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OTAR3088
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BioData-CellLine_annotated

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PMC9164404
F In vitro anticancer activity of cisplatin, CisPt(IV) and Abplatin.
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PMC11678130
A dose–response study was performed to verify the reaction of A375 melanoma cells and HaCaT keratinocytes to a 24 h treatment with QUE, 5-FU, or the QUE + 5-FU combination.
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PMC11757230
All experiments used cADSCs at passages 2 to 3.
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PMC10203589
thus, the expression of FGF18 in ccRCC and tumor progression were inhibited jointly.
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PMC11127909
J EFHD1 mRNA and protein expression levels in 143B and cisplatin-resistant 143BR cells, N = 3.
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PMC9429973
For in vivo experiments, we used xenograft models by subcutaneous injection of human B lymphoma cell lines, and used λMYC mice as a model of endogenous B cell lymphoma (these mice harbor a mutant human MYC gene controlled by a reconstructed Igλ locus).
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PMC11615828
MAPTau was tagged with FRB, allowing the resulting protein to rapidly stall VOIs through a dimerization reaction (t 1/2 = 17.0 ± 2.2 s; Figure S8c,d and Video S8, Supporting Information).
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PMC11700523
p<0.01 vs. aldosterone 0.
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PMC9268620
The slide was flooded with methanol for 5 min, followed by Wright’s stain (Sigma, St. Louis, MO, USA) for 3 min, and subsequently, phosphate-buffered saline was added without washing off the stain.
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PMC4395774
In a viral infection such as LCMV, the CD8 T cell cytotoxic and IFN-γ responses are vigorous, and the potential for immune-mediated pathology is substantial.
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PMC8973725
The relative expression level of ZNF677 mRNA and protein in the ccRCC 786–0 cell line was clearly decreased compared with the immortalized human proximal tubular cell line HK-2 cells evaluated by qPCR and Western blot.
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PMC11806106
around the EC50 and applied increasing concentrations of naloxone.
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PMC11615828
Expression of EMTB‐CFP‐FRB in COS7 cells did not affect vesicular dynamics, as the comparable velocities of LAMP1‐mNeon‐FKBP labeled lysosomes, PCM1F2‐mNeon‐FKBP‐labeled centriolar satellites, and TGN38‐mNeon‐FKBP‐labeled post‐Golgi vesicles were observed in the presence and absence of EMTB‐FRB expression (Figure S1a–f, Supporting Information).
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PMC11536589
The intracellular GSH levels and MDA levels of cells treated with different reagents were measured using a commercial MDA assay kit (Solarbio Life Sciences, Beijing, China) and GSH assay kit (Beyotime Biotechnology, Shanghai, China), following the directions provided by the manufacturer.
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PMC9429973
However, it provides a complementary information on red cells rheological behavior characterized by a decreased deformability and dehydration L. Jorda, L. Montllor, E. Krisnevskaya, V. Leguizamón, I. Hernandez, J. L. Gelpi, J.-L. Vives Corrons Supercomputing Center, BSC, Barcelona; Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC); Hematology Department, ICO-Hospital Universitari Germans Trias i Pujol, Badalona; Dept.
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PMC9429973
Magrolimab (Hu5F9-G4) is an antibody blocking CD47, a “don’t eat me” signal on cancer cells, resulting in tumor phagocytosis by macrophages.
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PMC11323699
Notably, albeit based on a limited sample size, a trend emerged wherein the highest levels of circulating TSP-1 were found in patients with CD47 tumors at diagnosis (Fig. 4c), those tumors also showing the least response to NACT in terms of lymphocyte immune response (see Fig. 3).
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PMC11495567
Furthermore, the observed decrease in the levels of RAC1 and CDC42 and the inhibitory effect on the migration and invasion of cells upon treatment with the PCAIs underline the potential of these compounds as anticancer therapeutic agents.
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PMC7759933
Three independent experiments were performed (N = 3).
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PMC11407042
Set the wavelength to 490 nm or 492 nm.
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PMC11751675
Concerning the structure activity relationships (SAR), the observed biological effect of SLs are attributed mainly to the α-methylene-γ-lactone group in their structures.
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PMC9429973
Methods: We applied RNA Next Generation Sequencing to find JAK2 fusion genes in a cohort of high risk BCP-ALL pediatric patients.
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PMC11286266
The approach involves a unique sgRNA/Cas9 sequence targeting the cgROSA26 locus (Gaidukov et al., 2018) and a landing pad donor plasmid containing homology arms (LHA and RHA) flanking a minigene encoding the promoter region of the cgBiP fused with the superfolder green fluorescent protein (sfGFP) to create a BiP::sfGFP reporter to monitor ATF6α activity in cells. (
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PMC11264242
Previous clinical studies indicated that HDAC inhibition alone is not enough to fully block synovial sarcoma growth and metastasis (Cassier et al., 2013; Chu et al., 2015).
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PMC7762347
DNA damage responsive genes CDKN1A (2.44-fold and 2.47-fold, respectively) and GADD45A (3.16-fold and 3.06-fold, respectively) were significantly up-regulated by CYN and CYN/MCLR combination, respectively.
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PMC11706297
These outcomes highlighted that the 4-bromophenyl and 4-trifluoromethylphenyl substitutions on the thiazole core increased the antilung cancer effects of pyrazoline–thiazole hybrids as observed in BTT-5 and BTT-8, respectively.
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PMC11155445
From metabolic studies, compound (110) was found more stable in mice, dogs, human liver microsomes and human plasma (Fig. 46).
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PMC9429973
These deaths were not related to eculizumab.
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PMC11777207
Whole bone marrow from femurs and tibias of mice were isolated and RBC lysed.
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PMC11240448
In previous work we showed that cSTAR can accurately detect cell states and devise precise interventions to convert undesired into desired cell states .
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PMC11473750
Collectively, this data highlighted an important link between RNF121 ploidy and MYCN amplification levels.
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PMC11791478
In contrast, tumor growth was observed 2 weeks after the second dose of 25A3–vedotin.
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PMC9429973
27% of patients had an average follow-up time of 4 months.
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PMC10823017
We hypothesized that PKC-ι plays a central role in multiple converging and bifurcating pathways, and that it controls the stability of c-Myc overexpression, which is a master regulator of oncogenic signaling.
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PMC11656657
L The graph shows the modulation of the distribution of CD4 + and CD8 + subpopulations of CAR.GD2 T-cells before (day 0) and after RD tumor cell addition at day + 5, + 10, + 15 and + 20.
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PMC7348793
In contrast to other available mtDNA sequences from Chlorocebus aethiops, the mtDNA of the COS-7 cell line was found to contain a variable number of perfect copies of a 108 bp unit tandemly repeated in the control region.
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PMC7171147
To identify major pathways that might contribute to COL11A1-mediated cisplatin resistance, we performed IPA on the proteins that were significantly upregulated in A2780cis cells.
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PMC11680578
Fig. 4Effect of paclitaxel (PTX) and rosiglitazone (RGZ) on the nuclear fragmentation of SKOV-3 ovarian cancer cells. (
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PMC9429973
Median (range) age for avapritinib and BAT patients was 68 (31−88) and 69 (21−88) years, and 59% versus 66% of patients were male, respectively.
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PMC9000591
In the present research, the expansion of mantle cell lymphoma (Mino) and myeloma (U266 and KMS11) cell lines was significantly reduced by fractional extracts from C. speciosa roots, which presented lower IC50 values ranging from 0.08 to 0.38 mg/mL (Table 3).
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PMC9964635
HRMS (ESI+): m/z calculated for [(C23H27ClN4OS)+H]: 444.1672; found: 444.1697 (Figure S30).
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PMC9621239
The siRNA (10 pmol) of MYC or the control was transfected into Huh 7 cells and Bel-7404 cells in a 6-well dish respectively. (
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PMC9599726
Our in vitro data are in line with the results of Morishita et al. , who reported that a depletion in GSH was required for VP cytotoxicity in acute lymphoblastic leukemia patient-derived xenografts.
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PMC11774112
Additional modifications to the carrier system may be necessary to improve stability and delivery efficiency in more complex biological environments.
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PMC11471157
Since the DFP we produced was fabricated in our laboratory, we were unable to ensure uniform quality.
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PMC11615101
The 2-fold increased concentration of α-Taxilin in RA patients compared to OA and SLE patients revealed that α-Taxilin is specifically upregulated by 2.22-fold, 3.566-fold, and 2.36-fold in RA compared to other inflammatory diseases such as OA, SLE, and HC, respectively.
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PMC11779605
The observed upregulation of multiple inflammatory pathways in the ascites compared to the tumor specimens is consistent with the large number of immune cells in ascites.
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PMC9019892
In addition, to test the inhibitory activity of nintedanib in cells with KIT wt and mutant proteins, we used an ADP‐Glo biochemical assay (Fig. 1D, Table S3).
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PMC9429973
The main risk factor for mortality was patient age, with 8-week mortality in age groups <60yr, 60-69yr, 70-79yr, 80-89yr and 90+yr being 2%, 26%, 30%, 51% and 86% respectively.
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PMC11200978
Secondly, these studies were conducted using adherent cell monolayers.
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PMC4277423
Seven days after the transduction, cells were stained with anti-CCR5 or isotype control antibody followed by FACS analysis.
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PMC11791432
Clusters of cells were further annotated, dividing cells into glioblastoma cells, immune cells, and normal cells (Fig. 5C).
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PMC9960565
H-NMR (400 MHz, D2O) [ppm]: δ= 2.59 (Hc + Hi +Ho + Hu, m 159H), 2.66 (HҰ, m, 145H), 3.05 (Ha + Hg + Hm + Hs, 64H), 3.26 (Hy, 73H), 3.40 (Hz + Hb, Hh, Hn, Ht, m, 253H), 3.59 (Hf + Hl + Hr, 36H), and 3.69 (Hx, 64H).
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PMC11714165
It also allows for integrating additional targeting ligands and therapeutic peptide payloads to prepare peptide therapeutics to combat a variety of diseases in the future.
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PMC11461833
The upregulated (A) or downregulated (B) DEGs in HA-progerin-expressing HEK293 cells overexpressing STXBP5 (relative to those overexpressing the empty vector) were identified through KEGG analysis.
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PMC11564322
In the MEG-A2 cell line, the VGVAPG and VVGPGA peptides and the c-SRC inhibitor I decreased the ERK1/2 protein expression by 24.28, 25.40, and 41.50%, respectively, compared to the control (Fig. 8F).
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PMC11758416
Alterations to ratio: While 10:1 is the optimal ratio; we have successfully performed this assay with 5:1 and 2:1 effector cell: target L cell ratios.
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PMC11271278
The rest of the cell lines were grown in RPMI media supplemented with 10% FBS.
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PMC11765988
A proteomic analysis comparing the DEPs in vitreoretinal lymphoma (VRL) with those in sarcoidosis and controls identified 1594 proteins in the vitreous humor of the samples.
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PMC6889484
One possible reason for the high genetic barrier is that the G-to-A hypermutation induced by A3G is a lethal “all-or-nothing” phenomenon.
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PMC10728200
Tissue microarray (TMA) containing 418 paraffin-embedded primary GIST surgical samples resected at our hospital between January 2014 and January 2021 with Institutional Review Board approval were constructed.
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PMC7229095
In this study, we demonstrate rich chemically defined media for Chinese hamster ovary (CHO) cells that are suitable as basal media both for cell line development and for final production of culture process.
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PMC8777939
Experiments were performed in triplicate for each group.
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PMC9429973
J. Meilstrup, C. Leitch, M. Kriegbaum, V. Andresen, B. T. Gjertsen, K. Wennerberg Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; Centre of Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen; KinN Therapeutics AS; Department for Medicine, Haematology Section, Haukeland University Hospital, Bergen, Norway Background: Acute myeloid leukemia (AML) is a disease driven by leukemia-initiating cells (LIC) that resemble early myeloid progenitors.
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PMC7612475
Data points represent fork speed from four independent experiments, with median fork speed for each condition indicated (red line).
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PMC9429973
The simulation incorporates experimentally-measured Bcl-2 expression profiles, generating a set of virtual DLBCL cell lines.
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PMC11700247
Our results emphasize the pathway's essential function in orchestrating a robust immune response and enhancing the therapeutic effects of the combined treatment.
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PMC11540664
The patients were divided into high and low groups based on the median absolute count of peripheral lymphocytes before systemic therapy and differences in overall survival (OS) and progression-free survival (PFS) between TKI and TKI+PD1 were compared between the two groups.
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PMC11279397
Additionally, it reduced interleukin (IL)-4 and IFN (interferon)-γ levels in serum while enhancing antioxidant activity in lung tissue .
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PMC11461874
Protein ubiquitination is mediated by three key enzymes; E1 (a ubiquitin-activating enzyme), E2 (a ubiquitin-conjugating enzyme) and E3 (a ubiquitin-protein ligase).
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PMC11013014
Absorption spectra were captured using a UV-1800 Shimadzu spectrophotometer (Shimadzu, Kyoto, Japan), while fluorescence measurements were conducted with a Horiba Scientific Fluoromax-4 spectrofluorometer (Horiba Scientific, Piscataway, NJ, USA).
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PMC11612626
Lysates were mixed with the antibody resin, incubated overnight at 4°C with gentle rotation, centrifuged at 800 × g for 5 minutes, washed with lysis buffer, washed with buffer 2 (20 mmol/L Tris-HCl, and 400 mmol/L NaCl, pH 8.0), washed with buffer 3 (20 mmol/L Tris-HCl, and 150 mmol/L NaCl, pH 8.0), and washed with buffer 4 (20 mmol/L Tris-HCl, pH 8.0).
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PMC11467800
This plasticity is a major contributing factor to the heterogeneity and complexity of tumours and a predominant prerequisites of metastasis.
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PMC11742670
Figure 1 represents an example of SMILES representation of Vidarabine.
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PMC11697189
Meanwhile, we also verified that HSPA7 promoted the proliferation, invasion and metastasis of ccRCC cells in vitro.
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PMC9429973
The genotyping of the SNP of HDAC3 (rs2530223) was conducted by the time-of-flight mass spectrometry system.
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PMC11066331
Before pre-processing of mass spectra, the low-quality spectra were identified by semi-automatic screening implemented in the MALDIrppa package.
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PMC10452486
KIRD may have long (KIRDL) or short (KIRDS) cytoplasmic tails and they perform a variety of roles in immune homeostasis.
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PMC9848491
The Kaplan Meier method and sequential inspection analysis of low-risk and high-risk group of patients with OS.
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PMC11724582
To validate our hypothesis, we assessed the level of YAP/TAZ expression in cancer cells treated with CAF-CM and observed a significant reduction in YAP/TAZ protein levels compared with those in cells treated with NC-CM (Fig. 6A).
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PMC9429973
The conditioning chemotherapy was melphalan alone in 46 patients (90.2%), a combination of melphalan and another drug in 4 patients (7.8%) and cyclophosphamide alone in 1 patient (2.0%).
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PMC6684588
Wild-type mice were given unilateral injections of ACE-083 (100 µg) in the TA muscle twice weekly for 4 weeks.
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PMC11269933
The solvent model employed was TIP3P, and appropriate counterions were added to neutralize the system.
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PMC11739670
Resultant pMHCIs were purified by anion exchange and size exclusion chromatography and biotinylated using BirA ligase (Avidity).
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PMC11770746
50.5 mg of the lipid was dissolved in 2 mL of methanol and transferred to a 10 mL round-bottom flask.
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PMC10976516
Increased necrotic effect on tumor cells but not on non-tumor cells and PBMCs.
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PMC11544122
No. CCL-1) were from American Type Culture Collection.
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PMC11055323
Additionally, the H3K27ac sites are more localized at 5’UTR and distal intergenic regions upon SS18-SSX expression (Supplementary Fig. 11d).Fig.
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PMC11585587
MM.1 S cells, MM.1R cells which is the steroid-based resistant strain of MM1S, and RPMI 8226 cells were purchased from the American Type Culture Collection (ATCC) and cryopreserved in a liquid nitrogen tank in the laboratory.
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PMC11761919
Briefly, 1 g of inulin (5000 Da, ≥99%, Sinopharm, Shanghai, China) was added to 5 mL of dimethyl formamide (DMF) (73.09 Da, ≥99.5%, Sangon Biotech, Shanghai, China).
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PMC9509578
Their findings indicated the inhibition of cell proliferation, disturbed angiogenesis and suppressed migration of cells in hypoxic conditions along with tumor growth inhibition in PC3 xenograft mice without elicitation of any immune reaction.
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PMC8751435
They were composed of trophism, neoadjuvant component, cytotoxic component, and cancer deterioration promoter as described as follows.
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PMC11206502
In the negative control, a lower level of basal autophagy was registered.
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PMC11699042
Preprocessed single nucleotide polymorphism array (Affymetrix SNP 6.0) derived CN analysis data from the Cancer Cell Line Encyclopedia (CCLE) for A-673, and MCF-7 wild-type cell lines were retrieved from DepMap portal.
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PMC11661024
Therefore, the findings of this research disclose that the antiproliferative consequence of postbiotics against HeLa cells was mainly via apoptosis induction.
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PMC9370419
Estradiol may mediate its anti-HBV function through the Estrogen receptor-α (ER-α) signaling pathway as it does in HIV replication , or through activation of the E3 ubiquitination pathway by estradiol benzoate which may contribute to a decrease in HBV-related protein .
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PMC10571053
The ability of some FINs to inhibit P-gp and ABCG2 suggests potential drug-drug interactions.
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PMC11763764
This observation again supports that the downregulation of SORL1 made cancer cells more vulnerable to carboplatin treatment.
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PMC9429973
Global protein synthesis was tested using a Click-iT OPP and proteasome function was evaluated by Proteasome 20S activity NS hallmarks were analyzed by confocal microscopy evaluating Ncl, NS sensor marker.
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PMC11489175
In keeping with this evidence, USP1 plays a pro-survival role dependent on EMT and stem cell state 80 as well as on the interaction with the microtubule-associated serine/threonine kinase 1 (MAST1) that extends MAST1 half-life by preventing K48-linked polyubiquitination and promotes MEK1 activation 128.
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