UVB irradiation.
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PMC7757104
These results were in agreement with a previous study, in which knockdown of endogenous tOPN potentiated various P-gp drug substrate-induced apoptosis of prostate cancer cells (6).
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PMC10965680
Chengdu goat is distinguished from Jintang goat at K = 5.
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PMC11740207
Given the availability of experimental material in the form of cell cultures, their increased proliferation compared to healthy cells, and the efficient method for enriching cultures with primitive stages, obtaining sufficient cells for single-cell scRNA-seq (transcriptomics) is possible.
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PMC11786156
Holm correction was performed using the following formula: corrected P-value of Ki-67 = P-value × (4 + 1 – rank of P-value).
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PMC8658661
Cholangiocytes, in turn, modulate the composition of bile, secrete chloride and carbonate ions, and secrete and absorb water when bile passes through the intrahepatic bile duct ; in the event of a malfunction of hepatocytes, cholangiocytes replace them .
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PMC11626627
Specific primers were designed to amplify the target sequence within the ERβ gene promoter.
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PMC9429973
If a complete remission (CR) is achieved the chemotherapy is followed by: a cure of ADE (Cytarabin, DNR, Etoposide) associated with 2 cures of high dose of Cytarabine (12g/m2) before 2011 and a cure of ADE associated with 3 cures of high dose of cytarabine (18g/m2) after January 2011.
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PMC9429973
A significant alteration was observed in the expression of genes involved in telomere maintenance, DNA damage, and cell senescence with a positive correlation between the telomere length and telomere maintenance genes TRF2 (r=0.788; p=0.007), TPP1 (r=0.636; p=0.04) and TOP1 (r=0,676; p=0.03) as well as with gene involved in DNA damage responses CDKN1A (r= 0.667; p=0.03) and ATM (r=0.783; p=0.007).
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PMC9351137
Scale bar = 10 μm Interactions between CRS and cytokinesis regulators.
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PMC10969097
Treatment of the cells with cordycepin was able to modulate P-gp expression and inhibit its function by stimulating P-gp ATPase activity in cells stably expressing P-gp (ABCB1/Flp-InTM-293) and in cancer cells with a multidrug resistance profile (KB-vin).
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PMC11773391
The expression of the MGMT protein was detected in A375 cells treated with DMSO and vMF (0, 1, 2 and 5 μM) for 24 h using Western blot analysis. (
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PMC11700523
COS-7 cells were transfected with MR reporter, incubated with or without aldosterone (10 to 10 mol/L) for 24 hours, and luciferase reporter assay was performed.
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PMC9429973
While limited by a small sample size, our study suggests that HMA/venetoclax may be associated with more favorable outcomes in patients with advanced MDS/MPN compared to those with advanced MPN.
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PMC11607764
Disease-free survival analyses from ACC, LGG and LUAD patients also exhibited a significant correlation with high PTBP1 expression (Figure 3B, p = 0.015, 0.000031,0.042).Figure 3.The associations between PTBP1 expression level and patient survival.
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PMC11487720
The efficiency of POD was retarded at 37 °C.
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