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OTAR3088
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PMC9429973
The trial population includes adults aged ≥18 y with r/r MM who failed ≥3 different prior lines of therapy, including an IMiD, a PI, and an anti-CD38 mAb, and who have measurable disease at enrollment per International Myeloma Working Group (IMWG) criteria.
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PMC11697189
Calculated the risk score for each sample in the cohort by the formula:, here xi represents the expression of each prognostic gene, coef represents the coefficient value, and k represents the amount of the prognostic gene.
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PMC11594806
Furthermore, 6-gingerol significantly increases the number of cells arrested in the sub-G1 phase of the cell cycle and activates caspase cascades, affecting the cellular levels of Bcl2 and Bax through AMPK activation.
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PMC8557138
It is important to mention here that despite the fascinating prospects, a lot of optimizations for bioprinting parameters such as concentration of the hydrogel, rheology of the bioink, extrusion pressure, and speed and cellular viability limits the progress of this field.
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PMC9429973
Therapeutic targeting of LSCs has been hindered by the controversy surrounding their phenotypic characterisation.
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PMC7519871
Up-regulation of pro-apoptotic effector proteins may contribute to overcome the resistance to cisplatin because in many resistant cases, up-regulation of anti-apoptotic and suppression of pro-apoptotic proteins has been observed.17 Mitogens activated protein kinases (MAPKs) are another class of proteins regulating gene expression in response to extracellular stimuli (stress activated SAPK/JNK and extracellular signal regulated kinases (ERKs).
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PMC11320834
The present study was designed to develop topotecan- and olaparib-loaded liposomes (TLL and OLL) and assess the effectiveness of their combination in patient-derived ovarian cancer samples.
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PMC11021472
Knockdown of circZDHHC11 had a strong negative effect on growth in ST486 and more moderate effects in DG75, BL41 and CA46 (Fig. 2).
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PMC11509309
These preliminary screenings particularly highlighted the interest of sponges.
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PMC9599726
Ferroptosis, a cell death driven by iron-dependent phospholipid peroxidation, is an emerging therapeutic approach in cancers.
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PMC11224020
The success of immune responses largely relies on the motility of immune cells that constantly circulate between peripheral tissues and/or lymphoid organs.
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PMC11402217
D–F) DKK1 and β-catenin IHC staining in OS tissue.
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PMC11534377
BCL3, linked with NF-κB signaling, had a marked change in expression levels (P = 0.0007), which may be indicative of altered cell survival pathways.
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PMC11767725
Postbiotics are bioactive compounds produced during the fermentation process by probiotic microorganisms.
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PMC9429973
Proteomic analysis was performed by mass spectrometry (LC-MS/MS).
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PMC4695073
Patients with T3-4 classification had significantly lower 5-year survival rates than those with T1-2 classification (OS, 67.7% vs. 83.3%; PFS, 65.7% vs. 76.7%); and 5-year survival rates were significantly lower in patients with N2-3 classification than those with N0-1 classification (OS, 64.6% vs. 78.1%; PFS, 58.5% vs. 78.1%).
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PMC11632064
Taken together, these analyses show that mitochondrial signatures are associated with distinct responses to RSK and PLK1 inhibitors (Fig 7J) and that targeting specific mitochondrial proteins is a valid approach to fine-tune the sensitivity of melanoma cells to PLK1 inhibition.
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PMC11704834
Total RNA was extracted from 5x10 cultured cells using the Qiagen RNeasy miniprep kit (Qiagen Sciences, Inc.) as prescribed by the manufacturer and the quantified by spectrophotometry (NanoDrop 8000; Thermo Fisher Scientific, Inc.).
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PMC11621493
Although total DAG and TAG levels were unchanged in KO cells, we observed the accumulation of saturated and monounsaturated subspecies, indicating that PLA2G4D deficiency moderately affects acylglycerol metabolism in keratinocytes under the applied conditions.
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PMC11615743
Because of these properties, L‐DNA and L‐RNA have been utilized in drug assembly, data storage, aptamer selection, and intracellular enzyme activity analysis.
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PMC11672617
The utilization of methodologies for the staining of cytochrome c within the mitochondria in intact cells without rupture, followed by detection via flow cytometry, enables the most accurate detection of cytochrome c within the cell and the quantification of the percentage of cells exhibiting reduced or absent cytochrome c content within their mitochondria .
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PMC11489351
The transfected MCF10A cells were then treated with EIPA (low pHi), NH4Cl (high pHi), or left untreated (control) for 24 h before Notch reporter activity was assessed in single cells using confocal microscopy (Fig. 4B).
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PMC11337594
However, overexpression of other upregulated genes identified in the RNA-seq results did not elicit this phenomenon.
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PMC11640555
Here, we aimed to investigate the ability of CX-4945, CK2 inhibitor, to counteract tumor aggressiveness, as well as to restore the homeostasis of the blood-brain barrier (BBB) and of tight junctions, through its antiproliferative activity.
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PMC10798140
The cell pellets were then stained with annexin V/PI according to the manufacturer's instructions (Invitrogen, Waltham, MA, USA).
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PMC11731161
This paradoxical finding suggests that ASB8 alone cannot sufficiently explain the variability in patient sensitivity to SEL, indicating that other mechanisms may also be involved.
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PMC10734950
The cells were plated with the compound itself, a solvent control (dimethyl sulfide; 1% DMSO; Millipore Sigma, St. Louis, MO USA), a positive control 1 mM hydrogen peroxide (H202; Millipore Sigma, St. Louis, MO USA), and untreated cells for reference.
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PMC11471157
Regions of DFP not covered by cells were also noted.
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PMC6222635
Based on our observation, the external properties of this medicinal plant planted in the wild and cultivated in the greenhouse are different.
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PMC11473843
We found that knockdown of ERK5 and CDK5 synergize in suppressing cancer cell proliferation and induce apoptosis of A549 cells only when combined, confirming a role of ERK5 and CDK5 in promoting the proliferation and survival of NSCLC cells (Fig. 2H,I).
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PMC11391695
In conclusion, our research identifies novel molecular mechanisms involving cytoplasmic and nuclear ACYP2 that inhibit the progression of HCC.
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PMC11754094
CRISPRi-stable cells were infected with a lentiviral library.
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PMC9429973
Patients with these variants rarely achieve durable remission or prolonged clinical outcomes with currently available chemotherapies and targeted therapies.
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PMC11534377
We explored 5-AZA alone and in combination with IR, depicting the effect on in vitro and in vivo models, indicating that 5-AZA may induce substantial changes in the epigenetic profile of NSCLC cells, leading to gene alterations that can enhance therapy.
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PMC11525028
Total proteins were separated by 10% SDS-PAGE using a 10% polyacrylamide gel (EpiZyme, China) and transferred to a PVDF membrane (Millipore, USA).
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PMC10142392
The synergistic effect of Dox and p53 plasmid DNA showed better cytotoxic efficacy against human hepatoma and human cervical adenocarcinoma cell lines compared to their single-agent counterparts.
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PMC5673955
Protein in samples was measured using the Bradford protein assay (Pierce Biotechnology, Rockford, IL).
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PMC9429973
Seventeen (36%) patients harbored high-risk (HR) cytogenetic, including t(4;14) (n = 8) or del17p (n = 10).
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PMC11748335
While the observations in the liver cancer cell line HepG2 do not support our conclusion , they do not contradict it either, as some cell lines in our study exhibit similar behavior.
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PMC8956657
5MERS ORF 4b protein localizes to the nucleus while mutations at the IMPα interface impair nuclear import efficiency.
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PMC10808409
This comes in agreement with a study carried by who found that FA treatment of HCT-116 cells with different concentrations for 48 h decreased the S phase compared to vehicle-treated cells.
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PMC11779960
The second most abundant TCRβ clonotype accounted for median frequencies of 4.1%, 0.8%, 11.8% and 0.1% in AITL, CTCL, PTCL, and TPLL, respectively (Fig. 2a).
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PMC9436459
Dehydroprenyl-2-arylbenzofuran type (Type A) MDAAs with 57 compounds were widely distributed in 14 species of three genera (Morus, Sorocea, and Chlorophora), belonging to the richest class on MDAAs, followed by dehydroprenylflavone type (Type D) MDAAs with 22 structures distribution in 13 species of three genera (Morus, Artocarpus, and Brosimopsis) and dehydroprenylstilbene type (Type B) MDAAs with 19 compounds distribution in ten species of three genera (Morus, Sorocea, and Chlorophora) (Table 1).
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PMC11615218
In CAR-T therapy, similar power of the TCR repertoire in predicting therapeutic responses and prognosis is observed in CAR-negative T cells [140–142].
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PMC8735881
In our previous studies, we also demonstrated that the CD4i epitope-specific domain antibody m36.4 when used as a GPI-anchored inhibitor was highly effective against both cell-free and cell-associated HIV-1 isolates .
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PMC9429973
Cell population shifts were also found.
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PMC11672617
Furthermore, LA and its derivatives have been demonstrated to possess a range of biological activities.
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PMC11750712
Transduced CAR cells were identified using CAR anti-idiotype antibody and secondary donkey anti-rabbit conjugated to PE (BioLegend).
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PMC10253553
Radiotherapy and alkylating drugs induce NDRG1 mRNA and protein in glioblastoma .
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PMC11040965
Cells were grown at 37 °C in a humidified atmosphere containing 5% CO2.
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PMC11747949
In the last step 3,3’,5,5’‐tetramethylbenzidine (TMB) substrate solution was added to each well.
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PMC11607321
Synthetically screened cancer cell lines revealed vulnerabilities consistent with genomic profiles, such as FLI1-EWSR1 fusion dependency.
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PMC10713411
TRIB3 was highly expressed in A498 cells and had a negative correlation with patients’ prognosis.
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PMC11129910
A total of 100 μg of protein was loaded onto a 10% SDS-PAGE gel and electrophoresed.
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PMC11464609
We thus conducted a proof-of-concept study to assess a viral nucleic acid enrichment protocol for FFPE specimens.
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PMC10213199
In Drosophila, the biological processes associated with this gene (CG13078) are currently unclear and there is no available phenotypic data.
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PMC7602170
PI3Ks are lipid kinases that phosphorylate the inositol ring 3-hydroxyl group in inositol phospholipid and hence produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3) .
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PMC9429973
Of those with watchful waiting, 27 experienced lymphoma progression and received chemotherapy.
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PMC9429973
According to 2011 census, in India, there is a large tribal community of about 180 million.
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PMC9388315
As shown in Figure 3(a), gene expression of HSF1 was significantly reduced at concentrations of 2.50 (P < 0.05) and 5 mg/ml (P < 0.001).
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PMC11397654
The highest ratio of CRT-positive cells was achieved when treating the cells with compound 36 (17.7% compared to 2.55% when treating the cells with PTX), and other derivatives provided a significant ratio as well (2.99% for 35, 2.96% for 38).
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PMC11218145
Cells were seeded in 13-mm glass coverslips and then transfected with cytosolic (cytAEQ) and mitochondrially targeted (mtAEQ) aequorin.
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PMC9429973
Known secondary alterations such as those involving chromosome 8 and deletion of 11q22 were found in 89% (8/9) and 67% (6/9) of cases, respectively.
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PMC11507371
Nrf2—the master regulator of oxidative stress responses—was first isolated and described in 1994 by Moi et al. as an activator of β-globin gene expression and is now recognised as the main activator of mechanisms that scavenge excessive ROS levels and restore redox homeostasis .
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PMC11673902
The main advantage of optical stretching is that it measures the mechanical properties of the cells without direct contact with the cells, and no radiation damage to the cells was observed throughout the process.
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PMC5673955
Relative amounts of proteins were determined by densitometry in GelAnalyzer 2010a (www.gelanalyzer.com).
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PMC9545714
Parameters of VISIA were obtained with using various VISIA modalities as elaborated below: Subject positioning was critical and had to be repeated at each time point.
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PMC11621565
The cytotoxicity and viability after treatment with rotenone, which was used as a positive control for the neuronal upregulation of α-synuclein, were also assessed (Fig. 2E).
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PMC11047729
Indole-3-carbinol (I3C) is a polyphenol responsible for the indirect inhibition of telomerase activity.
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PMC8382973
Representative chromatograms of 2P23 formulated in gel or in PBS.
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PMC11395280
HBEC-5i cells were seeded at 6.6 × 10 cells/mm in cDMEM:F-12 on 24-well transwell inserts (Corning 3472) that had been pre-coated with 10 µg/mL fibronectin (Sigma-Aldrich, FC010-10MG).
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PMC10729469
L3000001, Thermofisher, Waltham, MA) according to manufacturer’s instructions.
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PMC8540611
The approach using the analysis of FAM-positive cells is more interesting.
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PMC11291697
According to its biological function, dysregulation of IL-6 is implicated in various cognitive dysfunctions, and individuals with high concentrations of circulating IL-6 are at higher risk to develop global cognitive decline, schizophrenia, major depression, and bipolar disorder .
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PMC11700165
To compare the attributes conferred by the PH-TH domains of ITK and BTK, and the SAM-PNT domain of TEL-SYK in fusion kinases, constructs encoding ITK-SYK, BTK-SYK and TEL-SYK were co-expressed with the adapter protein SLP-76.
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PMC11026382
c Correlation between experimentally measured and computationally inferred log10(kcat/Km) values for 38 mutants of DHFR.
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PMC11650848
In relation to the primary mQTLs, an 8/10 would indicate that they are both highly likely to be regulatory variants and therefore both have a high probability of affecting gene expression.
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PMC11335267
Since reduced muscle mass can be associated with denervation or decreased neural input on the neuromuscular junction, we tested for the expression of genes known to be upregulated in response to denervation [32–34].
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PMC9429973
53 STAG2 mutations were identified in 25 patients (1 to 8 mutations per patient), mostly at low mutated cell fraction (median: 6%).
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PMC11626627
Proposed model for a feedback loop formation of the ERβ/circATP2B1/miR-204–3p/TWIST1 axis is involved in the regulation of EMT in ccRCC.
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PMC11734514
After a 24-hour treatment with the extract, PTEN expression (106 bp) decreased compared to the 0-hour expression (Figure 2A and E).
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PMC4369959
Similarly, shogaol targets NF-κB, STAT3, MAPK, PI3k/Akt Ca signals, COX-2, cyclin D1, survivin, cIAP-1, XIAP, Bcl-2, MMP-9, caspase activation, ER stress, and eIF2α.
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PMC11575040
A two-tailed p value lower than 0.05 was considered statistically significant.
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PMC11243198
Cells were cultured following the manufacturer’s instructions.
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PMC11627060
The UV light is activated, allowing for the visualization of DNA bands, and a photograph is captured using an orange filter.
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PMC11075223
Under certain conditions, such as pregnancy, the body may produce neovascularization and other conditions may lead to specific diseases, including cancer, rheumatoid arthritis, diabetic retinopathy .
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PMC11705547
PD-1 is primarily expressed on T cells, and its binding with PD-L1 suppresses T cell function and decreases cytokine production .
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PMC9429973
ChIP assay confirmed that CAT promoter harboring the T -but not C- allele was accessible to ETS-1 and GR-β, but not to the other analyzed TFs.
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PMC7841067
The expression of Shh, Smo, Ptc, and Gli-1 was measured by Western blot. (
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PMC3274243
Figure 5a shows the OCP profile for the human hepatocyte cell line, HepG2, and its response to camptothecin, a cytotoxic quinoline alkaloid that inhibits DNA topoisomerase I and induces apoptosis .
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PMC11733919
Considering that the supernatants contain the unbound Ab, the signal obtained in this assay will be inversely proportional to the amount of Ab attached to the MNPs (Figure 2d).
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PMC11674441
In brief, 96-well plates with nitrocellulose membranes (Millipore, Molshelm, France) were precoated with a primary anti-IFN-γ antibody and pretreated overnight at 4 °C with RPMI-1640 medium supplemented with 10% autologous serum.
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PMC11718817
For comparison of more than two groups, an ordinary one-way ANOVA followed by Tukey’s multiple comparisons was used, in which each group was compared to every other group.
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PMC9429973
Biopsies were checked against the agreed indications from the International Standards for Standardization in Hematology (ICSH) and their concluding diagnosis and aid to patient care assessed Results: 81 bone marrow biopsies were identified and assessed.
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PMC11673902
Cell swelling: electroporation temporarily disrupts the cell membrane, allowing water and small molecules to enter the cell, resulting in an increase in cell size.
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PMC11144200
Subsequently, the immunological complex specific to IFN-γ was subjected to streptavidin-AP processing, and it was observed in the BCIP/NBT substrate solution.
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PMC11489175
They represent a large family of proteins with around 100 members, mainly belonging to two subfamilies, i.e., the ubiquitin-specific peptidases/proteases and the Zn-dependent ones as well as pseudo-enzymes devoid of enzymatic function.
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PMC11470381
θ = angle perpendicular to the major axis, φ = angle (radians) subtended by the minor axis.
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PMC11247842
A QTL for CM and SCS at approximately 88–89 Mb on BTA6 (based on ARS_UCD1.2 assembly ) has been reported in many studies, including in Nordic dairy cattle breeds [18–23], in Nordic and Italian Holstein , US Holstein , German Holstein , Italian Valdostana Red Pied , and French Holstein and Montbéliarde cows .
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PMC10421378
These interactions between probiotics and ECM components provide additional anchorage and stability.
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