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OTAR3088
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BioData-CellLine_annotated

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PMC7022782
All the reagents in excess, as well as free ICG, were removed using an ultrafiltration procedure on Amicon devices (30,000 Da MWCO) (Merk Millipore Ltd, Cork, Ireland).
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PMC11742290
To date, studies investigating LGR5 in cancer cell adhesion and migration are limited.
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PMC10745221
Interestingly, a previous study has shown that PRMT1 and methionine are both required for Wnt signaling activity in HeLa cells .
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PMC11089031
The AUC was 0.675 with p < 0.05 The prognostic value of ZNF692 expression in ccRCC.
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PMC11720107
LDH release from cells into the culture medium was used as an indicator of cytotoxicity.
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PMC11476264
Xenograft tumors derived from control A549 cells and FBXO11 overexpression cells both formed well-defined envelope tumors (Figure 6C).
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PMC10631132
Media changes were performed every second day.
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PMC11350568
Substitution experiments were conducted by co-incubating AptGs with CCRF-CEM at 4 °C for 30 min.
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PMC11684297
The solution was properly mixed using a magnetic stirrer for 1 h and was further taken in a three-necked refluxing bottle.
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PMC8345486
Acquired platinum resistance remains a major challenge in gynecological oncology.
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PMC11746948
We also observed that while 2-BP alone did not alter cellular reactive oxygen species (ROS) levels, it significantly amplified the ROS increase triggered by RSL3 (Fig. 1i).
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PMC11680562
The gelation process is carefully controlled by pH and ionic strength parameters.
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PMC4443654
The transcription factor encoded by this gene has been identified as essential in maintaining B-cell identity and establishing early lineage commitment .
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PMC11033180
Table 1Summary of passive and active membrane properties of enteric neurons recorded in the whole-cell configurationNo.
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PMC9429973
A multivariate analysis is ongoing for deeper understanding of these data.
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PMC9031474
These results suggest that TRPA1 activation of drimane dialdehyde compounds is mediated by covalent modification of critical lysine residues within TRPA1.
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PMC11676670
They are resistant to common environmental stressors, adhere well to the culture plastic, and can easily be detached with 0.05% trypsin without being dislodged by gentle mechanical agitation, and they maintain a stable phenotype over long cultivation periods.
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PMC11265931
Glioblastoma is the most common type of brain tumor; it can occur at any age; however, it is particularly prevalent between the ages of 45 and 75.
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PMC11787355
i, j Cellular states of cancer cells in c and PTPRZ1 expression.
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PMC11684821
When considering that clone MC.27.759S possessed the only cancer-reactive TCR from the MR1-primed T cell lines from donor 0, then TRAJ42 constituted over 62% of cancer reactivity across all 7 donors.
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PMC4360730
In this example, the user has expanded the ‘Organ’ facet and selected ‘brain’.
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PMC11740508
The second trial with this combination in TNBC patients with intact HR status is near completion, and also shows limited actual benefit (personal communication).
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PMC9429973
IDH1-MC analysis on BMMCs was performed by BEAMing digital PCR (limit of detection 0.02%-0.04%).
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PMC11476264
Wild-type Ub, Ub-K48, and Ub-K63 plasmids with HA tags were co-transfected with the relevant plasmids.
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PMC4659567
Calcd.
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PMC9429973
A. Pavlovsky, N. L. Fiad, M. V. Prates, I. Fernandez, N. Kurgansky, A. Cerutti, F. Sackmann, F. Negri Aranguren, P. Negri Aranguren, G. Remaggi, L. Ferrari, R. Mariano, L. Guanchiale, J. Maradei, F. Giuliani, E. Roveri, A. Enrico, S. Zabaljauregui, M. D. R. Cabrejo, C. Gumpel, A. I. Varela, M. Riddick, S. Pavlovsky GATLA, Buenos Aires, Argentina Background: PET-CT adapted treatment for first line Hodgkin Lymphoma has been widely studied in the last decades.
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PMC9429973
Summary/Conclusion: Accrual is ongoing.
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PMC11682525
Viability of normoxic and hypoxic preconditioned HFSCs and SH-SY5Y cells following exposure to varying concentrations of H2O2. *
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PMC11721587
Fu condensates were collected by differential centrifugation of Sf9 cells expressing Fu and sequentially washed with 0.3 M NaCl and 1% Triton X-100 for 30 min at room temperature.
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PMC11257988
While KRAS mutations have traditionally been considered independent of upstream regulation, this perspective has been challenged by the work of Kruspig et al. Their research shows that multiple ERBB receptors are expressed and activated from the earliest stages of KRAS-driven lung tumor development.
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PMC9429973
PIK3IP1 expression is significantly associated with a lower overall response rate (96.55% vs 79.17%, p=0.047), higher relapse or death rate(58.33% vs 24.14%, p=0.029).
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PMC6643347
This cellular model of an HIV infection is preferable to that based on the use of continuous cell lines.
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PMC11748335
Additionally, the three groups of peaks exhibit distinct preferences for distribution across various genomic elements, including common PMDs/HMDs, promoters/intergenic regions, and DMVs/transposons.
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PMC5941560
INPP5D (SHIP1) has long been known to not be expressed in the Jurkat cell line .
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PMC10999934
In contrast to numerous prior research efforts, our study investigated potential biomarkers linked to chemoresistance in HGSOC combining single-cell RNA-seq and bulk RNA-seq data, taking into account their individual strengths.
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PMC11711663
The relatively small sample size might affect the generalization of the validated radiomics features in our model.
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PMC11721064
Additionally, Gopakumar et al. described a time-consuming method to generate CK12-positive cells, requiring 31 days of transdifferentiation .
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PMC11596967
Notably, peptides containing 2 to 10 amino acids comprise 88.2% of the total.
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PMC11755624
In the United States, psoriasis affects approximately 7.5 million people , and the financial impact of its treatment is significant, mainly due to systemic complications.
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PMC11206502
BCL-2 is an anti-apoptotic and anti-autophagy protein .
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PMC11129910
Quantitative PCR and western blots confirmed the expression levels of RAB25 at the mRNA and protein levels, respectively.
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PMC11750165
The merge image is displayed (C). (
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PMC6222635
After treatment with F1 and F3 for 24 h at a concentration of 400 μg/mL, the necrosis rate and percentage of HeLa cells in early and late phase apoptosis was 3.5%, 6.9%, and 1.3% and 2.4%, 9.9%, and 3.0%, respectively, which is statistically higher than in the control group treated with PBS.
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PMC11806818
Enzyme-based immunoassay is considered to be one of the most widely used detection techniques, and has been applied in the fields of environmental monitoring, food safety, and medical diagnosis [12–14].
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PMC11750161
Each curve was plotted using the data from three independent experiments.
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PMC8469018
The experiment was conducted three times with measurements also being done in triplicate.
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PMC11610461
Subsequently, the results from the Kaplan-Meier survival analysis revealed that patients with high PSENEN expression had a worse prognosis (Fig. 3B), and shorter OS, DSS, and PFI, which was consistent with some of the previous analysis results of Yang et al. (2023) (Figs. 3C–3E).
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PMC6268318
The plant is commonly known as “tram bâu” (Vietnam), “kê khao” (Laos) or “sang kaê” (Cambodia), and the seeds are used in Vietnamese traditional medicine as a remedy against round and tapeworm infections in humans .
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PMC11502962
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumors in the gastrointestinal tract (1).
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PMC9429973
Grade 3 hemolysis was reported in 1 pt (1.4%); no grade 4 hemolysis was reported.
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PMC7185206
More recently they have also been shown to alter signaling through modification of surface ligands and receptors such as Notch, HER2, EGFR, and NKG2D.
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PMC11742290
It is well-known that intestinal epithelium can continually regenerate .
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PMC7987994
Error bars stand for the standard error deviation of six replicates.
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PMC11437637
A BD Canto II system was used for flow cytometry with a corresponding absolute count microsphere kit.
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PMC10196713
OC has a very high recurrence rate and is classified as a platinum-resistant tumor if it recurs within 6 months of completing platinum-based chemotherapy (4).
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PMC9509578
Interestingly, Fan et al. developed beta cyclodextrin (β-CD)-based temperature-sensitive supramolecular nanoparticles by utilizing PEG-PNIPAAm for delivery of paclitaxel (β-CD-g-(PEG-v-PNIPAAm)7/PTX) and doxorubicin (β-CD-g-(PEG-v-PNIPAAm)7/Dox) both in-vitro (HepG2/MDR1 and H460/MDR1 cells) and in-vivo (HepG2/MDR1 bearing xenograft BALB/c mice).
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PMC11790971
Additionally, the optical redox ratio (ORR), calculated from FAD and NAD(P)H autofluorescence intensities, serves as a quantitative metric for assessing shifts between glycolytic and mitochondrial metabolism.
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PMC11754436
DHRS4-AS1 inhibits OS cell proliferation and promotes apoptosis in vitro.
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PMC11741906
The assay was run on StepOne plus™ Real-Time PCR System (Applied Biosystems, USA).
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PMC11087055
C-D”) Immunofluorescent staining images of control- and aphidicolin-treated embryos at HH3 with ZO-1 (magenta) and pMyosin (cyan).
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PMC9429973
Since the symptoms are absent initially, pediatric patients after cancer treatment should be screened for ferritin levels.
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PMC11066331
This phenomenon was reported e.g. in mass spectrometry imaging, quantitative MS and proteomics or bacterial biotyping [, , ].
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PMC9429973
51 patients gave information on COVID-19 and vaccintaion status, through phone interview.
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PMC9424261
The qPCR data is analyzed using the ΔΔCt method: ΔCt = Ct (target gene) − Ct (GAPDH), ΔΔCt = ΔCt (test group) − ΔCt (control group).
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PMC9920575
From these assays, the average inhibition concentration of cell proliferation by 50% (IC50) was determined, which was calculated using the linear regression equation and used in subsequent assays.
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PMC9429973
These factors often preclude these pts from enrollment on frontline clinical trials, since standard eligibility routinely exclude them.
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PMC11806182
While some exosomal miRNAs can drive tumor growth, others may suppress it by targeting tumor suppressor genes .
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PMC7189327
Here, we performed a PPI analysis for screened DEGs based on this database to identify significant protein pairs.
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PMC9429973
In 7 cases, there was an overlapping of indications.
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PMC11637820
Wells were subsequently washed and imaged at 4X magnification in an inverted microscope (Nikon TS2, Japan) Alternatively, crystal violet was solubilized with 30% acetic acid in water for 15 min and the absorbance was measured at 550 nm using a multimode plate reader (Molecular Devices).
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PMC11172027
The caspase-3 activity of NALM and NASeLM was compared to a negative control and a positive control (Camptomycin) after 24 h, 48 h, and 72 h of incubation on MTC-SK cells, as shown in Figure 6.
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PMC11394730
Cancer cells usually have high levels of ROS.
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PMC11218145
Following the observed activity on the MAPK signalling pathway, it could be hypothesized that part of the anticancer activity of TB on MPM has to be ascribed to the regulation of ERK1/2 and p38 pathways.
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PMC11244823
Therefore, we suggest that in future vaccine developments, type-common antigens should be avoided, while a broad range of type-specific antigens should be favored.
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PMC9019892
As expected, nintedanib, but not imatinib, reduced the phosphorylation of FRS2α, which is a downstream substrate of FGFR (Fig. 5E).
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PMC9429973
Data processing and T-cell clone fraction/frequency calculation were performed according to the MiXCR protocol (https://github.com/milaboratory/mixcr).
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PMC4659567
for RuCl3C17H18N2Br: C, 37.98; H, 3.37; N, 5.21; found: C, 37.88; H, 3.27; N, 4.99%.
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PMC11541409
However, it provides preliminary result of targeting the hypermethylation process in SDH-deficient GIST.George, S., et al., A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor.
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PMC9429973
Image: Summary/Conclusion: We report the development of a highly functional personalized MRD pipeline based on patient-specific mutations showing a high sensitivity to predict relapse and relapse-free survival.
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PMC9429973
Results: As of Oct 4, 2021, 30 patients were enrolled and received navitoclax.
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PMC11743316
It also offers an insight into how these ROS might be modulated in therapies.
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PMC11615828
These results demonstrated that immobilization of VOIs functionally suppresses the corresponding cargo delivery.
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PMC11533140
Finally, 16 was coupled with substituted boric acid esters to obtain the desired compounds 17a–17p (Dugar et al., 2015).
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PMC9436459
After a brief optimization of the Casnati−Skattebøl reaction conditions, the key ortho-formylation of S130 proceeded smoothly to deliver the desired S132 in 46% yield and a small amount of the byproduct S134 (9%) together with 29% recovery of S130.
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PMC11583690
Formulations containing DTX often include polysorbate 80 and ethanol, exacerbating reactions like hypersensitivity and neurological disorders.
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PMC10810426
For comparison, we used pNCA, the cloned parental virus from which p12-M63-PM15 was constructed.
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PMC11026382
Individual point mutant clones were constructed using the Quikchange II site-directed mutagenesis kit (Agilent).
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PMC11742670
Although the CNN regression model demonstrates better performance across all three cell lines, it gives the highest performance for the A-375 cell line shown by extremely low MSE (0.000194) and MAE (0.011517).
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PMC9243326
This coincides with the findings of Mu et al., who performed an evolutionary relationship analysis based on the mitochondrial genome, which suggested that P. canaliculata has a close evolutionary relationship with C. cathayensis (homologous to C. chinensis) (Mu et al., 2015).
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PMC9429973
Clonal evolution of genomic defects was observed mainly in treated CLL patients, whereas progression and therapy need occur at some point during the disease course suggesting clonal dynamics even in untreated patients.
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PMC11684297
So, we have used this wavelength as the excitation wavelength in the fluorescence studies.
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PMC11754291
Role of Cell Interactions in Melanogenesis: Co-culture experiments demonstrated that irradiated keratinocytes enhanced melanogenesis in melanocytes via paracrine signaling, offering insights into the cellular mechanisms of melanogenesis under blue light exposure. •
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PMC10213179
Finally, cells were washed again with cold PBS before collection.
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PMC11802929
Gene annotations on the bottom.
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PMC10723784
Data represent the mean ± SE of the mean n = 3. **
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PMC6190245
The analysis results were expressed as mean±SEM.
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PMC9454178
Immunoblotting analyses verified that OSR1 expression was significantly inhibited by THZ1 treatment with CDK7 knockdown (Fig. 8B, C).
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PMC11615828
The normalized mean speed of the indicated vesicles is shown in (b).
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PMC11777207
Digestion was stopped with Click’s medium containing 5 mM EDTA and 2.5% FBS, and the cells were washed and used for downstream flow cytometric analysis.
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PMC4360730
The major benefit from using ontologies to annotate the experimental metadata is an increased ability of search queries to return related experiments (https://www.encodeproject.org/help/getting-started#search).
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