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PMC10719213
Yet, we did not find any increase in mtDNA mutations, mtDNA copy number, or mitochondrial protein synthesis upon cladribine exposure.
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PMC11476837
The activity of NRF2 is tightly controlled by its repressor, KEAP1.
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PMC11588085
We performed XIST-KD in ovarian cancer cells using CRSPRi (CRISPR interference).
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PMC9429973
Summary/Conclusion: In conclusion, using single cell sequencing analysis over time, for the first time we have been able to study the impact effect of IFNa treatment on the whole HSPCs compartment at the single cell level in an unbiased manner.
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PMC9454178
The cells were seeded in 6-well plates at a density of 500 cells/well and cultured for 2 weeks.
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PMC9429973
Image: Summary/Conclusion: The Stellae-123 gene expression signature can predict overall survival in AML with greater precision than the ELN-2017 and the pediatric clinical risk score.
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PMC11046454
IL-2 secretion of CAR-J in corresponding samples of F, as assayed with BD CBA cytokine kit. (
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PMC11786704
PC solution (60 mg/mL, 1 mL) and Na2CO3 solution (0.33 M, 1 mL) were stirred with CaCl2 solution (0.33 M, 1 mL) at the speed of 1200 rpm for 30 s, then stood for 15 min to obtain PC-doped calcium carbonate particles (PC@CaCO3) .
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PMC11122631
Fraction D4E (65.3 mg) was separated by semi-preparative normal-phase HPLC (silica column) eluted with n-hexane/methylene chloride/methanol (80/10/1) to give compounds 6 (1.4 mg) and 9 (1.0 mg) and subfraction D4E4 (15.1 mg).
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PMC11564322
Effect of 10 nM VGVAPG and 10 nM VVGPGA on the mRNA expression of mTOR (A–C) and cMYC (D–F) after the 24-h exposure of the HL-60 (A, D), K562 (B, E), and MEG-A2 (C, F) cell lines in RPMI 1640 medium supplemented with 1% FBS.
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PMC9429973
Concerning the BMA analysis, the differential cell count (DCC) remains non-automated, being a tedious and time consuming task that is frequently affected by considerable interobserver variability.
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PMC6934009
In the present study, wogonin promoted acidic autophagic vacuole formation in A549 and A427 cells.
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PMC11394730
Moreover, anthocyanins can increase cancer cells’ sensitivity to chemotherapy by reversing their multidrug resistance .
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PMC9429973
We have successfully established AZA-R cell lines, whose UCK2 expression was lost or decreased.
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PMC9014716
First, human Bel-7404 and HepG2 cells were transfected with mimics or inhibitors of 5 miRNAs (miR-224-5p, miR-103a-3p, miR-101-5p, miR-713-3p, and miR-374b-5p) with 50 nm Lipofectamine 3000 reagent.
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PMC9429973
C. Wang, Y. Liu Hematology, Chongqing University cancer hospital, Chongqing, China Background: To investigate the effect of hypoxia on hypoxia-inducible factor 1α(HIF-1α) and CD47 expression in human acute myeloid leukemia (AML) cell lines.
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PMC10976516
So, cells can act as OV carriers.
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PMC5035325
The yellow color identifies co-expression of both molecules on tumor cells (merged) in 3LL-model (e) and 4T1-model (h).
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PMC6684588
Importantly, ACE-083 also increased the force of isometric contraction in situ by the injected tibialis anterior muscle in wild-type mice and disease models and increased ankle dorsiflexion torque in CMT mice.
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PMC11345828
H NMR (400 MHz, DMSO-d6) δ 7.89 (d, J = 8.4 Hz, 0.3H), 7.87 (d, J = 8.4 Hz, 0.7H), 7.41–7.37 (m, 1H), 7.13 (s, 0.3H), 7.02 (s, 0.3H), 7.01 (s, 0.7H), 6.78 (s, 0.7H), 6.73 (s, 1.4H), 6.70 (s, 0.6H), 4.68 (dd, J = 12.4, 3.6 Hz, 0.3H), 4.31 (dd, J = 13.6, 3.6 Hz, 1H), 4.04 (s, 0.7H), 4.00 (t, J = 6.0 Hz, 2H), 3.92–3.90 (m, 5H), 3.81–3.73 (m, 4H), 3.67–3.60 (m, 1H), 3.37–3.17 (m, 3H), 2.66 (s, 3H), 2.27 (s, 1H), 2.25 (s, 4H), 2.24 (s, 1H), 2.21 (s, 2H), 2.14 (s, 2H), 2.13 (s, 1H), 2.08–2.03 (m, 2H), 1.23 (d, J = 6.8 Hz, 2H), 1.11 (d, J = 6.8 Hz, 1H), mixture of rotamers.
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PMC9429973
Bone marrow evaluation showed erythroid precursors are quantitatively increased.
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PMC11541409
Ripretinib has better safety profile than sunitinib.
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PMC11607764
To reveal the potential roles of the obtained 150 genes, we used DAVID (https://david.ncifcrf.gov/) to perform Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.
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PMC11323699
Fluorescence quantification using FMT was conducted on live mice after 24 h (bottom panel).
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PMC11247842
For SCS, even though there have been many association studies performed previously and the list of QTL in the Animal QTLdb is long (1320 QTL, release 49), we still uncovered new QTL.
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PMC9268183
In order to confidently assess how many of the species cited in our surveys (i.e., the Catalan linguistic area) had been previously studied in depth, a review of pharmacological activities was carried out.
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PMC10914904
Previous reports have demonstrated that the expression of vtRNA 1-1 enhances activation of the mitogen-activated protein kinase (MAPK) pathway in cultured cortical neurons .
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PMC11718817
On the other hand, NLRP3 mediates potent antitumor effects.
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PMC7504302
Notably, the co-deletion of CDKN2A and CDKN2B genes is associated with a shorter overall survival rate in MPM.
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PMC11266100
The consent to perform animal experiments was obtained from the State Food and Veterinary Service (approval no. G2-266), carrying out the study strictly according to the Guide for the Care and Use of Laboratory Animals.
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PMC11266100
The gating strategy for electrotransfection analysis is presented in Figure 1.
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PMC11779960
Orange bars indicate 1 TCRβ clonotype above the threshold, purple bars indicate 2 TCRβ clonotypes above the threshold, and blue bars indicate over 2 TCRβ clonotypes above the threshold.
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PMC11310713
Scale bars, 400 μm. (
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PMC10759659
Then, the data from the three cohorts were normalized based on the length of the sequenced target region.
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PMC11727907
OCR was evaluated by an amperometric electrode (Unisense Microrespiration, Unisense A/S, Aarhus, Denmark) in a closed chamber.
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PMC10940855
Scale bar, 100 μm.
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PMC11742231
This is because the different layers of attention are designed to capture distinct levels and types of relationships between nodes in the graph, allowing the model to learn and incorporate more intricate patterns and dependencies among the nodes.
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PMC11354225
Due to characteristic EGCG structure , EGCG is able to chelate metal ions, leading to its autoxidation and generation of hydrogen peroxide, which induces cell apoptosis .
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PMC11367146
RMSF plot obtained during MD simulation of (C) apo-BCL2, BCL2-daucosterol and BCL2-gigantol (D) apo-ESR1, ESR1-daucosterol and ESR1-gigantol (F) apo-MMP9, MMP9-daucosterol and MMP9-gigantol complex.
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PMC9429973
Given that ERK hyperactivation stops B cell proliferation during early B cell development to allow them to rearrange their B cell receptor, we hypothesized that cell cycle inhibition upon ERK hyperactivation remains as a conserved mechanism of cell cycle regulation in KMT2A-R ALL.
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PMC10538569
Using these constructs, we demonstrated that the GPI anchor targeted the scFvs or HCDR3 molecules to lipid rafts of the plasma membrane of cells.
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PMC3019555
This change in P-body number is not because of an increase in Ago2 or GE-1 protein levels (Fig. 4 D).
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PMC11495567
The molecular structures of the PCAIs can be found in Tawfeeq et al. .
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PMC9429973
Interestingly, ASXL1 (36% vs. 1%, p=0.001), RUNX1 (9% vs. 0%, p=0.004), STAG2 (21% vs. 0%, p=0.013), TET2 (13% vs. 0%, p<0.001), and SRSF2 (18% vs. 0%, p=0.027) were more frequently found in de novo MDS (Table).
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PMC11470381
Mechanotransduction mechanisms in T lymphocytes enable them to efficiently navigate through diverse architectural and topographical features of the dynamic tissue macro- and micro-niches encountered during immune responses.
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PMC11095939
The switch from quiescence to proliferation is coupled with extensive changes in the transcriptional program coordinating metabolic and proliferation dynamics.
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PMC11594806
ALMB-0168 is a humanized monoclonal antibody that specifically binds to the extracellular domain of Connexin43 (Cx43).
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PMC11711063
Approval of the research protocol by an Institutional Review Board: All experiments were conducted in accordance with the guidelines approved by the University of Debrecen, the Hungarian Ethical Laws and regulations of the European Union.
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PMC10329074
Analysis of OS rates was conducted using Kaplan–Meier plots.
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PMC9429973
For assessing the natural course of disease, we screened for patients with non-intensive treatment only (best supportive care, lenalidomide, low-dose Ara-C, hydroxyurea).
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PMC9429973
Patients with prior CAR-T therapy may enroll with a washout period of 12 weeks post-CAR-T infusion.
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PMC11612794
While the 5 ng/mL nocodazole treatment did not affect the cell viability of CENP-C/CENP-T/Dsn1, CENP-C/CENP-T/Dsn1, or CENP-C/CENP-T/Dsn1 cells, the cell viability of CENP-C/CENP-T/Dsn1 cells was decreased by the treatment with the same concentration of nocodazole (Figures 6E and 6F), suggesting that CENP-C/CENP-T/Dsn1 cells are sensitive to the low-dose nocodazole treatment possibly due to the reduction in the kinetochore-localized Mis12C levels.
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PMC9587298
Amélia M. Silva: Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing, Supervision, Project administration, Funding acquisition.
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PMC11756514
Bacterial suspensions of either Reynolds (CP5), Reynolds (CP8), or Reynolds (CP-) cultivated on CSA were incubated with SP-D in the presence of either calcium or EDTA, since the binding of SP-D is calcium dependent.
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PMC11640555
Among the various events that characterize the genesis of the tumor, a correlation has been demonstrated between the inflammatory process and the production of reactive oxygen species (ROSs) in tumor cells as tumor cells constantly maintain a balance between the response to oxidative stress and the production of ROS for their survival , representing the main mechanisms of toxicity of tumor cells .
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PMC11802855
To lyse the cells, use 1X RIPA buffer containing Tris buffer (50 mM, pH 7.4), NaCl (150 mM), Triton X-100 (1%), PMSF (1 mM), SDS (0.1%), and protease inhibitor mixture from Beyotime Biotechnology.
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PMC9429973
The proportion of deaths that occurred in first week include 6.5% in low risk and 9% in high risk group.
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PMC11244823
For transfection, 12μg of maxi prep DNA were mixed with 1.5mL Opti-MEM (Gibco) and 60μL Plus Reagent (Invitrogen, Waltham, Massachusetts, USA), and incubated for eight minutes at room temperature (RT).
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PMC9429973
Two patients died due to SSN, corresponding to 25% causes of death in the total study sample.
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PMC11680049
For assessing the cytotoxic effects of complex extracts from the biomass obtained from callus tissue during the third cultivation cycle on the viability of cell cultures (FetMSC, HepG2, HeLa, and A-172), the MTT test was employed.
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PMC6487404
The LDH activity was measured in the incubation media using LDH-P kit from Kimia Pajouhan (Tehran, Iran).
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PMC10823017
The McCoys’s 5A Medium (30-2007™) was obtained from ATCC (Manassas, VA).
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PMC11185260
Western blot analysis of SMARCB1 and apoptosis markers (cleaved PARP and cleaved Caspase3) in CHLA-06 cells.
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PMC11763126
Therefore, the peptide derived from Cathepsin B (IESEVVAGIPRTD) attracted our attention.
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PMC9429973
3D spatial configuration of the models was studied by histological analysis, confocal microscopy and two photon techniques which allowed the 3D digital reproduction of the model structure.
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PMC11322866
A specific inhibitor of ERK1/2 phosphorylation (AG126) partially alleviated the abnormal expression of Lamin B1 and alleviated the cellular senescence induced by GSK126 ( Figure 4B‒E).
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PMC9429973
For this reason we conducted a prospective observational single-centre cohort study in LR-MDS patients.
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PMC6160470
Finally, cells were stained with 50 μg/ml of propidium iodide (PI) for 30 minutes on ice.
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PMC10998613
The fluorescence intensity per cell, as delineated by the Hoechst signal, was measured from the imagers.
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PMC11451829
Previous studies by our group demonstrated that it is possible to reproduce human pterygium-like changes in a rabbit model.
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PMC9429973
Safety was assessed in all pts (CLL/SLL and NHL).
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PMC11743316
The human transcriptome contains an extensive amount of protein-coding mRNAs along with noncoding RNAs .
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PMC11612315
The surgical site was then sutured, and iodine was applied for debridement.
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PMC9031474
Over the past decades, natural drimanes and coloratanes were isolated and their cytotoxic potential was evaluated.
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PMC11476106
We used quartile analysis of the cell count in each cluster of the ES cell lines, and a consensus was reached for cluster size classification (Table 1).
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PMC11322866
After treatment with cycloheximide (CHX) to inhibit protein synthesis, EZH2 was degraded faster in RRM2 OE cells than in RRM2 EV cells, indicating that RRM2 promoted EZH2 degradation ( Figure 2E).
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PMC11621493
All studies involving animals are reported in accordance with the ARRIVE guidelines for reporting experiments involving animals.
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PMC9429973
Results: Thirty one women and 23 men with median age of 37 years (range 18-76) were diagnosed between 2013 and 2021, with a High Grade B-cell Lymphoma, HGBCL (24 cases) and Primary Mediastinal B cell Lymphoma, PMBCL (30 cases).
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PMC11489351
Once the data was successfully uploaded to MetaCore, the TF Interactome Analysis was run.
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PMC10877303
Binding Affinities of the selected 10 inhibitors against MERS-CoV 3CL protein.
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PMC10092581
Notably, all complexes were much more effective than cisplatin against both three‐dimensional models.
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PMC9429973
With a median follow-up of 9.4 months (range 0.8-24) in the safety population of 121 pts, 12 pts (9.9%) discontinued therapy due to any drug-related AE.
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PMC8735881
While gp120 is responsible for binding with the primary cell receptor CD4 and a coreceptor (CCR5 or CXCR4), gp41 mediates fusion between viral and cell membranes, and both proteins induce neutralizing antibodies in HIV-infected individuals thus being major immunogens for vaccine development.
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PMC11628904
Immediately following burn injury, the presence of localised damage is visible by a change in tissue opacity (Figure 1B, blue outline).
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PMC11036064
Duan et al. have shown that miR-34a targets BCL-2 expression, upregulates CASP3, CASP8, and CASP9, and stimulates the apoptosis of U87 cells (Duan et al., 2016).
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PMC11244823
However, immunity against EHV-4 is not considered protective against EHM.
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PMC9429973
Increased expression of MCT1 and MCT4 was observed in MM cell lines after 48 hours of hypoxia.
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PMC11750165
At 27-hpf, an increase in the number of KA” neurons was also observed in another batch of maternal-zygotic PEX1 mutant (Fig. 5D, ~1.5±0.05-fold, p<0.01, n=5).
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PMC5261804
Correlations of PPI essentialities for each of the 14 significant drug/PPI pairs were significant by FDR < 0.05 (Table 1).
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PMC5963610
To study the combination we used the 7A7 mAb (anti-EGFR therapy) .
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PMC9473868
Therefore, the regulation of RA-FLS migration may be a new therapeutic strategy for the pathologic progression of RA .
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PMC11640555
The GBM microenvironment produces several pro-inflammatory cytokines and mediators, including interleukin-1β (IL-1β) and interleukin-8 (IL-18), that play key roles in the GBM through activation of downstream targets such as protein kinases signaling pathways, Janus kinase/signal transducer, and activator of transcription 3 (JAK/STAT3) .
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PMC11449273
TCEs from H1299-PG-p53-(WT, 175, 273) were processed for sequential reciprocal co-immunoprecipitation (Co-IP) and immunoblotting (IB) using p53, plakoglobin and control (IgG) antibodies.
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PMC11704834
To induce cell death or apoptosis, the mitochondrial Bit1 protein is released to the cytoplasm and complexes with the transcriptional regulator Amino Enhancer Split (AES) protein to turn off the TLE1-mediated survival gene transcriptional program (21,22).
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PMC10588957
Under various stressful conditions, SIRT1 and AMPK are potent stimulators of autophagy in most cells.
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PMC11731614
N = 3 biological replicates for both RD and HFD.
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PMC9952933
In addition, non-malignant bone cells were used: human osteoblasts HOB (PromoCell, Heidelberg, Germany).
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PMC9577200
Furthermore, at different concentrations, chitosan inhibits the growth and proliferation of the HeLa cell line and reduces cell viability (Li et al., 2019).
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PMC11478724
Incubation was done for 2 h at 37°C followed by absorbance measurement at 405 nm using an ELISA plate reader.
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PMC10443665
GT was purchased from markets in Isfahan province, I.R. Iran.
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