OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	As the indolent in character, we know that durable survival is expected but relapse could be not unusual.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "the", "indolent", "in", ...
PMC10914904	Activation of TLRs promotes pathogen clearance through the induction of autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "TLRs", "promotes", "pathogen", "clearance", "through", "the", "inductio...
PMC11277157	Due to the importance of siRNAs for research and as a promising therapeutic method, optimization is needed to achieve the desired responses while optimizing silencing efficiency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3730428	In this study, we examined the activity of a novel SMC in preclinical models of MPM to provide evidence for their clinical evaluation in this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	G. RIP assay in HCCLM3 cells and circUSP10 and miR-211-5p enrichment analysis.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G.", "RIP", "assay", "in", "HCCLM3", "cells", "and", "c...
PMC11297139	For live-cell imaging, 293T cell was transfected with the GFP-ARID1A construct a day before and imaged.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "live-cell", "imaging", ...
PMC11271800	Activation of the CCL2-CCR2 axis promotes TAM recruitment into the TME.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "the", "CCL2-CCR2", "axis", "promotes", "TAM", "recruitment", "into", ...
PMC7342409	Caspase-7 expression in tumor tissue detected by immunohistochemistry. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase-7", "expression", "in", "tumor", "tissue", "detected", "by", "immunohistochemistry", ".", "(" ]...
PMC9219615	Before use in experiments, the viability of each cell culture was quantified by flow cytometry following propidium iodide (PI) staining or visualized by trypan blue exclusion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11171319	Although HCMV was considered as a herpesvirus with no transforming capacity, twenty years ago, the oncomodulation paradigm emerged that could explain the accelerated progression of cancers fueled by HCMV-infected tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	Hierarchical clustering could not distinguish BC from non-cancer and luminal from basal cell subtypes, using the median values (see Supplementary Figure S2 in reference ) or average values (Supplementary Figure S5) of mass cytometry intensities of each antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	Following an additional three 10-minute washes with Tris-buffered saline/Tween-20 (TBST) at room temperature, the immunoreactivity was visualized using an ECL kit (Sangon Biotech), and the membranes were then exposed to Kodak XAR-5 film (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983	Methods: We synthesized a rhenium tricarbonyl complex (Complex 2) and its Tc analog (Complex 2’) by incorporating triphenylphosphine instead of bromine as the monodentate ligand and as the counter-ion, resulting in a positively charged compound that forms cationic structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11708541	Sulfasalazine 11, as an Immunomodulator and Crizotinib 12 is a tyrosine kinase inhibitor of the anaplastic lymphoma kinase (ALK), receptor tyrosine enzyme (ROS1) and mesenchymal epithelial transition (MET) kinases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	Our further experimental results show that CCDC25 promotes YAP phosphorylation and reduces nuclear entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "further", "experimental", "results", "show", "that", "CCDC25", ...
PMC11770199	With the aid of nuclear staining, we observed that the p14-induced cell fusion initiated at around 8 h after transfection, when cells with 2 nuclei first appeared.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672617	Lithocholic acid represents a rare example of a toxic endobiotic, and vertebrates have evolved a range of adaptive mechanisms to effectively detoxify it .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4005030	Fruits of Ficus species are rich source of polyphenolic compounds and flavanoids which are responsible for strong antioxidant properties that help in prevention and therapy of various oxidative stress related diseases such as neurodegenerative and hepatic diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8343815	An average dimension of 40nm×5nm can be observed in Figure-1(a) for AuNRs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "average", "dimension", "of", "40nm", "×", ...
PMC11574271	In contrast, the average tumor size from the T24-659-3p-RON group was comparable to that from the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC5963610	It does not mediate the same interactions than the endogenously synthetized NGcGM3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "does", "not", "mediate", "the", "same", "interactions", "than", "the", ...
PMC9952933	Both DMEM and HOB medium showed a proportional increase in hydrogen peroxide depending on the CAP exposure time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "DMEM", "and", "HOB", "medium",...
PMC10135767	Likewise, calcium signaling in rat osteoclasts is activated by integrin αvβ3 stimulated by its RGD (Arg-Gly-Asp) ligands, which are involved in osteoclast function .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	Clinical trials have demonstrated the feasibility of manufacturing CAR-VST products at clinical scale level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "trials", "have", "demonstrated", "the", "feasibility", "of...
PMC11300085	To date, most referenced multifunctions of chemerin are attributed to the chemokine-like receptor 1 (CMKLR1), distributing broadly in many tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11767725	Metabolic inflammation amplifies these immune dysregulations, with adipokines like leptin promoting Th2 polarization and IL-4/IL-13 production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolic", "inflammation", "amplifies", "these", ...
PMC11720107	Moreover, both SOD1 and CAT are reportedly influenced by garlic extracts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "both", "SOD1", "and", "CAT", "are", "reportedly", "influenced",...
PMC11486946	The obtained indices for our system were 6% for CV, 6.2 for S/B, and 0.69 for Z’-factor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "indices",...
PMC4355729	In addition to UMPP3, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has also been identified as an important pathway in RCC26.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ],...
PMC11190538	Concerning HepG-2, human liver cancer cells, C-phycocyanin exerted notable antitumor activity up to 70 % even with the small concentration, 6.25 μg, exceeded that of Doxorubicin that reached about 55 % using the lowest concentration, 6.25 μg; and about 65 % using the highest concentration, 50 μg (Fig. 4).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11477621	H NMR (400 MHz, CDCl3) δ 7.52 (dd, J = 8.6, 5.4 Hz, 1H), 7.06 (d, J = 3.2 Hz, 1H), 7.00 (dd, J = 10.0, 2.3 Hz, 1H), 6.86 (ddd, J = 9.6, 8.6, 2.3 Hz, 1H), 6.46 (dd, J = 3.1, 0.9 Hz, 1H), 4.12 (q, J = 7.1 Hz, 2H), 4.04 (t, J = 7.1 Hz, 2H), 2.27 (t, J = 7.5 Hz, 2H), 1.82 (p, J = 7.3 Hz, 2H), 1.64–1.58 (m, 2H), 1.40–1.29 (overlap, 4H), 1.25 (t, J = 7.1 Hz, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748618	Human Immunodeficiency Virus Type 1 remains a major risk to global health with approximately 1.3 million new infections in 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "Immunodeficiency", ...
PMC10094992	Very few compounds have been described as selective for ALDH1A3 enzyme .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Very", "few", "compounds", "have", "been", "described", "as", "selective", "for", "AL...
PMC9920575	In some tumor cell lines, the release of cytochrome-c, a promoter of apoptosis via the intrinsic pathway, is promoted by plant phytochemicals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11756514	It has been reported that langerin can sense the β-GlcNAc but not the α-GlcNAc WTA modification (17, 22), whereas MBL recognizes both modifications (23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190238	H1 – H1 hESC, ME – mesendoderm, TRO – trophoblast-like cell, NPC – neural progenitor cell and MSC – mesenchymal stem cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5035325	Normal lung weight value is indicated (dashes lines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "lung", "weight", "value", "is", "indicated", "(", "dashes", "lines", ")", "." ...
PMC11721295	Lungs were then sectioned into multiple pieces for downstream assays: RNA isolation, protein isolation, or histology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lungs", "were", "then", "sectione...
PMC11643491	In order to assess the effect of drug release from engulfed particles in the absence of drug-containing particles in the surrounding medium, we seeded an additional plate where the medium was replaced 24 h after the introduction of the drug-containing particles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10813895	Haploinsufficiency of ELF5 expression in mice resembles women who are BRCA1 mutation carriers in terms of ELF5 expression, suggesting potential overlapping ELF5 function between mice and humans in terms of regulation of milk production by ELF5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	Analysis of the ROC curve confirmed that the prediction model developed in this study is reliable, indicating its potential application in clinical practice for predicting the prognosis of patients with ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At inclusion, the risk level of developing TLS, assessed in 149 patients, was low (28.2%) moderate (69.8%) or high (2.0%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Recently, we estimated that up to two thirds of B-other-ALL can be classified into novel subtypes using FISH and MLPA alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", "...
PMC11632064	QuantStudio Design and Analysis (Applied Biosystems) was used for data analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "QuantStudio", "Design", "and", "Analysis", "(", "Applied", "Biosystems", ")...
PMC11531744	It was indicating that the higher the expression of NSG1, ZBP1, GBP1P1, KIF26B, STX18 and CACNA1C, the stronger the sensitivity to the abovementioned drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Approximately 29% of patients with DLBCL are ≥75 years old.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "29", "%", "of", "patients", "with", "DLBCL", "are", "≥75", "years", ...
PMC11725127	In this study, we reveal that USP2 is a novel deubiquitinating enzyme for KRAS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "reveal", "that", "U...
PMC11670407	Previous studies reported that GPX4 might act as an inhibitory molecule of the mitochondrial apoptotic pathway; therefore, we hypothesized that GPX4 might be a downstream target protein of OTULIN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	Statistical significance was shown as: * P< 0.05, P< 0.01. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", ...
PMC10745221	The methyl donor of these enzymes is S-adenosylmethionine (AdoMet), a direct product of methionine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "methyl", "donor", "of", "these", "en...
PMC11806613	Images were captured using confocal microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "using", "confocal", "microscopy", "." ] } ]
PMC11489351	All RNA-Seq transcript data were analyzed compared to control MCF10A, with fold changes averaged across the six biological replicates (Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC9429973	3.	[ { "tags": [ "O", "O" ], "tokens": [ "3", "." ] } ]
PMC11367146	Daucosterol exhibited hydrogen bonds with ASN 519, HIS 516, and SER 512 amino acid residues as well as alkyl bond at ILE 451, LEU 479, LEU 508, and ARG 515 residues of ESR1 (Fig. 4C), while gigantol formed hydrogen bonds at GLY 521, GLU 353, and LEU 387 residues, with binding energies of −10.1 and −9.3 kcal/mol, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684269	Fu et al. revealed that, in DKD, junctional adhesion molecule-like protein (JAML) boosts podocyte lipid accumulation and subsequent podocyte damage via SIRT1-mediated SREBP1 signaling (99).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	Bar graphs show mean of cytokine concentration + SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "graphs", "show", "mean", "of", "cytokine", "concentration", "+", "SD", "." ] } ]
PMC10728200	This encompasses aspects such as the immune tolerance of late-stage ferroptotic cancer cells and the immunogenicity of early-stage ferroptotic cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "encompasses", ...
PMC9429973	Further study of the combination without a 2-week window (of itacitinib alone) and with objective measurement of patient reported symptoms is planned.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11412752	It is important to note that our understanding of STING's role in bacterial infections, including Salmonella, is still developing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", ...
PMC11402217	Data was analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "was", "analyzed", "by", "one-way", "ANOVA", "followed", "by", ...
PMC6835762	The ability of bare PGA, and PGA with the polymer backbone substituted with varying amounts of pendant C18 (stearate) and C8 (octanoate) chain length acyl groups, to encapsulate the water soluble drug dexamethasone phosphate (DXMP) into NPs was investigated in two papers from the Garnett group .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. Granau, P. Andersen, T. Jakobsen, L. Sommer Kristensen, J. Bay Mogensen, G. Dias Correa Guldbergsen, K. Dimopoulos, K. Grønbæk Faculty of Health and Biomedical Sciences, University of Copenhagen; Department of Hematology, Rigshospitalet, Copenhagen; Department of Biomedicine, University of Aarhus, Aarhus; Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark Background: Venetoclax (Ven), a BH3 mimetic inhibiting BCL2, appears to be highly cytotoxic to most Mantle Cell Lymphoma (MCL) cells due to their high BCL2 levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11514418	Astragalus polysaccharide (APS), a pure Chinese medicine preparation primarily made from the traditional Chinese herb Astragalus, plays a positive role in the treatment of many malignant tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	This will enable a greater understanding of not only emissions but also how they can be reduced most cost effectively and by how much.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Tumor bulky (≥7cm) was present in 34.5% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "bulky", "(", "≥7", "cm", ")", "was", "present", "in", ...
PMC11271278	H Summary of AmpliconArchitect data from PCAWG tumor samples: most of oncogene amplicons contain additional trans or cis DNA segments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "Summary", "o...
PMC11754784	The fluorescent intensity after computation was further confirmed by confocal imaging as shown in Fig. 3h and Supplementary Figs. 19–22.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluorescent", "intens...
PMC10747160	Filtered lentiviral pseudovirus solution was stored as 450 μL aliquots in low-binding 1.5 mL tubes (ThermoFisher Cat # 90410, Waltham, MA, USA) at −75 °C until use in future assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	Based on the results observed, the cytotoxicity of cells subjected to combination therapy was significantly (P<0.001) higher in both cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based",...
PMC9429973	11 eligible adult (r/r) B-ALL patients with a median age of 37 years (range 19 - 61 years) were enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9512971	Age groups: ≥ 65 years vs < 65 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Age", "groups", ":", "≥", "65", "years", "vs", "<", "65", "years", "." ] } ]
PMC8992508	Results suggested that the ester portion of the lead compound Ko143 is not necessary for the activity and can be replaced by more stable and simple groups, such as a methyl group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	The optical density for each condition was calculated as a percentage of the untreated control after subtracting for background absorbance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optical", "density", ...
PMC9429973	The remaining eight subjects had a median treatment duration of 38 weeks (range 11-60 weeks).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "remaining", "eight", "subj...
PMC11513571	To compare unstimulated and stimulated cells with different stimulants, Student’s paired t-test was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "compare", "unstimulated", "and", "stimulated", "...
PMC11739504	To validate disrupted cilia assembly by Kat2b absence, comparison between Arl13b, well-established ciliary marker, and acetylated α-tubulin was verified (Fig. 2e,f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11675244	In addition to its central role in Wnt signaling, GSK3β acts downstream of tyrosine kinase receptors and regulates its activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ...
PMC10135767	MAdCAM-1 binds to integrin α4β7, which mediates the rolling and arrest of circulating lymphocytes upon the vascular endothelia during lymphocytic homing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAdCAM-1", "...
PMC6160470	Slides were then incubated with 1:100 antibody dilution in blocking solution for 30 minutes at room temperature (RT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "then", ...
PMC11397654	It can thus be concluded that 32h is a potential antitumour drug, since it has a high anti-proliferative ability and can possibly induce apoptosis in the cancer cells, not just inhibit proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	It represents one of the most prevalent circRNAs derived from exons and is associated with the gene symbol SMA4; therefore, has_circRNA_103870 is also referred to as circ_SMA4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	l Representative IHC images of GPX4 and quantitative analysis of GPX4-positive cells (n = 6) (scale bars: 200 μm and 400 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	Cell lysates were collected 72 h post-transduction, and western blotting was performed using an anti-MAML2 antibody to detect YM and MAML2 proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", ...
PMC11286266	This analysis identified genes whose loss confers repression of the ATF6α reporter during ER stress without impacting ER-stress-induced IRE1, compared to treated-unsorted (TUS) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	We used 4 PCs for CM and 12 PCs for SCS, based on the MR-MEGA guideline for the number of PCs to fit to equal the number of populations minus 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	As different HEK293 lineages are propagated under different conditions and the observation that immortalized continuously cultured cell lines, such as HEK293, have a high degree of genomic instability with frequent chromosome rearrangements it can be expected that different HEK293 lineages are differentiated at the genomic and transcriptomic level compared to the parental cell line.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC11541241	Pathogens including F. graminearum could modulate their growth and metabolism to respond to environmental cues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathogens", "including", "F.", "graminearum", "could", "modulate"...
PMC11088135	The proteins were then transferred to PVDF membranes (Millipore) and blocked with a blocking solution containing 5% skimmed milk for 1 h. After blocking, the protein-containing membranes were incubated with primary antibodies overnight at 4 °C, including anti-YAP1, anti-Bax, anti-Bcl-2, anti-GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9918897	However, one of the main differences was the presence of an alcoholic medium, which in our case was more than six times higher than the exposure used in the abovementioned study by Ferk et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9592219	Consistent with these reports, miR-22-5p mimics reduced the HCC cell proliferation, migration, and invasion, in addition to inducing apoptosis, which was rescued by the overexpression of TOP2A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	In most cases, the copper complex is more efficient than temozolomide, whereas the gold complex is only slightly more efficient than temozolomide at high concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791432	ANXA1 expression was correlated with progression of glioma with higher expression levels observed in GBM, which was validated using PCR and WB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANXA1",...
PMC11209164	TPF increased Ad5-GFP-associated fluorescence in MRC5 (peak ~ 30 µM), A549 (peak ~ 30 µM), HT1080 (peak ~ 50 µM), and HepG2 (peak ~ 50 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O"...
PMC11681005	However, the top enriched motif in both datasets was FOXA1 instead of AR, suggesting that AR binding to DNA is partially mediated by other transcription factors (Figure S6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	Once the inhibitory properties of HLA-G depend on the interaction with its receptors , the present study has evaluated both univariate and multivariate associations with vitiligo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10758402	The anti-inflammatory effects of DMF are well-known which might overall dampen lymphocyte responses despite greater infiltration of CD3+ cells (31).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	Aims: To evaluate efficacy and safety of Sd in Chinese RRMM pts previously treated with CAR-T. Methods: The study enrolled 82 pts previously exposed and refractory to a proteasome inhibitor (PI), an immunomodulatory agent (IMiD), and last line of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, considering PMF and SMF separately, a different behavior of CD34+ cells was detected: in detail, in PMF pts circulating hematopoietic precursors gradually decreased from 3 to 24 mts of RUX therapy in parallel with the persistence of a reduction in the spleen size (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There were 153 patients in the Len-only group, and 78 in the Len-combo group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "153", "patients", "in", "the", "Len-only",...
PMC9429973	Eligible participants were males or females aged 18-55 years with no clinically significant medical or physical conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eligible", "participants", "were", ...

PMC9429973

As the indolent in character, we know that durable survival is expected but relapse could be not unusual.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "the", "indolent", "in", ...

PMC10914904

Activation of TLRs promotes pathogen clearance through the induction of autophagy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "TLRs", "promotes", "pathogen", "clearance", "through", "the", "inductio...

PMC11277157

Due to the importance of siRNAs for research and as a promising therapeutic method, optimization is needed to achieve the desired responses while optimizing silencing efficiency.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3730428

In this study, we examined the activity of a novel SMC in preclinical models of MPM to provide evidence for their clinical evaluation in this disease.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10565698

G. RIP assay in HCCLM3 cells and circUSP10 and miR-211-5p enrichment analysis.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G.", "RIP", "assay", "in", "HCCLM3", "cells", "and", "c...

PMC11297139

For live-cell imaging, 293T cell was transfected with the GFP-ARID1A construct a day before and imaged.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "live-cell", "imaging", ...

PMC11271800

Activation of the CCL2-CCR2 axis promotes TAM recruitment into the TME.

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PMC7342409

Caspase-7 expression in tumor tissue detected by immunohistochemistry. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase-7", "expression", "in", "tumor", "tissue", "detected", "by", "immunohistochemistry", ".", "(" ]...

PMC9219615

Before use in experiments, the viability of each cell culture was quantified by flow cytometry following propidium iodide (PI) staining or visualized by trypan blue exclusion .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11171319

Although HCMV was considered as a herpesvirus with no transforming capacity, twenty years ago, the oncomodulation paradigm emerged that could explain the accelerated progression of cancers fueled by HCMV-infected tumor cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11240448

Hierarchical clustering could not distinguish BC from non-cancer and luminal from basal cell subtypes, using the median values (see Supplementary Figure S2 in reference ) or average values (Supplementary Figure S5) of mass cytometry intensities of each antibody.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11739484

Following an additional three 10-minute washes with Tris-buffered saline/Tween-20 (TBST) at room temperature, the immunoreactivity was visualized using an ECL kit (Sangon Biotech), and the membranes were then exposed to Kodak XAR-5 film (Sigma-Aldrich).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11434983

Methods: We synthesized a rhenium tricarbonyl complex (Complex 2) and its Tc analog (Complex 2’) by incorporating triphenylphosphine instead of bromine as the monodentate ligand and as the counter-ion, resulting in a positively charged compound that forms cationic structures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11708541

Sulfasalazine 11, as an Immunomodulator and Crizotinib 12 is a tyrosine kinase inhibitor of the anaplastic lymphoma kinase (ALK), receptor tyrosine enzyme (ROS1) and mesenchymal epithelial transition (MET) kinases.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10988808

Our further experimental results show that CCDC25 promotes YAP phosphorylation and reduces nuclear entry.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "further", "experimental", "results", "show", "that", "CCDC25", ...

PMC11770199

With the aid of nuclear staining, we observed that the p14-induced cell fusion initiated at around 8 h after transfection, when cells with 2 nuclei first appeared.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11672617

Lithocholic acid represents a rare example of a toxic endobiotic, and vertebrates have evolved a range of adaptive mechanisms to effectively detoxify it .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC4005030

Fruits of Ficus species are rich source of polyphenolic compounds and flavanoids which are responsible for strong antioxidant properties that help in prevention and therapy of various oxidative stress related diseases such as neurodegenerative and hepatic diseases.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8343815

An average dimension of 40nm×5nm can be observed in Figure-1(a) for AuNRs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "average", "dimension", "of", "40nm", "×", ...

PMC11574271

In contrast, the average tumor size from the T24-659-3p-RON group was comparable to that from the control group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC5963610

It does not mediate the same interactions than the endogenously synthetized NGcGM3.

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PMC9952933

Both DMEM and HOB medium showed a proportional increase in hydrogen peroxide depending on the CAP exposure time.

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PMC10135767

Likewise, calcium signaling in rat osteoclasts is activated by integrin αvβ3 stimulated by its RGD (Arg-Gly-Asp) ligands, which are involved in osteoclast function .

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PMC11774747

Clinical trials have demonstrated the feasibility of manufacturing CAR-VST products at clinical scale level.

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PMC11300085

To date, most referenced multifunctions of chemerin are attributed to the chemokine-like receptor 1 (CMKLR1), distributing broadly in many tissues.

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PMC11767725

Metabolic inflammation amplifies these immune dysregulations, with adipokines like leptin promoting Th2 polarization and IL-4/IL-13 production.

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PMC11720107

Moreover, both SOD1 and CAT are reportedly influenced by garlic extracts .

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PMC11486946

The obtained indices for our system were 6% for CV, 6.2 for S/B, and 0.69 for Z’-factor.

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PMC4355729

In addition to UMPP3, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has also been identified as an important pathway in RCC26.

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PMC11190538

Concerning HepG-2, human liver cancer cells, C-phycocyanin exerted notable antitumor activity up to 70 % even with the small concentration, 6.25 μg, exceeded that of Doxorubicin that reached about 55 % using the lowest concentration, 6.25 μg; and about 65 % using the highest concentration, 50 μg (Fig. 4).

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PMC11477621

H NMR (400 MHz, CDCl3) δ 7.52 (dd, J = 8.6, 5.4 Hz, 1H), 7.06 (d, J = 3.2 Hz, 1H), 7.00 (dd, J = 10.0, 2.3 Hz, 1H), 6.86 (ddd, J = 9.6, 8.6, 2.3 Hz, 1H), 6.46 (dd, J = 3.1, 0.9 Hz, 1H), 4.12 (q, J = 7.1 Hz, 2H), 4.04 (t, J = 7.1 Hz, 2H), 2.27 (t, J = 7.5 Hz, 2H), 1.82 (p, J = 7.3 Hz, 2H), 1.64–1.58 (m, 2H), 1.40–1.29 (overlap, 4H), 1.25 (t, J = 7.1 Hz, 3H).

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PMC11748618

Human Immunodeficiency Virus Type 1 remains a major risk to global health with approximately 1.3 million new infections in 2022.

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PMC10094992

Very few compounds have been described as selective for ALDH1A3 enzyme .

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PMC9920575

In some tumor cell lines, the release of cytochrome-c, a promoter of apoptosis via the intrinsic pathway, is promoted by plant phytochemicals .

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PMC11756514

It has been reported that langerin can sense the β-GlcNAc but not the α-GlcNAc WTA modification (17, 22), whereas MBL recognizes both modifications (23).

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PMC11190238

H1 – H1 hESC, ME – mesendoderm, TRO – trophoblast-like cell, NPC – neural progenitor cell and MSC – mesenchymal stem cell.

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PMC5035325

Normal lung weight value is indicated (dashes lines).

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PMC11721295

Lungs were then sectioned into multiple pieces for downstream assays: RNA isolation, protein isolation, or histology.

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PMC11643491

In order to assess the effect of drug release from engulfed particles in the absence of drug-containing particles in the surrounding medium, we seeded an additional plate where the medium was replaced 24 h after the introduction of the drug-containing particles.

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PMC10813895

Haploinsufficiency of ELF5 expression in mice resembles women who are BRCA1 mutation carriers in terms of ELF5 expression, suggesting potential overlapping ELF5 function between mice and humans in terms of regulation of milk production by ELF5.

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PMC10919056

Analysis of the ROC curve confirmed that the prediction model developed in this study is reliable, indicating its potential application in clinical practice for predicting the prognosis of patients with ccRCC.

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PMC9429973

At inclusion, the risk level of developing TLS, assessed in 149 patients, was low (28.2%) moderate (69.8%) or high (2.0%).

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PMC9429973

Recently, we estimated that up to two thirds of B-other-ALL can be classified into novel subtypes using FISH and MLPA alone.

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PMC11632064

QuantStudio Design and Analysis (Applied Biosystems) was used for data analysis.

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PMC11531744

It was indicating that the higher the expression of NSG1, ZBP1, GBP1P1, KIF26B, STX18 and CACNA1C, the stronger the sensitivity to the abovementioned drugs.

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PMC9429973

Approximately 29% of patients with DLBCL are ≥75 years old.

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PMC11725127

In this study, we reveal that USP2 is a novel deubiquitinating enzyme for KRAS.

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PMC11670407

Previous studies reported that GPX4 might act as an inhibitory molecule of the mitochondrial apoptotic pathway; therefore, we hypothesized that GPX4 might be a downstream target protein of OTULIN.

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PMC11357960

Statistical significance was shown as: * P< 0.05, ** P< 0.01. ***

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PMC10745221

The methyl donor of these enzymes is S-adenosylmethionine (AdoMet), a direct product of methionine.

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PMC11806613

Images were captured using confocal microscopy.

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PMC11489351

All RNA-Seq transcript data were analyzed compared to control MCF10A, with fold changes averaged across the six biological replicates (Table S1).

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PMC9429973

3.

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PMC11367146

Daucosterol exhibited hydrogen bonds with ASN 519, HIS 516, and SER 512 amino acid residues as well as alkyl bond at ILE 451, LEU 479, LEU 508, and ARG 515 residues of ESR1 (Fig. 4C), while gigantol formed hydrogen bonds at GLY 521, GLU 353, and LEU 387 residues, with binding energies of −10.1 and −9.3 kcal/mol, respectively.

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PMC11684269

Fu et al. revealed that, in DKD, junctional adhesion molecule-like protein (JAML) boosts podocyte lipid accumulation and subsequent podocyte damage via SIRT1-mediated SREBP1 signaling (99).

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PMC11144200

Bar graphs show mean of cytokine concentration + SD.

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PMC10728200

This encompasses aspects such as the immune tolerance of late-stage ferroptotic cancer cells and the immunogenicity of early-stage ferroptotic cancer cells.

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PMC9429973

Further study of the combination without a 2-week window (of itacitinib alone) and with objective measurement of patient reported symptoms is planned.

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PMC11412752

It is important to note that our understanding of STING's role in bacterial infections, including Salmonella, is still developing.

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PMC11402217

Data was analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test.

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PMC6835762

The ability of bare PGA, and PGA with the polymer backbone substituted with varying amounts of pendant C18 (stearate) and C8 (octanoate) chain length acyl groups, to encapsulate the water soluble drug dexamethasone phosphate (DXMP) into NPs was investigated in two papers from the Garnett group .

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PMC9429973

A. Granau, P. Andersen, T. Jakobsen, L. Sommer Kristensen, J. Bay Mogensen, G. Dias Correa Guldbergsen, K. Dimopoulos, K. Grønbæk Faculty of Health and Biomedical Sciences, University of Copenhagen; Department of Hematology, Rigshospitalet, Copenhagen; Department of Biomedicine, University of Aarhus, Aarhus; Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark Background: Venetoclax (Ven), a BH3 mimetic inhibiting BCL2, appears to be highly cytotoxic to most Mantle Cell Lymphoma (MCL) cells due to their high BCL2 levels.

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PMC11514418

Astragalus polysaccharide (APS), a pure Chinese medicine preparation primarily made from the traditional Chinese herb Astragalus, plays a positive role in the treatment of many malignant tumors.

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PMC9261184

This will enable a greater understanding of not only emissions but also how they can be reduced most cost effectively and by how much.

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PMC9429973

Tumor bulky (≥7cm) was present in 34.5% of cases.

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PMC11271278

H Summary of AmpliconArchitect data from PCAWG tumor samples: most of oncogene amplicons contain additional trans or cis DNA segments.

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PMC11754784

The fluorescent intensity after computation was further confirmed by confocal imaging as shown in Fig. 3h and Supplementary Figs. 19–22.

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PMC10747160

Filtered lentiviral pseudovirus solution was stored as 450 μL aliquots in low-binding 1.5 mL tubes (ThermoFisher Cat # 90410, Waltham, MA, USA) at −75 °C until use in future assays.

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PMC10823017

Based on the results observed, the cytotoxicity of cells subjected to combination therapy was significantly (P<0.001) higher in both cells.

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PMC9429973

11 eligible adult (r/r) B-ALL patients with a median age of 37 years (range 19 - 61 years) were enrolled.

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PMC9512971

Age groups: ≥ 65 years vs < 65 years.

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PMC8992508

Results suggested that the ester portion of the lead compound Ko143 is not necessary for the activity and can be replaced by more stable and simple groups, such as a methyl group.

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PMC3931643

The optical density for each condition was calculated as a percentage of the untreated control after subtracting for background absorbance.

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PMC9429973

The remaining eight subjects had a median treatment duration of 38 weeks (range 11-60 weeks).

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PMC11513571

To compare unstimulated and stimulated cells with different stimulants, Student’s paired t-test was used.

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PMC11739504

To validate disrupted cilia assembly by Kat2b absence, comparison between Arl13b, well-established ciliary marker, and acetylated α-tubulin was verified (Fig. 2e,f).

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PMC11675244

In addition to its central role in Wnt signaling, GSK3β acts downstream of tyrosine kinase receptors and regulates its activity.

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PMC10135767

MAdCAM-1 binds to integrin α4β7, which mediates the rolling and arrest of circulating lymphocytes upon the vascular endothelia during lymphocytic homing.

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PMC6160470

Slides were then incubated with 1:100 antibody dilution in blocking solution for 30 minutes at room temperature (RT).

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PMC11397654

It can thus be concluded that 32h is a potential antitumour drug, since it has a high anti-proliferative ability and can possibly induce apoptosis in the cancer cells, not just inhibit proliferation.

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PMC11422497

It represents one of the most prevalent circRNAs derived from exons and is associated with the gene symbol SMA4; therefore, has_circRNA_103870 is also referred to as circ_SMA4.

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PMC11670407

l Representative IHC images of GPX4 and quantitative analysis of GPX4-positive cells (n = 6) (scale bars: 200 μm and 400 μm).

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PMC11609529

Cell lysates were collected 72 h post-transduction, and western blotting was performed using an anti-MAML2 antibody to detect YM and MAML2 proteins.

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PMC11286266

This analysis identified genes whose loss confers repression of the ATF6α reporter during ER stress without impacting ER-stress-induced IRE1, compared to treated-unsorted (TUS) cells.

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PMC11247842

We used 4 PCs for CM and 12 PCs for SCS, based on the MR-MEGA guideline for the number of PCs to fit to equal the number of populations minus 2.

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PMC7642379

As different HEK293 lineages are propagated under different conditions and the observation that immortalized continuously cultured cell lines, such as HEK293, have a high degree of genomic instability with frequent chromosome rearrangements it can be expected that different HEK293 lineages are differentiated at the genomic and transcriptomic level compared to the parental cell line.

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PMC11541241

Pathogens including F. graminearum could modulate their growth and metabolism to respond to environmental cues.

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PMC11088135

The proteins were then transferred to PVDF membranes (Millipore) and blocked with a blocking solution containing 5% skimmed milk for 1 h. After blocking, the protein-containing membranes were incubated with primary antibodies overnight at 4 °C, including anti-YAP1, anti-Bax, anti-Bcl-2, anti-GAPDH.

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PMC9918897

However, one of the main differences was the presence of an alcoholic medium, which in our case was more than six times higher than the exposure used in the abovementioned study by Ferk et al. .

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PMC9592219

Consistent with these reports, miR-22-5p mimics reduced the HCC cell proliferation, migration, and invasion, in addition to inducing apoptosis, which was rescued by the overexpression of TOP2A.

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PMC11052306

In most cases, the copper complex is more efficient than temozolomide, whereas the gold complex is only slightly more efficient than temozolomide at high concentrations.

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PMC11791432

ANXA1 expression was correlated with progression of glioma with higher expression levels observed in GBM, which was validated using PCR and WB.

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PMC11209164

TPF increased Ad5-GFP-associated fluorescence in MRC5 (peak ~ 30 µM), A549 (peak ~ 30 µM), HT1080 (peak ~ 50 µM), and HepG2 (peak ~ 50 µM).

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PMC11681005

However, the top enriched motif in both datasets was FOXA1 instead of AR, suggesting that AR binding to DNA is partially mediated by other transcription factors (Figure S6).

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PMC9954564

Once the inhibitory properties of HLA-G depend on the interaction with its receptors , the present study has evaluated both univariate and multivariate associations with vitiligo.

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PMC10758402

The anti-inflammatory effects of DMF are well-known which might overall dampen lymphocyte responses despite greater infiltration of CD3+ cells (31).

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PMC9429973

Aims: To evaluate efficacy and safety of Sd in Chinese RRMM pts previously treated with CAR-T. Methods: The study enrolled 82 pts previously exposed and refractory to a proteasome inhibitor (PI), an immunomodulatory agent (IMiD), and last line of therapy.

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PMC9429973

However, considering PMF and SMF separately, a different behavior of CD34+ cells was detected: in detail, in PMF pts circulating hematopoietic precursors gradually decreased from 3 to 24 mts of RUX therapy in parallel with the persistence of a reduction in the spleen size (Fig. 1C).

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PMC9429973

There were 153 patients in the Len-only group, and 78 in the Len-combo group.

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PMC9429973

Eligible participants were males or females aged 18-55 years with no clinically significant medical or physical conditions.

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