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OTAR3088
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BioData-CellLine_annotated

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PMC11345828
H NMR (400 MHz, CDCl3) δ 7.83 (d, J = 8.8 Hz, 1H), 7.49 (s, 1H), 7.37 (d, J = 8.8 Hz, 0.3H), 7.36 (d, J = 8.8 Hz, 0.7H), 6.84 (s, 0.3H), 6.80 (s, 0.7H), 6.61 (s, 1.4H), 6.59 (s, 0.6H), 4.95–4.92 (m, 1H), 4.42 (dd, J = 12.8, 4.0 Hz, 0.3H), 4.30–4.23 (m, 2H), 4.19 (dd, J = 13.6, 4.0 Hz, 0.7H), 4.12 (s, 1H), 4.08–3.97 (m, 6H), 3.95–3.89 (m, 1H), 3.87–3.79 (m, 2H), 3.55–3.50 (m, 1H), 3.43–3.30 (m, 2H), 2.94 (s, 1H), 2.92 (s, 2H), 2.55 (s, 1H), 2.52 (s, 2H), 2.35 (s, 3H), 3.21 (s, 6H), 2.20–2.15 (m, 3H), 2.10–2.03 (m, 1H), 1.39 (t, J = 7.2 Hz, 3H), 1.30 (d, J = 6.4 Hz, 2H), 1.19 (d, J = 6.4 Hz, 1H).
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PMC11610461
Therefore, PSENEN may affect cancer progression through oxidative phosphorylation.
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PMC11672617
Secondly, it allows for the synthesis of compounds with specified properties, namely, with antitumor pharmacophores.
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PMC8956657
Overall, there was clear overlap in the binding sites of MERS-CoV ORF4b and NF-κB on both IMPα2 and IMPα3 (Fig. 6C, D).
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PMC11657744
Data represent means ± SD from three independent experiments.
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PMC9429973
In 2021, IMWG proposed that revised the diagnostic criteria of PCL as CPCs ≥ 5% by peripheral blood (PB) smear.
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PMC11371627
The diagnosis of RLS has been made about 20 years ago.
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PMC11453018
Analysis of ChIP-Seq data revealed EWS::FLI1 binding in the regulatory elements of both LMNB1 and P15.
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PMC9429973
ctDNA sequencing could be an attractive, prospective measure for disease monitoring.
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PMC10452486
The first indication for the presence of B2m-free HCs of HLA-I on the cell surface emerged from the works of Krangel et al. in 1979.
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PMC11678368
A2780 cells were cultured in an RPMI + GLUTAMAX medium (GIBCO, Thermo Fisher Scientific, Waltham, MA, USA) with 10% fetal bovine serum (FBS) (HyClone, Cytiva, Marlborough, MA, USA).
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PMC11593084
The animal experiments aimed at establishing anti-PDPN mAbs were approved by the Animal Care and Use Committee of Tohoku University (approval no. 2016MdA-153).
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PMC11746948
We further analyzed the expression of genes associated with the ferroptosis signaling pathway, including glutathione synthesis, oxidative reduction regulation, lipid metabolism, and iron homeostasis.
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PMC11306331
We engineered a NIH3T3 mouse fibroblast cell line in which both the 3xFUS-FusionRed- FRB-iLID and MBP-SspB-iRFP constructs were stably expressed using lentiviral vectors (Fig. 1A).
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PMC9429973
A. Gómez-De León, A. Noyola-Pérez, L. Gil-Flores, E. Ramos-Barrera, E. Rojas-Guerrero, H. Martínez-Espinosa, V. Rodríguez-González, P. Colunga-Pedraza, L. Tarín-Arzaga, O. Cantú-Rodríguez, H. Gutiérrez-Aguirre, G. Ruíz-Argüelles, D. Gómez-Almaguer Hematology, Universidad Autónoma de Nuevo León; Instituto Tecnológico de Estudios Superiores de Monterrey, Monterrey; Centro de Hematología y Medicina Interna.
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PMC11306019
Long-term treatment revealed that repeatedly treating cells with BTZ at its ABC induced marked cytotoxicity by the 11th day.
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PMC5874706
With a suitable targeting moiety, the in vivo efficacy, distribution, and toxicity of this carrier system can be characterized and used to improve the CK2 inhibitory effect on animal tumor models.
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PMC11476666
To identify and characterize CSCs in the A549 lung adenocarcinoma cell line, SP cells were isolated by fluorescence-activated cell sorting (FACS) as previously described .
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PMC8662250
While on the contrary, SP caused a marked decrease of RhoA GTP (−30%, −55%, −84% vs. vehicle group, respectively) in the cytoplasmic cellular portion of Caco‐2 (Figure 2a–d).
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PMC8740518
Pathway analysis of the differential metabolites was performed with an online tool (https://www.metaboanalyst.ca/).
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PMC11320834
The OLL and TLL combination is a promising subject for further animal studies, especially for eliminating BRCA-wild-type EOC.
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PMC11394112
Prior to BLI imaging, mice were anesthetized using isoflurane and imaged after 10 min of D-Luciferin (1.5 mg/mouse, Perkin Elmer, Waltham, MA, USA) via intraperitoneal injection.
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PMC11240571
When ICP inhibitors, such as antibodies against PD-L1 and PD-1, “release the brakes” and are allowed to react to a specified antigen, PD-1 is unable to transmit PD-L1 signals, and an anti-tumor effect is exerted .
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PMC10197932
Finally, further study would be required to identify what other anti-apoptotic proteins and detoxifying enzymes might also contribute to lymphocyte survival after US -- treatment.
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PMC2944824
It is found in almost all neurons and in some white matter tracts .
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PMC11391695
Furthermore, it has been documented that ACYP2 polymorphisms are correlated with an increased susceptibility to a range of malignancies, such as gastrointestinal cancer, renal cell cancer, and squamous carcinoma of the larynx .
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PMC11128598
We have previously reported that treatment with NHEJi decreased cell proliferation in ovarian cancer cell lines (4).
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PMC10938336
Using the MTT cytotoxicity assay, we first identified the anticancer activity of the monocarbonyl curcuminoid derivatives and investigated their underlying anticancer activity in the HL-60 cell line.
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PMC11574029
T24 and 5637 cells transfected with sh-NC and sh-NOTCH3 were injected into the tail vein of nude mice to establish a lung metastasis model, observed 5 weeks later.
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PMC10728200
Fig. 6Subcutaneous tumor models of gastrointestinal stromal tumor (GIST) were established to analyze the synergy effect of Imatinib (IM) and RSL3.A GIST-T1 cells were subcutaneously transplanted into the dorsolateral side of nude mice.
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PMC11711127
Though it is ever important to refine definitions of tolerance states and mechanisms, we suggest also taking a step back to consider the wider shared feature of ‘resistance to activation’.
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PMC11470381
B. The cell ROIs across time frames (F0–F10) were fitted into an ellipse.
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PMC11597291
The nCGO-PEG/PCT particles exhibited sustained slow PCT release at pH 7.4 with no burst effect (Figure 4A).
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PMC11507371
Furthermore, it is crucial to recognise that while much emphasis has been placed on the study of ROS, RNS have also been demonstrated to be essential .
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PMC9429973
SYK also cooperates with internal tandem duplication (ITD)-mutated FMS-like tyrosine kinase 3 (FLT3) to drive leukemogenesis.
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PMC10996034
Therefore, in the present study, Taxol resistance-related gene targets in patients with EOC were selected to break through the reversal of drug resistance, promote the clinical efficacy of Taxol and ultimately improve the survival rate of patients with EOC.
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PMC10530622
Studies have indicated that suppressing hepatic LDHA expression via RNAi may have metabolic effects, including potential alterations to tricarboxylic acid (TCA) cycle metabolites .
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PMC11790971
The pipeline includes image preprocessing, cell segmentation, cell selection, feature extraction, feature engineering, and downstream analysis (Fig. S4).
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PMC11535726
Kirschsteiniothelialongirosrata (GZCC 23-0733, holotype) a unidentified submerged wood b colonies on natural substrate c, d conidiophores, conidiogenous cells e–g conidiophores, conidiogenous cells bearing conidia h–p conidia (red arrows indicate mucilaginous sheaths) q a germinated conidium; r Upper surface view of culture s lower surface view of culture.
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PMC9429973
Fourteen patients (43.7%) had risk organ involvement.
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PMC10747160
Alternatively, it could be possible that Griffithsin cross-linked SARS-CoV-2 pseudoviral particles to such an extent that the virions were able to be pelleted by centrifugation without the need to be captured by DC-SIGN-expressing cells.
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PMC11754436
Based on the aforementioned results, the key target genes were identified by analyzing the association between lncRNAs and target genes.
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PMC9822769
To assess the growth inhibition of the compounds under investigation, a cell viability test (i.e., the resazurin reduction assay) was used.
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PMC11655536
B Images of tumors of HA treatment groups and the control group.
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PMC11266100
Following this, 150 μL of 0.9% NaCl solution was added, and the samples were analyzed using flow cytometry.
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PMC10729469
Scale bar = 50 µm.
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PMC11015054
p < 0.05, **p < 0.01. ***
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PMC11248911
Calcd.
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PMC9429973
Peripheral CD34+ HSPCs were collected by apheresis after mobilization with G-CSF and plerixafor.
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PMC9780037
Second, the induction of cancer cell apoptosis has outstanding therapeutic potential .
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PMC11585565
Black time points represent the duration post-transfection (0–48 h), while blue time points indicate the intervals following treatment with actinomycin D or cycloheximide. (
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PMC11530949
The most identifiable ingredient is the primary synthesized (CuO and Ag) nanoparticle, according to a number of findings indicating that green synthesized CuO and Ag NPs have a spherical and nanoscale [31-33].
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PMC11585254
Membranes were washed three times with TBS-T at room temperature and then incubated with horse-radish peroxidase tagged antirabbit antibody (Vector Laboratories; PI-1000) at a dilution of 1:5000 in 5% milk/TBS-T for 30 minutes at room temperature.
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PMC11719944
A Spearman correlation analysis showed that there was a weak positive correlation between serum prolactin levels and %HbA1c (r = 0.3411, p = 0.038).
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PMC10093184
In osteosarcomas, MALAT1 is involved in proliferation and metastasis, vasculogenic mimicry, development and regulation of osteosarcoma stem cells, and drug resistance .
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PMC11612508
Conversely, exposure to a magnetic field significantly reduces cell viability compared to the untreated control group (P < 0.001 for 24 h and P < 0.0001 for 48 h) and also compared to the group not exposed to the magnetic field (P < 0.05 for 24 h and P < 0.01 for 48 h).
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PMC11724582
The (A) heatmap and (B) volcano map are shown.
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PMC11590005
However, it is important to note that skin colour has no biological meaning, and the observed differences can be physiological expressions of social injustice such as racism .
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PMC9429973
Especially proteins involved in cell cycle regulation exhibited reduced translation rates upon loss of LINC01547.
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PMC8711270
It was also reported that expression of the large T-antigen improved lentiviral vector production (Gama-Norton et al., 2011).
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PMC11539788
T24 and 5637 cells were cultured in McCoy’s 5a (Gibco, USA) and RPMI 1640 media (Gibco, USA), respectively.
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PMC11754432
5ALOX15B modulates cholesterol homoeostasis through EGFR/ERK.Gene expression analysis of cholesterol biosynthesis pathway enzymes in keratinocytes transfected with ALOX15B siRNA for 72 h (A) or treated with 2 µM 5 PD168393, 10 µM PD98059 or vehicle (DMSO) for 24 h. (D).
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PMC9429973
How the differences between these two clinically and biologically different subgroups are brought about in the context of the same MLL-AF9 genetic background is currently unknown.
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PMC11155445
According to Hirshfeld surface analysis, crystal packing of the molecule was due to the presence of intermolecular N–H⋯OC and N–H⋯SC hydrogen bonding in the molecules (Fig. 9).
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PMC4005030
Protocatechuic acid is its major chemical constituent.
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PMC9429973
No differences were observed in pre-ASCT quality of responses (89.2 vs 89.7% ≥VGPR; P=0.532).
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PMC11188874
Treatment of patient CD138 cells with HDAC6 inhibitors significantly promoted the antimyeloma activity of autologous CD8 T cells.
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PMC11411004
Using HDACis to increase productivity has shown variable success, and their effect on productivity may depend on the productivity of the clone itself (Yang et al. 2014; Backliwal et al. 2008).
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PMC6442998
For YAP quantification, the ratio between the cytoplasmic YAP mean fluorescence by the nuclear YAP mean fluorescence has been calculated.
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PMC11541409
Another clinical trial evaluated the long-term efficacy, tolerability and overall survival in patients with unresectable or metastatic PDGFRA D842V-mutant GIST treated with avapritinib (38 patients enrolled), results demonstrated that 300–400 mg/day achieved an ORR of 95%, with a complete response (CR) of 13% (5/38 patients) and partial response (PR) of 82% (31/38 patients), confirming the efficacy of avapritinib in targeting PDGFRA D842V-mutant GIST (regardless of prior therapy) .
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PMC11700165
In order to study this further, we cloned BTK-SYK, as the corresponding fusion protein for B cells and compared it with ITK-SYK.
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PMC11754436
The tumor size (Fig. 2B) and weight (Fig. 2C) were measured.
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PMC9096373
The differences in the SUVmax ratio among groups were calculated as: The 6 tumor-bearing mice in each group that underwent micro-PET/CT scanning were euthanized via cervical dislocation.
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PMC11755467
The effects of miRNA mimic transfections combined with Enoxacin treatment on HIV-1 replication were assessed.
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PMC11365427
GSH levels were detected by a GSH Assay Kit (Beyotime, Shanghai, China) according to the manufacturer's instructions.
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PMC9111184
After 24 ​h of being in contact with Caco-2 monolayer, the quantification of cholesterol on the basolateral compartment indicated that these compounds significantly decreased the permeation of cholesterol (Table 3).
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PMC11740207
Compared to VSELSCs, MIAMICs and LT-HSCs both exhibit higher expression of genes involved in immunoregulation, as well as low proliferative activity.
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PMC11739504
Scale bar: 20 μm.
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PMC9952933
At moderate concentrations, signal cascades such as mitogen-activated protein kinase, c-Jun N-terminal kinase, and vascular endothelial growth factor (VEGF) are stimulated.
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PMC6379402
Apart from this modification, SAFE is applied as originally demonstrated and adopting the default settings from Baryshnikova et al.. To assess the statistical significance of the numbers of functional domains that SAFE uncovers in a given iCell, we compare the number of functional domains that is found in an iCell to the one that is found in a random network.
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PMC11248911
Metastasis is a complex process which implicates angiogenesis, invasion and cell migration and is accountable for most tumor related deaths.
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PMC10734950
The positive control, H2O2, was diluted in 1 x phosphate-buffered saline (PBS).
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PMC7812570
A The expression levels of gp160, gp120, gp41, P24, and β-actin in HEK293T cells coexpressing GPI-m36.4 or GPI-FluIgG03 and NL4-3 (left panel) or THRO.c/2626 (right panel) were detected by Western blotting.
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PMC10551595
Validation of docking protocol. (
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PMC11283030
OAA is transformed into aspartate and nicotinamide adenine dinucleotide phosphate reduced form (NADPH).
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PMC11499381
Each column within a panel shows the same well and well position, all images within a panel are from the same independent experiment.
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PMC9429973
Globally approved BCL-2 inhibitor venetoclax has shown efficacies in certain hematologic malignancies (HMs) but requires weekly ramp-up to the target dose to mitigate the risk of tumor lysis syndrome (TLS).
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PMC5363531
Untreated MPM cells were highly motile, being MSTO cells able to repopulate the scratched area within eight hours, while REN and MPP89 cells repaired the wound within 24–30 hours.
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PMC9429973
A total of 206 patients’ blood samples have been collected to perform a DBS.
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PMC9822769
At the end of the treatment (72 h), viability was evaluated with 100 μg·mL resazurin (Acros Chemicals, France) in a fresh medium for 1 h at 37°C, and the amount of the reduced product, resorufin, was measured by fluorescence (excitation λ = 535 nm, emission λ = 595 nm) with a Tecan Infinite F200Pro plate reader (Tecan, Austria) .
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PMC11708541
Human African trypanosomiasis (sleeping sickness) is a parasitic infection that leads to death.
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PMC9429973
The 5-year and 10-year cumulative risk of VTE was 4.9% and 11.5%, respectively.
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PMC10047551
However, since these measures are weakly associated, this study highlights the need for further research before PD-L1 DNA methylation can be implemented as a biomarker and drug target for measures to improve the effectiveness of PD-1/PD-L1 immunotherapy in NSCLC.Programmed cell death protein 1 (PD-1) is a co-inhibitory surface receptor expressed on a wide range of immune cells, including antigen-stimulated T cells .
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PMC9429973
In the ESA-treated group, OS was poorer in those who had been transfused prior to commencing ESA (Fig 1b, p<0.001).
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PMC10218459
Differences were examined using an ANOVA test or t-test, as indicated in the figure captions.
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PMC11047729
Manisa propolis is a wax-like substance collected by honeybees.
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PMC11486946
Scale bar, 5 μm.
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PMC11773391
vMF increased the sensitivity of melanoma (MM) to TMZ in vitro and in vivo through downregulating MGMT and promoting the TMZ induced DNA damage in MM.
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PMC11401350
For ex vivo generation of CAR T cells LVs are pseudotyped with envelope glycoproteins (gps), which are not suited for in vivo gene therapy since they are not T cell specific and are quickly inactivated in vivo .
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PMC10761571
7 Cytotoxicity of Fe3O4@Glu-Gingerol on a) MRC-5 cell line, b) A549 cell line, c) Gingerol on A549 cancer cell line and d) Fe3O4 NPs on A549 cancer cell line.
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