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OTAR3088
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BioData-CellLine_annotated

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PMC11767725
Additionally, the identification of skin-specific immune mechanisms, as shown by Gribonika et al. offers potential for localized therapeutic strategies aimed at modulating microbial interactions and controlling inflammation or infection directly at the skin barrier.
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PMC11451940
IR (ATR; cm): 3429, 3362, 3286, 3075, 3062, 3039, 2989, 2963, 2908, 2876, 2848, 1635, 1587, 1557, 1478, 1451, 1400, 1325, 1272, 1245, 1220, 1166, 1097, 1062, 1038, 1022, 953, 879, 783, 728, 672, 650, 547, 504, 442.
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PMC11345828
Compound 46 could then be alkylated with MeI to afford 47, which could in turn be hydrogenated to afford phenol 48.
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PMC11530949
The formation of biosynthesized NPs as agglomerates, with sizes varying and less than 40 nm, was also verified by TEM analysis.
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PMC11763126
E Enrichment analysis of Hallmark pathwaysFig.
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PMC11469524
Given a full systematic perturbation and measurements regime, these direct network connectivities can be estimated from the global response matrix as: R=−r−1*p (1) Where p is a matrix containing the coefficients for direct target perturbation strengths, each column with only non-zero entries on the perturbed node(s).
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PMC11779876
This is particularly evident when TRB J1 and J2 family genes, which are linked to TRBC1 and 2 expression, are utilized by different subclones.
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PMC2192239
Stimulation of cells with anti-IgM led to increased activity of a nuclear kinase that could phosphorylate the peptide, and this activity was reduced by 10 microM KN-62.
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PMC11706491
Among these, the MAP kinase Sty1 is the archetype that has always been believed to be regulating cell cycle progression, even in the absence of an exogenous stress.
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PMC11532793
The and ψt parameters tend to be abundance-dependent between transcripts whereas the τt are far more transcript-specific and vary by several orders of magnitude between transcripts.
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PMC9429973
Aims: To know the strategies of clinicians in the management of IFI in onco-hematological patients and the role of guidelines and recommendations in decision making.
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PMC11730305
The percentage of cells at the G2/M and subG1 phases was 14.7 and 0.62%, respectively.
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PMC11474209
In earlier studies, researchers recommended that the mitochondrial ETC and phosphorylation system were affected by MCs, which caused a decline in NADH dehydrogenase activity in rabbit liver.
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PMC9429973
72 h treatment of MDS and AML cells were inhibited by GLS inhibitor or venetoclax in a dose dependent manner.
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PMC11352311
786-O and A498 cells were inoculated into 96-well plates.
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PMC9429973
Inclusion criteria: Age 18 year and above, diagnosis with diffuse large B-cell lymphoma at high risk of CNS involvement and adequate haematological, renal and hepatic function.
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PMC10114490
The chosen significance level was p < 0.05.
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PMC11337594
B, C) A375 and CASP3-KO cells were treated with different doses (0, 1.0, 2.0 and 3.0 µg/ml) of TER for 24 h, followed by Annexin V-FITC/PI staining and flow cytometry analysis (n = 4).
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PMC11487720
Also, the full-length ECFP-TRAF2 inhibited BCD in L929S cells in a time-related manner (Fig. 6D; p < 0.05 for ECFP versus ECFP-TRAF2 in each time point; Student’s t test).
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PMC11506670
Significant compression of tumor spheroids amplifies cancer cell proliferation and metastatic process .
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PMC7022782
PECA-NPs described in a recent paper can be considered as a specific potential therapeutic platform for the treatment of solid tumors.
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PMC10170482
However, the knowledge on whether there are qualitatively and quantitatively different cellular responses in 2D vs 3D cultures remains rather fragmented.
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PMC11752767
Immortalized human NK cell lines, apheresis of peripheral blood lymphocytes, archived samples of umbilical cord blood, and the supervised differentiation of iPSCs constitute the multiple sources of CAR-NK cell manufacture .
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PMC11463018
Complete characterisation of 19 at HDAC isoforms (IC50, nM).
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PMC11711347
This approach aimed to optimize the therapeutic properties and safety of the compound, including enhanced cellular uptake, increased water solubility, and improved selectivity and specificity at the molecular level while reducing toxicity.
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PMC9429973
Aims: The purpose of this study was to dissect the functional role of BCAT1 in T-ALL, with particular emphasis on a putative link between BCAT1 and NOTCH1 in promoting T-ALL initiation and progression.
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PMC11411131
Treatment with tunicamycin, an endoplasmic reticulum stress inducer, for 24 h led to a 1.6-fold increase in luciferase activity in Cos-7 cells expressing ERAI-Luc.
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PMC11583010
Temperature measurements and ophthalmologic assessments were included.
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PMC8903741
The use of these two plasmids was likely to have similar expression rates because promoter, combination of RNA polymerase binding site, and response elements were identical.
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PMC5925824
Each data point represents the average of 4 replicates, with error bars representing the SD.
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PMC11489175
Upon ubiquitin-binding receptor recognition, the poly-Ub chain is removed and recycled into the pool of free ubiquitin before substrate degradation 58.
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PMC11670954
In both scenarios, the integrity of cell tight junctions is compromised, resulting in decreased expression of claudin-5 and ZO-1, as well as reduced mRNA expression of claudin-5 and Occludin.
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PMC11730311
A Schild plot slope higher than 1 can reside from a slow onset of action of the antagonist, which causes pA2 to underestimate the true pKB.
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PMC9429973
30 (26%) of 114 patients had a detectable fusion gene by Q30 (Figure 1).
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PMC11753435
Mismatched pairs, each containing a peptide and a nonmatching protein, both from the validation dataset, were also scored via the CLIP module.
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PMC11473750
Mouse #1929 showed no tumour at 61 weeks of age, and this tumour-suppressed phenotype was inherited in its offspring (Fig. 1b).
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PMC10391797
MB: CD3/CD28 microbeads.
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PMC6642070
Cells with indicated treatment were washed with PBS and harvested using ice-cold cell lysis buffer (150 mM NaCl, 50 mM Tris-HCl pH 8.0, 1% NP-40) containing protease and phosphatase inhibitors.
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PMC11687167
The increased expression of SOCS3 led to the inhibition of STAT3 phosphorylation, which in turn increased PCSK9 expression in hepatocytes .
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PMC11092418
In another study, Buzzetti et al have also found that dinaciclib was more effective than palbociclib in inhibiting the growth of medulloblastoma cells .
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PMC9046263
A recent retroelement specific array demonstrated DNA hypomethylation for several HERV superfamilies (HERV-K, HERV-H, HERV-W) in head and neck cancer patients compared to adjacent normal tissues.
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PMC11802855
The expression level of CXCL7 in the CXCL7-OE and NC H929 (B)/RPMI 8226 (C) cell lines was evaluated via qPCR.
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PMC11525028
However, the therapeutic effect for osteosarcoma has remained stagnant over the past 30 years.
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PMC11615828
The graph was created using BioRender.
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PMC8992508
These bonds induce NBD dimerization and formation of the so called “ATP sandwich”, and the switch of the TMDs from the high-affinity inward conformation to the low-affinity outward conformation, which releases the substrate out of the cell.
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PMC11286266
The interaction kinetics were calculated over the entire 1200s of the association phase and 2400s of the dissociation phase.
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PMC11365427
DR5 co-localized with caspase-8 on the cytomembrane of NCI-H929 cells.
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PMC2777936
Recently, it was reported that WNT5a polarizes the cytoskeleton, allowing chemokine directed motility in melanoma cell lines .
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PMC11453378
J. Ng: None.
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PMC9429973
Recent reports indicate that statins might improve chemosensitivity of tumor cells to doxorubicine and diffuse large B cell lymphoma (DLBCL) patients concomitantly treated with statins in addition to R-CHOP might experience improved response rates and improved survival.
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PMC7802142
0.
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PMC11139449
The effect of CASP8AP2 silencing on the constitutive expression of JRed was investigated using flow cytometry, showing that the expression of JRed increased by up to 1.3 folds in knockout CHO cells in comparison with CHO-K1 cells (Fig. 6).
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PMC11424574
The human protease array kit (ARY021B) was purchased from R&D Systems, Inc. (Minneapolis, MN, USA).
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PMC11389534
The burgeoning interest in UFMylation's role in cellular processes, particularly in immune homeostasis and disorders, represents an exciting avenue for future research.
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PMC11209164
The results detailed in (Figure 3D,E); Table S1 indicate a marked variation in TPF’s efficacy to potentiate viral infectivity.
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PMC11060216
This trend was more significant in adenocarcinoma with a BAC component.
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PMC11334037
We explored the mechanism of IGF2 in imatinib resistance in GISTs and whether IGF2 enhanced metastasis and imatinib resistance by driving glycolysis by targeting IGF1R signaling transduction.
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PMC11615828
Immobilization of LAMP1‐FKBP‐labeled lysosomes using RIVET simultaneously slowed down the motility of RFP‐Rab7a‐positive vesicles (Figure 2e,f; Video S18, Supporting Information).
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PMC11593713
Cells attached to the surface of wells were treated with trypsin (Gibco™, Thermofisher Scientific, Waltham, MA, USA) and collected in 15 mL sterile centrifuge tubes.
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PMC11496491
The results of GO directed acyclic graph analysis on molecular function showed that the most significant enrichment of the farthest Term was metal ion binding.
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PMC3931643
Rapalogs inhibit phosphorylation of S6 kinase (S6K) very efficiently, but have lesser impact on the phosphorylation of 4EBP1 and 4EBP2 by TORC1 .
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PMC8956657
F Reporter assay testing inhibition of TNFα-induced activation of an NF-κB-responsive promoter by ORF4b and the indicated ORF4b mutants.
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PMC11768927
Preclinical studies have demonstrated the efficacy of VSV against a wide range of malignancies, including prostate, pancreatic, ovarian, endometrial, and hepatocellular carcinoma, as well as T-cell lymphoma, acute myeloid leukemia (AML), and melanoma.
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PMC11774251
I, J) Statistical charts of acanthosis (I) and dermal infiltrating cells in (H). (
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PMC11755624
Long non-coding RNAs (lncRNAs) are composed of over 200 nucleotides and exert a large variety of functions, including the regulation of gene expression.
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PMC11711663
Its use necessitates careful validation to confirm its predictive power for OS, thereby embodying the balance between timely patient-centric research and the need for methodological precision.
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PMC10965315
To investigate the role of ROS in harmaline‐induced cell death, the levels of ROS were measured using fluorimetry.
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PMC11791432
Cells were seeded in 6-well plates and cultured in cell incubator.
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PMC11066331
Fig. 1 Mass spectra processing workflow.
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PMC9583612
In this work, we demonstrate a quantification, monitoring, reporting, and verification framework that pairs snapshot measurements with continuous emissions monitoring systems (CEMS) to reconcile measurements with inventory estimates and account for intermittent emission events.
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PMC10197932
Human myeloid leukemia cell lines (OCI AML-3, MOLM-13) were obtained from (Leibniz Institute DSMZ- German Collection of Microorganisms and Cell Cultures GmbH).
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PMC7868205
This is due to the fact that an increased dose can cause a decline in the antitumor effect and an upsurge in unintended toxicity.
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PMC11365427
Body weight and tumor volumes were measured (Fig. 8G and H).
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PMC11794588
Fractions tested for activity (percentage inhibition of cancer cells).
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PMC10530622
The reduction of the GFR causes elevation of plasma oxalate even before ESRD develops and systemic oxalosis ensues with significant morbidity, affecting bones, retina, skin, blood marrow, and vessels .
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PMC7369657
These results show that CQDs can activate apoptotic proteins and induce apoptosis of osteosarcoma cells through the mitochondrial apoptotic pathway.
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PMC11770199
Ten million cells were harvested with TRIzol reagent 20 h after transfection.
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PMC11541409
These mutations, although rare in primary GIST, often arise as secondary mutations following imatinib treatment, and significantly aggravate the phenomenon of drug resistance (Fig. 1B).Fig.
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PMC9964635
It also interacts with Val654, Ile789, Leu647, Ile808, Ile653, and Phe811 residues through van der Waals interaction.
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PMC11747467
E, F) Cell viability of the ERBB2-overexpressing and control basal cells after exposure to RC48 (25 μg/ml). (
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PMC11206502
These strategies aim to improve response rates and increase overall and progression-free survival .
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PMC9844987
Box-and-whisker plots displaying the difference in TPM normalized promoter expression between in the absence (blue) or presence (orange) of TF binding sites.
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PMC8973725
Different expression of ZNF677 in ccRCC based on individual cancer stages. (
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PMC9429973
D5PSS-4 category was evaluated visually (visual assessment) and additionally according to the criterion of “1.4x”.
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PMC11753435
Using TOPFlash, a luciferase reporter for reliable readout of Wnt/β-catenin signaling (42), as an initial screening tool, we observed a statistically significant reduction in β-catenin transcriptional activity in cells transfected with β-cat_PpC_1, β-cat_PpC_2, β-cat_PpC_3, and β-cat_PpC_4 constructs compared to cells transfected with an empty vector control (Fig. 4B). (
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PMC11525293
Overall, our work sheds new light onto current comprehension of Thal and p63 molecular details at various levels.
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PMC9429973
We observed a higher incidence of aberrant karyotypes in dn-AML-MDS vs. s-AML-MDS (71.4% vs. 40%, p=0.02).
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PMC5941560
Density of SnpEff “High Impact” SNVs with rare ExAC allele frequencies (gold); 3.
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PMC9964635
They exhibit anti-tubercular , anti-cancer , anti-fungal , anti-microbial , anti-viral , and other biological properties such as genotoxicity and lipid peroxidation , and anti-inflammatory properties .
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PMC11528603
However, the presence of steroids might also raise caution due to their adverse effects.
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PMC11727062
Furthermore, ginsenoside Rg3 triggers apoptosis by facilitating Bax protein upregulation and Bcl-2 protein downregulation, thereby suppressing melanoma cell invasion and metastasis, aligning with the current research and targeted therapeutic approaches focused on apoptosis signaling pathways in contemporary oncology.
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PMC8009078
The SARS-CoV-2 needs to enter into the cells, which is allowed through ACE2 via the action of transmembrane protease serine-2 (TMPRSS2).
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PMC11792090
Mice were euthanized upon meeting predefined euthanasia criteria (significant weight loss, signs of distress) or as recommended by the veterinary staff.
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PMC11332076
A value of P < 0.05 was considered statistically significant.
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PMC7709199
Activation occurs through the binding of CSF-1 or IL-34 to the second (D2) and third (D3) Ig domains in the CSF-1R ectodomain, eliciting ligand-induced dimerization and initiation of the intracellular signaling cascade (Verstraete & Savvides, 2012 ▸).
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PMC10858941
Furthermore, hypoxia has been shown to modulate the expression of TTCCs , which regulate cell cycle progression and chemoresistance in GBM .
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PMC11471157
On the third day of culture, NIH/3T3 cells had proliferated, covering the surface of the DFP (Fig. 3G).
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PMC11063646
As 1 g of ANG5, ANG11 and ANG 12 contain approx.
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PMC8806312
Enrichment plots of gene ontology annotation between high- and low-risk groups The CIBERSORT algorithm was used to calculate the fraction of the immune cells and thus further identify the differences in the TIIC profiles between the two risk groups.
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PMC11547972
Indeed, cdk1, cdk2 along with cyclin A and B were all potently diminished by the combination protocol in this cell line.
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