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OTAR3088
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BioData-CellLine_annotated

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PMC8409415
C and D, In A2780cisR and SKOV3cisR xenograft models, tumor growth in the cisplatin group was similar to that in the PBS group (A2780cisR: 1548.4 vs 1829.8 mm, P = .10 and SKOV3cisR: 605.0 vs 733.4 mm, P = .45).
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PMC11545737
Caspase-1 or GSDMD deficiency in the intraperitoneal infection model increased mice survival with attenuated secretion of IL-1β, IL-6 and TNFα .
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PMC11767725
HIF-1α upregulates glycolytic enzymes, shifting cellular metabolism toward anaerobic glycolysis.
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PMC3681794
Cells simultaneously plated and treated with and without PI-103 were harvested at the end of the experiment (after 96 hours of PI-103 treatment) for western blotting.
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PMC9509578
Mittal et al. synthesized nanomicelles for co-delivery of gemcitabine and miRNA-205 in pancreatic cancer MIA PaCa-2 and CAPAN-1 cells and nude xenograft mice.
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PMC9429973
We found that maintenance treatment after CAR-T therapy could significantly improve patients’ long-term survival and disease-free time, while HSCT showed no significant benefit to long-term prognosis.
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PMC9429973
Lymph node responses occurred later (median of 4.1 months to normalization).
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PMC9577200
Chitosan concentrations (0.2 and 1.5%) exhibited antibacterial activity against BC with inhibition zone diameters of 4 and 12 mm, respectively, and against PAO1 with 2 and 10 mm, respectively.
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PMC10092581
After an overnight incubation, cell growth inhibition was detected by measuring the absorbance of each well at 570 nm using a Bio‐Rad 680 microplate reader.
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PMC9429973
The last follow-up and survival data of the patients were obtained in January 2022.
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PMC10589262
This treatment strategy showed invariable effects even on imatinib-resistant GIST, which is a major challenge in clinical practice.
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PMC11699178
After clustering, the differential feature genes in each cell type were analyzed using the FindAllMarkers function.
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PMC11496491
Differential gene and cluster analysis. (
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PMC11463018
Compound 19 with a piperonyl showed the best potency against HDAC6 with IC50 of 4.3 nM, better than those of SAHA and ACY-1215, and it also showed preferable JAK1 activity (IC50 = 165 nM).
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PMC11269933
In the S11 phosphorylated system, higher RMSF values were observed for most residues, indicating that S11 phosphorylation can enhance the flexibility of PK protein residues (including D122, F253, K279xE281, D305, and T337 etc.),
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PMC11740907
The IC50 value (µg/mL) was determined using Prism 5.0 software (GraphPad Software; California, USA).
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PMC10840195
Protein lysate (1 mg) was added to a 25 µl suspension, including 1:1 S beads and 2 µg of a protein antibody; 4 °C shaking table incubation was performed for 2–4 h. After binding, centrifugation was performed at 1400 rpm x 1 min, 4 °C.
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PMC11680982
The membranes were blocked with 5% blocking solution and incubated with primary antibodies overnight at 4 °C.
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PMC11766332
A homozygous truncating mutation in B4GALT1 was the cause of a non-complex ASD diagnosis in an individual with no other known genetic or environmental factors contributing to the condition.
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PMC11706491
Cytokinesis end was considered when a parental cell splits into 2 daughter cells.
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PMC9341513
These reveal that the CCND1 promoter often interacts with polycomb-associated regions (arrow ‘i’ in the figure); this is because there is enrichment of H3K27me3 at the promoter.
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PMC11703896
S. hygroscopicus (2%) was inoculated and incubated for a period of 7 days and at 28 °C.
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PMC7351993
The advent of image-activated cell sorting and imaging-based cell picking has advanced our knowledge and exploitation of biological systems in the last decade.
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PMC9429973
Many patients were receiving comedications at baseline, including antihypertensives (44.1%), anticoagulants (14.5%), and/or antipsychotics or antidepressants (12.5%).
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PMC9509578
Co-delivery of docetaxel and thymoquinone in borage oil-based nanoemulsion reduces the concentration necessary for effective treatment in breast cancer (MCF-7 and MDA-MB-231) cells as compared to drug-free treatment .
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PMC11206251
To conduct the HPLC analysis, a Waters Alliance 2695 HPLC Pump (Waters, Milford, MA, USA) was employed along with a Thermo Gold C18 column, of which the specification was 2.1 mm × 100 mm, 1.9 μm (Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11666785
We observed a similar trend to that of first sample.
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PMC8382973
In the postmortem individual Eckstein score (maximum score 16) for the rectum and vagina of male and female rabbits at 4 mg/day, the 20 mg/day dose group was generally comparable between the two groups and ranged from none to minimal magnitude (ranging from 1 to 4 in the rectum and vagina).
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PMC9429973
It is crucial to quickly bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematopoietic reconstitution.
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PMC9436459
Subsequent detailed studies including a computational investigation showed the acceleration of the cycloaddition reaction by the OH group arises both from the LUMO-lowering effect of the OH–carbonyl hydrogen bond and from better coplanarity between the diene and its aryl substituent in the transition structures .
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PMC11089031
The first sample in the tissue microarray was used as a reference for normalization among sections.
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PMC10142392
The results showed that these pH-sensitive and biodegradable copolymer micelles containing hydrazine exhibited strong toxicity against HepG2 cells .
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PMC9926039
The best group, having 35 out of 150 conformers, presented −5.63 mean energy.
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PMC11743414
We selected the signaling pathways that showed the most significant enrichment based on the normalized enrichment score.
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PMC11394227
The fluorescence intensity of the ER and Golgi apparatus in cells expressing antibodies (CHO-PAb and CHO-PAb-QS) was slightly higher than that of cells not expressing antibodies (CHO-K1 and CHO-QS), indicating that the overexpression of antibodies would have a minimal effect on the ER and Golgi apparatus.
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PMC11380454
Transfected cells were selected using gentamicin.
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PMC11063646
This study presents a novel phytotherapeutic strategy for skin cancer treatment, emphasizing the safety and effectiveness of the formulation.
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PMC9985266
GraphPad 8.0 was used to analyze and prepare graphs in this study.
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PMC11449273
Samples from the same TCEs ran on a different gel were processed for blotting with actin antibodies.
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PMC11401350
Our objective is to generate CAR T cells that will eliminate these CD4 + T cells from the tumor tissue.
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PMC11397654
This work not only proposed a new supramolecular drug delivery platform but also provided interesting in vivo results, which are notable given the rarity of such consistently favourable outcomes in similar studies.
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PMC11519077
In addition, in the case of treating MSCs and their CM, MMP9 was lower expressed in the AD-MSC and AD-CM groups in comparison to the IL-1β-induced Caco-2 group (Figure 6(d)).
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PMC11754784
n = 3 from three independent experiments).
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PMC5600151
One of the advantages of primary amines on a PAMAM is that it can be easily conjugated with different targeting or shielding moieties.
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PMC11621493
Eighteen to twenty-two hours posttransfection, 150 μl of ExpiFectamine 293 Transfection enhancer 1, and 1.5 ml of ExpiFectamine 293 transfection enhancer 2 (A14524, Gibco) were added to the culture.
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PMC9792775
One section (n = 8) of each experimental tumor containing PTX was placed in a pestle and mortar, crushed and mixed with water (2 µl/mg of tumor tissue).
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PMC11026382
THF limitation due to DHFR loss of function restricts the production of several growth-linked factors, including thymidine, methionine, glycine, and the purine precursors inosine and AICAR.
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PMC10589262
Mutations in KIT are most frequently detected in exon 11 (juxtamembrane domain, 70%), followed by exon 9 (extracellular domain, 10%) and less frequently in exon 13 (adenosine triphosphate (ATP)-binding pocket, 1%), or in exon 17 (activation loop, 1%) .
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PMC11799978
Our data suggest that pH restoration downregulates the FAP expression in CAFs, which could provide an explanation for the inhibited tumor cell proliferation and migration.
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PMC7582629
We introduce the importance of an automated and objective assessment of cancer cell diagnosis, showing the use of multivariate analyses, such as PCA/LDA, for Raman data managing.
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PMC11532793
A decoy-aware mapping-based indexed transcriptome generated from the human hg38 reference genome with k-mers of length 31 and the complete human Gencode transcriptome annotation version 33 was used during quantification.
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PMC9429973
S.-J. Wu, C.-K. Liao, Y.-W. Wang, M.-C. Wang National Taiwan University Hospital, Taipei City; Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan Background: Glofitamab, a T-cell-engaging bispecific antibody (Ab) with a novel 2:1 configuration conferring robust bivalency for CD20 and monovalency for CD3, has recently shown promising activity in its phase I/II trial as a salvage therapy in various major subtypes of B-cell lymphoma.
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PMC7582629
These changes were observed in both the fingerprint range (1265–1298 cm) and in the high-frequency Raman range (between 2700–3100 cm), that reflects the differences in lipid to protein distributions for the different cells .
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PMC11532793
Although transcripts exclusively reported as DE under the Gibbs sampling pipeline were, in general, more lowly expressed (median average log CPM −0.55; Supplementary Figure S10), several of them were associated with cancer and non-small cancer pathways (Figure 5D).
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PMC11741906
These miRNAs could influence many biological processes and pathways related to apoptosis, cell survival, and treatment response.
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PMC11731161
USP7 stabilizes XPO1 in MM cells via its deubiquitinating activity.
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PMC9429973
Five-year CI of sCNSi was 7.3% in arm A and 2.9% in arm B (Gray’s test, p = 0.11).
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PMC6181431
The 129 genes showed modest overlap with two hallmark gene sets (E2F targets, and mitotic spindle), 4 genes each with FDR q = 0.044, and no enrichment for any other hallmark gene set.
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PMC9429973
To the best of our knowledge, the study of the epidemiology of such a hematological finding in our area has not been previously published.
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PMC9164404
Due to the enhanced permeability and retention (EPR) effect, nano drugs can effectively accumulate at tumor tissues, hence leading to lower toxicity and better efficacy .
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PMC11718109
The following plasmids: untagged synaptophysin, synaptophysin-FLAG, untagged synapsin 1a, mCherry-synapsin 1a, VAMP2-mCherry, mCherry-Rab3a, mCherry-SCAMP5, Synaptotagmin1-mCherry were previously generated in the laboratory of Pietro De Camilli.
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PMC11119602
Most of the interactive residues were grouped into a 22 amino acid long linear motif, located at the C-terminus of the β-barrel domain B1 (Figure 7).
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PMC11438317
Next, we tested whether LYP could affect T-cell activation via SLP76.
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PMC11644761
These changes contribute to the development of various diseases, including neurodegenerative disorders, cardiovascular diseases, malignant tumors, and, ultimately, an increased risk of mortality .
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PMC11301095
Here, we report the clinical characteristics, diagnosis, and treatment of a 14-year-old male child with PAM admitted to our pediatric intensive care unit, combined with a literature analysis.
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PMC11351758
After incubating the cells with high and low glucose and staining, we mounted the cells on a Zeiss LSM 510 META NLO confocal microscope for imaging.
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PMC10092581
Subsequently, the thiol content was measured as previously described.
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PMC11321678
In SHH clusters, GLI1 and GLI2, which regulate the SHH pathway, have specific activity.
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PMC9429973
Overall survival after 5, 10, and 15-years was 95.7%, 92,5%, and 84,2% respectively.
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PMC4485786
Survival was evaluated with Kaplan-Meier curves and compared with log-rank test.
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PMC8922418
The "base editor", cytosine base editor (CBE), has an approximate "active window", typically bases 4–8 of protospacer where PAM is counted as 21–23 bases, which can be edited efficiently.
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PMC9599726
We studied hallmarks of ferroptosis, i.e., lipid peroxidation, iron and glutathione content, and GPX4 protein expression in imatinib-sensitive (GIST882) and -resistant (GIST48) GIST cell lines.
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PMC11075223
With the development of TCM system in the Song Dynasty, more prescriptions related to Cimicifugae Rhizoma appeared.
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PMC11046454
Values represent relative cell number normalized to the group of mixed CAR-T, CEM, and Ramos (mixed at a cellular ratio of 10:1:1), as assayed with flow cytometry cell count beads. (
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PMC11680391
We identified a sample of 498 eligible herds that met the above-mentioned criteria.
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PMC11767817
Cyclins and cyclin-dependent kinases (CDKs) are critical for cell cycle regulation.
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PMC4005030
A variety of research work has been carried out on protocatechuic acid, its derivatives, and coforms (esters, aldehydes, etc.).
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PMC10713411
After the harvest of total proteins in A498 cells, equal amounts of proteins (30 μg) were used for SDS-PAGE electrophoresis.
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PMC11700523
Immunostaining of IS and MR in renal sections was performed using the streptavidin-biotinylated peroxidase complex method.
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PMC11224206
As concluded by Kruglov et al. in a recent review entitled ‘Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry’, ‘currently, it is difficult to name a good sensor for measuring temperature in mitochondria’.
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PMC11637276
Bafilomycin A1 and E64d were added at the time of seeding in 10% FBS DMEM.
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PMC9429973
On multivariate analysis, patients with TP53 disruption/aneuploidy, chromatin/spliceosome mutation, or homozygous JAK2 showed a higher risk of disease progression to myelofibrosis or acute leukemia (HR: 14.5, 95%CI: 3.1-68.7, p=0.001) regardless of the presence of SVT at diagnosis, age and sex.
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PMC7433824
In our experiments, A172 cells continued to grow until 72nd hour of culturing, while U87 cell growth declined around after 40th hour of culture.
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PMC10870498
A Genes positively and negatively related to KIF23 were obtained using the Linkedomics database; B The 80 genes positively related to the expression of KIF23.
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PMC9429973
Negative PET3 patients had a PFS of 85.4%, while positive PET3 patients had a PFS of 43% (p=0,0001).
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PMC2118063
2 ml of room-temperature RPMI medium (Life Technologies) supplemented with 200 U/ml penicillin G, 10 μg/ml gentamycin, and 10% FCS was added, and cells were placed in a 12-well plate to incubate at 37(C overnight.
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PMC11306331
A Schematic of approach.
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PMC9429973
Correspondence to: Dr Jian Huang, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine.
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PMC11536589
Activation of AKT signaling could inhibit the activity of the downstream target protein GSK-3β, promote the accumulation of β-catenin, thus cause the activation of β-catenin pathway (Zhou et al. 2004).
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PMC3765139
Further in vitro and in vivo studies are warranted to validate these results at the gene and protein level and to assess the potential diagnostic and prognostic relevance of MGP, CD133, and IGF expression in clinical melanoma specimens.
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PMC9429973
Prospective as well as retrospective studies were included, but had to include at least 50 participants and to reflect current treatment.
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PMC11344246
RO-3306 was able to inhibit two out of three MOC cell lines tested and had no significant effect on fibroblasts.
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PMC11741577
Cytokine array analysis of HMC-1 CM and FSL-1-treated HMC-1 CM. (
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PMC11612315
The fluorescence 340/380 ratio was measured via digital video microfluorometry with an intensified camera (OptiMOS; QImaging, Surrey, Canada) coupled to the microscope.
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PMC11438317
Scale bar represents 5 μm This study shows that LYP dephosphorylates a number of adaptor proteins involved in TCR signaling, including SLP76, FYB, HS1, Vav, SKAP1 and SKAP2.
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PMC11802855
K Activation status of the “JAK/STAT3” pathway in MM cells.
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PMC9429973
Among the positive samples the most common silent mutation was the-101(C>T)(n=15).
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PMC11180402
The miR-129 inhibitor and short hairpin RNA constructs for MMP-2, MMP-9, and PTEN, along with their respective scrambled controls, were acquired from Abm (Richmond, Canada) and Open Biosystems (Pittsburgh, PA, USA), respectively.
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PMC9024365
All chimeras were transfected in COS cells either alone or with full-length SD4 (Figures 4B–D).
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PMC10421378
Lastly, adhesion was measured in bacteria cultured in optimal conditions and treated with heat shock.
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