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OTAR3088
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BioData-CellLine_annotated

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PMC11310713
Th and an enhancement in Tb.
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PMC11424574
Lung tissue sections were fixed, deparaffinized, and rehydrated.
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PMC11248911
C NMR (DMSO-d6, δ ppm): 16.10, 46.77, 65.64, 122.70, 123.94, 124.42, 126.98, 127.55, 127.86, 128.78, 130.40, 141.53, 143.88, 152.25.
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PMC11307990
When treated with DNA nanotape-SUN and free SUN, the 786-0 cells exhibited different dose–response curves (Figure 5B), and the EC50 values of DNA nanotape-SUN and SUN were 10.23 and more than 500 nM, respectively.
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PMC9884169
In this study, the expression of autophagy-related proteins was detected by Western Blot.
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PMC6901583
The Committees for Ethical Review of Research Involving Human Subjects at the Second Hospital of Jilin University issued an approval for ethical consent.
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PMC11777207
Representative flow plots showing KikRed (photoconverted) skin-derived cDC subsets in KikGR mice crossed to Pdl1 or Pdl1.
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PMC3813807
The overexpression of miR-373 in the gastric cancer cells increased cell proliferation.
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PMC11806106
Taken together, our methodology enabled the development of receptor conformation sensors for the µ opioid receptor (MOR), kappa opioid receptor (KOR), and nociceptin/orphanin FQ receptor (NOP), functional for both FRET-based and BRET-based measurements, for MOR and KOR, respectively.
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PMC10093184
Strong nuclear positivity was seen in the majority of COS3600B cells, while COS4288 revealed a mixed population consisting of strongly and moderately positive cells.
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PMC9596868
Uncropped image for Fig. 5B. (
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PMC11721587
WB analysis of the phosphorylation of the indicated Fu variants in S2R cells. (
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PMC9454178
Previously, Yu Liu analysed quantitative proteome profiling of GIST and adjacent normal tissue and found that several kinases were significantly upregulated in GIST, including KIT and CDK7 .
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PMC11397654
The calixarene derivative induced the activation of caspase-3 (an executive molecule in apoptosis regulation) in the MDA-MB-231 cells, with the concentration of activated caspase-3 increasing as the concentration of the derivative increased.
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PMC10218459
Significant differences were evident after an incubation time of 48 h, and increased at longer incubation times.
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PMC11395280
Characterization assays (Figure 1 and Figure 2) provided a starting point for the doses that we used in subsequent studies both in vitro and in vivo.
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PMC4355729
After two weeks of culture, colonies were stained with 0.5% crystal violet solution for 30 min at room temperature.
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PMC2614415
Interestingly, at low concentrations VE-465 has a Ki more specific to Aurora-A (1 nM) than Aurora-B (26 nM) or -C (9 nM).
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PMC11798926
However, subsequent studies have shown that they are single-pass type II transmembrane proteins with internal N-termini and extracellular C-termini (Kalashnikova et al., 2010; Kirk et al., 2016; Ling et al., 2016; Martin et al., 2021; Weston et al., 2014).
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PMC11754436
The satisfactory discrimination performance was evaluated based on the area under the curve (AUC) of the ROC curve, which was > 0.7.
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PMC11098378
Representative GFP fluorescence images and quantitative GFP signals (normalized to cell number with CellTracker signals) were used as a readout for viral replication and are shown in Fig 1A and 1B.
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PMC5173112
As expected, our qRT-PCR and Western blot results showed that both mRNA and protein expression level of USP21 were higher in ALDH than in ALDH cell populations (Figure 4A and 4B), demonstrating that higher USP21 levels are associated with cells reported to possess CSC-like properties.
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PMC11011837
The results are illustrated in Figure 5.
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PMC9545474
The effects of therapy were assessed by frequent monitoring growth of the tumours and body weight.
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PMC11015054
By 2025, it is projected to affect over one million people annually.
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PMC11629192
About 10 %–30 % of pediatric anti-NMDAR encephalitis patients need second-line immunotherapy with RTX prefer to be used [, , , ].
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PMC11484188
The incidence of MM increased between 1999 and 2020, with a 40% rise in the United States and a ~130% increase globally since 1990 (28,29).
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PMC11740399
C, D, and E) Qualitative and quantitative results of Western blot revealed that T24 cells and 5637 cells treated with 3025@ML showed downregulation of PKM2 protein levels and induced apoptosis. (
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PMC11682525
After inducing oxidative stress, a cell viability assessment was conducted using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).
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PMC8358176
Primer sequences were designed for TNF, CD40LG, TNFSF10, TNFSF8, CD40, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, and TNFRSF9 and also for the housekeeping genes β-actin and glyceraldehyde 3-phosphate dehydrogenase.
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PMC11363012
Plots show the concentration for each of these compounds in each cell.
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PMC11742047
Samples were centrifuged for 10 min at 16,000 g at 4 °C.
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PMC11733919
The amount of CD26 antibody (2.5 and 10 μg/mL) used to functionalize the MNPs was considered as a control (100%).
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PMC11224020
Among migratory DCs, migratory cDC1s (mcDC1) were identified as CD11bCD103, and migratory cDC2s (mcDC2) were identified as CD11bEPCAM.
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PMC9583612
Technologies that allow high sampling frequency such as CEMS, paired with a mechanistic understanding of facility-level events, are key to an accurate accounting of short-duration, episodic, and high-volume events that are often missed in snapshot surveys and to scale snapshot measurements to annualized emissions estimates.
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PMC11678368
Among them are the azaindole derivatives, which have gained attention for their ability to modify the properties of metal complexes, improving both cytotoxicity and selectivity .
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PMC7305184
Cells were exposed to EP in every generation, which would influence the sensitivity of cells for PEF treatment, making cells more resistant to electroporation pulses, i.e, shifting the survival curve towards higher % values.
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PMC11628309
These studies are essential for discovering new therapeutic strategies and moving toward more effective treatments for PD.
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PMC11604015
Recently, several studies have reported that CAR-transduced T cells gradually lose their surface target proteins, such as CD5 and CD7, without any artificial intervention of target genes or proteins; thus, fratricide among these CAR-T cells is partial and transient .
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PMC9429973
Results: A total of 47 surveys were returned including 33 who described themselves as reporters and 14 who described themselves as service users.
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PMC9429973
The complexity of therapy lies in the high risk of infections due to prolonged cytopenia during therapy.
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PMC11806106
A HEK293 cell line stably expressing the G267-MOR-FRET-sensor and MOR-BRET-sensor was established and used for measurements of this sensor construct.
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PMC11656380
This result suggests that Tat-Ram13 does not activate caspase-3 during cell death.
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PMC11515150
Moreover, engineered NK cells mediated potential cytotoxicity relied on the presence of a full array of native receptors other than specificity of the CAR, avoiding the relapse incurred by the loss of CAR-targeted antigen .
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PMC11763764
They are receptor tyrosine kinases and form homodimers or heterodimers upon ligand binding.
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PMC9429973
The biological action of glucocorticoids is mediated by glucocorticoid receptor (GR); however, the underlying mechanism of glucocorticoid-resistance remains unknown.
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PMC9817179
After paraformaldehyde (PFA) fixation, additional puncta appear, and pre-existing puncta get bigger and brighter relative to the nucleoplasm, consistent with the trend shown in Figure 1A.
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PMC11271800
CCL: CC ligand; GIST: Gastrointestinal stromal tumor; SPARCL1: Secreted protein acidic and rich in cysteine 1.
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PMC11742864
Radio-chemotherapy is widely applied for those not suitable for surgery.
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PMC11734514
p<0.05. (
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PMC11247842
The QTL identified around BTA1:131.4 Mb, BTA6:87.0 Mb, BTA9:10.5 Mb, BTA16:25.2 Mb, and BTA20:22.4 Mb were consistent between the meta-analysis and the single breed analyses.
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PMC9429973
The molecular relapse is defined as loss of MMR or confirmed loss of MR3.0 (figure).
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PMC11394386
DNA methylation immunoprecipitation was performed using Methylated-DNA IP Kit (Zymo, D55101-A, Irvine, CA, USA), according to the manufacturer’s instructions.
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PMC9429973
Of the 7 patients, 5 elected to terminate the pregnancy after a positive prenatal diagnosis of beta-thalassemia major, and the remaining 2 couples did not respond and were lost to follow-up.
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PMC10976516
Tumor tropism of ZD55-loaded CIKs was very high.
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PMC11519583
Scale bar: 100 μm.
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PMC10926885
NDE1 was shown to be strongly expressed in BLCA, BRCA, CHOL, COAD, COADREAD, ESAD, ESCA, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, OSCC, READ and STAD after analysis of matched samples of malignant and paracancerous tissues.
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PMC10218459
In the current study, the following chemotherapeutic agents, typical for the treatment of ES, were used: doxorubicin (DOX) and vincristine (VIN) (Cayman Chemical, Ann Arbor, MI, USA).
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PMC11770130
Ceramide may exert diverse effects on metabolism-related phenotypes via interaction with brown/beige adipocytes or the CNS.
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PMC9429973
Median and IQR were used to describe Continuous variables, and proportions were used with categorical variables.
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PMC11518702
ROCK’s phosphorylation of MYPT1 is inhibitory and sustains MRLC activity (50, 51).
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PMC11697065
Ying Bai: Writing – original draft, Methodology, Data curation.
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PMC11703992
Setting the p threshold as 5 × 10, we screened the associated phenotypes related to the SNPs of 6 identified causal genes using the database.
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PMC10976516
Ended prematurely.
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PMC11295144
These cells were fluorescently labeled by transiently expressing the green fluorescent protein (GFP) and co-cultured with GABAergic medium spiny neurons (Figure 1A).
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PMC10849234
However, upon stimulation, the granules are released in reverse order, which corresponds with content toxicity.
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PMC7553912
The following TaqMan Gene Expression Assays (Applied Biosystems) were used: OSM (Mm01193966_m1), OSMRβ (Mm00495424_m1), F4/80 (Mm00802529_m1), TNF-α (Mm00443258_m1), IL-1β (Mm00434228_m1), MCP-1 (Mm00441242_m1), OPN (Mm00436767_m1), ANXA1 (Mm00440225_m1), ANXA2 (Mm01150673_m1), KIM-1 (Mm00506686_m1), TGF-β (Mm01178820_m1), Col1a2 (Mm00483888_m1), αSMA (Mm00725412_m1), Timp2 (Mm00441825_m1), and 18S (Hs99999901_s1).
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PMC11257988
Eliminating these inhibitory mechanisms in tumors can pave the way for more effective anti-tumor responses.
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PMC10882807
RBPs influence RNA biology post-transcriptionally, and an increasing amount of evidence suggests that abnormal RBPs expression and function are associated with cancer metastasis .
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PMC9592219
Likewise, TOP2A overexpression reversed the invasion-suppressive effect of miR-22-5p on MHCC97L and BEL-7404 cells (Figure 7(d)).
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PMC9429973
New therapeutic strategies to further improve the management of MM and to overcome drug resistance are therefore urgently needed.
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PMC8728081
For cell morphology study, the images were captured by confocal microscopy, followed by FITC and PI staining after 48 h from drug exposure.
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PMC11252553
mL; positive control), & Taurine -treated with irradiation (100 µg.
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PMC11269933
ns” indicates non-significant differences.
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PMC7348793
After confirming the presence of the mtDNA insert by restriction digest with EcoRI and HindIII restriction enzymes, the plasmid DNA was used for sequencing or other analyses.
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PMC11583010
Comparative in vitro cytotoxicity experiments (n = 3) were performed on nectin-4–expressing tumor cell lines (MDA-MB-468 and SUM190PT) and on differentiated keratinocytes.
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PMC11604768
We first assayed two non-aminergic GPCRs: the adhesion class protease-activated receptor-1 (PAR1) and the recently de-orphaned succinate receptor (GPR91/SUCR1).
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PMC11496491
Fig. 9Histogram and bubble analysis results of the top 10 signal pathway graphs with the most significant KEGG enrichment. (
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PMC6650823
Screening various amino acid prodrugs to overcome the barriers of both efflux and metabolism in addition to solubility-related issues resulted in the discovery of the L–Phe–Sar dipeptide prodrug that takes advantage of a self-immolative process of drug release.
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PMC11024707
It was aimed to match study groups in terms of the relevant factors such as age, sex, and ethnicity.
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PMC11463018
White solid, 79.2% yield.
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PMC9429973
Statistically significant differences in overall survival according to ELN 2017 (T.logrank p=0.028) are also found in patients receiving intensive treatment.
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PMC9429973
Median OS was 26 months (95% CI, 26-NR); 12-month OS rate was 91%.
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PMC11394730
Apoptosis is a sign of allicin’s antagonistic action on tumor growth in mice harboring lymphomas .
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PMC11711347
A stronger binding interaction with the estrogen receptor-α protein suggests greater stability and a higher affinity of the complex for the receptor .
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PMC11791432
Some recent reports found that ANXA1 is highly expressed in MES-like glioma cells compared to normal cells, which is consistent with the results of this study.
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PMC10253973
In addition, complex 62 breaks down into pyridine (py) and 2,3-bis(2-pyridyl) benzoquinoxaline (dpb) upon irradiation.
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PMC4360730
The set of methods and conditions to survey the biological input (i.e. experimental assay; e.g. RRBS and MeDIP-seq in Figure 1).
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PMC11367939
Furthermore, it is crucial to investigate the colocalization of ATG9A and synaptophysin on normal endosomes in future studies, considering that we utilized a mutant form of Rab5 to produce enlarged endosomes.
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PMC11615101
Furthermore, the effective time (3h) of TNF-α induction was selected based on the effective upregulation of mRNA level of α-Taxilin (Supplementary Figure S4A), pro-inflammatory cytokines IL-1β, TNF-α, IL-6 (Supplementary Figure S4B–D respectively), and NF-kB p65 protein expression (Supplementary Figure S4E and F).
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PMC11637276
Reduced cysteines were alkylated with 17 mg/ml iodoacetamide for 10 min at 4°C.
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PMC9429973
Methods: Adult patients with RRMM who have been assigned IRd as ≥2nd line treatment were enrolled in 18 centers of Russian Federation from April 2019 till May 2020.
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PMC11507371
The cluster of the 60 s plasma treatment was localised towards that of the hydrogen peroxide stimulation, which implies a similar adaptive response to oxidative stress.
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PMC11787355
All analyses were performed with two-way ANOVA multiple comparison corrected with Holm-Šidák method.
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PMC11434983
The results showed that complex 2 could cross the cell membrane and inhibit the receptor, exhibiting an EGFR phosphorylation inhibition IC50 value of 130.6 nM (Figure 3 and Figure 4).
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PMC9429973
Fondaparinux is a suitable alternative.
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PMC9429973
Data was collected from clinical records and analyzed with IBM SPSS 25.0.
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PMC9429973
The characteristics of changes in the composition of the microbiome at the Phylum level before and after autoHSCT were studied.
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PMC10440586
Ten formalin-fixed paraffin-embedded (FFPE) glioma tissues were obtained from Shandong Provincial Hospital.
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PMC11201989
Depletion of PD-L1, liberates these vesicles, enhancing their delivery to the cilium.
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