OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11607638	EC50 = 251 pM. The abscissa in panels (A–I) is time in min as indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EC50", "=", "251", "pM.", "...
PMC9429973	These findings should further reduce vaccine hesitancy among ITP patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "should", "further", "reduce", "vaccine", "hesitancy", "among", "ITP", "pati...
PMC11703992	B Intersection of DEGs of CD4+ Memory T cells-reference and CD4+ Naive T cells-reference, conducted in old samples and GCA samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11742290	PE04 ovarian cancer cells programmed into pluripotent stem cells (iPSCs) expressed high levels of LGR5 and were more resistant to cisplatin and taxol compared to parental PEO4 cells .	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cell cycle synchronization was obtained using SynchroSet kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cycle", "synchronization", "was", "obtained", "using", "SynchroSet", "kit", "." ] } ]
PMC11271800	This may be because high levels of proinflammatory factors in inflammation contribute to the generation of M2 TAMs, resulting in a high expression level of M2 TAMs, which in turn favor metastasis and largely predicts that the associated tumors are progressing or have progressed and deteriorated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Pvt.	[ { "tags": [ "O", "O" ], "tokens": [ "Pvt", "." ] } ]
PMC11459296	To address these challenges, we aimed to use cord blood mononuclear cells (CB-MNCs) as an alternative immunologically naïve source for humanization in NSG and NSG-Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (NSGS) mice which express human interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	Cells were stained with the following antibodies: APC anti–mouse H-2Kb-SIINFEKL-specific antibody (BioLegend 141606), APC mouse IgG1, κ isotype control (BioLegend, 981806), APC rat anti–mouse CD8a (BD Biosciences, 553035), and APC mouse IgG2a κ isotype control (BD Biosciences, 550882).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7582629	The positive differences at both the 752 and 1088 cm bands are assigned to the increased nucleic acid content which corresponds to the overexpression of HER2 protein in BT474 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	Dose–response curves were generated using Graph Prism software (version 9.5.1) (https://www.graphpad.com/demos/, accessed on 11 February 2024), and IC50 values were calculated using polynomial curves (four- or five-parameter logistic equations) with the same software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582828	Genetic recombination can occur with both DNA and RNA viruses, including viruses of the Coronaviridae families.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genetic", "recombination", "can", "occur", "with"...
PMC10854447	The retain option specifies the number of poses (30) to pass to the refinement for energy minimisation in the pocket before restoring with the GBVI/WSA dG scoring function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	A Averaged BRET-based measurement of HEK293 cells stably expressing MOR BRET-sensor.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Averaged", "BRET-based", "measurement", "of", "HEK293", "cells", "stably", "e...
PMC11271278	We used the “aggregated results” file in the “PCAWG – full” dataset released on August 29, 2023, which listed the DNA segments included in each amplicon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	Annotations of Homo_sapiens.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Annotations", "of", "Homo_sapiens", "." ] } ]
PMC6684588	Scale bar, 100 µm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "100", "µm", ".", "(" ] } ]
PMC10734950	To gage the phosphorylation of essential biological pathways sometimes responsible for oncogenesis, a MAPK and JAK-STAT Array was conducted (RayBiotech Human/Mouse MAPK Phosphorylation Array AAH-MAPK-1-2, Human JAK-STAT Pathway Phosphorylation Array C1 AAH-JAK-STAT-1-2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	Ⅰ: Control, Ⅱ: PGP, Ⅲ: Mn@PGP, Ⅳ: Cis/Mn@PGP, Ⅴ: Mn/NH@PGP, Ⅵ: Cis/Mn/NH@PGP.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ⅰ", ...
PMC11413393	Respective oligonucleotides were ordered from IDT and then cloned into the sgRNA delivery LRG plasmid (Addgene Plasmid #65656) using a BsmBI digestion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10810426	However, it is clear that even in nondividing DCs, the MLV p12 protein is still required for integration of viral DNA into the chromosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	A comprehensive update on our cohort, sequencing data and MSC characterization will be shown at the conference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comprehensive", "update", "on", "...
PMC11597167	Relevant to the amyloid cascade hypothesis, β-site amyloid precursor protein cleaving enzyme-1 (BACE1, also known as β-secretase or memapsin 2) is an enzyme primarily known for its role in the amyloidogenic pathway leading to the production of Aβ peptides, which are implicated in the pathogenesis of AD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017	Box plot comparing the PFS of patients with or without antigen loss at relapse. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "plot", "comparing", "the", "PFS", "of", "patients", ...
PMC3730428	cIAP1 was from Enzo (Exeter, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cIAP1", "was", "from", "Enzo", "(", "Exeter", ",", "UK", ")", "." ] } ]
PMC7812570	TZM-bl cells expressing GPI-m36.4 or GPI-FluIgG03 were used as targets and cocultured with CEMss-CCR5 donor cells that were preinfected with one of the three viruses. %	[ { "tags": [ "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543935	The printed part is connected with a luer-lock system to a 20 ml syringe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "printed", "part", "is", "connected", "with", "a", "luer-l...
PMC9429973	Consistently, FTO silencing mediated by lentivirus exhibited exquisite sensitivity to ibrutinib in CLL cells (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistently", ",", "FTO", "silen...
PMC11718817	It is tempting to speculate that NLRP3-induced increased expression of coinhibitory molecules such as PD-L1 on intraspheroidal macrophages and tumor cells is causing the slight decrease in spheroid rejection that was observed in our spheroid model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	The TSL-induced macropinosomes acquire characteristics of early and late endosomes, as indicated by the presence of Rab5 and Rab7 proteins on the membrane of macropinosomes, respectively (Figures 3C, D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	Thoracic injections of dsSK, dsSKR, dsGFP, or DEPC water were performed in adult mosquitoes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thoracic", "injections", "of", "dsSK", ",", ...
PMC11055323	Sheared DNA was size selected using VAHTS® DNA Clean Beads N411.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sheared", "DNA", "was", "size", "selected", "using", "VAHTS", "®", "DNA", ...
PMC11674441	We selected the HLA class II-restricted neoantigen long peptide derived from the nonsynonymous SNV from TTN that included an amino acid sequence with high affinity to HLA class I. As shown in Figure 3, both CD8-positive T cells (CD8 purity = 97.8%) and CD4-positive T cells (CD4 purity = 98.4%) obtained after Neo-P DC vaccination responded to mDCs pulsed with the HLA class II-restricted mutant long peptide (TTN-II).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	The current study therefore aimed to investigate whether and how the interaction between GABAARs and NL2 may lead to the establishment of functional synapses in the absence of other synaptic proteins using a reduced in vitro co-culture system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	4The binding mode of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 Dock score from Glide and Autodock vina, and binding energy from Prime-MMGBSA The binding interaction of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 The binding mode of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 Cyclohexane ring substituted with 5′ OH group was found to interact with Ile452 to form two HBs with a distance of 2.09 and 3.04 Å. Another pyran ring contains two hydroxyl and two methoxy functional groups was seen to form HB along with a distance of 2.44 Å. Furthermore, A1 interacted with the TMPRSS2 to with better affinity as suggested by the highest Prime-MMGBSA binding energy (− 70.472 kcal/mol), along with a Glide dock score (− 9.574 kcal/mol) and the ADV binding energy (− 8.80 kcal/mol).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Dual Myc/Bcl2 expressor (DEL) was present in 42.2% of early PD patients (n=45) compared to 25.5% in non-ePD patients (n=736)(p=0.013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	Furthermore, when in touch with the toxic plant components, the leaves and fruits alleviate allergic reactions, nausea, and skin itching (Wangpan et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11354225	Cells were treated with MAL-PDT (MAL 2 mM) and MAL-PDT + EGCG (10, 20 and 40 µM), both with red light irradiation using 4 J/cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659734	The micronucleus assay, on the other hand, provides insights into clastogenicity (chromosome breakage) and aneugenicity (chromosome missegregation), which are crucial for understanding the broader genotoxic impact (Fenech, 2007).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	Statistical analysis: one-way ANOVA with Tukey’s test for (c, f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", ":", "one-way", "ANOVA", "with", ...
PMC11391695	As a result, we postulated that the interaction between ACYP2 and TERT influences the length of telomeres .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "we", "...
PMC11138140	Single-cell tracking of both cardiomyocyte surface area and three-dimensional optical volume revealed dynamic increases in these parameters throughout the 24 h imaging period, demonstrating the potential of this technology to explore cardiomyocyte hypertrophic responses with greater temporal resolution; however, technological limitations were also observed and should be considered in the experimental design and interpretation of results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8903741	The mixture was incubated at room temperature for 1 h. andwashed three times using 500 μL of PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "incubated", "...
PMC7602170	In another study, BEZ235 plus imatinib remarkably improved the efficacy, with decreasing tumor volume and increasing pro-apoptotic effects in both imatinib-resistant (UZLX-GIST2) and imatinib-sensitive (UZLX-GIST3 and UZLX-GIST4) xenograft models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10898159	The epigenetic silencing of SH3BP2 leads to decreased oncogenic KIT and PDGFRA expression at both mRNA and protein levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "epigenetic", "silencing", ...
PMC9429973	Aims: this study was designed to evaluate glycoproteins IIb-IIIa levels (CD41and CD61) by flowcytometry on the platelet surface of patients with GT in addition to bleeding score for proper typing and bleeding assessment of Egyptian patients with GT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673955	Telomerase inhibitors have been expected to become promising agents for cancer treatment 11, 12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Telomerase", "inhibitors", "have", "been", "expected", "to", ...
PMC11655536	D Statistical analysis of apoptotic cells of RPMI-8226 (upper) and U266 (lower) in (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Statistical...
PMC11323699	Necropsy (bottom panel, right image) reveals metastases in the omentum (highlighted by white arrows) To assess the efficacy of TAX2 and/or PARPi treatment, we used ID8 cells harboring Trp53 and Brca2 mutations; these cells exhibit accelerated tumor growth rates as compared with wild-type ID8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	These findings provide insights into the molecular mechanisms underlying the failure of the maintenance of epithelial gland morphology, which often takes place in early stages of breast carcinogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Bottom, representative images of live DCs expressing LifeAct–GFP (gray) and DNA (red); scale bar, 10 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11638255	Animals aged 8–10 weeks were inoculated subcutaneously with 5 × 10 mesothelioma cell lines, AB1-HA (Balb/c) or AE17-OVA (C57BL/6), both generated from intraperitoneal exposure to crocidolite asbestos.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", ...
PMC11541241	We can control the dose of the selected TOR inhibitors to make them effective for fungal pathogens but pose no threat to plants or human health.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10055960	The solubility of the compounds did not allow a testing of over 100 µM, and the calculation of the quantitative IC50 value was not possible for the selected compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	No protective atmosphere was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "protective", "atmosphere", "was", "used", "." ] } ]
PMC5034105	ZIKV is the first flavivirus known to be associated with congenital malformations, and sexual and vertical transmissions in human.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZIKV", "is", "the", "f...
PMC9100622	Atorvastatin also induced a strong increase in p21 (CDKN1A) expression (Figure 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Atorvastatin", "also", "induced", "a", "strong", "incr...
PMC11679033	This finding agreed with previous comet assay study by Stupin Polančec et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "agreed", "with", "previous", "comet", "assay", "study", ...
PMC11224020	h, Ccr7 expression in response to treatment with BI605906 (30 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "h", ",", "Ccr7", "expression", "in", "response", "to", "treatmen...
PMC10823017	C, D) are graphical representations of apoptosis on Caki-1 and 786-0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "D", ")", "are", "graphical", "representations", ...
PMC9920575	Several edible varietal groups have been described with different antiproliferative effects on different tumor cell lines , but the potential of the wild species Sechium chinantlense (Lira & F. Chiang) is unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711127	However, the discriminatory power of the TCR is imperfect and T cells can respond to very low affinity pMHC, which explains why self-Ags can sometimes trigger autoimmune reactions (26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	We hypothesize that I3C/DIM pretreatment primes the T cells to become hyperresponsive upon PMA/ionomycin stimulation which in turn differentially induces two major downstream Ca-dependent inflammatory pathways, NF-κB and NFAT1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Baseline disease parameters, treatment and outcomes are detailed in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Baseline", "disease", "parameters", ",", "treatment", "and", "outcomes", "are", ...
PMC10538569	Every 3 days, 500 μl cells in upper layer were replaced by fresh complete RPMI 1640, while 670 µl supernatant in bottom layer were collected and replenished with fresh complete RPMI 1640 medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The Kaplan-Meier method was used to estimate time to next treatment (TTNT) and overall survival (OS), both measured from the time of transplant; curves were compared using the log-rank test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808	Scale bar, 10 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "10", "μm", ".", "(" ] } ]
PMC7504302	Conclusively, individual or combinatorial inhibition of activins, activin-receptor-like kinases, and ERK pathway evokes a therapeutic window against MPM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conclusively", ",", ...
PMC11468365	After that, the outputs of the two subnetworks are concatenated and fed to another subnetwork to predict the synergy score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", "...
PMC9429973	Subsequent scRNA-Sequencing (4 WT vs. 4 Pax5 mice, pool of 20,000 cells hashtag labeled, with 50,000 reads/cell and VDJ-rearrangement analysis) confirmed a delayed BCR assembly and showed a skewing of light chain rearrangements towards the lambda isotype in Pax5 mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199	Wild-type-derived rod-shaped crystals were obtained of significant size and good morphology, but X-ray diffraction screening on the microfocus beamline P14 only resulted in diffraction patterns to ∼8 Å resolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11644761	Indeed, the expression level of cyclin CCND1, a marker specific to the transition from the G0 to G1 phase of the cell cycle, revealed contrasting effects of pterostilbene in SK-N-BE cells depending on their cell division status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	Images were captured at 10× magnification on an EVOS FL Auto Imaging System.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "at", "10", "×", "magnification", "...
PMC9429973	day 0 or day 1, cyclophosphamide 750 mg/m i.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "day", "0", "or", "day", "1", ",", "cyclophosphamide", "750", "mg/m", "i.v", "." ] } ...
PMC11773391	Therefore, we believe that the transcription of the MGMT promoter could be blocked by inhibiting the ERK pathway to reduce the level of MGMT protein, thus antagonising the drug resistance of tumour cells to TMZ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among this subset MYC-IGH-R was detected in 17/38 (44.7%) cases: 14 DH/THL and 3 DLBCL NOS (Table 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11634027	All ds; ds and ds wings had no PCV loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "ds", ";", "ds", "and", "ds", "wings", "had", "no", "PCV", "loss", ...
PMC3765139	Statistical analysis on the gene expression profile were performed by using Fisher’s analysis of variance (ANOVA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "on", "...
PMC11451829	In our study, histopathological analysis revealed the presence of lymphocytes and plasmocytes in the different stages of lesions; this identified cellular profile is similar to that of other studies that evaluated the immunologic basis involved in the pathogenesis of pterygium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	To operate the study data, the microarray probes with null gene test value were first eliminated and the remaining probes were mapped to human genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11576293	Also, compound 22 caused a big drop in the amount of Bcl-2 protein (0.90 ng/mL), followed by compound 29 (1.10 ng/mL) in the A-549 cell line compared to staurosporine (1.10 ng/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	Then, the sambamba software was utilized to remove PCR duplicates from the BAM files .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "sambamba", "software", "was", "utilized...
PMC9429973	The risk of death, need for hospital care, oxygen and intensive care was lower in this study compared with most previous studies, possibly because of less missing asymptomatic patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The only two grade 3-4 adverse events were neutropenia(7%,1/15) and f infections(7%,1/15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "only", "two", "grade", "3", "-", "4", ...
PMC5925824	1Binding and blocking properties of LY3300054.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Binding", "and", "blocking", "properties", "of", "LY3300054", "." ] } ]
PMC11194678	Various human STAU1 plasmids (Uniprot ID: O95793, RRID:SCR_002380) were individually cloned into a modified version of pET32a vector (Shan et al., 2018) (62310; Addgene).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10047551	Altogether, the above analyses did not reveal the presence of CpG sites that presented DNA methylation levels correlating with a PD-L1 mRNA expression that was more pronounced than that observed for cg19724470 and cg(chr9:5450951).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	T cells serve as a crucial mediator for immune surveillance and cancer elimination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cells", "serve", "as", "a", "crucial", "mediator", "for", "immun...
PMC9512971	The local tests were used for the primary endpoint in consideration of the time involved to send and analyze samples at the central laboratory and the potential difficulty of hospitalizing patients until the central laboratory had processed the tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	In the mixture preferentially ACKR3 positive VAL-wt migrated to the draining lymph node along with VAL-wt, which do not express ACKR3 at the surface and CFP VAL-ko ( Figure 3C ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10123657	In this regard, the co-culture of mouse MSC and human leukemic cells has been used to study the protection against chemotherapeutic drugs and intercellular mitochondrial transfer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given their composition and abundance, sEV are commonly involved in cell-to-cell communication through the transfer of genetic material and proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "their", ...
PMC11806106	The negative control trace with just application of external buffer was subtracted and the trace was normalized to the baseline luminescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "negative", ...
PMC9429973	A. Pina Monteiro, A. R. Henriques, M. Mota, C. Salgado, J. Coelho, S. Quintas, M. J. Palaré, A. Ferrão Hematologia, Instituto Português de Oncologia de Lisboa; Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN); Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa; Unidade de Hematologia Pediátrica, Serviço de Pediatria, Departamento de Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa; Unidade de Neurologia Pediátrica, Serviço de Pediatria, Departamento de Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa, Lisboa, Portugal Background: Sickle cell anemia (SCD) is a multiorgan disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The rest 10 patients were alive in the period of the research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rest", "10", "patients", "were", "alive", "in", "the", "period", "o...
PMC11633763	Therefore, studying the specific molecular mechanisms underlying glycolysis in osteosarcoma is a promising research direction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "studying", "the", "specific", "molec...
PMC8540611	These did not depend on the cell line and were subsequently used in all subsequent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "did", "not", "depend", "on", "the", "ce...
PMC9429973	The analysis of the samples was performed in the Archimed laboratory using ArchimedLife platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "of", "the", "samples", "was", "performed", "i...
PMC11467964	The HR of the BMRG risk level was 1.174 (95% confidence interval [CI]: 1.118–1.233) and 1.147 (95% CI:1.084–1.213) in univariate and multivariate Cox regression, respectively (Supporting Information S1: Figure S5k,l).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	The WashU Epigenome Browser (Li et al., 2022) (http://epigenomegateway.wustl.edu/browser), the 3D Genome Browser (http://3dgenome.fsm.northwestern.edu) (Wang Y. et al., 2018), Ensembl (v104) website (Martin et al., 2023) and the Integrative Genomics Viewer, IGV (Robinson et al., 2011) were used for data visualisation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11607638

EC50 = 251 pM. The abscissa in panels (A–I) is time in min as indicated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EC50", "=", "251", "pM.", "...

PMC9429973

These findings should further reduce vaccine hesitancy among ITP patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "should", "further", "reduce", "vaccine", "hesitancy", "among", "ITP", "pati...

PMC11703992

B Intersection of DEGs of CD4+ Memory T cells-reference and CD4+ Naive T cells-reference, conducted in old samples and GCA samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11742290

PE04 ovarian cancer cells programmed into pluripotent stem cells (iPSCs) expressed high levels of LGR5 and were more resistant to cisplatin and taxol compared to parental PEO4 cells .

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Cell cycle synchronization was obtained using SynchroSet kit.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cycle", "synchronization", "was", "obtained", "using", "SynchroSet", "kit", "." ] } ]

PMC11271800

This may be because high levels of proinflammatory factors in inflammation contribute to the generation of M2 TAMs, resulting in a high expression level of M2 TAMs, which in turn favor metastasis and largely predicts that the associated tumors are progressing or have progressed and deteriorated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11680562

Pvt.

[ { "tags": [ "O", "O" ], "tokens": [ "Pvt", "." ] } ]

PMC11459296

To address these challenges, we aimed to use cord blood mononuclear cells (CB-MNCs) as an alternative immunologically naïve source for humanization in NSG and NSG-Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (NSGS) mice which express human interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612626

Cells were stained with the following antibodies: APC anti–mouse H-2Kb-SIINFEKL-specific antibody (BioLegend 141606), APC mouse IgG1, κ isotype control (BioLegend, 981806), APC rat anti–mouse CD8a (BD Biosciences, 553035), and APC mouse IgG2a κ isotype control (BD Biosciences, 550882).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7582629

The positive differences at both the 752 and 1088 cm bands are assigned to the increased nucleic acid content which corresponds to the overexpression of HER2 protein in BT474 cells.

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PMC11013014

Dose–response curves were generated using Graph Prism software (version 9.5.1) (https://www.graphpad.com/demos/, accessed on 11 February 2024), and IC50 values were calculated using polynomial curves (four- or five-parameter logistic equations) with the same software.

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PMC10582828

Genetic recombination can occur with both DNA and RNA viruses, including viruses of the Coronaviridae families.

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PMC10854447

The retain option specifies the number of poses (30) to pass to the refinement for energy minimisation in the pocket before restoring with the GBVI/WSA dG scoring function.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

A Averaged BRET-based measurement of HEK293 cells stably expressing MOR BRET-sensor.

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Averaged", "BRET-based", "measurement", "of", "HEK293", "cells", "stably", "e...

PMC11271278

We used the “aggregated results” file in the “PCAWG – full” dataset released on August 29, 2023, which listed the DNA segments included in each amplicon.

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PMC9599726

Annotations of Homo_sapiens.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Annotations", "of", "Homo_sapiens", "." ] } ]

PMC6684588

Scale bar, 100 µm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "100", "µm", ".", "(" ] } ]

PMC10734950

To gage the phosphorylation of essential biological pathways sometimes responsible for oncogenesis, a MAPK and JAK-STAT Array was conducted (RayBiotech Human/Mouse MAPK Phosphorylation Array AAH-MAPK-1-2, Human JAK-STAT Pathway Phosphorylation Array C1 AAH-JAK-STAT-1-2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11783017

Ⅰ: Control, Ⅱ: PGP, Ⅲ: Mn@PGP, Ⅳ: Cis/Mn@PGP, Ⅴ: Mn/NH@PGP, Ⅵ: Cis/Mn/NH@PGP.Fig.

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PMC11413393

Respective oligonucleotides were ordered from IDT and then cloned into the sgRNA delivery LRG plasmid (Addgene Plasmid #65656) using a BsmBI digestion.

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PMC10810426

However, it is clear that even in nondividing DCs, the MLV p12 protein is still required for integration of viral DNA into the chromosomes.

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PMC9429973

A comprehensive update on our cohort, sequencing data and MSC characterization will be shown at the conference.

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PMC11597167

Relevant to the amyloid cascade hypothesis, β-site amyloid precursor protein cleaving enzyme-1 (BACE1, also known as β-secretase or memapsin 2) is an enzyme primarily known for its role in the amyloidogenic pathway leading to the production of Aβ peptides, which are implicated in the pathogenesis of AD .

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PMC11738017

Box plot comparing the PFS of patients with or without antigen loss at relapse. (

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PMC3730428

cIAP1 was from Enzo (Exeter, UK).

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PMC7812570

TZM-bl cells expressing GPI-m36.4 or GPI-FluIgG03 were used as targets and cocultured with CEMss-CCR5 donor cells that were preinfected with one of the three viruses. %

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PMC11543935

The printed part is connected with a luer-lock system to a 20 ml syringe.

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PMC9429973

Consistently, FTO silencing mediated by lentivirus exhibited exquisite sensitivity to ibrutinib in CLL cells (Figure 1B).

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PMC11718817

It is tempting to speculate that NLRP3-induced increased expression of coinhibitory molecules such as PD-L1 on intraspheroidal macrophages and tumor cells is causing the slight decrease in spheroid rejection that was observed in our spheroid model.

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PMC11790599

The TSL-induced macropinosomes acquire characteristics of early and late endosomes, as indicated by the presence of Rab5 and Rab7 proteins on the membrane of macropinosomes, respectively (Figures 3C, D).

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PMC11607638

Thoracic injections of dsSK, dsSKR, dsGFP, or DEPC water were performed in adult mosquitoes.

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PMC11055323

Sheared DNA was size selected using VAHTS® DNA Clean Beads N411.

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PMC11674441

We selected the HLA class II-restricted neoantigen long peptide derived from the nonsynonymous SNV from TTN that included an amino acid sequence with high affinity to HLA class I. As shown in Figure 3, both CD8-positive T cells (CD8 purity = 97.8%) and CD4-positive T cells (CD4 purity = 98.4%) obtained after Neo-P DC vaccination responded to mDCs pulsed with the HLA class II-restricted mutant long peptide (TTN-II).

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PMC11295144

The current study therefore aimed to investigate whether and how the interaction between GABAARs and NL2 may lead to the establishment of functional synapses in the absence of other synaptic proteins using a reduced in vitro co-culture system.

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PMC8009078

4The binding mode of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 Dock score from Glide and Autodock vina, and binding energy from Prime-MMGBSA The binding interaction of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 The binding mode of A1, A2, A3, A4 and A5 with the active site of the TMPRSS2 Cyclohexane ring substituted with 5′ OH group was found to interact with Ile452 to form two HBs with a distance of 2.09 and 3.04 Å. Another pyran ring contains two hydroxyl and two methoxy functional groups was seen to form HB along with a distance of 2.44 Å. Furthermore, A1 interacted with the TMPRSS2 to with better affinity as suggested by the highest Prime-MMGBSA binding energy (− 70.472 kcal/mol), along with a Glide dock score (− 9.574 kcal/mol) and the ADV binding energy (− 8.80 kcal/mol).

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PMC9429973

Dual Myc/Bcl2 expressor (DEL) was present in 42.2% of early PD patients (n=45) compared to 25.5% in non-ePD patients (n=736)(p=0.013).

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PMC11653533

Furthermore, when in touch with the toxic plant components, the leaves and fruits alleviate allergic reactions, nausea, and skin itching (Wangpan et al., 2019).

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PMC11354225

Cells were treated with MAL-PDT (MAL 2 mM) and MAL-PDT + EGCG (10, 20 and 40 µM), both with red light irradiation using 4 J/cm.

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PMC11659734

The micronucleus assay, on the other hand, provides insights into clastogenicity (chromosome breakage) and aneugenicity (chromosome missegregation), which are crucial for understanding the broader genotoxic impact (Fenech, 2007).

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PMC11746948

Statistical analysis: one-way ANOVA with Tukey’s test for (c, f).

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PMC11391695

As a result, we postulated that the interaction between ACYP2 and TERT influences the length of telomeres .

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PMC11138140

Single-cell tracking of both cardiomyocyte surface area and three-dimensional optical volume revealed dynamic increases in these parameters throughout the 24 h imaging period, demonstrating the potential of this technology to explore cardiomyocyte hypertrophic responses with greater temporal resolution; however, technological limitations were also observed and should be considered in the experimental design and interpretation of results.

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PMC8903741

The mixture was incubated at room temperature for 1 h. andwashed three times using 500 μL of PBS.

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PMC7602170

In another study, BEZ235 plus imatinib remarkably improved the efficacy, with decreasing tumor volume and increasing pro-apoptotic effects in both imatinib-resistant (UZLX-GIST2) and imatinib-sensitive (UZLX-GIST3 and UZLX-GIST4) xenograft models .

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PMC10898159

The epigenetic silencing of SH3BP2 leads to decreased oncogenic KIT and PDGFRA expression at both mRNA and protein levels .

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PMC9429973

Aims: this study was designed to evaluate glycoproteins IIb-IIIa levels (CD41and CD61) by flowcytometry on the platelet surface of patients with GT in addition to bleeding score for proper typing and bleeding assessment of Egyptian patients with GT.

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PMC5673955

Telomerase inhibitors have been expected to become promising agents for cancer treatment 11, 12.

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PMC11655536

D Statistical analysis of apoptotic cells of RPMI-8226 (upper) and U266 (lower) in (C).

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PMC11323699

Necropsy (bottom panel, right image) reveals metastases in the omentum (highlighted by white arrows) To assess the efficacy of TAX2 and/or PARPi treatment, we used ID8 cells harboring Trp53 and Brca2 mutations; these cells exhibit accelerated tumor growth rates as compared with wild-type ID8.

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PMC11587606

These findings provide insights into the molecular mechanisms underlying the failure of the maintenance of epithelial gland morphology, which often takes place in early stages of breast carcinogenesis.

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PMC11224020

Bottom, representative images of live DCs expressing LifeAct–GFP (gray) and DNA (red); scale bar, 10 µm.

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PMC11638255

Animals aged 8–10 weeks were inoculated subcutaneously with 5 × 10 mesothelioma cell lines, AB1-HA (Balb/c) or AE17-OVA (C57BL/6), both generated from intraperitoneal exposure to crocidolite asbestos.

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PMC11541241

We can control the dose of the selected TOR inhibitors to make them effective for fungal pathogens but pose no threat to plants or human health.

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PMC10055960

The solubility of the compounds did not allow a testing of over 100 µM, and the calculation of the quantitative IC50 value was not possible for the selected compounds.

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PMC10890055

No protective atmosphere was used.

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PMC5034105

ZIKV is the first flavivirus known to be associated with congenital malformations, and sexual and vertical transmissions in human.

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PMC9100622

Atorvastatin also induced a strong increase in p21 (CDKN1A) expression (Figure 4E).

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PMC11679033

This finding agreed with previous comet assay study by Stupin Polančec et al. .

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PMC11224020

h, Ccr7 expression in response to treatment with BI605906 (30 µM).

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PMC10823017

C, D) are graphical representations of apoptosis on Caki-1 and 786-0.

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PMC9920575

Several edible varietal groups have been described with different antiproliferative effects on different tumor cell lines , but the potential of the wild species Sechium chinantlense (Lira & F. Chiang) is unknown.

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PMC11711127

However, the discriminatory power of the TCR is imperfect and T cells can respond to very low affinity pMHC, which explains why self-Ags can sometimes trigger autoimmune reactions (26).

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PMC5535901

We hypothesize that I3C/DIM pretreatment primes the T cells to become hyperresponsive upon PMA/ionomycin stimulation which in turn differentially induces two major downstream Ca-dependent inflammatory pathways, NF-κB and NFAT1.

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PMC9429973

Baseline disease parameters, treatment and outcomes are detailed in Table 1.

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PMC10538569

Every 3 days, 500 μl cells in upper layer were replaced by fresh complete RPMI 1640, while 670 µl supernatant in bottom layer were collected and replenished with fresh complete RPMI 1640 medium.

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PMC9429973

The Kaplan-Meier method was used to estimate time to next treatment (TTNT) and overall survival (OS), both measured from the time of transplant; curves were compared using the log-rank test.

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PMC11720808

Scale bar, 10 μm. (

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PMC7504302

Conclusively, individual or combinatorial inhibition of activins, activin-receptor-like kinases, and ERK pathway evokes a therapeutic window against MPM.

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PMC11468365

After that, the outputs of the two subnetworks are concatenated and fed to another subnetwork to predict the synergy score.

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PMC9429973

Subsequent scRNA-Sequencing (4 WT vs. 4 Pax5 mice, pool of 20,000 cells hashtag labeled, with 50,000 reads/cell and VDJ-rearrangement analysis) confirmed a delayed BCR assembly and showed a skewing of light chain rearrangements towards the lambda isotype in Pax5 mice.

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PMC7709199

Wild-type-derived rod-shaped crystals were obtained of significant size and good morphology, but X-ray diffraction screening on the microfocus beamline P14 only resulted in diffraction patterns to ∼8 Å resolution.

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PMC11644761

Indeed, the expression level of cyclin CCND1, a marker specific to the transition from the G0 to G1 phase of the cell cycle, revealed contrasting effects of pterostilbene in SK-N-BE cells depending on their cell division status.

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PMC10033453

Images were captured at 10× magnification on an EVOS FL Auto Imaging System.

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PMC9429973

day 0 or day 1, cyclophosphamide 750 mg/m i.v.

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PMC11773391

Therefore, we believe that the transcription of the MGMT promoter could be blocked by inhibiting the ERK pathway to reduce the level of MGMT protein, thus antagonising the drug resistance of tumour cells to TMZ.

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PMC9429973

Among this subset MYC-IGH-R was detected in 17/38 (44.7%) cases: 14 DH/THL and 3 DLBCL NOS (Table 1a).

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PMC11634027

All ds; ds and ds wings had no PCV loss.

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PMC3765139

Statistical analysis on the gene expression profile were performed by using Fisher’s analysis of variance (ANOVA).

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PMC11451829

In our study, histopathological analysis revealed the presence of lymphocytes and plasmocytes in the different stages of lesions; this identified cellular profile is similar to that of other studies that evaluated the immunologic basis involved in the pathogenesis of pterygium.

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PMC11531744

To operate the study data, the microarray probes with null gene test value were first eliminated and the remaining probes were mapped to human genes.

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PMC11576293

Also, compound 22 caused a big drop in the amount of Bcl-2 protein (0.90 ng/mL), followed by compound 29 (1.10 ng/mL) in the A-549 cell line compared to staurosporine (1.10 ng/mL).

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PMC11748335

Then, the sambamba software was utilized to remove PCR duplicates from the BAM files .

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PMC9429973

The risk of death, need for hospital care, oxygen and intensive care was lower in this study compared with most previous studies, possibly because of less missing asymptomatic patients.

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PMC9429973

The only two grade 3-4 adverse events were neutropenia(7%,1/15) and f infections(7%,1/15).

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PMC5925824

1Binding and blocking properties of LY3300054.

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PMC11194678

Various human STAU1 plasmids (Uniprot ID: O95793, RRID:SCR_002380) were individually cloned into a modified version of pET32a vector (Shan et al., 2018) (62310; Addgene).

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PMC10047551

Altogether, the above analyses did not reveal the presence of CpG sites that presented DNA methylation levels correlating with a PD-L1 mRNA expression that was more pronounced than that observed for cg19724470 and cg(chr9:5450951).

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PMC11409031

T cells serve as a crucial mediator for immune surveillance and cancer elimination.

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PMC9512971

The local tests were used for the primary endpoint in consideration of the time involved to send and analyze samples at the central laboratory and the potential difficulty of hospitalizing patients until the central laboratory had processed the tests.

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PMC9878562

In the mixture preferentially ACKR3 positive VAL-wt migrated to the draining lymph node along with VAL-wt, which do not express ACKR3 at the surface and CFP VAL-ko ( Figure 3C ).

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PMC10123657

In this regard, the co-culture of mouse MSC and human leukemic cells has been used to study the protection against chemotherapeutic drugs and intercellular mitochondrial transfer .

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PMC9429973

Given their composition and abundance, sEV are commonly involved in cell-to-cell communication through the transfer of genetic material and proteins.

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PMC11806106

The negative control trace with just application of external buffer was subtracted and the trace was normalized to the baseline luminescence.

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PMC9429973

A. Pina Monteiro, A. R. Henriques, M. Mota, C. Salgado, J. Coelho, S. Quintas, M. J. Palaré, A. Ferrão Hematologia, Instituto Português de Oncologia de Lisboa; Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN); Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa; Unidade de Hematologia Pediátrica, Serviço de Pediatria, Departamento de Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa; Unidade de Neurologia Pediátrica, Serviço de Pediatria, Departamento de Pediatria, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa, Lisboa, Portugal Background: Sickle cell anemia (SCD) is a multiorgan disease.

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PMC9429973

The rest 10 patients were alive in the period of the research.

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PMC11633763

Therefore, studying the specific molecular mechanisms underlying glycolysis in osteosarcoma is a promising research direction.

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PMC8540611

These did not depend on the cell line and were subsequently used in all subsequent experiments.

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PMC9429973

The analysis of the samples was performed in the Archimed laboratory using ArchimedLife platform.

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PMC11467964

The HR of the BMRG risk level was 1.174 (95% confidence interval [CI]: 1.118–1.233) and 1.147 (95% CI:1.084–1.213) in univariate and multivariate Cox regression, respectively (Supporting Information S1: Figure S5k,l).

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PMC11319300

The WashU Epigenome Browser (Li et al., 2022) (http://epigenomegateway.wustl.edu/browser), the 3D Genome Browser (http://3dgenome.fsm.northwestern.edu) (Wang Y. et al., 2018), Ensembl (v104) website (Martin et al., 2023) and the Integrative Genomics Viewer, IGV (Robinson et al., 2011) were used for data visualisation.

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