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PMC11751675
This compound has showed anti-influenza A H1N1 and H3N2 viruses' activity with IC50 values of activity 29.3 and 47.3 μM. Three sesquiterpene lactones, 13-acetyl solstitialin A (6), centaurepensin or chlorohyssopifolin A (7), and chlorojanerin (8), were isolated from the chloroform extract of the aerial parts of Centaurea solstitialis L. ssp.
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PMC11721064
For our analysis, we utilized gene sets curated from the Molecular Signatures Database (MSigDB) (https://www.gsea-msigdb.org/gsea/msigdb/index.jsp), encompassing KEGG, Gene Ontology (GO), Reactome, and Hallmark pathways.
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PMC9429973
Depression of HDAC6 by TBA was sufficient for increasing the expression of FOXO1, ac-FOXO1, and inducing autophagic flux.
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PMC11726848
The cells were seeded in 96-well culture plates at a concentration of 5 × 10 cells per well in DMEM with 10% FBS.
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PMC11742290
LGR5, as a receptor involved in WNT signaling, may facilitate the controlled activation of this pathway, ensuring that it supports tissue maintenance and repair while preventing its excessive activation, which could drive tumorigenesis .
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PMC9429973
Three karyotypes and 25 metaphases were analyzed according to the International System for Human Cytogenetic Nomenclature.
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PMC9429973
Thrombotic event was associated with age (p=0.020) and marginally with leukocyte count at diagnosis (p=0.065) but not with JAK2 VAF.
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PMC11391695
Following that, the cells were stained with 200 µL of Annexin V-Alexa Fluor 647/PI-containing dye (Beyotime, China) under dark conditions and incubated on ice.
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PMC5673955
At the days 15–25, consequent reduction of the number of cells in G2/M phase and an increase of apoptotic cells was determined.
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PMC11536589
The cells were transfected with a concentration of 20 nM siRNA for 48 h. The human siRNAs used in this study were obtained from Sangon Biotech (Shanghai).
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PMC11180402
Western blot analysis of SOX2 expression in 5637 (SOX2) and 5637 (Vector) cells; GAPDH as control. (
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PMC11322866
Cell lysates were subjected to immunoprecipitation with anti-EZH2 antibody, followed by western blot analysis with an anti-ubiquitin antibody. ***
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PMC10669966
The RNA samples were subjected to RNA sequencing, resulting in sequences from 152 samples.
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PMC8711270
Advancements in cell line developments would see more HEK293 clones or derivatives developed for growth in a serum-free suspension medium for high-titer viral vector production.
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PMC10761571
The assays were performed in three replicates and the p-value<0.05 was considered significant.
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PMC11478724
VDAC1 is a key regulator of the exchange of ATP/ADP and respiratory control in the outer mitochondrial membrane.
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PMC11155445
Anti-oxidant activity of the compound (98) and its Cu(ii) complex (99) suggested that the ligand (MBT) exhibited higher activity than the Cu(ii) complex and had the highest percentage inhibition of 36.41% at a concentration of 22.5 μg mL (Fig. 35).
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PMC10975211
Surface modification of nanoparticles or liposomes with targeting ligands, such as antibodies or peptides, enhances their specificity for cancer cell receptors, leading to increased cellular uptake .
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PMC11463018
White solid, 33.5% yield.
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PMC11172027
Increasing the concentration to 250 µg/mL caused a decrease in cell growth (104.5 ± 41.0%; n = 3; p < 0.05) compared to 125 µg/mL NALM, while no significant reduction in cell growth was achieved at 375 and 500 µg/mL NALM.
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PMC11611077
To assess the voltage dependence of membrane capacitance, triangular voltage ramps were superimposed on the above-mentioned square test wave.
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PMC11243198
As Z27613695 showed no significant inhibition of activity in any of the Hh assays (Table 1), this compound was no longer included for subsequent testing.
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PMC9429973
We herein highlight the existence of “de novo” AML patients that debut with a normal or elevated platelet count.
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PMC11343332
Previous studies have demonstrated that pycnogenol induces apoptosis in various cancer cell lines, including breast cancer.
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PMC11726848
The level of PI fluorescence reflects the amount of DNA in the cell, which allows the pre-replication phase, the replication period, and the post-replication phase of DNA to be separated from each other.
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PMC11127909
Scale bar = 1 cm.
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PMC11347429
Therefore, in addition to the analyses presented here, our data may also be used to study gene expression changes in a single patient over time.
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PMC9119314
The prospect of eradicating malaria continues to be challenging in the face of increasing parasite resistance to antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage malaria parasites are urgently needed.
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PMC11599565
Transcripts were amplified using random oligo-dT primers.
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PMC11742047
HL-60 and K-562 cells were plated in opaque multi-96 well plates (Corning, Italy) at 1 × 10 cells/well and treated with CBD at 10 and 23 µM, respectively, in the presence of the bioluminescent annexin and fluorescent necrosis detection reagents using RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay (Promega.
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PMC11672881
Studies have shown that TQ exerts its anti-neoplastic effects by inhibiting cell proliferation, inducing apoptosis, arresting the cell cycle, generating reactive oxygen species (ROS), and inhibiting metastasis and angiogenesis .
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PMC11754436
The weight were measured. (
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PMC11394730
Protein analysis revealed that mesenchymal indicators like vimentin and N-cadherin were downregulated dose-dependent.
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PMC10218459
These results, obtained in vitro, represent a promising first step towards novel concepts to treat Ewing’s sarcomas and related metastases.
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PMC11188874
At higher concentrations, ACY-1215 and ACY-738 reduced cell viability 15%–20%.
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PMC11283030
Yun Lin: Supervision, Software.
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PMC9429973
However, the extent to which these different signals contribute to the growth and survival of the leukemic cells in vivo has still not been fully established.
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PMC11746948
Statistical analysis: two-way ANOVA with Tukey’s test for (c, j); one-way ANOVA with Tukey’s test for (g, h, l).
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PMC11461833
ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
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PMC11758416
Determine number of T cells in each condition using a hemocytometer.
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PMC11534035
Cells were allowed an incubation period of 72 h to proliferate under the treatment conditions before the addition of 20 μl of a redox indicator, the fluorogenic dye, resazurin (Thermo Fischer Scientific).
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PMC10538569
Thus, in transduced human primary CD4 T cells, GPI-scFv X5 significantly blocks trans-infection of iDC- or mDC-captured HIV-1, further supporting the findings in Figures 2 , 3 .
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PMC6901583
d The level of MMP9, LOX, and VEGFA expression in xenograft tumors was analyzed by Western blotting; *P < 0.05.
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PMC10165258
This protocol yielded one-to-one pairing of primary (spheroid containing) and secondary (drug solution) droplets.
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PMC11406030
Surviving patients had a median follow-up duration of 14.0 years.
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PMC9592219
The normal liver cell line L02) and HCC cell lines (MHCC97H, MHCC97L, HCCLM3, SMMC7721, BEL-7404, HepG2 SK-EP-1, and Huh7) were obtained from the Typical Culture Centre Reserve (Shanghai, China).
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PMC9964635
C NMR (126 MHz, DMSO) δ 166.56, 158.12, 148.93, 139.65, 139.28, 134.53, 129.50, 129.27, 127.43, 126.81, 126.14, 125.14, 44.07, 37.07, 35.48, 30.04, 29.53, 22.13, 20.97 (Figures S18–S20).
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PMC11116779
The contact of airborne plastics with the respiratory tract by inhalation represents one of the prime routes of human exposition to air pollution.
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PMC6163708
The use of GANT61 in combined targeted therapy of sensitive tumors, such as melanomas, seems to be immensely helpful.
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PMC10758402
This analysis is detailed in ( Supplementary Table S1 ), which presents the Combination Index Score (CSI) consistently between 0.7-0.8 in CT26.wt cells, confirming a synergistic interaction.
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PMC11738017
Notably, after being refractory to anti-BCMA TCE, MM-19 achieved a stringent complete remission that lasted 15 months with anti-GPRC5D TCE (talquetamab).
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PMC11564322
Our experiments showed that none of the tested concentrations (1–100 nM and 1–100 µM) of the VGVAPG and VVGPGA peptides changed the cell metabolism measured by the resazurin reduction test.
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PMC11767817
Total protein concentrations were measured using a bicinchoninic acid protein assay (BCA, Thermo Fisher Scientific, USA), with bovine serum albumin used as the protein standard.
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PMC11095939
H–J) The effect of Nedd4 OE on quiescent exit in 3T3 cells determined by WB (H), IF staining of Ki67 and Nedd4 (I), and Ki67/PI staining (J) at the indicated time points.
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PMC9429973
Notable differences in the incidence of grade 3-5 adverse events (%) reported (before HSCT) were: febrile neutropenia (37% for DEC vs 57% for IC), decrease in platelets (24% for DEC vs 32 % for IC), oral mucositis (2% for DEC vs 10% for IC), diarrhea (1% for DEC vs 8% for IC), decrease in neutrophils (19% for DEC vs 13% for IC).
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PMC11678448
To gain deeper insights into the function of DEGs in the process of PBLs in P. multocida type D, we performed GO and KEGG analyses.
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PMC10734950
It is projected that by the end of the year 2023, 59,610 new cases of leukemia will be diagnosed, and 23,710 people will die from the disease in the U.S. .
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PMC8481254
Our data showed CDK19 plays an indispensable role in YAP-mediated O-GlcNAcylation.
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PMC11766332
Interestingly, in patients, GALNT2’s loss of function causes a neurodevelopmental disorder with global developmental delay, intellectual disability with language deficit, autistic features, and behavioral abnormalities.
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PMC10538569
The epitope recognized by antibody X5 resides within a conserved region (amino acid residues 417 to 434) of the Env gp120 core, which is nearby the CD4 and co-receptor binding sites (44).
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PMC11144382
Overall, expression of the CRABP2 (Crabp2) and VCAM1 (Vcam1) genes was found to be consistently altered in the Nfix MEFs compared with all other MEFs, and in the majority of MSS human fibroblast cells, and we therefore focused further investigations on the promoters of these 2 genes.
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PMC11085211
Indeed, arbutin has been tested on GIST cells with negative results, and its non-anticancer activity was also confirmed by the absence of activity in the 2A-20 subfraction, which predominantly contained arbutin (Supplementary Figure S6a).
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PMC10976516
Since ICIs promote anti-tumor adaptive responses by removing blocks on immune activation, which is known to break tolerance to self-antigens and induce autoantibody formation, a subset of these autoantibodies may thus mediate anti-tumor responses and enhance ICI efficacy.
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PMC10957991
Immunofluorescence stainings of 184A1 cell cultures on space-restricted patterns.
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PMC9429973
It is an orally administered treatment but expensive and a potential source of drug interactions.
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PMC10698968
These observations concord with the tendency of MFS to recur in the same anatomical site, especially in the case of surgery with positive margins when few residual cells may be still viable .
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PMC11549062
The relative level of PTP1B/GAPDH (n = 5). (
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PMC10674574
The validation of the Caco-2 cell line should demonstrate the correlation between the experimental transport data (Papp) and human intestinal absorption (fa) of selected model drugs.
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PMC11720808
Figure 1SCU inhibits the growth of OS cells. (
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PMC11544771
Apoptosis was determined as described .
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PMC10734950
In the secondary screening, we used concentrations ranging from 0.01 μM to 30 μM to determine the concentration of the experimental compound required to disrupt 50% of the cell population .
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PMC5415764
The P-gp inhibitor, tetrandrin (TET) which is a bis-benzylisoquinoline alkaloid isolated from the root of Stephania tetrandra S. Moore, exhibits potent reversal of MDR by directly binding to P-gp and increasing intracellular drug accumulation5.
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PMC9872547
On the other hand, curcumin altered the expression of these genes at a 50-μM concentration.
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PMC11783017
N, O) In vitro invasion evaluation of 143B cells after treatment for 24 h by transwell assays.
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PMC11300639
These data suggested that RNF26 promotes tumorigenesis mainly through the mTOR signaling pathway in ccRCC.Fig.
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PMC11788920
In this study, we demonstrate transcription regulation via a synergistic use of CRISPR–dCas9 and G-quadruplex (GQ) structures to achieve both CRISPRa and CRISPRi within the same system .
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PMC11643491
In cases of toluene stretching, the film was immersed in toluene for 20 h before stretching and 30 min after stretching.
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PMC10213179
In contrast, EphA2 protein expression in normal tissue is typically low, except for tissues that contain a high proportion of dividing epithelial cells, such as the brain, colon, urinary bladder, uterus, testis, and prostate; nevertheless, its expression is still lower than in tumor samples.
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PMC6450504
By using LSC analysis based on Hoechst-stained DNA content and cell morphology, cells were gated and classified as live, sub-G1 on early apoptotic cells (Supplementary Figure S2(a)).
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PMC11711347
The melting point of the Ni(II) proline dithiocarbamate (Ni(II)ProDtc) complex was measured with an Electrothermal IA 9100 apparatus.
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PMC11754094
For example, UBE2T coordinates the repair pathway in the Fanconi anaemia (FA) pathway which is one of DNA damage responses; UBE2B is involved in monoubiquitylating histones when replication forks encounter lesions in the post-replication repair pathway; UHRF1 plays a crucial role in the DNA damage response during the S phase; RFWD3 interacts with RPA to facilitate the DNA damage response; and RNF8 ubiquitylates histones as part of the DNA damage response.
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PMC11680982
Specifically, several groups were established, including a normal saline control group; a group administered CDK4/6 inhibitor combined with endocrine therapy; a triple therapy group administered a medium-dose of neratinib (20 mg/kg), CDK4/6 inhibitor, and endocrine therapy; a low-dose neratinib triple therapy group (10 mg/kg); and a separate group administered a medium-dose of neratinib (20 mg/kg) alone.
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PMC11506827
The optimized MS/MS conditions included ion spray voltages of −3.5 to −4.5 kV (negative mode) and 5.5 kV (positive mode), a capillary temperature of 400–450 °C, and specific gas flows for nebulizing, auxiliary, and curtain gases.
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PMC11188874
Lysates were prepared under nondenaturing conditions, immunoprecipitated using FLAG-sepharose, eluted using 3X-FLAG peptide and proteasome activity assay buffer added (20 mmol/L Tris-HCl, pH 7.6, 20 mmol/L NaCl, 3 mmol/L ATP, 5 mmol/L MgCl2, 1 mmol/L DTT, 10% glycerol).
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PMC10933092
To construct a stable cell line (short hairpin (sh)-TRMT61A), 293T packaging cells were used for lentiviral production.
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PMC11543885
Seed 5 ×10 cells per well on a 6-well plate in 2 mL complete medium and incubate the cells for 16 h at 37°C with 5% CO2.
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PMC11730311
This analysis confirmed the overexpression of CALCRL and RAMP1.
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PMC11098378
This model was used for molecular replacement phasing of the native Ceg10 and the S-nitrosylated Ceg10.
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PMC9878278
Therefore, we next evaluated if ZIKV infection alters the mRNA expression of TGF-β superfamily members, TGF-β1 and Activin A. As seen in Figure 5A, ZIKV does not induce changes in the mRNA expression of INHBA (Activin A) or TGF-β1.
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PMC11633763
Moreover, HK2 knockdown inhibits glycolysis and the proliferation of liver cancer cells .
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PMC11787381
Results are expressed as mean ± SEM [n = 6 except for Aβ (n = 5), bambuterol 1 nM (n = 5), bambuterol 1 μM (n = 5) and donepezil 1 μM (n = 5)] as a percentage of control (control (white) = 261 ± 8 PSD95 + /Synaptophysin+ synapses/field). *
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PMC9429973
While there were significant improvements in knowledge regarding the latest data with epigenetic agents for T-cell lymphomas, with 29% improving and 25% reinforcing knowledge (P<0.001), 65% still did not know this information after education.
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PMC8839885
Dasatinib activity was dependent on ERK1/2 activation, whereas 2HE2 was independent of the activation of ERK1/2.
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PMC10748106
Curiously, only D9, D10, D36, and D56 present a dipole vector with a similar direction to the most active simple iridoids (Euphrasin, Campsinol, Artselaenin A, and Artselaenin B); this could be attributed to the aldehyde in C4, that was common to these four designed iridoids.
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PMC11618052
Nevertheless, effective chemotherapeutic agents with minimal side effects have garnered significant interest.
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PMC9429973
Variables associated with higher TRM were older age, Ph negative ALL and earlier diagnosis.
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PMC4360730
To the right are all the available experiments on biological samples annotated to a specific term in Uberon, CL or EFO that slims to the parent term brain—UBERON:0000955.
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PMC11585565
Two-way ANOVA was performed to assess the statistical differences between wild-type and mutant mRNA and protein levels (*p < 0.05, **p < 0.005). (
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PMC9621239
Differences in Sn at each amino acid site between genotype-B and genotype-(C&D) clones; Significant sites with P≤0.05 are shown in red bars. (
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PMC11798926
Schematic diagram of SynDIG deletion mutants used in this study.
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