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OTAR3088
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BioData-CellLine_annotated

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PMC11462673
Previous study of jurkat cells revealed that transcription factor of binding in the aberrant MYB-initiated enhancer complex interacts with the promoter region of LMO1, thus driving high levels of oncogene expression .
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PMC10006224
Resulting average fragment size is 300 bp from which 120 bp correspond to adapter sequences.
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PMC10809689
The most mRNA expression of GLS and GDH in this cell line was seen at 72 h post Gal-9 treatment compared to PMA and control group (mean = 228.33 ± 27.77, p = 0.001) and (mean = 2012.82 ± 13.02, p = 0.0001), respectively.
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PMC10631132
Data are shown as the means ± SD.
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PMC11551844
β-Sitosterol has shown great promise as an anti-cancer molecule, but its poor aqueous solubility and bioavailability coupled with low targeting efficacy limit its therapeutic efficacy.
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PMC11013014
2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(2-(3-(4 fluorophenyl)ureido)ethyl) acetamide (16b).
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PMC11719944
The serum was also separated by centrifugation and stored at −20 °C for the determination of cytokines.
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PMC7090062
Similar effects were observed on GIST-T1 cells (Fig. 2d).
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PMC9429973
Patients admitted on Mondays and Thursdays were selected as the experimental group, and patients admitted on other times were selected as the control group, with 50 patients in each group.
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PMC10818573
The sequences of the probes and labeled primers are listed below (Table 2).
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PMC10854447
In silico docking simulations were performed for the most potent antiproliferative compounds, 7h, 7i, 7j, 7k, and 7l, to study their molecular interaction with the epidermal growth factor receptor tyrosine kinase EGFR.
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PMC9429973
Higher-risk MDS (HR-MDS, IPSS-R > 3.5) and CMML patients were enrolled first; after a dose was deemed safe, lower-risk MDS (LR-MDS, IPSS-R 3.5, transfusion-dependent post/ineligible for ESA or severe neutropenia/thrombocytopenia) was evaluated.
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PMC11747467
We observed frequent CNV and mutations of ERBB2 in bladder cancer ( Supplementary Figure S6A ).
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PMC11756514
The bacteria were washed and fixed in 1% formaldehyde in PBS for 15 min.
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PMC11612626
Complexes were detected by native-PAGE and immunoblotting.
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PMC10094712
According to the presented results, it can be concluded that recombinant hSELENOM was able to reduce the proliferative activity of A-172 cancer cells in direct proportion to the increase in the concentrations of this protein in the nutrient medium.
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PMC11055510
Approximately 1 × 10 cells were added to a six-well plate, and the next day, the pipette tip was used to scratch parallel lines on the cell layer.
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PMC9646302
In the present study, we hypothesized that LAPTM5 regulates the MAPK pathway by interacting with RAC1.
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PMC11243198
Cells treated with 0.1% DMSO were used as a control.
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PMC10998613
The diffusion coefficients and fc values were consistent with a larger CXCR4 complex in MDA-MB-231 cells compared to simple dimerization in COS-7 cells (Fig. 2F).
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PMC11354225
Due to incubation with MAL, a precursor of the photosensitizer PpIX, carried out for 4 h, all assays with EGCG were carried out during that time.
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PMC11772585
Additionally, glucose consumption, ATP production, and lactate concentration all increased following ATF4 rescue (Fig. 6C–E).
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PMC11612794
These arginine residues of CENP-T and the acidic region of Nsl1 are highly conserved (Figures S4A and S4B).
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PMC11653168
The observed dose-dependent reduction in the viability of CCRF-CEM and Jurkat cells underscores the potent cytotoxic effects of Stattic against T-ALL cells.
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PMC9429973
I rarely eradicates measurable residual disease (MRD), whereas V (alone or with anti-CD20) can eradicate MRD permitting time limited therapy.
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PMC10547921
William Olson's team described the new glucocorticoid class.
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PMC7685376
Volcano map showing the down-regulated, up-regulated and unchanged proteins after Huaier treatment. (
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PMC9429973
Moreover, the cumulative incidence of nasopharyngeal swabs turned negative was significantly lower in patients treated with ICT (p 0.001).
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PMC9429973
with dialysis data).
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PMC11707832
Aberrations in glycosylation enzymes are linked to lysosomal storage disorders (LSDs), immune interactions, congenital disorders and tumour progression.
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PMC11066331
Expression was relatively quantified using TaqMan probes specific for TUSC3, Hs00185147_m1 and β2-microglobulin, Hs99999907_m1 (Applied Biosystems) as described elsewhere and expressed as expression fold change .
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PMC11078693
Images were acquired using a 107 nm pixel size, 200 nm Z step, 22 μm Z range, with 30 ms exposure time, and 100% power for 640 nm, 561 nm, 488 nm and 405 nm lasers, used with emission filters 700/75 nm, 600/50 nm, 525/50 nm, and 450/50 nm.
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PMC11731614
Notably, several annexins were differentially expressed, with annexin VII in fraction 2/3 of our immunoblots (Fig. 3F); annexins play a role in ESCRT-III mediated plasma membrane repair (Häger and Nylandsted, 2019, Creutz, 1992, Sønder, 2019, Williams et al., 2023) and wound healing (Häger and Nylandsted, 2019).
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PMC8524093
They found that NET release occurs through a TLR7- and ROS-dependent mechanism during CHIKV infection (Hiroki et al., 2020).
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PMC10142392
The competition between lignin nucleation and PCL-g-lignin intermolecular interactions determines the crystallization behavior of PCL-g-lignin.
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PMC11707577
Percentage of living cells (white), cells undergoing apoptosis (purple), and necrotic cells (dark grey), 3 and 24 h after PDT treatment with M13EGFR(TNP).
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PMC3931643
Luciferase reporter construct pRSTF-CVB3 containing the 5 ' NCR of the Coxsackie B3 virus .
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PMC9429973
Sleep apnea, defined as respiratory disturbance index (RDI) > 1 event/hour, was found in 18/30 (60%) of patients (14 males and 4 females).
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PMC7612475
SF3B1-associated xenografts are sensitive to etoposide and olaparib.
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PMC11597167
Moreover, synaptic dysfunction or cholinergic deficit, neuroinflammation, and dysregulated mitochondrial function have been recognized as prominent features of AD pathology .
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PMC11672142
-bound sTf plays vital functions of regulating Fe homeostasis and bioavailability in blood and delivering the metal to all cells in the body.
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PMC6034753
The ability of the N-terminal 140, 170 and the full length Meq constructs, but not the N-terminal 80 or the 130 constructs, to pull down apoptin indicated that the potential interaction of apoptin occurs between amino acids 130 and 140 of Meq (Figure 3C). (
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PMC11640419
Our previous research demonstrated that a shortened p53 ψ transcript is expressed in Jurkat cells in response to exposure to ionic compounds, with the level of an expressed protein exhibiting considerable variability .
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PMC11555465
The results indicated that T. gondii tachyzoite culture supernatant was able to alter the morphology of bladder cancer 5637 cells.
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PMC11172027
Most of them can be turned and metabolized into selenides and incorporated into Selene-proteins .
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PMC11564405
Within LUSC, a substantial positive correlation was observed between the expression of RILPL2 and CXCL9 (R = 0.203, P = 4.9e − 06), CXCL10 (R = 0.26, P = 4.03e − 09), CCL4 (R = 0.316, P = 6.1e − 13), CCL5 (R = 0.393, P = 2.2e − 16), CXCL16 (R = 0.297, P = 1.39e − 11), and CX3CL1 (R = 0.151, P = 0.000686) expression (Fig. 4).Fig.
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PMC7351993
The entire process is operated in a fully automated and real-time manner.
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PMC9822769
Taking into account that one million human female diploid nuclei contain 6.55 μg of DNA, the total amount of DNA-bound Pt per million cells was calculated by multiplying the experimental PDNA by 6.55 .
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PMC11413393
Cell cultures were monitored for mycoplasma infection (Universal Mycoplasma Detection Kit, Cedarlane #30-1012 K) and cell culture identity verification was done by short tandem repeat profiling (GenePrint® 10 System, Promega #B9510).
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PMC11765678
Data presented in Figure 2A,B shows that these inducers are indeed able to sensitize NCI/ADR-RES cells to ADR, albeit only slightly by ER without significantly affecting the parent OVCAR-8 cells.
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PMC11705067
The multivariate cox results suggested that only FDX (HR 1.479; 95% CI 1.023-2.140, P = 0.038) and DLAT (HR 2.001; 95% CI 1.373-2.917, P < 0.001) were identified as independent prognostic factors affecting OS in patients with ccRCC (Fig. 3J).
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PMC10174970
PAAD, pancreatic adenocarcinoma.
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PMC6461034
It is a highly connected, central node in the network.
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PMC8973085
Yellow solid [A] (92%); [B] (71%); mp: 250–253 °C (EtOH); IR (KBr, v, cm): 3473–3387 (NH2), 3304 (NH), 1659 (C=O), 1619 (C=O); H NMR (DMSO-d6): δ 2.30 (s, 3H, CH3), 2.49 (s, 3H, CH3), 2.60 (s, 3H, CH3), 6.36–7.40 (m, 10H, CH-Ar + NH2), 10.45 (bs, 1H, NH); C NMR (DMSO-d6): δ 20.60, 21.60, 53.10, 115.40, 119.30, 123.20, 126.10, 126.80, 127.50, 130.40, 131.20, 132.20, 135.20, 136.40, 157.30, 160.70, 163.40, 164.90, 165.50, 168.10; MS m/z (%): 433 [M] (7), 323 (9), 110 (98), 83 (100).
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PMC9080589
Similarly, PCDH8 protein was also significantly down-regulated in PTC tissues (Fig. 1B).
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PMC9739791
Rhodamine B is a widely used fluorescent dye that bears an internal photoswitch.
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PMC11746948
Previous studies have indicated that ferroptosis affects the metastatic spread of cancer cells.
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PMC11670954
Following treatment with Y-27632, the epithelial barrier function, along with the mRNA and protein expression and distribution of ZO-1 and Occludin were further normalized upon inhibition of the pathway.
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PMC9429973
A. Cellini, C. A. Cavarretta, S. Pravato, M. Pizzi, M. Gregianin, F. Crimì, F. Piazza, L. Trentin, A. Visentin Hematology and Clinical Immunology Unit, Department of Medicine; Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padua, Padua; Nuclear Medicine Unit, Veneto Institute of Oncology IOV-IRCCS, Castelfranco; Institute of Radiology, Department of Medicine, University of Padua, Padua, Italy Background:: Hodgkin’s Lymphoma (HL) has been commonly recognized as a chemo-sensitive and potentially curable neoplastic disease.
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PMC10852540
For this, the yellow tetrazolium MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) test solution prepared at the dose of 5 mg/mL was pipetted into all wells at a rate of 20 μL/well.
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PMC11277157
We attribute this observation to the role of these genes in membrane trafficking.
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PMC11633763
Moreover, scatter plots showed a strong positive correlation between USP22 and HK2 mRNA expression levels (Figure 4I).
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PMC9100622
A pharmacological screening of off-patent approved drugs (FDA agency) and the investigation of downstream targets of EGR2 were performed.
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PMC11754432
Treatment of psoriatic skin equivalents co-cultured with T cells with EPA was shown to reduce phosphorylation of both STAT1 and STAT3 along with p65.
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PMC11306331
Lenti-X cells were plated at approximately 30% confluency in a 6 well plate.
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PMC10631132
GMPs differentiate into granulocytes, monocytes, macrophages, dendritic cells, and OCs [65–70].
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PMC11766174
After incubation, the PBMCs were washed three times with cRPMI by centrifugation at 200× g for 5 min.
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PMC9812014
In most cases, influenza A (IAV) infects tracheal cells and as well the bronchial epithelial cells, causing localised cellular damage and inducing an acute inflammatory response within the host .
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PMC11471176
Moreover, Morsy et al. was consistent that carnosine has weaker potentiation effects for doxorubicin-induced cytotoxicity at the micromolar range in resistant cancer cells .
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PMC11759751
P < 0.05; **P < 0.01; ***P < 0.001 Then, we explored the interaction between chidamide and prepared CD19 CAR T cells.
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PMC11653533
Peduncles are broad as well as 4–6 cm tall with pubescent (Shilpakar, 2009).
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PMC11464609
In our cohort, 3/5 cases with JC polyomavirus infection showed high evidence of chromosomal integration, a phenomenon well known from the closely related BK polyomavirus but thus far unrecognized in the human brain.
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PMC3734024
B cells were incubated with anti-FasL blocking antibody or an isotype control antibody for 1 hour and washed with PBS prior to co-culture with CD4 T cells.
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PMC11549062
KY226 (inhibitor of PTP1B) was administered to ApoE mice with atherosclerosis to explore whether PTP1B deficiency decreases the level of atherosclerosis in vivo.
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PMC11543853
Fig. 1Rhinovirus 2 infection of a cell imaged using cryo-ET and cryo-EM.a Tomographic reconstruction of the cytoplasm of an infected cos-7 cell.
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PMC9429973
A marker of the cellular senescence is the shortening of the telomere length.
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PMC11644761
Several studies indicate that this cell cycle re-entry might represent an attempt to replace damaged neurons, with the accumulation of Neurofibrillary Tangles (NFTs) potentially reflecting the failure of neurons to repair the damage .
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PMC10854447
The docking protocol was validated by redocking the co-crystallised ligand with an S score of −10.73 kcal/mol with an RMSD value of 0.46 Å. Again, the trimethoxy compound 7l showed the highest negative score (−9.10 kcal/mol) among the tested compounds (Table 5).
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PMC11216402
We identify CN DNA alterations as genomic aberrations responsible for the dysregulation of these core TFs.
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PMC9878278
These data collectively show that viral RNA sensing pathways and IFN signaling are functional and are activated by ZIKV infection in SC.
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PMC11704135
The study revealed a spectrum of biological activities across the synthesized derivatives, with modifications often resulting in diminished bioactivity compared to the parent compound 1.
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PMC11188874
Error bars indicate the relative SD.
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PMC9429973
Standard of care therapy with systemic steroids is associated with broad and deleterious immunosuppression, and fails to achieve adequate disease control in a third of patients.
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PMC10605143
HSF1 is a long-lived protein with a half-life of approximately 14–20 h, which allows it to exert an immediate cytoprotective effect .
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PMC9429973
Q.-S. Huang, J. Xue, F.-Q. Liu, Q. Chen, G.-C. Zhang, X.-Y. Sun, C.-C. Wang, L.-P. Yang, Y.-Y. Li, Q.-F. Wang, J. Peng, M. Hou, X.-J. Huang, X.-H. Zhang Peking University People’s Hospital; National Clinical Research Center for Hematologic Disease; Chinese Academy of Sciences (CAS) Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, CAS, Beijing, China; China National Center for Bioinformation; University of Chinese Academy of Sciences, Beijing; Department of Hematology, Shangdong Key Laboratory of Immunochematology, and Shandong Provincial Clinical Medicine Research Center for Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation; Collaborative Innovation Center of Hematology, Beijing, China Background: Bone marrow physiological hypoxia plays a crucial role in haematopoietic stem cell homeostasis.
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PMC11377827
Schematic of the pooled DUB sgRNA library screen.
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PMC4277423
Using the prime pair CR1/2/3F2559 and CR1/2/3R3893, a total of 20 indels mutant were detected.
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PMC11591794
The ability of GA to upregulate P53, seen in our study, has been detected by other researchers on different cancer cells.
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PMC11739696
The integrity of mitochondrial membrane potential was analyzed in both untreated and Co3O4NPs-treated melanoma A-375 cells using the fluorescent Rhodamine-123 dye.
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PMC9429973
Blood count recovery was not delayed.
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PMC10729469
Our central hypothesis is that given the Aβ reactivity of engineered Tregs, those Tregs will migrate to and accumulate in amyloid rich brain regions.
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PMC11361748
Therefore, TAR is primarily regulated by the cytoplasmic pool of K17 in stressed epidermal keratinocytes.
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PMC11742231
Convolutional Neural networks (CNNs) are engineered to automatically capture and assimilate salient features from input data, effectively manage complex and high-dimensional data, possess the ability to withstand noise and variability, and incorporate the spatial relationships that exist between features.
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PMC5716223
e Representative images (×40) of L6C5 cells grown in DM medium for 9 days with and without NGF (20 ng/ml).
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PMC9429973
In these experiments, we observed a massively diminished lymphoma cell killing in the EµMyc Nr4a1-/- setting, when we used Ctla4+/+ OT-1 CD8+ T cells.
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PMC9429973
To our knowledge, this was the first case of AMSAN complicating COVID-19.
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PMC5673060
Heat map of proteins in network cluster based on the log2(PazR/A204) SILAC ratio. (
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PMC9895440
Therefore, we rested T cells+/− SNX9 KO at 6 days post electroporation, in fresh human serum medium and 10 U/ml IL2 overnight.
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PMC11087055
A-P and L-R; anterior-posterior and left-right body axes, respectively. (
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PMC10093184
Neither colonies nor cell clusters were found in COS3600 and COS4074 cells, despite a prolonged cultivation time of 56 days.
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