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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Summary/Conclusion: In conclusion, the standardization of experimental operation and improvement of biological information pipline of WRTS are very important factors in its use in standard diagnostic procedures.
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PMC5716223
3Effects of NGF supplementation on NFκB, αB-crystallin and Hsp27 during L6C5 in vitro differentiation.
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PMC9847912
Growth was then continued overnight, and culture supernatants were collected on the second day after DNA addition.
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PMC11637276
Given the requirement of α2β1 integrin/p38 MAPK axis in ECM internalisation and invasion in PDAC cells, we looked at the relationship between the expression of α2 integrin, β1 integrin, and MAP3K1 and disease outcomes in PDAC patients.
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PMC11290772
Photograph of PBMC-NK and ROBO1-NK lysing efficacy on primary ovarian tumor cells after 48 h co-culturing.
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PMC9429973
Results: The database included a total of 13,615 (claims) and 22,626 (EHR) patients with an index diagnosis of MM and ≥1 line of therapy.
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PMC10024132
Compared to untreated cells, pre-exposure of VAL cells to ZA resulted in improved cytotoxicity by γ9δ2 T cells and further enhanced blinatumomab-secreting γ9δ2 T cell cytotoxicity against VAL cells (Fig. 3D).
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PMC11705484
RT‐qPCR analysis of HMOX2 mRNA expression in tumours from the mice. (
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PMC9436459
Their combined yields were 51%, 13%, 62%, 45%, 20%, and 47%, respectively.
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PMC10958426
D2 method on the top 10 PCs of inferred CNV level to perform cell clustering, and use cutree function to classify cells into tumor subclones.
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PMC10669966
Luminescence was recorded with a Hidex Sense microplate reader (Hidex Oy, Turku, Finland).
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PMC10907726
Xin Liu: Writing – review & editing.
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PMC11750161
The results are expressed as mean±SD of a single representative experiment performed in triplicate. *
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PMC5716223
The β-actin was used as housekeeping for both markers.
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PMC7351993
If this sorting experiment was manually performed by conventional Raman microscopy with pipetting, it would take about 2 days, but we performed it within 4 min (about 700 times faster).
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PMC11441402
Therefore, it may be beneficial to use the automated cell imaging system in conjunction with the new method employed by the NCI, whereby high throughput screening of drugs is used first to identify compounds of interest, followed up by the automated cell imaging system that may uncover details of cellular responses and mechanisms of cell death.
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PMC9429973
New treatment options that can improve outcomes in this population are needed.
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PMC11720107
In the CACO-2 cell line, the Violeta garlic extract did not cause changes in caspase-3 activity (Figure 4G).
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PMC11597291
The vials were put in a mildly agitated water bath (37 °C).
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PMC2362953
Recently, we demonstrated that CIK cells transfected with cytokine genes possess an improved proliferation rate and a significantly higher cytotoxic activity as compared to non-transfected cells.
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PMC10335954
Twenty-seven paired samples were further analyzed to verify the relationship between TRIP13 expression and carcinogenic status.
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PMC9429973
CCL5 and S100A8/A9 cytokines were elevated at baseline in 50% (16/32) and 78%, respectively; at Day 84, 81% and 68%, respectively, showed reductions of at least 10% and of those, 100% (CCL5) and 47% (S100A8/A9) normalized.
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PMC11535726
Conidia germinating on PDA within 24 hours.
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PMC11742670
The assay was conducted using SRB assay for IC50 calculation 5 different concentrations 0.01, 0.1, 1, 10, and 100 µg/mL compared to 5-Fluorouracil (5-FU) as a positive control.
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PMC11269792
miRNA sponging is the most well-studied mechanism of circRNA action, and circRNA competitively binds miRNA through complementary base pairing to inhibit the binding of miRNA to its target molecule, thereby regulating the expression of target Mrna.
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PMC11538390
GRHL3 is important for keratinocyte and periderm differentiation, as is IRF6, and the IRF6 gene is also associated with CP.
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PMC11711345
Cell viability (%) was calculated as the ratio between the absorbance of the sample well and that of the negative control and was expressed as the mean ± standard error of the mean (SEM) of two independent experiments performed in triplicate.
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PMC8711270
Of the three adenoviral vectored vaccines approved for emergency use by the World Health Organisation (as of August 2021), Ad5-nCOV(Zhu et al., 2020) and ChAdOX1-nCoV (Doremalen et al., 2020) are produced in HEK293 cells, while Ad26.
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PMC11705630
Consistent with this result, we found that knockdown of GLDC also increased ROS generation (Fig. 1C).
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PMC11767725
The involvement of metabolic dysfunction-associated steatotic liver disease in HS patients further underscores the systemic metabolic impact of the disease .
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PMC9429973
SMARCA4 overexpression in AML cell lines leads to higher proliferation rate and to a worse overall survival in transplanted mice.
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PMC7081114
The kinesin superfamily protein member KIF21B plays an important role in regulating mitotic progression; however, the function and mechanisms of KIF21B in cancer, particularly in hepatocellular carcinoma (HCC), are unknown.
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PMC9351137
Fixed HeLa cells stained with DAPI (blue), anti-CRS (red), and anti-α-tubulin (green).
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PMC9596868
Densitometric analysis of p53, p21 and γ-H2AX expression in PA-1 cells normalised to β-Actin.
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PMC11711127
Throughout the early naive T cell phase, quiescence and ignorance actively contribute to maintaining tolerance.
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PMC11687167
A study by Cao et al. showed that OSM suppressed hepatic PCSK9 mRNA and protein expression in hypercholesterolemic hamsters in vivo.
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PMC8316344
However, the function of TRIB2 to desensitize the cells to RSL3- and erastin-induced ferroptosis seemed merely dependent on TFRC and βTrCP (Fig. 6).
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PMC11653533
F. religiosa has a place for Rasayana, which is a class of Ayurveda traditionally utilized as rejuvenators, antioxidants and push relievers (Makhija et al., 2010).
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PMC9429973
Nine subjects presented cardiovascular risk factors and 4 a prior, non-active, cancer; 3 were on anticoagulation for atrial fibrillation.
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PMC9895440
Recently, genome-wide CRISPR/Cas9 screens using polyclonal stimulation have been used to discover potential regulators of T cell exhaustion.
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PMC9817179
Because protein–protein interactions that drive LLPS are highly dynamic with binding residence times in the range of seconds to tens of seconds (Chong et al., 2018), fixation likely happens with either lower or comparable rates than protein binding and dissociation.
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PMC6600253
In a study by Kim et al., the stress hormone norepinephrine (NE) augmented cancer cell proliferation via the β2-adrenergic receptor and induced hTERT activity via Slug, which subsequently increased ovarian cancer cell invasion .
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PMC11803918
For analysis of the protein profile of hybrid exosomes, the same amount of proteins within exosomes and hybrid exosomes were separated by electrophoresis on a 10% SDS-PAGE gel, which was then stained with Coomassie Blue Fast Staining Solution (Beyotime) for 1 h at room temperature and washed with ddH2O overnight.
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PMC9352806
In addition, BMS increased the level of autophagy in HepG2 cell lines with OA treatment.
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PMC9429973
Overall higher AUC values were achieved for DVT than for PE prediction, with IMPROVEDD score having highest AUC values for both DVT and PE prediction (DVT AUC 0.650, >3 points sensitivity 75% and specificity 48%; PE AUC 0.603, >2 points sensitivity 88% and specificity 29%).
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PMC11806182
Gene Ontology (GO) and pathway enrichment analyses were performed using the clusterProfiler package .
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PMC11190538
Materials used for yoghurt preparation were of food grade and stored in a refrigerator.
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PMC4270159
Media only [additional].Vehicle control.0.001 µM–10 µM PLX4032 + no ligand.0.001 µM–10 µM PLX4032 + 50 ng/ml NRG1.0.001 µM–10 µM PLX4032 + 50 ng/ml NRG1 + 0.5 µM lapatinib.0.5 µM lapatinib + no ligand [additional].Cohort 3: KHM-3S cell line.
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PMC11711663
In this study, CT resolution sizes varied from 0.3 × 0.3 × 0.5 mm to 1.3 × 1.3 × 5 mm.
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PMC11641532
This comprehensive and iterative validation approach strengthens the overall impact and novelty of our research.
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PMC11715478
More recently, the concept of brain lymph drainage has sparked interest as it may shed light on how the dynamics of T cell interactions contribute to AD.
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PMC11752767
The fifth generation of CAR-T is designed to simultaneously activate TCR, co-stimulatory domains CD28, and cytokines.
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PMC7612475
In line with our previous reports, we identified a significant increase in the amount of nuclear mRNA species and a corresponding decrease in cytoplasmic mRNA levels in the SF3B1 cells when compared with the SF3B1 cells, indicative of defective splicing and mRNA export in SF3B1 cells (16).
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PMC9429973
Summary/Conclusion: We tested the feasibility of a new peer to peer intervention in family caregivers of newly diagnosed hematologic patients.
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PMC10955424
The signal produced is proportional to the amount of analyte bound.
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PMC9429973
Developing more specific/effective first/second-line protocols to achieve long-term response rates/eradication and preserve safety profiles remain highly desirable.
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PMC8584666
CD63 is a marker for EVs, and therefore, the authors examined the association of sGPI-80 with CD63 using sandwich ELISA, wherein sGPI-80 was trapped using anti-GPI-80 mAb (3H9) and detected using anti-CD63 mAb (IgG2a) (Figure 1g).
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PMC7334607
The A673 cell line contains the t(11;22) translocation resulting in the EWSR1/FLI1 gene fusion (Szuhai et al., 2006; Martınez-Ramırez et al., 2003).
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PMC9429973
Aims: Our aim was to understand the impact of social determinants of health on outcomes in CMML.
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PMC9429973
Overlapping our transcriptome, total proteome, and nascent proteome data sets, we identify potential downstream targets through which LINC01547 presumably exerts its newly uncovered pro-oncogenic function.
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PMC11240448
All CYTOF data after normalization and pre-processing are given in Supplementary Table S1.
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PMC10761571
According to Scherrer formula, the average size of crystals was 7.07 nm.
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PMC11648299
The patients have provided written informed consent for the publication of their photos Patients with Darier diseases a) Typical V-shaped notch at the free margin of the nail on a patient with Darier disease, b) Patient with Darier disease with acute worsening in his face due to eczema herpeticum, c) Red-scaly itching patches in the neck and face area on a patient with Darier disease, d) Red thick patches at the dorsal side of hand with red-white stripes on nails, e) Yellowish larger warty lesions covering the back of a patient with Darier disease, f) Oily crusted lesions on face, similar to seborrhoeic dermatitis, g-h) Small brown papules with a firm, harsh sandpaper-like texture on the back and neck of a patient with Darier disease, i) Patient with Darier disease who was initially misdiagnosed as having intertriginous eczema.
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PMC11672881
The individual treatments, TQ and CU, have focused yet distinct effects on gene expression, with CU having a broader impact.
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PMC9429973
On the other hand, the first-line treatment used in patients was analysed, and in both the EMEA and US cohorts, the use of bortezomib (46% vs 47% in the EMEA cohort; 62% vs 70% in US cohort), lenalidomide (43% vs 57% in EMEA cohort, 15% vs 18% in US cohort) and daratumumab (0% vs 4% in EMEA cohort, 2% vs 4% in US cohort) increases over the years comparing the 2010-2014 vs 2015-2019 time cohorts.
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PMC11585565
The intracellular CBS and CNBH domains are involved in protein dimerization and Mg-ATP binding.
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PMC9268183
Even if the relationship between food and vegetable intake and cancer does not seem to be clear in most cases, their consumption is encouraged in trouble-preventive healthy diets .
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PMC11506670
Additionally, a parallel setup was performed, designated as the ‘uninduced setup’ because it lacked the apoptotic inducer sodium butyrate in the media.
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PMC7887261
GELCC study (Genetic Epidemiology of LC Consortium, 380 LCs): This included 122 familial and 258 sporadic LC cases.
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PMC11803149
Left schematic diagrams show the experimental design (created with BioRender.com).
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PMC11209164
Effectiveness was notably high in pancreatic and ovarian tumor samples.
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PMC5916734
The resulting clones were sequentially subdivided into groups according to the expression level of soluble PACE/furin and the level of procoagulationally active FIX.
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PMC11188874
Cell lysates were prepared and immunoprecipitated using an antibody (M1/42) to the murine pan-MHC-I molecule.
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PMC11525028
To reveal the association between NAT10 expression and clinical outcomes in patients with osteosarcoma, we examined NAT10 expression in osteosarcoma tissues by immunohistochemistry (IHC) staining of paraffin sections.
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PMC9429973
RT-PCR was performed using reagents and primers from Synthol (Moscow, Russia).
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PMC11761919
In brief, a 96-well plate was coated with 100 μL of Fiber2 protein (10 μg/mL) per well and incubated overnight at 4°C.
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PMC8164677
It can be interpreted from these results that higher platinum content has been compartmentalized somewhere from where it could not reach DNA in case of A2780.
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PMC9429973
Aims: To determine whether OPN might represent a druggable target in PMF we assessed the inhibition of signaling pathways responsible for its production.
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PMC11802855
In the CXCL7-OE RPMI8226 (G) and H929 (H) cell lines, the incorporation of JAK1 inhibitors gave rise to a significant reduction in the expression levels of p-STAT3, MMP13, and C-myc.
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PMC11290772
In the clinical context, four out of fifteen ovarian cancer samples were identified as displaying positive ROBO1 expression (Figure 1C).
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PMC11594074
We found that compound 4 visibly inhibited MDA-MB-468 and HCT116 cancer cell migration in a dose- and time-dependent manner.
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PMC11247842
However, in our analyses, this QTL was identified for CM.
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PMC10944868
These microtubules play a fundamental role in various cellular processes, including cell division, intracellular transport, and cell shape maintenance (Howard et al., 2009).
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PMC7338939
At day 0 after measuring the length and width of developed tumors, the treatment with DAPT was started.
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PMC11772585
Additionally, research by Xie et al. has revealed that METTL1 promotes the m7G modification of miR-760 to expedite the degradation of the ATF3 mRNA, thereby accelerating bladder cancer growth.
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PMC11697189
For example, HSP90 inhibitors have been used to enhance the sensitivity of chemotherapy drugs and have shown therapeutic potential against multiple cancer types in clinical trials.
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PMC9429973
In TP53-mutant (TP53m) AML, it demonstrated an objective response rate of 69%, complete response (CR) rate of 45%, and median overall survival (OS) of 12.9 months.
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PMC11648299
Conducting research on rare diseases presents challenges due to the limited number of patients available.
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PMC10170482
Examples of confocal microscopy imaging of Ki-67 staining.
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PMC8996378
To date, other ABC transporters have been found, such as ABCC1, ABCC2 and ABCG2, which are associated with MDR (Takano et al., 2006; Lu et al., 2015).
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PMC9429973
Summary/Conclusion: We have developed an integrated pipeline for full-spectrum flow cytometry that improves the applicability and performance of flow-cytometry-based MRD detection in AML.
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PMC9429973
If the observed prevalence will be significantly higher than predicted, the identification of potential risk predictors in the selected population will be carried out Methods: This is an observational, prospective, cross-sectional, multicenter study.
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PMC9429973
Results: Molecular HR features were identified in 44% (43/97) of pts at pretreatment and 48% (31/64) at progression.
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PMC9429973
Aims: Identify different miRNA expression patterns, depending on the severity of bone involvement in patients with GD and, evaluate its predictive value.
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PMC9429973
This case did not have any of the characteristic alterations of SMZL.
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PMC11394227
Therefore, we conducted a study to investigate changes in ER and Golgi content of cells.
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PMC10253973
Several ruthenium complexes have demonstrated low IC50 values in TNBC cells, which makes them attractive for further research .
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PMC6487404
The cells with passage numbers of 35-40 were used for the drug transport experiments.
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PMC11754432
Along with IL-17A secretion, polarisation of cells to Th1 and Th17 was reduced but an increased number of FOXP3+ (Th22) cells with EPA treatment occurred.
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PMC10728535
The significance threshold for DEGs was taken as adj p‐value < .05 and − 1 > logFC > 1.
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