OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	We hypothesize that persistent antibody-producing plasma cells can be the source of the treatment failure in some ITP patients and treatment that directly targets plasma cells may overcome resistance to treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094712	XBP1 also promotes the removal of proteins with irreversibly disrupted conformations from the ER .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XBP1", "also", "promotes", "the", "removal", "of", "proteins", "...
PMC11367146	CytoHubba, a plugin of Cytoscape, was used to filter topologically important genes based on their ranking methods, i.e degree, maximal clique centrality (MCC) and maximum neighbourhood component (MNC) score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806	CDDP resistance has also been studied in ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CDDP", "resistance", "has", "also", "been", "studied", "in", "ovarian", "cancer", "." ] } ]
PMC11470999	Molecular glues are monovalent molecules without linkers, mediating protein dimerization through the formation of a ternary complex (target‐molecular glue‐E3 ligase). ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11590005	These programmes are crucial to increase the opportunities of low-income groups, which consist mainly of non-whites, to have access to higher education.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10798140	Under all treatment conditions, there was a noticeable increase in the number of cells in the G0G1 phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "all", "treatment", "cond...
PMC11190538	Finally, 1 ml of the filtrate was injected into HPLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "1", "ml", "of", "the", "filtrate", "was", "injected", "into", "...
PMC10936243	Consequently, some veterinarians did not give their cat patients bedding or a litter tray.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "some", "veterinarians", "did", "not", ...
PMC11787355	ACT on s.c.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "ACT", "on", "s.c", "." ] } ]
PMC11078693	Note: The imaging parameters used were as follows: samples were mounted in PBS on a 63× NA1.2 water immersion lens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ...
PMC9429973	However, a fraction of patients still encounters disease recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "fraction", "of", "patients", "still", "encounters", "disease", "recurrence"...
PMC11637276	Cassettes were then rinsed with sterile ice-cold water (Gibco).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cassettes", "were", "then", "rinsed", "with", "sterile", "ice-cold", "water", "(", "G...
PMC10887351	Moreover, TRK-380 showed minor or no activity for human β1- and β2-ARs and, as with mirabegron, it might cause less cardiovascular effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Results: A total of 5,874 patients with severe SCD were identified [mean (SD) age: 20.5 (6.0) years, 54.4% female, 87% African Americans].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Nested PCR showed full-length amplicon in untreated cells, whereas no full-length amplicon was seen in the RNP-treated cells (Figure 7c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nested"...
PMC3730428	Although treatment with SMC in the presence of TNFα promoted interaction between caspase 8 and the necrosis-promoting RIPK1, the cell death induced by combined treatment with SAHA and SMC was apoptotic and mediated by caspase 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516447	The superscript indicates the KRAS mutation for each cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "superscript", "indicates", "the", "KRAS", "mutation", "for", "each", "cell", "line", ...
PMC9429973	80%, spec.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "80", "%", ",", "spec", "." ] } ]
PMC9429973	Patients’ data will be entered in the clinical database after all necessary local approvals from Ethics Committees and following the patient’s signed informed consent, if applicable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	Regarding the occurrence of DNA lesions (500 T-T lesions per 10 normal bases) , hypothetically, shorter genes contain less or no lesions than longer genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	C1-C11 esterification.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "C1-C11", "esterification", "." ] } ]
PMC11082662	SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B; qRT-PCR, quantitative real-time polymerase chain reaction; CCK-8, cell count kit-8; OD, optical density.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11787355	Collectively, the results confirm that PTPRZ1 is highly expressed in malignant brain tumor cells, most abundantly in GSCs, and that AC-like cells and GSCs are primarily targeted by PTPRZ1 TCR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	Fig. 2Basic performance of the RIACS.a SRS spectra of PS and PMMA particles obtained by an SRS microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2Basic", "performance", "of", ...
PMC9672323	317,302) and anti-CD28 (0.085 μg/mL, Biolegend, clone CD28.2, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "317,302", ")", "and", "anti-CD28", "(", "0.085", "μg/mL", ",", ...
PMC9429973	For a better accuracy of classification algorithms, a discretization was set on the quantitative dimensions (CD148, CD180 and CD200 MFI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9622879	The maximum charging rate and maximum discharging rate of the ESS at each home are the same, and kW. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "maximum", "charging",...
PMC6468656	Total cellular RNA was extracted by TRIzol reagent (Invitrogen, Carlsbad, CA, USA) in accordance with the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11789597	Gln, glutamine; Glu, glutamate, Cys, cysteine; Gly, glycine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gln", ",", "glutamine", ";", "Glu", ",", "glutamate", ...
PMC7039683	Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves using the gkmSVM trained on zGPAEs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Receiver", "Operating", "Characteristic", "(...
PMC11394386	Similarly, the synergy of Wnt inhibitors directed against PORCN protein (ETC-159) and PI3K inhibitors (GDC-0941) has been observed in in vitro and in vivo models of pancreatic cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	This experiment was repeated 3 times with similar results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "experiment", "was", "repeated", "3", "times", "with", "similar", "results", "." ] } ]
PMC9429973	Methods: All patients who received inpatient care between 2004 and 2013 for an initial diagnosis of DLBLC in NHID were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC9429973	Patients classified as ETV6-RUNX1-like (n=21) were characterised by multiples abnormalities of ETV6, including rearrangements (n=17) and/or deletion (n=12) as well as rearrangements (n=7) and/or deletions (n=6) of IKZF1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	A, Changes in nonfasting blood glucose levels of Ins1 NOG mice after porcine pancreatic islet transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "Changes", "in", "nonfasting", "bl...
PMC11721277	In system A, Tc-labeled HYNIC-Chl and the reduced hydrolyzed technetium colloid (RHT, [Tc]TcO2) stayed at the application point (Rf = 0.0), whereas free forms of radionuclide ions and Tc-labeled complexes with tricine and EDDA migrate with the solvent front (Rf = 0.8–1.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11441402	Additionally, the whole well is analyzed, ensuring that all cells are accounted for in assessing viability status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "whole...
PMC11265931	This emphasizes the potential of garlic exosome-like nanovesicles as promising options for advanced and targeted anticancer treatments without negative side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "emphasizes", ...
PMC9429973	In which, the most frequent grade <=2 AEs were hemorrhage(18.2% all grade 1), rash(9.1%), hyperglycemia (13.6%), infection(9.1%), nausea and vomiting (9.1%), hypogammaglobulinemia(4.5%), neutropenia(9.1%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	These studies support the idea that sophocarpine is capable of reducing endothelial cell injury and maintaining vessel integrity and therefore may be used to treat atherosclerosis or vessel dysfunction after balloon angioplasty.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	Statistically significant difference, with p < 0.05, is observed only at 1250 V/cm between CTRL and EP group of 15 generation in experiment 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11589157	After trimming the low-quality reads and adaptor sequences, 143.4 Gb of PacBio HiFi data were obtained (~49X coverage).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "trimming", ...
PMC9429973	Since KIT mutations do not fully explain the pathophysiology of the disease, we sought to identify other mutations that could act synergistically with KIT D816V to induce the disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A transient reduction of lymphocytes was observed in all patients and recovered in about one month with CD7-negative.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "transient", "reduction", "of", "l...
PMC11621493	All primers are listed in supplemental Table S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "primers", "are", "listed", "in", "supplemental", "Table", "S3", "." ] } ]
PMC11706491	Outliers are depicted as dots. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Outliers", "are", "depicted", "as", "dots", ".", "(" ] } ]
PMC11769516	STG consists of a xanthone nucleus attached to a bisfuran structure (Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STG", "consists", "of", "a", "xanthone", "nucleus", "attached", ...
PMC11742231	By identifying unexpected sensitivities, the model can propose existing drugs as candidates for new therapeutic applications, accelerating the development of effective cancer treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6379402	Fig. 4Kaplan–Meier survival curve analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "4Kaplan", "–", "Meier", "survival", "curve", "analysis", "." ] } ]
PMC5363531	According to the approach reported in the Material and Method section, the best-fit estimate of the IC50 for PEM, when combined with dasatinib, was 5 μM in REN cells, 1 μM in MPP89 cells and 0.5 μM in MSTO cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627060	DNA is taken out of a homogenate of lysed cells and electrophoresed on an agarose gel in this experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "is", "taken", "out", ...
PMC11665555	Briefly, virus was added to 5637 cells in suspension at different ratios including an uninfected control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "virus", "was", "added", ...
PMC11476222	Additionally, our findings confirmed that ganglioside diversity is more influenced by the glycan head group than by the ceramide moiety, as previously reported .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11615828	After washing away unbound Transferrin‐594, cells were then incubated in serum‐containing medium at 37 °C for 30 min and fixed by incubation with paraformaldehyde (Electron Microscopy Sciences) diluted in PBS at room temperature for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	By multivariate analysis, only PS at relapse (2-3 vs 0.1, HR 1.96, p=0.01) independently influenced OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", ...
PMC11672881	Relative viability was calculated as the percentage of luminescence signals from cells or spheroids treated versus untreated with drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "viability", "was", "c...
PMC11655536	Although advances in the past decades have led to improved outcomes and longer survival, MM remains largely incurable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "advances", "in", "the...
PMC11578343	Although approximately 50% of the single cells we measured had a viscosity that fell below our detection threshold value, defined as viscous G″ modulus < 0.1 Pa in at least one zone, we emphasize that mz‐visco‐NPS is still effective in assessing the actin cytoskeleton contribution to a cell's overall elasticity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9872547	Student’s t-test was used for deference examination between two groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Student", "’s", "t-test", "was", "used", "for", "deference", "examination", "between", ...
PMC10713411	To construct the prognosis-related risk signature, the LASSO-penalized Cox (LASSO Cox) regression analysis was then conducted based on the glmnet R-package and 10-fold cross-validation in KIRC-training dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11046454	Group i was treated with an equivalent volume of DPBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Group", "i", "was", "treated", "with", "an", "equivalent", "volume", "of", "DPBS", "." ...
PMC9429973	Hospital visits or hospitalization were mentioned in 11% of the conversations, and 62% of them included crisis that patients faced due to symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4277423	DNA plasmids encoding HIV-1 envelopes pDOL and Yu-2 were obtained from ARRRP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "plasmids", "encoding", "HIV-1", "envelopes", "pDOL", "and", "Yu-2", "were...
PMC11767725	Simultaneously, reduced ceramides in psoriatic lesions impair epidermal lipid organization, weakening the skin’s ability to prevent microbial colonization and promoting dysbiosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11297139	GO analysis was performed using DAVID with GO BP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "analysis", "was", "performed", "using", "DAVID", "with", "GO", "BP", "." ] } ]
PMC9429973	Methods: We performed a single center prospective study of CLL patients treated with BTK, BCL2 and PI3K inhibitors out of clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11583690	DTX release (%) at pH 7.4 (A) and pH 5.5 (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DTX", "release", "(", "%", ")", "at", ...
PMC11544122	These data suggest that while SNX9 KO and SNX18 depletion might affect CPP dynamics, it does not have a global effect on agonist-stimulated GPCR endocytosis and that the effect on CXCR4 endocytosis is likely due to a specific effect on this receptor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	We intended to use hFOB 1.19 for the testing of Zn-based degradable metallic materials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "intended", "to", "use", "hFOB", "1.19", "for", "the", ...
PMC11576293	The Bcl-2 protein, another family member, was recognized for suppressing apoptosis (Youssif et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Bcl-2", "protein", ...
PMC6803987	In this study, we isolated a coumarin compound from Microsorium fortunei (Moore) Ching; the compound was identified as esculetin by hydrogen and carbon spectroscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	It also has anti-fibrotic potential in the lung fibrosis model (13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "has", "anti-fibrotic", "potential", "in", "the", "lung", ...
PMC11257988	Yu et al. retrospected 677 patients with metastatic or recurrent KRAS-mutant lung cancer and evaluated the relationship between KRAS mutation type, clinical factors, and overall survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	However, we used additional concentrations (2 µM and 4 µM) to better understand the activity of the compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "w...
PMC11075223	In the Northern and Southern Dynasties, processing with Polygonati Rhizoma juice, cleansing and steaming of Cimicifugae Rhizoma were recorded in Leigong Paozhi Lun.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11711871	We propose that systemic rather than renal GR protein abundance is relevant for this negative feedback control , since nephron-tubule specific GR knockout mice did not exhibit hypercortironemia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesRabbit monoclonal to E CadherinAbcamCat#ab18203Mouse monoclonal to E CadherinAbcamCat#ab231303Rabbit monoclonal to N cadherinAbcamCat#ab18203Rabbit monoclonal to DKK1AbcamCat#ab307367Rabbit monoclonal to β-cateninAbcamCat#ab32572Rabbit monoclonal to β-catenin phosphor(active) S45AbcamCat#ab30561Goat Anti-Rabbit IgG H&L (HRP)AbcamCat#ab6721Goat Anti-Mouse IgG H&L (HRP)AbcamCat#ab205719Goat Anti-Rabbit Alexa Fluor® 488AbcamCat#ab150077Goat Anti-Mouse Alexa Fluor® 594AbcamCat#ab150116Rabbit monoclonal to GAPDHAbcamCat#ab181602Rabbit monoclonal to PARPCell Signaling TechnologyCat#9542Rabbit polyclonal to cleaved-PARPCell Signaling TechnologyCat#9548Rabbit polyclonal to caspase-12Cell Signaling TechnologyCat#35965Rabbit polyclonal to BAXCell Signaling TechnologyCat#2772Rabbit polyclonal to Bcl-2Cell Signaling TechnologyCat#3498Rabbit polyclonal to caspase-3Cell Signaling TechnologyCat#9662Rabbit polyclonal to cleaved-caspase-3Cell Signaling TechnologyCat#9661Bacterial and virus strainsHuman-DKK1 plasmidHanyin companyN/ABiological samplesMICE OS tumorThis paperN/AMICE lung/spleen/heart/kidney/liverThis paperN/AChemicals, peptides, and recombinant proteinsXD23Laboratory Synthesis from Shenyang Pharmaceutical Universityhttps://www.sciencedirect.com/science/article/pii/S0223523422004810MTXSigmaPHR1396Deposited dataRaw RNAseq dataGEO datasetsGSE262143Original, unprocessed dataMendeley datahttps://doi.org/10.17632/kb6g5n2nnz.1Experimental models: Cell linesHuman osteosarcoma cell lines 143BStem Cell Bank of the Chinese Academy of SciencesN/AHuman osteosarcoma cell lines MG63Stem Cell Bank of the Chinese Academy of SciencesN/AHuman skin fibroblasts HSFStem Cell Bank of the Chinese Academy of SciencesN/Ahuman chondrocytes C28/I2Stem Cell Bank of the Chinese Academy of SciencesN/ARat osteosarcoma cell line UMR-106Stem Cell Bank of the Chinese Academy of SciencesN/AOligonucleotidesSee Table S1 for primer sequencesN/AN/ASoftware and algorithmsImageJNIHVersion 1.52GraphPad PrismGraphPadVersion 9.0.0 Human osteosarcoma cell lines 143B, MG63 and Sasos2, rat osteosarcoma cell line UMR-106, human skin fibroblasts (HSF), and normal human chondrocytes (C28/I2) were procured from the Stem Cell Bank of the Chinese Academy of Sciences in Shenzhen, China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Lower: Scatter plot representing the droplet size of STAU1 and STAU1 HKΔRBD4 at 10 μM. >150 droplets counted for each batch.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower",...
PMC11769516	Agahi et al. in their study evaluated the effect of mycotoxins α-ZEL and β-ZEL, which are metabolites of ZEA and BEA, in combination and individually on the enzymatic antioxidant activity of GST, GPx, CAT and SOD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The 30-day mortality rate was 3.6% for DEC and 6.4% for IC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "30-day", "mortality", "rate", "was", "3.6", "%", "for", ...
PMC11499381	Again, all constructs were detected at the cell surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Again", ",", "all", "constructs", "were", "detected", "at", "the", "cell", "surface", "." ...
PMC11594074	Considering the standard deviation, compounds 4 and 2 also exhibited favorable docking scores of −9.85 ± 0.14 kcal/mol and −9.76 ± 0.15 kcal/mol, respectively, indicating comparable performances to compound 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	Furthermore, analysis of the co-crystal structure of the human PD-1/PD-L1 co-crystal indicates that the N63 residue is part of the 6Ǻ binding site of PD-1 on PD-L1 ().	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	TAC40 and ATOM40 serve as positive and negative controls, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TAC40", "and", "ATOM40", "serve", "as", "positive", "and", "negative", "controls", ",...
PMC4485786	Figure 2.I-labeled NHS-IL12 accumulates in the lesions of a human A204 tumor xenograft. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Figure", "2.I-labeled", "NHS-IL12", "accumulates", "in", "the", ...
PMC11194678	Source data are available for this figure: SourceData FS2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "available", "for", "this", "figure", ":", "SourceData", "FS2", "....
PMC11696576	All three compounds were broadly effective in the screen, with average IC50 values < 20 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "three", "compounds", "were", "b...
PMC11718809	A total of 277 host genes correspond to 302 DE circRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "277", "host", "genes", "correspond", "to", "302", "DE", "ci...
PMC11499381	We used receptors for calcitonin gene-related peptide (CGRP) as a model system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "receptors", "for", "calcitonin", "gene-related", "peptid...
PMC11473843	Tunel-positive cell quantification in lung tissue from LSL-Kras;p53 mice, treated as in (B); n mice/group: 4, 3, 4, 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	12 x 75-mm round bottom tubes for flow cytometry. -	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "12", "x", "75-mm", "round", "bottom", "tubes", "for", "flow", "cytometry", ".", "-" ] ...
PMC11650848	There is no significant difference between the placebo group symbol search score and the FA symbol search scores for the CC/CG genotype (p = 0.807).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977	Recent studies have demonstrated the critical role of O-GlcNAcylation nutrient sensing in regulating Th17 cell function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "demonstrated", "the", "cr...
PMC11587606	The expression of PKCζ was visualized in a Boxplot .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "PKCζ", "was", "visualized", "in", "a", "Boxplot", "." ] } ]
PMC11334037	After 4 wk, we killed the mice with an overdose of pentobarbital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "4", "wk", ",", "we", "killed", "the", "mice", "with", ...
PMC3995603	lignans ((+)-sesamin, pluviatide, honokiol, etc.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "lignans", "(", "(+)-sesamin", ",", "pluviatide", ",", "honokiol", ",", "etc", ".", ...
PMC11761919	The total number of bacterial colonies in a 2 mL culture of E. faecalis with an OD value of 1.0 was used to calculate the encapsulation rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10882807	qRT-PCR detected the expression of EIF4A3 in HCCLM3 cells transfected with shNC or shEIF4A3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "qRT-PCR", "detected", "the", "expression", "of", "EIF4A3...
PMC11727062	The proposed mechanism of action involves modulation of the expression of proteins implicated in glycolysis, including pyruvate dehydrogenase (PKM2), lactate dehydrogenase (LDHA), and the monocarboxylate transporter protein (MCT4), along with interference with glycolytic metabolism in tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We hypothesize that persistent antibody-producing plasma cells can be the source of the treatment failure in some ITP patients and treatment that directly targets plasma cells may overcome resistance to treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10094712

XBP1 also promotes the removal of proteins with irreversibly disrupted conformations from the ER .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XBP1", "also", "promotes", "the", "removal", "of", "proteins", "...

PMC11367146

CytoHubba, a plugin of Cytoscape, was used to filter topologically important genes based on their ranking methods, i.e degree, maximal clique centrality (MCC) and maximum neighbourhood component (MNC) score.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594806

CDDP resistance has also been studied in ovarian cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CDDP", "resistance", "has", "also", "been", "studied", "in", "ovarian", "cancer", "." ] } ]

PMC11470999

Molecular glues are monovalent molecules without linkers, mediating protein dimerization through the formation of a ternary complex (target‐molecular glue‐E3 ligase). ,

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PMC11590005

These programmes are crucial to increase the opportunities of low-income groups, which consist mainly of non-whites, to have access to higher education.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10798140

Under all treatment conditions, there was a noticeable increase in the number of cells in the G0G1 phase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "all", "treatment", "cond...

PMC11190538

Finally, 1 ml of the filtrate was injected into HPLC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "1", "ml", "of", "the", "filtrate", "was", "injected", "into", "...

PMC10936243

Consequently, some veterinarians did not give their cat patients bedding or a litter tray.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "some", "veterinarians", "did", "not", ...

PMC11787355

ACT on s.c.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "ACT", "on", "s.c", "." ] } ]

PMC11078693

Note: The imaging parameters used were as follows: samples were mounted in PBS on a 63× NA1.2 water immersion lens.

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PMC9429973

However, a fraction of patients still encounters disease recurrence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "fraction", "of", "patients", "still", "encounters", "disease", "recurrence"...

PMC11637276

Cassettes were then rinsed with sterile ice-cold water (Gibco).

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PMC10887351

Moreover, TRK-380 showed minor or no activity for human β1- and β2-ARs and, as with mirabegron, it might cause less cardiovascular effects.

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PMC9429973

Results: A total of 5,874 patients with severe SCD were identified [mean (SD) age: 20.5 (6.0) years, 54.4% female, 87% African Americans].

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PMC8633974

Nested PCR showed full-length amplicon in untreated cells, whereas no full-length amplicon was seen in the RNP-treated cells (Figure 7c).

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PMC3730428

Although treatment with SMC in the presence of TNFα promoted interaction between caspase 8 and the necrosis-promoting RIPK1, the cell death induced by combined treatment with SAHA and SMC was apoptotic and mediated by caspase 8.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9516447

The superscript indicates the KRAS mutation for each cell line.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "superscript", "indicates", "the", "KRAS", "mutation", "for", "each", "cell", "line", ...

PMC9429973

80%, spec.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "80", "%", ",", "spec", "." ] } ]

PMC9429973

Patients’ data will be entered in the clinical database after all necessary local approvals from Ethics Committees and following the patient’s signed informed consent, if applicable.

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PMC8873393

Regarding the occurrence of DNA lesions (500 T-T lesions per 10 normal bases) , hypothetically, shorter genes contain less or no lesions than longer genes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10874773

C1-C11 esterification.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "C1-C11", "esterification", "." ] } ]

PMC11082662

SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B; qRT-PCR, quantitative real-time polymerase chain reaction; CCK-8, cell count kit-8; OD, optical density.

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PMC11787355

Collectively, the results confirm that PTPRZ1 is highly expressed in malignant brain tumor cells, most abundantly in GSCs, and that AC-like cells and GSCs are primarily targeted by PTPRZ1 TCR-T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7351993

Fig. 2Basic performance of the RIACS.a SRS spectra of PS and PMMA particles obtained by an SRS microscope.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2Basic", "performance", "of", ...

PMC9672323

317,302) and anti-CD28 (0.085 μg/mL, Biolegend, clone CD28.2, cat.

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PMC9429973

For a better accuracy of classification algorithms, a discretization was set on the quantitative dimensions (CD148, CD180 and CD200 MFI).

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PMC9622879

The maximum charging rate and maximum discharging rate of the ESS at each home are the same, and kW. .

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PMC6468656

Total cellular RNA was extracted by TRIzol reagent (Invitrogen, Carlsbad, CA, USA) in accordance with the manufacturer’s instructions.

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PMC11789597

Gln, glutamine; Glu, glutamate, Cys, cysteine; Gly, glycine.

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PMC7039683

Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves using the gkmSVM trained on zGPAEs.

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PMC11394386

Similarly, the synergy of Wnt inhibitors directed against PORCN protein (ETC-159) and PI3K inhibitors (GDC-0941) has been observed in in vitro and in vivo models of pancreatic cancer .

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PMC10810426

This experiment was repeated 3 times with similar results.

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PMC9429973

Methods: All patients who received inpatient care between 2004 and 2013 for an initial diagnosis of DLBLC in NHID were included.

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PMC9429973

Patients classified as ETV6-RUNX1-like (n=21) were characterised by multiples abnormalities of ETV6, including rearrangements (n=17) and/or deletion (n=12) as well as rearrangements (n=7) and/or deletions (n=6) of IKZF1.

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PMC11745600

A, Changes in nonfasting blood glucose levels of Ins1 NOG mice after porcine pancreatic islet transplantation.

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PMC11721277

In system A, Tc-labeled HYNIC-Chl and the reduced hydrolyzed technetium colloid (RHT, [Tc]TcO2) stayed at the application point (Rf = 0.0), whereas free forms of radionuclide ions and Tc-labeled complexes with tricine and EDDA migrate with the solvent front (Rf = 0.8–1.0).

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PMC11441402

Additionally, the whole well is analyzed, ensuring that all cells are accounted for in assessing viability status.

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PMC11265931

This emphasizes the potential of garlic exosome-like nanovesicles as promising options for advanced and targeted anticancer treatments without negative side effects.

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PMC9429973

In which, the most frequent grade <=2 AEs were hemorrhage(18.2% all grade 1), rash(9.1%), hyperglycemia (13.6%), infection(9.1%), nausea and vomiting (9.1%), hypogammaglobulinemia(4.5%), neutropenia(9.1%).

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PMC11092382

These studies support the idea that sophocarpine is capable of reducing endothelial cell injury and maintaining vessel integrity and therefore may be used to treat atherosclerosis or vessel dysfunction after balloon angioplasty.

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PMC7305184

Statistically significant difference, with p < 0.05, is observed only at 1250 V/cm between CTRL and EP group of 15 generation in experiment 1.

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PMC11589157

After trimming the low-quality reads and adaptor sequences, 143.4 Gb of PacBio HiFi data were obtained (~49X coverage).

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PMC9429973

Since KIT mutations do not fully explain the pathophysiology of the disease, we sought to identify other mutations that could act synergistically with KIT D816V to induce the disease.

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PMC9429973

A transient reduction of lymphocytes was observed in all patients and recovered in about one month with CD7-negative.

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PMC11621493

All primers are listed in supplemental Table S3.

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PMC11706491

Outliers are depicted as dots. (

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PMC11769516

STG consists of a xanthone nucleus attached to a bisfuran structure (Figure 8).

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PMC11742231

By identifying unexpected sensitivities, the model can propose existing drugs as candidates for new therapeutic applications, accelerating the development of effective cancer treatments.

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PMC6379402

Fig. 4Kaplan–Meier survival curve analysis.

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PMC5363531

According to the approach reported in the Material and Method section, the best-fit estimate of the IC50 for PEM, when combined with dasatinib, was 5 μM in REN cells, 1 μM in MPP89 cells and 0.5 μM in MSTO cells.

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PMC11627060

DNA is taken out of a homogenate of lysed cells and electrophoresed on an agarose gel in this experiment.

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PMC11665555

Briefly, virus was added to 5637 cells in suspension at different ratios including an uninfected control.

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PMC11476222

Additionally, our findings confirmed that ganglioside diversity is more influenced by the glycan head group than by the ceramide moiety, as previously reported .

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PMC11615828

After washing away unbound Transferrin‐594, cells were then incubated in serum‐containing medium at 37 °C for 30 min and fixed by incubation with paraformaldehyde (Electron Microscopy Sciences) diluted in PBS at room temperature for 15 min.

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PMC9429973

By multivariate analysis, only PS at relapse (2-3 vs 0.1, HR 1.96, p=0.01) independently influenced OS.

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PMC11672881

Relative viability was calculated as the percentage of luminescence signals from cells or spheroids treated versus untreated with drugs.

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PMC11655536

Although advances in the past decades have led to improved outcomes and longer survival, MM remains largely incurable.

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PMC11578343

Although approximately 50% of the single cells we measured had a viscosity that fell below our detection threshold value, defined as viscous G″ modulus < 0.1 Pa in at least one zone, we emphasize that mz‐visco‐NPS is still effective in assessing the actin cytoskeleton contribution to a cell's overall elasticity.

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PMC9872547

Student’s t-test was used for deference examination between two groups.

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PMC10713411

To construct the prognosis-related risk signature, the LASSO-penalized Cox (LASSO Cox) regression analysis was then conducted based on the glmnet R-package and 10-fold cross-validation in KIRC-training dataset.

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PMC11046454

Group i was treated with an equivalent volume of DPBS.

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PMC9429973

Hospital visits or hospitalization were mentioned in 11% of the conversations, and 62% of them included crisis that patients faced due to symptoms.

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PMC4277423

DNA plasmids encoding HIV-1 envelopes pDOL and Yu-2 were obtained from ARRRP.

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PMC11767725

Simultaneously, reduced ceramides in psoriatic lesions impair epidermal lipid organization, weakening the skin’s ability to prevent microbial colonization and promoting dysbiosis .

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PMC11297139

GO analysis was performed using DAVID with GO BP.

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PMC9429973

Methods: We performed a single center prospective study of CLL patients treated with BTK, BCL2 and PI3K inhibitors out of clinical trials.

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PMC11583690

DTX release (%) at pH 7.4 (A) and pH 5.5 (B).

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PMC11544122

These data suggest that while SNX9 KO and SNX18 depletion might affect CPP dynamics, it does not have a global effect on agonist-stimulated GPCR endocytosis and that the effect on CXCR4 endocytosis is likely due to a specific effect on this receptor.

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PMC10890055

We intended to use hFOB 1.19 for the testing of Zn-based degradable metallic materials.

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PMC11576293

The Bcl-2 protein, another family member, was recognized for suppressing apoptosis (Youssif et al., 2019).

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PMC6803987

In this study, we isolated a coumarin compound from Microsorium fortunei (Moore) Ching; the compound was identified as esculetin by hydrogen and carbon spectroscopy.

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PMC10329237

It also has anti-fibrotic potential in the lung fibrosis model (13).

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PMC11257988

Yu et al. retrospected 677 patients with metastatic or recurrent KRAS-mutant lung cancer and evaluated the relationship between KRAS mutation type, clinical factors, and overall survival.

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PMC11767817

However, we used additional concentrations (2 µM and 4 µM) to better understand the activity of the compounds.

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PMC11075223

In the Northern and Southern Dynasties, processing with Polygonati Rhizoma juice, cleansing and steaming of Cimicifugae Rhizoma were recorded in Leigong Paozhi Lun.

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PMC11711871

We propose that systemic rather than renal GR protein abundance is relevant for this negative feedback control , since nephron-tubule specific GR knockout mice did not exhibit hypercortironemia .

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PMC11402217

REAGENT or RESOURCESOURCEIDENTIFIERAntibodiesRabbit monoclonal to E CadherinAbcamCat#ab18203Mouse monoclonal to E CadherinAbcamCat#ab231303Rabbit monoclonal to N cadherinAbcamCat#ab18203Rabbit monoclonal to DKK1AbcamCat#ab307367Rabbit monoclonal to β-cateninAbcamCat#ab32572Rabbit monoclonal to β-catenin phosphor(active) S45AbcamCat#ab30561Goat Anti-Rabbit IgG H&L (HRP)AbcamCat#ab6721Goat Anti-Mouse IgG H&L (HRP)AbcamCat#ab205719Goat Anti-Rabbit Alexa Fluor® 488AbcamCat#ab150077Goat Anti-Mouse Alexa Fluor® 594AbcamCat#ab150116Rabbit monoclonal to GAPDHAbcamCat#ab181602Rabbit monoclonal to PARPCell Signaling TechnologyCat#9542Rabbit polyclonal to cleaved-PARPCell Signaling TechnologyCat#9548Rabbit polyclonal to caspase-12Cell Signaling TechnologyCat#35965Rabbit polyclonal to BAXCell Signaling TechnologyCat#2772Rabbit polyclonal to Bcl-2Cell Signaling TechnologyCat#3498Rabbit polyclonal to caspase-3Cell Signaling TechnologyCat#9662Rabbit polyclonal to cleaved-caspase-3Cell Signaling TechnologyCat#9661Bacterial and virus strainsHuman-DKK1 plasmidHanyin companyN/ABiological samplesMICE OS tumorThis paperN/AMICE lung/spleen/heart/kidney/liverThis paperN/AChemicals, peptides, and recombinant proteinsXD23Laboratory Synthesis from Shenyang Pharmaceutical Universityhttps://www.sciencedirect.com/science/article/pii/S0223523422004810MTXSigmaPHR1396Deposited dataRaw RNAseq dataGEO datasetsGSE262143Original, unprocessed dataMendeley datahttps://doi.org/10.17632/kb6g5n2nnz.1Experimental models: Cell linesHuman osteosarcoma cell lines 143BStem Cell Bank of the Chinese Academy of SciencesN/AHuman osteosarcoma cell lines MG63Stem Cell Bank of the Chinese Academy of SciencesN/AHuman skin fibroblasts HSFStem Cell Bank of the Chinese Academy of SciencesN/Ahuman chondrocytes C28/I2Stem Cell Bank of the Chinese Academy of SciencesN/ARat osteosarcoma cell line UMR-106Stem Cell Bank of the Chinese Academy of SciencesN/AOligonucleotidesSee Table S1 for primer sequencesN/AN/ASoftware and algorithmsImageJNIHVersion 1.52GraphPad PrismGraphPadVersion 9.0.0 Human osteosarcoma cell lines 143B, MG63 and Sasos2, rat osteosarcoma cell line UMR-106, human skin fibroblasts (HSF), and normal human chondrocytes (C28/I2) were procured from the Stem Cell Bank of the Chinese Academy of Sciences in Shenzhen, China.

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PMC11194678

Lower: Scatter plot representing the droplet size of STAU1 and STAU1 HKΔRBD4 at 10 μM. >150 droplets counted for each batch.

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PMC11769516

Agahi et al. in their study evaluated the effect of mycotoxins α-ZEL and β-ZEL, which are metabolites of ZEA and BEA, in combination and individually on the enzymatic antioxidant activity of GST, GPx, CAT and SOD.

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PMC9429973

The 30-day mortality rate was 3.6% for DEC and 6.4% for IC.

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PMC11499381

Again, all constructs were detected at the cell surface.

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PMC11594074

Considering the standard deviation, compounds 4 and 2 also exhibited favorable docking scores of −9.85 ± 0.14 kcal/mol and −9.76 ± 0.15 kcal/mol, respectively, indicating comparable performances to compound 1.

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PMC5925824

Furthermore, analysis of the co-crystal structure of the human PD-1/PD-L1 co-crystal indicates that the N63 residue is part of the 6Ǻ binding site of PD-1 on PD-L1 ().

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PMC11637284

TAC40 and ATOM40 serve as positive and negative controls, respectively.

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PMC4485786

Figure 2.I-labeled NHS-IL12 accumulates in the lesions of a human A204 tumor xenograft. (

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PMC11194678

Source data are available for this figure: SourceData FS2.

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PMC11696576

All three compounds were broadly effective in the screen, with average IC50 values < 20 µM).

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PMC11718809

A total of 277 host genes correspond to 302 DE circRNAs.

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PMC11499381

We used receptors for calcitonin gene-related peptide (CGRP) as a model system.

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PMC11473843

Tunel-positive cell quantification in lung tissue from LSL-Kras;p53 mice, treated as in (B); n mice/group: 4, 3, 4, 4.

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PMC10587429

12 x 75-mm round bottom tubes for flow cytometry. -

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PMC11650848

There is no significant difference between the placebo group symbol search score and the FA symbol search scores for the CC/CG genotype (p = 0.807).

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PMC11106977

Recent studies have demonstrated the critical role of O-GlcNAcylation nutrient sensing in regulating Th17 cell function.

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PMC11587606

The expression of PKCζ was visualized in a Boxplot .

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PMC11334037

After 4 wk, we killed the mice with an overdose of pentobarbital.

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PMC3995603

lignans ((+)-sesamin, pluviatide, honokiol, etc.),

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PMC11761919

The total number of bacterial colonies in a 2 mL culture of E. faecalis with an OD value of 1.0 was used to calculate the encapsulation rate.

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PMC10882807

qRT-PCR detected the expression of EIF4A3 in HCCLM3 cells transfected with shNC or shEIF4A3. (

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PMC11727062

The proposed mechanism of action involves modulation of the expression of proteins implicated in glycolysis, including pyruvate dehydrogenase (PKM2), lactate dehydrogenase (LDHA), and the monocarboxylate transporter protein (MCT4), along with interference with glycolytic metabolism in tumor cells.

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