PMCID
string
Sentences
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ner
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PMC11297139
The generated libraries were sequenced in 100 bp paired-end mode using MGI DNBSEQ-G400.
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PMC10976516
The study is ongoing.
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PMC10578720
Acetylation is an essential post-translational modification that regulates protein function and is ubiquitous in enzymes that catalyze intermediate metabolism.
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PMC8777939
Treated and untreated cells were harvested after washing twice with ice-cold PBS.
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PMC7039683
Nearest EVL genes (within 100.0 kbp) of the GPAEs with ‘GRHL+TEAD+FOS’ and ‘KLF+TFAP2+GATA’ combination.
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PMC11684821
The work presented here strongly supports our earlier work and refutes 2 claims made by Cornforth et al. (29).
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PMC11711871
The size measurements were evaluated using QuPath (vO.4.4), and the plasma concentrations were evaluated by two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.
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PMC9429973
Aims: To analyse the characteristics and outcomes of limited-stage DLBCL in a single center series and evaluate the prognostic impact of EN involvement.
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PMC11610461
Surprisingly, PSENEN is associated with survival and immune infiltration in low-grade gliomas (Chen et al., 2022).
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PMC11461833
The expression of the Human endogenous retrovirus K internal coding sequence (HERVK-int) was upregulated in human mesenchymal progenitor cells (hMPs) from individuals with HGPS, whereas the knockdown of HERVK alleviated premature senescence.
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PMC2614416
The dried pellet was re-suspended in 20 μL 8 M urea/100 mM ammonium bicarbonate (ABC), and 0.6 μL of 100 mM Dithiothreitol (DTT) in 100 mM ABC (i.e. 3 mM DTT) was stirred in Eppendorf Thermomixer R for 1 hr at 29°C.
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PMC11568601
In resting cells, three key UPR activators, ATF6, PERK and IRE1, bind to BiP to maintain an inactive state.
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PMC11676169
Interestingly, the “Apoptosis signaling” and “p53 signaling” pathways were amongst the top hallmark gene sets enriched in shBCAT1 cells (Figure 1E).
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PMC10809689
The calibration curve was determined by linear regression in the range of 40-4000 µg/ml with the regression equation of y = 0.0009x + 0.7132, where X was the concentration of α-KG (µg/ml) with the R correlation factor of 0.9971.
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PMC11599565
Panel A: naturally occurring, dark-colored cells generating cells with different morphology than the whole cell population (arrows in pictures A-D).
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PMC11549612
Together, these findings not only expand our understanding of BOLA1, BOLA2, and BOLA3 biology but also underscore the diverse therapeutic potential of targeting BOLA1, BOLA2, and BOLA3 with existing anti-tumor agents, offering promising prospects for future cancer treatment strategies.
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PMC11265931
Figure 5 shows the effect of garlic SEVs on caspase-3 activation, as assessed by a commercially available caspase-3 ELISA kit.
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PMC11489275
The lowest tertile was 0.490 × 10^9/L (n = 106), defined as “Lymphocyte group 0.490”, the range of lymphocytes was [0.08 to 0.60]; the median tertile was 0.785 × 10^9/L (n = 70), defined as “Lymphocyte group 0.785”, the range of lymphocytes was [0.61 to 0.90]; The highest tertile was 1.320 × 10^9/L (n = 87), defined as “Lymphocyte group 1.320”, the range of lymphocytes was [0.91 to 3.40].
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PMC11481779
However, in our problem, we want to strongly guide the generation in order to reflect the actual physical nature of the underlying polymer.
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PMC7057940
no. 67-56-1; Sigma-Aldrich; Merck KGaA) and glacial acetic acid (cat.
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PMC11802929
Our analysis is, in several aspects, aligned with existing literature.
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PMC11683130
Reduced expression of SerpinA12 in KC reduces keratinocyte differentiation and exacerbates inflammation by reducing the expression of differentiation-related genes and psoriasis related inflammatory gene.
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PMC11695623
The results showed that OS was shortened in high expression group.
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PMC8336407
For instance, it was previously reported that benzoquinone is a chemical found in Pyrus family extract and that it effectively induces apoptosis in hepatoma cell lines .
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PMC9429973
UDP-galactose-4-epimerase enzymatic activity was measured by HPLC/MS/MS.
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PMC6181431
Furthermore, a variety of activating mutations in MTOR are well-known in both RCC and other cancer types [10–12,27,30], and in some cases are associated with exceptional response to rapalog therapy.
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PMC11279598
ANOVA was used for comparison of tumor xenograft volumes in preclinical models.
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PMC11335267
Lower energy expenditure in mutant mice was observed during the entire 24 h daily cycle when fed with HFD, whereas when fed under a SCD regime, lower energy expenditure was observed predominantly during the night phase coinciding with increased locomotor activity or during forced exercise on a treadmill.
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PMC6617630
We exploited and identified 4 DHLs (OCILY10, OCILY1, DOHH2, and SUDHL2) and 1 THL (Val) along with WT-MYC (U2932 and Karpas 422) DLBCL lines by comprehensive cytogenetic analysis.
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PMC9046263
Proximity to the gene nearest to each HERV locus was calculated using the R package Genomic Ranges via the ‘DistanceToNearest’ function.
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PMC9429973
Results: Trial in progress.
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PMC11534377
After 48 hours of treatment, the A549, SK-MES-1, H1792 and H522 cell lines exhibited IC50 values of 2218 nM, 1629 nM, 1471 nM and 1948 nM, respectively.
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PMC11758416
See note regarding concentration.
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PMC9429973
There were no grade 4-5 adverse events.
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PMC11763111
Each experimental group consisted of five mice to ensure adequate statistical power for detecting significant differences.
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PMC7090062
f Electron microscopy was used to observe autophagic vacuoles in GIST-T1/GIST-882 cells after infected with miR-30 mimics or inhibitors.
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PMC9429973
A multicohort prospective study (NCT02113982) demonstrated a tolerable safety profile and a durable overall response rate of 75% (median duration 24.9 months) in first-line (1L) pts.
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PMC11509224
A spongian diterpene, spongionellol A (213, Figure 16), was obtained from the marine sponge Spongionella sp. .
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PMC9429973
Logistic regression was used to find risk factors for thrombosis.
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PMC11802855
The extracted bone marrow was placed into a dish containing sterile PBS, and the marrow was gently squeezed out using a syringe piston.
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PMC10669128
Research findings support that sarcoma patient-derived cells predict STS patient response to therapy since these models preserve the genetic characteristics of the original tumor and the association between drug sensitivity and patient response .
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PMC11607638
This notion will, however, need verification in future studies of the detailed distribution of SKR‐expressing sensory neurons.
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PMC9429973
Only a few number of AEs occurred and were mild.
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PMC8469018
This is due to an increase in the mitochondrial membrane permeability caused by—e.g., overproduction of reactive oxygen species (ROS)—energy depletion or Ca ions imbalance .
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PMC11085211
For this reason, they are treated with imatinib, a tyrosine kinase inhibitor (TKI) .
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PMC11569208
Thus, the genetic or pharmacological modulation of cellular processes that ultimately impinge upon the IFN-1 response represents a logical strategy to improve the therapeutic gain of OVs.
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PMC11774112
We also investigated the cytotoxicity of the combined use of DTIC and miRNA 34a as well as Co-PHRD at different ratios.
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PMC11352746
Our goal is to identify trends and recommendations based on published studies to advance live-cell imaging in CNS drug discovery.
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PMC9429973
Methods: We analyzed pts with RS treated with a ven-based regimen at MDACC (n=37) or Mayo Clinic (n=18) between 12/2013 and 8/2021.
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PMC10024132
γ9δ2 T cells were expanded from PBMCs for 17 days and then isolated for adoptive transfer. (
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PMC8708099
Hyperactivity of the immune system in the gastrointestinal tract leads to the development of chronic, inflammation-associated disorders.
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PMC11513011
Since DIB inhibited the growth and invasion of high grade cancer cells, it is expected to have anti-tumor effects against malignant muscle-invasive bladder cancer.
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PMC10606998
The resulting short-range secondary radiation localizes the energy absorption near these elements and affects only the adjacent biological structures.
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PMC9412887
When DOX-PLGA/CPT/PD was treated at pH 6.5, the hydrolysis of amide in PD occurred, facilitating the elimination of electrostatic interaction between PLGA/CPT and PEI, ultimately resulting in the deshielding of PD to reveal DOX-PLGA/CPT and transformation of the charge from −24 to +19.2 mV (Figure 2b).
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PMC11739484
P*-value < 0.05.
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PMC10988808
G Survival curves using the GEPIA database are shown for OS.
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PMC9429973
In ZUMA-2, a 93% objective response rate (ORR; 67% complete response [CR] rate) was reported with KTE-X19 in pts with R/R MCL (median follow-up: 12.3 mo; 60 efficacy-evaluable pts; Wang et al. N Engl J Med.
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PMC7917457
A549 cells were infected with VALO-D102 at a MOI of 10.
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PMC11464609
d Illustration of case #4 with progressive multifocal leukoencephalopathy (PML) due to JC virus (JCPyV) infection.
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PMC11323699
Fig. 2a and Suppl.
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PMC11352746
Neuronal cell cultures can be categorized into different types based on their sources and applications, but for the purpose of this paper, only three types will be discussed: primary, immortalized/cancer, and stem cell derived cultures.
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PMC11367939
E COS7 cells were triple transfected with mRFP-Rab5 Q79L, ATG9A-EGFP, and synaptophysin-HA.
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PMC7090062
P < 0.01, ***P < 0.001 vs. IM.
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PMC11306331
We further tested whether light-induced dissolution behaved stoichiometrically – that is, whether cells with higher 3xFUS expression required proportionally higher MBP expression to drive dissolution.
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PMC10454535
Similar to our results, a study by Schmeel et al. showed PIC to have greater cytotoxic effects in RPMI 8226 versus U266 cells , while Sun et al. observed similar RES efficacy in RPMI 8226 and U266 cells .
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PMC9429973
Low level of protein S is associated with prolonged positivity, unfavourable evolution and hiperinflamation.
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PMC9429973
Similarly, AFM28 induced depletion of leukemic cells in patient bone marrow samples, without lysis of CD34/CD123 cells, suggesting sparing of healthy hematopoietic progenitors.
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PMC10411253
The data published before 2017 are from Picard 2017.
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PMC11365983
Meningeal expression of the core Hh signaling components Gli1, Gli3 and Sufu was dysregulated, with comparable dysregulation of Pdgfrα signaling evident from significantly altered Pdgfrα and phosphorylated Pdgfrα expression.
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PMC11549062
The bilateral common carotid arteries were harvested and stored in 4% paraformaldehyde for histological staining and immunohistochemistry.
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PMC11536589
The IC50 of MRTX1133 treated for 72 h in MRTX1133-resistant PDAC cells. (
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PMC11612794
To test this hypothesis, we generated a Dsn1 construct lacking the basic motif (aa 93–114; Dsn1) and introduced it into the endogenous Dsn1 locus of CENP-C cells (Figures 4B, S1D, and S5A).
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PMC11755467
HIV-1HBX2 virus stock was generated by transfection of 293T cells with the HIV-1 full-length plasmid pHXB2, kindly provided by Dr. Marek Fischer, University of Zurich, Switzerland.
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PMC11024707
At the same time, there was a positive correlation between mi-RNA-28 2 value and item 11 of CARS “Verbal Communication” in the ASD group (p = 0.035).
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PMC10936243
The current study used a mixed methods approach of two phases, to investigate the barriers Malaysian veterinarians face in seeking to provide good cat care in practice.
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PMC11535726
Kirschsteiniothelialongirostrata displays solitary, acrogenous, cylindrical, obpyriform to obclavate, rostrate, smooth, straight or curved and guttulate conidia that are paler towards the apex, consisting of 6–18 septa, slightly constricted and darker at the septa, with a mucilaginous sheath surrounding the tail-like upper part of the apex.
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PMC11732628
no. 12465-1-AP; 1:600; Proteintech), activating transcription factor 3 (ATF3) (cat.
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PMC10798140
It is a critical requirement that anticancer medications are able to selectively decrease cancer growth while not causing damage to normal cells.
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PMC11747949
PBMCs were isolated using Ficoll‐ Paque PREMIUM (#17‐5442‐02, GE Healthcare) according to manufacturer protocol.
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PMC11684269
Briefly, JHU083 inhibits glutamine metabolism in CD4 and CD8 T cells, thus alleviating AKI.
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PMC9646302
All primer sequences are listed in Table S2 in the Supplementary Material.
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PMC9429973
Results: N/A Summary/Conclusion: N/A E. Vaneeva, A. Turubanova, M. Sarpova, D. Dyakonov, V. Rosin, S. Samarina ФГБУН КНИИГиПК ФМБА России, ФГБУН КНИИГиПК ФМБА России, Kirov, Russia Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin’s lymphoma.
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PMC10243817
We overexpressed β-glucuronidase (GUSB) encoding β-glucuronidase as a non-MEX protein control, to eliminate the influence of stress upon forcing cells to overexpress a protein under the CMV promotor of pcDNA.
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PMC10669128
Significantly decreased proliferation and angiogenesis inhibition characterized all the xenografts treated with the TKRi pazopanib .
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PMC11545737
S. paratyphi, which express FepE , or S. typhimurium mutants overexpressing FepE are weaker inductors of pyroptosis compared to wild-type S. typhimurium strain .
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PMC11679892
When the control and P. sidoides group cells were compared, the TAS value was 0.3455 mMOL Trolox Equiv./L for the control group, while it was 0.2915 mMOL Trolox Equiv./L in the P. sidoides dose group cells.
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PMC10907726
Consequently, EGFR/AKT/mTOR inhibitors have attracted considerable attention in cancer research.
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PMC11792888
Scorpion venom is a rich, highly complex, and heterogeneous source of biomolecules, including small-molecule peptides and enzymes such as hyaluronidase and phospholipase.
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PMC8873393
Scale bar = 50 μm.
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PMC11085211
An analogous preparation of FR2 was followed for its subfractions in the biological assays.
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PMC11628904
We find that microbial colonisation of viable zone 2 tissue, analogous to the zone of stasis in humans, is significantly greater in larvae that exhibit increased epithelial damage resulting from keratinocyte migration.
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PMC10329074
Finally, ImageJ software was used to analyze the optical density value of the bands.
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PMC10522430
The use of Annexin V-FITC allowed for the detection of early apoptosis, as it can identify phospholipid phosphatidylserine (PS) exposed on the outer plasma membrane.
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PMC9429973
Patients symptomatology consisted mostly in dyspnea and peripheral edema (54%), with a mean duration of 12 ± 4 months.
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PMC11484188
It is primarily controlled by the ATG gene family and signaling pathways, including the mTOR and AMPK signaling pathway, liver Kinase B1), ULK1 (Unc-51-Like Kinase 1) and Beclin1(29).
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PMC9429973
Results: 64% of the MOMENTUM pts had BL PLT of ≤150 x 10/L. Of this subset, 60 (74%) of 81 MMB pts and 25 (58%) of 43 DAN pts completed the 24-week randomized treatment (RT) phase.
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PMC11186948
As the variant was predicted to be likely pathogenetic and to affect the sequence of nuclear localization signal, we performed immunocytochemistry and lysates fractionation, observing a nuclear mis-localization of HDAC2 compared to HD LCLs.
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PMC11470999
CIP2A stabilizes c‐Myc by inhibiting PP2A activity, thereby activating a series of pathways that promote cancer progression.
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PMC9351137
Moreover, both BAF53a and Tip60 interacted with MRG15 and α-tubulin.
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PMC9429973
However, the predominance of gram positive bacteria had also increased in later past years.
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