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OTAR3088
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PMC10788478
Univariate and multivariate analysis of overall survival in patients with lung adenocarcinoma.
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PMC9512971
The vertical axes show the cumulative percentages of patients.
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PMC2193049
Cells were labeled for 90 min at 37°C in the presence of 200 μCi of [S]Express (New England Nuclear).
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PMC5417661
From the SI, graphs were plotted using GraphPadPrism 5.0 (GraphPad Software Inc., San Diego CA, USA) and IC50-values for each cell type and compound were determined from the curves.
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PMC11025866
The number of cellular genes whose expression is altered by VPM was much lower than the number regulated by VPA (Table 2).
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PMC9429973
Of the 12 pts who were marrow NGS MRD+ at 10 after Cycle 12, 4/12 had an MRD recurrence in blood in follow-up vs. 1/26 who were NGS MRD negative/indeterminate (p = 0.02).
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PMC11488203
Effects of taxol substance between 0.1 nM and 10 nM as a reference confirmed that the amount of applied MSC-derived taxol exosomes confer a comparable cytotoxicity like a 1 nM to 10 nM taxol treatment (Fig. 6C).
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PMC8567602
A, Optical densitometry–quantified glycerol gradients of SS18–SSX and SMARCB1 in two human synovial sarcoma cell lines, as well as tumors from fusion-only and combination genotype mice.
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PMC11495567
Monolayers of NCI-H23 cells were seeded onto an 8-well μ slide plate (ibidi) and treated with the indicated concentrations of NSL-YHJ-2-27 and NSL-YHJ-2-46.
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PMC11754094
The indicated genes (LIG IV, POLQ and RAD52) represent the NHEJ, TMEJ and SSA pathways, respectively.
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PMC8658661
Available experiments do not allow the whole picture of the proteome and metabolome to be seen .
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PMC11665584
The CCL3-CCR1/5 signaling axis is known to promote the recruitment of granulocytes, including neutrophils, to the skin (49).
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PMC11680391
In other areas of veterinary medicine, successful communication has been linked to quality (Abood (2008), Churchill and Ward (2016)) ; therefore, we associated the agreement in perceived communication with the actual BTSCC on a farm.
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PMC11045125
Other advantages of the new model are the ability to compare the phenotypes of in vivo tumors with and without Myc, and to examine how LMP1 is regulated by Myc in the absence of EBNA2 expression.
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PMC11377827
Representative of three biological replicates.
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PMC11543885
Upon Nigericin treatment (activated NLRP3), NLRP3-APEX2 oligomerizes to form puncta close to the nucleus, with corresponding specks formed by the biotinylated proteins.
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PMC8973725
Monoclonal anti-ZNF677 antibody (ab155075, 1:100, Abcam) was used for IHC.
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PMC9429973
In conclusion, vaccination is strongly recommended to all CLL patients.
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PMC11683130
Serpins are abundant in skin and play an important role in maintaining skin homeostasis.
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PMC9884169
A p value < 0.05 was considered statistically significant (p < 0.05, p < 0.01, p < 0.001, and p < 0.0001).
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PMC10831439
Interestingly, a slight release of granzyme A and granulysin was observed when CD19-CAR-iNKT cells were challenged with K562-WT cells, which could explain the ‘background’ cytotoxicity observed in this setting.
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PMC7452526
In the other hand, the other concentrations (5 μgmL and 10 μgmL) significantly inhibit the cell growth by more than 50% and 70% after 48h and 72h exposure time respectively.
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PMC10898159
Conversely, KIT can expedite the expression of SH3BP2 and MITF, demonstrating a positive feedback loop that exists in these molecules .
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PMC11538390
This study included 309,154 participants from DF7 as the discovery cohort and 200,100 participants from DF8 through DF12 in the replication cohort.
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PMC10094992
The real-time reverse transcription-PCR was performed using the double-stranded DNA-binding dye SYBR Green PCR Master Mix (Fermentas-Thermo Scientific, Burlington, ON, Canada) on an ABI GeneAmp 7000 Sequence Detection System machine, as described by the manufacturer.
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PMC11549612
This investigation unveiled a few important drugs with the capabilities to reduce the mRNA expressions of BOLA genes (Table 1). -
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PMC11721064
To further assess the transdifferentiation state of KPCs following induction with LN-KS and LN-SH, we examined the expression of CK12, PAX6, and ΔNP63α.
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PMC11615743
The absence of any of these sequences did not trigger an HCR (Figure S17, Supporting Information).
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PMC11126803
E, in A498 cells, VM formation was significantly increased when ERβ was overexpressed, but this process could be effectively reversed by sh-ZEB1.
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PMC9504875
TRIM25 was targeted by NS1 of influenza A virus (IAV) .
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PMC9454178
Taken together, our results highlight elevated CDK7 expression as a predictor of poor outcome in GIST and present the combination of CDK7 and RTK inhibitors as a potent therapeutic strategy to improve the efficacy of GIST treatment.
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PMC11201245
The OC cell lines as positive controls exceed this value at 38%, 67%, and 54%.
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PMC11791264
Summarized data of LC3B half-life are shown (D), and representative immunoblot images of LC3B levels are indicated (E).
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PMC10589262
On the other hand, the levels of phospho-AKT and phospho-ERK were minimally affected by BFA treatment in CC cells, whereas KIT was retained in the ER (Supplementary Fig. S6A).
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PMC9966931
According to the Clarkson’s toxicity criterion , plant extracts and natural compounds can be considered non-toxic when treatments have LC50 values above 1000 µg/mL, whereas LC50 between 1000–500 µg/mL are lowly toxic and treatments with LC50 100–500 µg/mL and 100–0 µg/mL are moderately and highly toxic, respectively.
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PMC9325715
Instead, at pH 4.5 the formation of iron phosphate precipitate has occurred which disturbs both the UV–Vis and ICP-MS analysis of the process.
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PMC11741577
Mouse back skin samples were fixed with 4% formaldehyde, paraffin-embedded, sectioned at a 5 μM thickness, placed on slides, and stained using hematoxylin and eosin (H&E).
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PMC11707832
Nonetheless, these adverse effects were fully reversible upon treatment cessation.
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PMC10747160
While Wild-Type Griffithsin has been tested as a potential antiviral against COVID-19, oxidation has been found to occur at Methionine 78 (Figure 1A–C), which complicates its status as a viable therapeutic for use in humans since the Food and Drug Administration requires a thorough assessment of post-translational modifications on protein-based therapeutics .
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PMC11737091
Whether DBF4 is involved in the progression of ccRCC is a question that warrants further investigation.
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PMC11583010
Excess quenched cysteine-reactive linker exatecan compound and other reaction components were removed by ultrafiltration/diafiltration of the ADC with 10 volumes of 20 mmol/L histidine, pH 6.0.
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PMC11442172
Nevertheless, it remains to be determined whether the nutrient concentrations observed in murine TIF are comparable to those in human tumors.
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PMC11001582
a,b, Representative confocal images of immunofluorescence staining showing colocalization between neuronal marker NeuN (yellow) and HA-tag (red) in (GR)400 mouse brain cortex (a) and lumbar spinal cord ventral horn (b) at 6 months of age, n = 5 mice per genotype.
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PMC9503669
Addition of Nef inhibitors to a regimen of LRAs and therapeutic vaccines may enhance reduction of the latent reservoir to effect a functional cure.
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PMC10723784
Both CBD and CBG increased the caspase 3/7 activity in both carcinoma cells in dose‐dependent manner at 24 h contact time (Figure 7).
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PMC11779993
The DPPH solution (0.1 mM in methanol) was mixed with SPEE for 30 min in the dark and the absorbance was read at 517 nm using a Synergy microplate reader (Bio-tex, VT, USA).
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PMC6337547
Salvianolic acid A protects against acute hepatic injury induced by concanavalin A (ConA) in mice.
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PMC11126803
Differences were considered statistically significant when the p value was less than 0.05 (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).
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PMC11740508
We predict that clinical benefit of such a drug combination will more likely be apparent in patients with DNA repair defective tumors, and suggest to focus clinical exploration of this drug combination in these patients, with the goals of enhancing tumor cell death at minimal toxicities and avoidance of long term sequelae.
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PMC9429973
However, the m7G modification pattern of multiple myeloma (MM) is still unclear.
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PMC11721295
Inhibition of KRAS with MRTX was equivalent in both lines, as tested by surrogate phosphorylation of ERK1/2 (Supplemental Figure 5D).
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PMC9503541
In starting a new project in MS-DIAL, soft ionization was chosen, and chromatography for the separation type.
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PMC11706776
Quantitative Polymerase Chain Reaction was performed using SYBR Select Master Mix (ThermoFischer) and the primers listed in Table 1.Table 1Primers used for qPCR experiments.
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PMC8978939
On the other hand, VBC complex formation itself does not ensure its functionality, as it must recognize HIF-α subunits in order to target them for proteasomal degradation.
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PMC11615828
The intensity of Spike protein in the region 3 µm inward from the cell periphery was measured by Nikon NIS element software.
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PMC9622879
Subsequently, in the real-time stage, each building participated in a transactive market to maximize the profits.
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PMC9784246
Herein, in our screening of local plants in the KSA to discover anticancer and anti-L. major drugs, C. macrocarpa leaf extract exhibited potent antineoplastic activity confirmed by the in vitro evaluation of the extract and its fractions against the A549 lung cancer cell line.
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PMC11412752
Protein sample was separated by SDS-PAGE electrophoresis and then transferred to polyvinylidene difluoride (PVDF) membranes.
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PMC9261184
All studies assess the life cycle GHG emissions associated with exporting LNG to different locations and included the LNG shipping transport as one part of the supply chain.
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PMC11696576
A full list of genes where mutations were associated with sensitivity to AVX420 can be found in Table S3.
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PMC2614416
Alkylation was then carried out by incubating the mixture for 45 minutes in a darkroom.
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PMC9325715
The present study has shown that changes in electrophoretic mobility of Fe-bLTF were observed in the case when non-reducing SDS-PAGE was utilized.
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PMC11638764
Further analysis of the compartment-specific effects revealed significant variations in both upregulated and downregulated proteins across the cellular compartments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "analysis", "of", "the"...
PMC10040136
CCK-8 assay showed that recombinant TGF-β2 increased the survival of GIST cells under IM treatment, and silencing of the TGF-β receptor and PI3K-AKT inhibitor antagonized this effect (E).
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PMC9884169
Reactive oxygen species (ROS) assay, lipid ROS assay, lipid peroxidation assay (MDA), and transmission electron microscopy were performed to assess the level of lipid peroxidation in 5637 cells.
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PMC11622247
Under these conditions, only a small fraction of the cells will receive probes.
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PMC11348300
However, unequal tissue distribution of the two dyes can lead to inaccurate data acquisition, making this approach unsuitable for ratiometric sensing.
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PMC9964635
By introducing some electron-withdrawing substitutions and comparing them to electron-donating group substitutions, we reported structure–activity relationships for the phenyl group.
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PMC11694066
Indeed, DSRCT is an ultrarare disease (frequency < 1/1 million), and cell line models are challenging to create, probably because the desmoplastic microenvironment of this tumor type also favors cancer cell growth.
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PMC11011837
The MMC consists of 1 mL of IS diluted 1:10 in MeOH, 10 mL of MeOH, 11 mL of MTBE, and 11 mL of CHCl3.
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PMC11506827
After serum deprivation, the cells were treated with various GEF concentrations or DMSO (control) for 12 h. Subsequently, they were exposed to different TRAIL/Apo2L concentrations (PeproTech, Cranbury, NJ, USA) for another 12 h. Cell viability was assessed with 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1) assay using the EZ-cytox kit (Dogen, Seoul, Republic of Korea); the absorbance was measured at 450 nm with a reference wavelength of 600 nm using a SpectraMax M2e microplate reader (Molecular Devices, San Diego, CA, USA).
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PMC11301095
The patient was confirmed with pediatric primary amebic meningoencephalitis.
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PMC11594806
The use of CD73-specific inhibitors did not reduce MMP-2 production, but CD73 neutralizing antibodies did lead to decreased MMP-2 levels, suggesting that CD73 influences MMP-2 production through a non-enzymatic mechanism.
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PMC10898159
In addition to mRNA's role in producing antigens or therapeutic proteins, different types of RNA have a variety of functions and play important regulatory roles in cells and tissues.
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PMC9874064
Therefore, inhibition of DNA damage response pathways (TLS and FA) by targeting USP1 improves the sensitivity of tumor cells to cisplatin.
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PMC9429973
Results from the phase 3 OPTIMISMM trial (NCT01734928) demonstrated that pomalidomide (P) in combination with bortezomib + dexamethasone (Vd) significantly improved progression-free survival (PFS) in lenalidomide (LEN)–pretreated pts with relapsed/refractory MM (RRMM) vs Vd, irrespective of age and Eastern Cooperative Oncology Group performance status (ECOG PS).
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PMC9143157
Progression-free survival (PFS) for the PLD-C was statistically superior to the TC arm (HR, 0.821; p = 0.005), where the median PFS was 11.3 months versus 9.4 months, respectively.
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PMC11190538
NB: All yogurt variants were fermented with L. rhamnosus KU985435, C: control without C-PC, T1: treatment with 150 mg free C-PC, T2: treatment with 300 mg free C-PC, T3: treatment with 150 mg C-PC nanophytosomes (at molar ratio 1:2), T4: treatment with 300 mg C-PC nanophytosomes (at molar ratio 1:2).
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PMC11047729
Enzyme expression was found in germ cells and self-renewing tissues, such as the intestinal epithelium, the ovary, and hematopoietic stem cells .
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PMC11675244
Next, the protein is polyubiquitinated by the ubiquitin ligase complex and subsequently degraded by the 26S proteasome .
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PMC8540611
Figure 3 gives a summary of the results for the optima cellular uptake.
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PMC9429973
SCD patients actively campaigned to raise awareness of the disease, whilst also expressing the physical and emotional impact that SCD had on their lives.
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PMC11543885
DMEM complete medium (500 mL)ReagentFinal concentrationAmountDulbecco’s Modified Eagle Medium (DMEM)N/A440 mLFetal bovine serum (FBS)10%50 mL100× GlutaMAX Supplement2 mM5 mL100× Penicillin/Streptomycin1%5 mLTotalN/A500 mL CRITICAL: Store at 4°C for up to 1 month.
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PMC10213179
To ensure specificity of the aptamers, a double counter-selection step was used during the cell-internalization SELEX process.
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PMC11119602
The uptake of cisplatin caused the majority of sensitive HepG2 cells (90%) to undergo apoptosis, with a small proportion of cells surviving cisplatin cytotoxicity and acquiring resistance to the drug.
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PMC11291490
n = 3).
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PMC11454362
H. Hosseini: None.
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PMC9429973
Aims: We wanted to investigate if MRK-560 would show synergy with currently used chemotherapeutic drugs, such as dexamethasone, vincristine and doxorubicin, and if it could be safely combined with chemotherapy for treating T-ALL patients.
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PMC11055323
SS, SS18-SSX1 The dramatic co-localization of H3K27ac, H2AK119ub (a gene silencing marker by PRC1 ), and SS18-SSX, but not SS18, highlights extensive remodeling of chromatin when HDACs are excluded.
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PMC10589262
The slides were incubated overnight at 4 °C with primary antibodies against KIT (Cell Signaling Technology), calnexin (Cell Signaling Technology), GM130 (Cell Signaling Technology), mannosidase II (Abcam), Golgin-97 (Cell Signaling Technology), HA (Cell Signaling Technology), BLZF1 (Novus Biologicals), LAMP1 (Cell Signaling Technology), and ATF6 (Abcam).
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PMC11763111
B Schematics of the genome editing approach design.
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PMC7757104
In response to OPNc knockdown, the viability of drug-resistant ovarian cancer cells decreased, resulting in higher sensitivity to CDDP and Dox exposure compared with that of the control cells.
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PMC8609870
a Showed the relationship between downregulated lncRNAs and upregulated miRNAs.
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PMC11489351
These findings support prior data showing low pHi upregulates the expression of CCND1 in mouse fibroblasts (20).
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PMC11476106
All PDX73 clusters showed similar cell morphology regardless of culture time or scaffold composition (2/3 weeks of culture and without/with added VN).
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PMC11792740
Increased complexity in treatment protocols. -
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PMC9352806
Except for lipolysis, LDs can also be accessed by lipophagy, a specific subset of selective autophagy that catabolizes the components of LDs.
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PMC11787355
To dehydrate the slides, they were then serially immersed in 50%, 70% and 100% EtOH at RT.
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PMC9429973
In contrast, ONO7161 and anti-E-selectin had little effect.
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PMC9429973
OS was significantly improved with CAR-T as compared to SOC, HR 0.77, [95% confidence interval (CI) 0.60-0.98, 865 patients, 3 trials] (figure 1).
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