OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11672881	The synergy between TQ and CU results in elevated ROS levels, preferentially activating the mitochondrial apoptotic pathway via caspase-9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "synergy", "between", ...
PMC10490530	We considered that such weak expression in cancer cells might be due to its lower codon adaptive index and/or the presence of rare codons that are not adequately expressed in the human cell system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7022782	Tokyo, Japan), using a yellow filter to better identify the ICG content.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tokyo", ",", "Japan", ")", ",", "using", "a", "yellow...
PMC9429973	Among those 5 pts, all had ongoing CR as radiologically documented by PET-CT or CT at 12 months and all completed a 2-year follow-up visit without evidence of relapse as per investigator assessment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	Terpenoids, also referred to as isoprenoids, constitute a class of secondary metabolites found in plants characterized by diverse chemical structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Terpenoids", ...
PMC11656380	Notch receptors (NOTCH1–4) are transmembrane glycoproteins that regulate differentiation, proliferation, and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notch", "receptors", "(", "NOTCH1–4", ")", "are", ...
PMC9587298	In contrast, only two samples of R. geoides at 500 µg/mL showed cytoprotective effect (67.8 and 64.8 % of cell viability, from San Juan and Lago Blanco, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553	The expression of tissue-type Plasminogen Activator (tPA) and Plasminogen in intracranial aneurysm (IA) lesions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "tissue-type", ...
PMC11782508	Its structure includes an extended α-helix with protein transduction activity, a C-terminal four-loop region structurally similar to immunoglobulin variable domains, and a β-sandwich core with an immunoglobulin fold, which may contribute to its ability to evade the immune response and exert its anticancer effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	IHC staining was conducted using the IHC Detection Kit (ab64264, Abcam, UK) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IHC", "stain...
PMC9429973	The most commonly used regimens in R/R patients at any subsequent episode of treatment included BTKi (66.3%), rituximab monotherapy (52.8%) or rituximab plus other regimens (31.5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	DNA methylation of individual CpG sites is shown for CpG sites 1–6, using primers in Additional File 1: Table S1 (CpG pyroassay).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9019892	The biochemical assay of a series of KIT protein was tested by Invitrogen (Carlsbad, CA, USA) as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10093184	OAZ1, RPL8, RPL27, and RPL32 were included as potential reference genes (RGs) and measured in all experimental samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OAZ1", ...
PMC11566417	The second highest number of total, as well as unique proteins (i.e., 33 proteins), was found in CM from immortalized MDECs at p20, whereas the CM from primary MDECs at p20 and immortalized MDECs at p10 contained the lowest number of identified proteins (i.e., 25 and 13 unique proteins, respectively) (Fig. 6a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10218459	It is well known that the reduction of the cytostatic dose leads to fewer side effects, but it also reduces the efficiency of the antitumoral treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	Our preliminary study revealed the vital role of ACLY in tumor immunity of ccRCC, which suggests that the combination blockade of ACLY and immune checkpoints may serve as a promising anticancer strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The inhibition of HIPK2 was predicted to be the causal upstream condition of the under-expression of six DEGs from the set (FECH, ANK1, SCL4A1, EPOR, GATA1, HBZ) with activation Z score of -2.449 and p value of overlap = 1.02E-09.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There were 17 people in the high-NLR group, including 10 pts with ALL and 7 people with AML who achieved remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "wer...
PMC11489351	LDHA fluorescence is shown in green, and nuclei Hoechst stain in cyan (DAPI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LDHA", "fluorescence", "is", "shown", "in", "green", ...
PMC5035325	Therefore, we evaluate the frequency of co-expression of EGFR and NeuGcGM3 ganglioside in human tumors and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055323	n = 3 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "independent", "experiments", "." ] } ]
PMC11321678	Thus, they were annotated as progenitor‐like cells (Figure S1C,D, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "they", "were", "annotated", "a...
PMC11547972	Jurkowska recently discovered that the isothiocyanate, 4-hydroxybenzyl isothiocyanate, down-regulates the level of mitochondrial rhodanese, forcing increased reactive oxygen species (ROS) production and inhibition of tumor cell growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Created in BioRender.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]
PMC9429973	Regarding later lines, 402 (39.9%) patients received a 2 treatment (L2); median time from end L1 to beginning of L2 was 15.1 months (0-163).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	One recent study suggested that, in AD under hypoxia and other non-hypoxic stimuli, such as oxidative stress and inflammation, TfR1 upregulation may be associated with HIF-1 activation causing iron dyshomeostasis in the brain, which ultimately contributes to AD pathology .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11796104	Fig. 3Significantly enriched GO terms and KEGG pathways of common gene found in host genes and DEmRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Significantly", "enriched", "GO", "terms...
PMC11011837	Specifically, Molt-4 and Molt-16 cells exhibit a relatively higher presence of long-chain fatty acids (with 16–18 carbon atoms) compared to the other two cell lines.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8010066	However, a Significant reduction of PA-2, PA-3, and PAO1 were observed during the co-culture with SA-1 (P-value Unlike other strains, the colony count of PA-4 strain after co-culture indicated a slight decrease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10996034	The drug resistance index (RI) of the A2780/Taxol cell line in the present study was 33.62, exhibiting highly resistant characteristics (Fig. S1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215832	mRNAs from the same cell pellets (as for the drug uptake) were extracted and cDNAs were generated for gene expression analysis by RT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9895440	n = 10.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "n", "=", "10", "." ] } ]
PMC9429973	Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action which can mitigate the risk of higher incidence of VTE without an observable increase in bleeding rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Without binding, no yeast growth occurred at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Without", "binding", ",", "no", "yeast", "growth", "occurred", "at", "37", "°", ...
PMC11637276	Interestingly, the phosphatase activity of PP2A has been shown to dephosphorylate p38 after its activation downstream of collagen I signalling in platelets .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC11575040	In addition to these samples, basic information was obtained from the same hospital’s department of pathology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "these", "sampl...
PMC8540692	Finally, we wanted to analyze if the RASSF1A methylation level is altered after the treatment with CCM and NaBu, and their combination treatment (Figure 11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	Conditioned medium: HS-5 cells were plated at 18.7 × 10 cells/cm in 75 cm cell-culture flasks and incubated overnight in 10 mL culture medium for processing within a mono-culture conditioned medium (CM).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587866	Candidates such as PARP, LSD1, and insulin growth factor-1 receptor inhibitors have been tested in the clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Candidates", "such", "as", ...
PMC11679892	Finally, the pellet was dissolved with 40 μL of RNase–DNase-free water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "pellet", "was", "dissolved", "with", "40"...
PMC9429973	After treatment, peripheral blood mononuclear cells (PBMCs) were obtained, and after further testing and purification, RNAs that met the experimental requirements were obtained from them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	Using the Inucyte Cell-by-Cell analysis software, red and green, fluorescent cells were analyzed (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "Inucyte", "Cell-by-Cell", ...
PMC11707577	So, spherical 3D thiophene nanoparticles (3D‐TNP) based on the TM core were prepared using a standard two‐step procedure: i) synthesis of a TM‐like polymer, using as repetitive unit that contain a TM derivative, connected by an alkyl linker (Figure S1, Supporting Information); ii) preparation of TM‐like polymer nanoparticles (3D‐TNP) via the reprecipitation method (see details in SI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	Carbamidomethylation of cysteines was searched as a fixed modification, while oxidation of methionines and acetylation of the protein N-terminal were searched as variable modifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11407042	Determine cell number 3 times using the Count Star automated cell counter.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Determine", "cell", "number", "3", "times", "using", "the", "Count", "Star", ...
PMC11782508	Agarose gel electrophoresis for detection of the azurin gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Agarose", "gel", "electrophoresis", "for", "detection", "of", "the", "azurin", "gene", "." ] } ]
PMC11488203	Accordingly, abundant CXCR4 expression is detectable on human breast cancer cells including MDA-MB-231 in contrast to normal human mammary epithelial cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O" ...
PMC11585565	Relative c.1484 C > T mRNA levels decreased significantly to 76 ± 9.6% and 27 ± 12.5% at 4 and 24 h, respectively, after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3019555	Moreover, it remains unclear whether HIF-1α mRNA interacts with miRNAs after its entry into P-bodies or is first targeted by miRNAs in the cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10440586	Right, results from IDHwt gliomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "results", "from", "IDHwt", "gliomas", "." ] } ]
PMC11351758	Data are presented as the means ± standard error (SE) of at least three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the"...
PMC11354225	The cytotoxic effect of EGCG is mediated by ROS and it promotes apoptosis through mitochondrial damage, membrane depolarization and release of cytochrome C, which is inhibited by catalase or other antioxidant molecules .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5839394	The EEM scan spectra were measured by scanning simultaneously both the excitation (Eex), which ranged from 200 to 320 nm, and the emission (Eem), which ranged from 200–700 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	In this study, our findings demonstrate that MGST1-mediated ferroptosis inhibition conferred the resistance of KRAS inhibitor MRTX1133 in PDAC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ...
PMC11021472	Cells were infected with a lentiviral vector carrying a shRNA targeting circZDHHC11 or a transgene (for overexpression of miR-150 or circZDHHC11) together with a reporter gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5854676	Lower order polynomial produce larger error.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", "order", "polynomial", "produce", "larger", "error", "." ] } ]
PMC11240448	Next, we analyze the HCC2157 cell line, which itself forms a distinct group separate from other basal cell line groups.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ...
PMC10919056	To further explore the relationship between the RS prognostic model and clinical characteristics, univariate and multivariate stepwise Cox analysis were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "furthe...
PMC11449273	H1299 transfectants were processed for subcellular fractionation using NE-PER reagent and cytoplasmic and nuclear extracts of equal cell numbers were processed for immunoblot with p53 and plakoglobin antibodies.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774112	The complexes were incubated for 30 min at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complexes", "were", "incubated", "for", "30", "min", "at", "RT", "." ] } ]
PMC11531744	We established the ovarian cancer cell line W038 for this study.	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "We", "established", "the", "ovarian", "cancer", "cell", "l...
PMC11194678	Data were collected from three independent experimental cell culture batches, with >300 cells counted for each batch. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "collected", ...
PMC10565698	Total RNA from cells was incubated at 37 °C for 2 min with RNase R (Geneseed, Guangzhou, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total",...
PMC11759543	SV-HUC1 cells were plated at 96-well plate in a final volume of 100 μl which was treated with doxorubicin and/or vorinostat at the indicated concentrations for 24, 48 and 72 h. Ten μl of MTT stock solution was added to each well, followed by incubation at 37 °C for 3 h to allow MTT reduction.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	As a next step, we aimed to develop nonlinear models to predict phenotypic transitions of breast cancer cell lines at a larger scale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11092382	The mechanism underlying this effect was associated with autophagy induction and the regulation of the PTEN/PI3K/AKT pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", "underlying", "this", "effect"...
PMC10376064	This is particularly true with respect to GSH and GSH analogs, which were demonstrated earlier to be transported by ABCC1 under competitive inhibition of the ABCC1-mediated transport of daunorubicin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3681794	In a wide range of different tumour types hypoxia-induced drug resistance can be reversed by HIF-1 inhibition. , , , , , , , , , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380329	Previous identification of pinocembrin, galangin, p-coumaric acid, and caffeic acid in Egy P, Ger P, and Fre P were noted [69–71].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	P = 0.0004, one-way ANOVA. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "=", "0.0004", ",", "one-way", "ANOVA", ".", "(" ] } ]
PMC11538390	Experiments with F1 embryos from multiple transgenic lines may be needed to detect the subtle effects of a common variant on the activity of this enhancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11519583	The middle histograms show the distribution of CSA in control and Ror2 cKO mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "middle", "histograms", "show", "the", "distribution", "of", ...
PMC11291490	Fig. 2dusCD40L promotes T/B cell activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2dusCD40L", "promotes", "T/B", "cell", "activation", "." ] } ]
PMC9429973	Image: Summary/Conclusion: The dynamic changes in the H3K27me3 epigenetic landscape of JAK2 V617F positive cells following persistent high dose ruxolitinib administration has potential therapeutic implications and may sensitise cells to epigenetic therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745355	The authors note that Fig. 3 appeared incorrectly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "note", "that", "Fig.", "3", "appeared", "incorrectly", "." ] } ]
PMC11297139	The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "representative", "images", "supported...
PMC11320084	Tumor metastasis is the leading cause of tumor death, accounting for about 90% of tumor deaths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "metastasis", "is", "the", "le...
PMC9577200	Mixing graphene with chitosan may suppress the toxicity of chitosan.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mixing", "graphene", "with", "chitosan", "may", "suppress", "the", "toxicity", "of", "chitosan",...
PMC10840195	All experiments were repeated in triplicate in three independent experiments. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "repeated", "in", "triplicate", "in", "three", "independent", ...
PMC11742670	This section compares the results of the proposed DL model (DRY LAB) to the findings of the WET LAB to validate its efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	For DT after IM DISC, average DT at 2/3 months was much shorter in those lost molecular response (10.6 / 10.7 days) than those who did not (23.5 / 30.1 days).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Patient-derived cell-based tumor organoids and xenografts have shown some promise in advancing precision medicine, enabling the development of personalized chemotherapeutic regimens .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient-derived", ...
PMC10674574	Additionally, drugs with Papp values in the range of 1–10 × 10 are classified as moderate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "drugs", "with", "Papp", ...
PMC9429973	Leucocytes <15x10e9/ and JAK2 were correlated with better survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leucocytes", "<", "15x10e9/", "and", "JAK2", "were", "correlated", "with", "better", "survival",...
PMC11442172	In solid tumors, the microenvironment is frequently acidified due to elevated levels of acidic metabolites, such as lactate, and the secretion of protons (H) through specific pumps and transporters (101).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	DNA methylation or Chromatin remodeling genes may occur in the early stage of leukemogenesis while RAS/RTK signaling genes may indicated later events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "methy...
PMC10538569	Co-cultures were collected and resuspended in 1 ml of RPMI supplemented with IL-2 (100 IU/mL) in 24 well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-cultures", "were", ...
PMC11078693	Process images with ImageJ and Imaris software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Process", "images", "with", "ImageJ", "and", "Imaris", "software", "." ] } ]
PMC10969097	The studies reviewed investigated a variety of mushrooms, including Agaricus blazei Murill, Reishi, Krestin, Agaricus bisporus, Lentinula edodes, Ganoderma lucidum, Pleurotus pulmonarius, Tricholoma anatolicum, Fomes fomentarius, Pleurotus tuber-regium and Trametes robiniophila Murr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	Through self‐renewal, CSCs facilitate tumor growth by generating new CSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "self‐renewal", ",", "CSCs", "facilitate", "tumor", "growth", "by", "generating",...
PMC11387401	Of note, the individual Gag subuntis NC and MA are cleaved and generated only during or after budding of the HIV-1 particle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", ...
PMC11045125	Similar studies performed using human primary tonsil GC B cells and the same feeder layer system likewise found that stable Myc-expressing cell lines could not be obtained when cells were infected with a Myc expressing retrovirus alone, presumably due to Myc-induced apoptosis, but could be obtained when cells were co-infected with both a BCL2- and Myc-expressing retrovirus .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	Ultimately, these methods resulted in improved permeability of Kushen recipe and significantly enhanced transdermal parameters of the four alkaloids in rat experiments after 48 h (Peng et al., 2007).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11351758	It is worth noting that p-MPT was achieved much faster in the NARP cells, at just 220 s, compared with the 143B cells, which started much later at 620 s. Therefore, these results confirm that the mitochondrial complex V mutation enhanced high-glucose stress on mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC11638255	b Heatmap of log2FC in expression between treatment arms for genes associated with migration and extravasation within the neutrophils cluster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Heatmap", "of", "...
PMC7057940	Samples were precleared by incubating with 2–4 µg of normal IgG and 50 µl of protein A/G-agarose beads (Santa Cruz Biotechnology) for 1 h at 4°C with agitation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The extent of reduction in sBCMA from baseline to C2D1 EOI was significantly correlated with best overall response rate (PR or better) (p=1.8x10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10907726	The molecular weight of DATS (#D3202, LKT Labs, USA) is 178.34 and the purity is 99.2%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molec...
PMC11705862	K, M) Western blotting assessed IRIS-1 and IRIS-2 protein levels post-knockdown, respectively (n = 11, each).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K", ",", ...

PMC11672881

The synergy between TQ and CU results in elevated ROS levels, preferentially activating the mitochondrial apoptotic pathway via caspase-9.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "synergy", "between", ...

PMC10490530

We considered that such weak expression in cancer cells might be due to its lower codon adaptive index and/or the presence of rare codons that are not adequately expressed in the human cell system.

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PMC7022782

Tokyo, Japan), using a yellow filter to better identify the ICG content.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tokyo", ",", "Japan", ")", ",", "using", "a", "yellow...

PMC9429973

Among those 5 pts, all had ongoing CR as radiologically documented by PET-CT or CT at 12 months and all completed a 2-year follow-up visit without evidence of relapse as per investigator assessment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11279397

Terpenoids, also referred to as isoprenoids, constitute a class of secondary metabolites found in plants characterized by diverse chemical structures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Terpenoids", ...

PMC11656380

Notch receptors (NOTCH1–4) are transmembrane glycoproteins that regulate differentiation, proliferation, and survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notch", "receptors", "(", "NOTCH1–4", ")", "are", ...

PMC9587298

In contrast, only two samples of R. geoides at 500 µg/mL showed cytoprotective effect (67.8 and 64.8 % of cell viability, from San Juan and Lago Blanco, respectively).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10850553

The expression of tissue-type Plasminogen Activator (tPA) and Plasminogen in intracranial aneurysm (IA) lesions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "tissue-type", ...

PMC11782508

Its structure includes an extended α-helix with protein transduction activity, a C-terminal four-loop region structurally similar to immunoglobulin variable domains, and a β-sandwich core with an immunoglobulin fold, which may contribute to its ability to evade the immune response and exert its anticancer effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11746948

IHC staining was conducted using the IHC Detection Kit (ab64264, Abcam, UK) according to the manufacturer’s instructions.

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PMC9429973

The most commonly used regimens in R/R patients at any subsequent episode of treatment included BTKi (66.3%), rituximab monotherapy (52.8%) or rituximab plus other regimens (31.5%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11650848

DNA methylation of individual CpG sites is shown for CpG sites 1–6, using primers in Additional File 1: Table S1 (CpG pyroassay).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9019892

The biochemical assay of a series of KIT protein was tested by Invitrogen (Carlsbad, CA, USA) as described previously .

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PMC10093184

OAZ1, RPL8, RPL27, and RPL32 were included as potential reference genes (RGs) and measured in all experimental samples.

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PMC11566417

The second highest number of total, as well as unique proteins (i.e., 33 proteins), was found in CM from immortalized MDECs at p20, whereas the CM from primary MDECs at p20 and immortalized MDECs at p10 contained the lowest number of identified proteins (i.e., 25 and 13 unique proteins, respectively) (Fig. 6a).

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PMC10218459

It is well known that the reduction of the cytostatic dose leads to fewer side effects, but it also reduces the efficiency of the antitumoral treatment.

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PMC11283030

Our preliminary study revealed the vital role of ACLY in tumor immunity of ccRCC, which suggests that the combination blockade of ACLY and immune checkpoints may serve as a promising anticancer strategy.

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PMC9429973

The inhibition of HIPK2 was predicted to be the causal upstream condition of the under-expression of six DEGs from the set (FECH, ANK1, SCL4A1, EPOR, GATA1, HBZ) with activation Z score of -2.449 and p value of overlap = 1.02E-09.

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PMC9429973

There were 17 people in the high-NLR group, including 10 pts with ALL and 7 people with AML who achieved remission.

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PMC11489351

LDHA fluorescence is shown in green, and nuclei Hoechst stain in cyan (DAPI).

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PMC5035325

Therefore, we evaluate the frequency of co-expression of EGFR and NeuGcGM3 ganglioside in human tumors and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c).

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PMC11055323

n = 3 independent experiments.

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PMC11321678

Thus, they were annotated as progenitor‐like cells (Figure S1C,D, Supporting Information).

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PMC11547972

Jurkowska recently discovered that the isothiocyanate, 4-hydroxybenzyl isothiocyanate, down-regulates the level of mitochondrial rhodanese, forcing increased reactive oxygen species (ROS) production and inhibition of tumor cell growth .

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PMC11787355

Created in BioRender.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]

PMC9429973

Regarding later lines, 402 (39.9%) patients received a 2 treatment (L2); median time from end L1 to beginning of L2 was 15.1 months (0-163).

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PMC11591038

One recent study suggested that, in AD under hypoxia and other non-hypoxic stimuli, such as oxidative stress and inflammation, TfR1 upregulation may be associated with HIF-1 activation causing iron dyshomeostasis in the brain, which ultimately contributes to AD pathology .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11796104

Fig. 3Significantly enriched GO terms and KEGG pathways of common gene found in host genes and DEmRNAs.

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PMC11011837

Specifically, Molt-4 and Molt-16 cells exhibit a relatively higher presence of long-chain fatty acids (with 16–18 carbon atoms) compared to the other two cell lines.

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PMC8010066

However, a Significant reduction of PA-2, PA-3, and PAO1 were observed during the co-culture with SA-1 (P-value Unlike other strains, the colony count of PA-4 strain after co-culture indicated a slight decrease.

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PMC10996034

The drug resistance index (RI) of the A2780/Taxol cell line in the present study was 33.62, exhibiting highly resistant characteristics (Fig. S1B).

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PMC7215832

mRNAs from the same cell pellets (as for the drug uptake) were extracted and cDNAs were generated for gene expression analysis by RT-PCR.

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PMC9895440

n = 10.

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PMC9429973

Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action which can mitigate the risk of higher incidence of VTE without an observable increase in bleeding rates.

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PMC11487720

Without binding, no yeast growth occurred at 37 °C.

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PMC11637276

Interestingly, the phosphatase activity of PP2A has been shown to dephosphorylate p38 after its activation downstream of collagen I signalling in platelets .

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PMC11575040

In addition to these samples, basic information was obtained from the same hospital’s department of pathology.

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PMC8540692

Finally, we wanted to analyze if the RASSF1A methylation level is altered after the treatment with CCM and NaBu, and their combination treatment (Figure 11).

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PMC10178190

Conditioned medium: HS-5 cells were plated at 18.7 × 10 cells/cm in 75 cm cell-culture flasks and incubated overnight in 10 mL culture medium for processing within a mono-culture conditioned medium (CM).

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PMC9587866

Candidates such as PARP, LSD1, and insulin growth factor-1 receptor inhibitors have been tested in the clinical trials.

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PMC11679892

Finally, the pellet was dissolved with 40 μL of RNase–DNase-free water.

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PMC9429973

After treatment, peripheral blood mononuclear cells (PBMCs) were obtained, and after further testing and purification, RNAs that met the experimental requirements were obtained from them.

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PMC11225860

Using the Inucyte Cell-by-Cell analysis software, red and green, fluorescent cells were analyzed (A).

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PMC11707577

So, spherical 3D thiophene nanoparticles (3D‐TNP) based on the TM core were prepared using a standard two‐step procedure: i) synthesis of a TM‐like polymer, using as repetitive unit that contain a TM derivative, connected by an alkyl linker (Figure S1, Supporting Information); ii) preparation of TM‐like polymer nanoparticles (3D‐TNP) via the reprecipitation method (see details in SI).

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PMC11727000

Carbamidomethylation of cysteines was searched as a fixed modification, while oxidation of methionines and acetylation of the protein N-terminal were searched as variable modifications.

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PMC11407042

Determine cell number 3 times using the Count Star automated cell counter.i.

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PMC11782508

Agarose gel electrophoresis for detection of the azurin gene.

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PMC11488203

Accordingly, abundant CXCR4 expression is detectable on human breast cancer cells including MDA-MB-231 in contrast to normal human mammary epithelial cells .

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PMC11585565

Relative c.1484 C > T mRNA levels decreased significantly to 76 ± 9.6% and 27 ± 12.5% at 4 and 24 h, respectively, after treatment.

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PMC3019555

Moreover, it remains unclear whether HIF-1α mRNA interacts with miRNAs after its entry into P-bodies or is first targeted by miRNAs in the cytoplasm.

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PMC10440586

Right, results from IDHwt gliomas.

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PMC11351758

Data are presented as the means ± standard error (SE) of at least three independent experiments.

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PMC11354225

The cytotoxic effect of EGCG is mediated by ROS and it promotes apoptosis through mitochondrial damage, membrane depolarization and release of cytochrome C, which is inhibited by catalase or other antioxidant molecules .

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PMC5839394

The EEM scan spectra were measured by scanning simultaneously both the excitation (Eex), which ranged from 200 to 320 nm, and the emission (Eem), which ranged from 200–700 nm.

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PMC11536589

In this study, our findings demonstrate that MGST1-mediated ferroptosis inhibition conferred the resistance of KRAS inhibitor MRTX1133 in PDAC.

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PMC11021472

Cells were infected with a lentiviral vector carrying a shRNA targeting circZDHHC11 or a transgene (for overexpression of miR-150 or circZDHHC11) together with a reporter gene.

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PMC5854676

Lower order polynomial produce larger error.

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PMC11240448

Next, we analyze the HCC2157 cell line, which itself forms a distinct group separate from other basal cell line groups.

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PMC10919056

To further explore the relationship between the RS prognostic model and clinical characteristics, univariate and multivariate stepwise Cox analysis were performed.

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PMC11449273

H1299 transfectants were processed for subcellular fractionation using NE-PER reagent and cytoplasmic and nuclear extracts of equal cell numbers were processed for immunoblot with p53 and plakoglobin antibodies.

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PMC11774112

The complexes were incubated for 30 min at RT.

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PMC11531744

We established the ovarian cancer cell line W038 for this study.

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PMC11194678

Data were collected from three independent experimental cell culture batches, with >300 cells counted for each batch. (

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PMC10565698

Total RNA from cells was incubated at 37 °C for 2 min with RNase R (Geneseed, Guangzhou, China).

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PMC11759543

SV-HUC1 cells were plated at 96-well plate in a final volume of 100 μl which was treated with doxorubicin and/or vorinostat at the indicated concentrations for 24, 48 and 72 h. Ten μl of MTT stock solution was added to each well, followed by incubation at 37 °C for 3 h to allow MTT reduction.

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PMC11240448

As a next step, we aimed to develop nonlinear models to predict phenotypic transitions of breast cancer cell lines at a larger scale.

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PMC11092382

The mechanism underlying this effect was associated with autophagy induction and the regulation of the PTEN/PI3K/AKT pathway.

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PMC10376064

This is particularly true with respect to GSH and GSH analogs, which were demonstrated earlier to be transported by ABCC1 under competitive inhibition of the ABCC1-mediated transport of daunorubicin .

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PMC3681794

In a wide range of different tumour types hypoxia-induced drug resistance can be reversed by HIF-1 inhibition. , , , , , , , , , ,

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PMC11380329

Previous identification of pinocembrin, galangin, p-coumaric acid, and caffeic acid in Egy P, Ger P, and Fre P were noted [69–71].

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PMC11377827

P = 0.0004, one-way ANOVA. (

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PMC11538390

Experiments with F1 embryos from multiple transgenic lines may be needed to detect the subtle effects of a common variant on the activity of this enhancer.

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PMC11519583

The middle histograms show the distribution of CSA in control and Ror2 cKO mice.

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PMC11291490

Fig. 2dusCD40L promotes T/B cell activation.

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PMC9429973

Image: Summary/Conclusion: The dynamic changes in the H3K27me3 epigenetic landscape of JAK2 V617F positive cells following persistent high dose ruxolitinib administration has potential therapeutic implications and may sensitise cells to epigenetic therapies.

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PMC11745355

The authors note that Fig. 3 appeared incorrectly.

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PMC11297139

The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.

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PMC11320084

Tumor metastasis is the leading cause of tumor death, accounting for about 90% of tumor deaths.

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PMC9577200

Mixing graphene with chitosan may suppress the toxicity of chitosan.

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PMC10840195

All experiments were repeated in triplicate in three independent experiments. *

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PMC11742670

This section compares the results of the proposed DL model (DRY LAB) to the findings of the WET LAB to validate its efficacy.

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PMC9429973

For DT after IM DISC, average DT at 2/3 months was much shorter in those lost molecular response (10.6 / 10.7 days) than those who did not (23.5 / 30.1 days).

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PMC7823217

Patient-derived cell-based tumor organoids and xenografts have shown some promise in advancing precision medicine, enabling the development of personalized chemotherapeutic regimens .

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PMC10674574

Additionally, drugs with Papp values in the range of 1–10 × 10 are classified as moderate .

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PMC9429973

Leucocytes <15x10e9/ and JAK2 were correlated with better survival.

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PMC11442172

In solid tumors, the microenvironment is frequently acidified due to elevated levels of acidic metabolites, such as lactate, and the secretion of protons (H) through specific pumps and transporters (101).

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PMC9429973

DNA methylation or Chromatin remodeling genes may occur in the early stage of leukemogenesis while RAS/RTK signaling genes may indicated later events.

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PMC10538569

Co-cultures were collected and resuspended in 1 ml of RPMI supplemented with IL-2 (100 IU/mL) in 24 well plates.

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PMC11078693

Process images with ImageJ and Imaris software.

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PMC10969097

The studies reviewed investigated a variety of mushrooms, including Agaricus blazei Murill, Reishi, Krestin, Agaricus bisporus, Lentinula edodes, Ganoderma lucidum, Pleurotus pulmonarius, Tricholoma anatolicum, Fomes fomentarius, Pleurotus tuber-regium and Trametes robiniophila Murr.

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PMC11659921

Through self‐renewal, CSCs facilitate tumor growth by generating new CSCs.

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PMC11387401

Of note, the individual Gag subuntis NC and MA are cleaved and generated only during or after budding of the HIV-1 particle.

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PMC11045125

Similar studies performed using human primary tonsil GC B cells and the same feeder layer system likewise found that stable Myc-expressing cell lines could not be obtained when cells were infected with a Myc expressing retrovirus alone, presumably due to Myc-induced apoptosis, but could be obtained when cells were co-infected with both a BCL2- and Myc-expressing retrovirus .

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PMC11092382

Ultimately, these methods resulted in improved permeability of Kushen recipe and significantly enhanced transdermal parameters of the four alkaloids in rat experiments after 48 h (Peng et al., 2007).

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PMC11351758

It is worth noting that p-MPT was achieved much faster in the NARP cells, at just 220 s, compared with the 143B cells, which started much later at 620 s. Therefore, these results confirm that the mitochondrial complex V mutation enhanced high-glucose stress on mitochondria.

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PMC11638255

b Heatmap of log2FC in expression between treatment arms for genes associated with migration and extravasation within the neutrophils cluster.

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PMC7057940

Samples were precleared by incubating with 2–4 µg of normal IgG and 50 µl of protein A/G-agarose beads (Santa Cruz Biotechnology) for 1 h at 4°C with agitation.

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PMC9429973

The extent of reduction in sBCMA from baseline to C2D1 EOI was significantly correlated with best overall response rate (PR or better) (p=1.8x10).

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PMC10907726

The molecular weight of DATS (#D3202, LKT Labs, USA) is 178.34 and the purity is 99.2%.

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PMC11705862

K, M) Western blotting assessed IRIS-1 and IRIS-2 protein levels post-knockdown, respectively (n = 11, each).

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