PMCID string | Sentences string | ner list |
|---|---|---|
PMC5673060 | Protein annotation enrichment analysis of the phosphoproteome dataset was performed using the DAVID functional annotation tool and a modified Fisher Exact Test called EASE (Expression Analysis Systematic Explorer) score, comparing up-regulated phosphorylated proteins of PazR and DasR with their corresponding up-regulated phosphorylated proteins in the A204 parental cell line. | [
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PMC11707577 | The grids were blotted for 2 s in 100% humidity at 4 °C and were immediately plunged into liquid ethane. | [
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PMC11525028 | The HRP-conjugated secondary antibody was then added to the blots at room temperature for 1 h. Membrane was detected with Chemiluminescent Imaging System (Tanon 5200 SF, China). | [
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PMC9503685 | CSA-131 was determined as the antimicrobial agent with the highest antimicrobial activity, while the antimicrobial effects of AMPs were found to be much lower than those of ceragenins. | [
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PMC11335267 | Representative spectra from which measurements were carried out. | [
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PMC11206251 | As a type of TCM, Illicium simonsii Maxim (ISM) is used as an anti-inflammatory, anti-bacterial, and anti-virus. | [
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PMC11502962 | In vitro, flow cytometry and Real-time PCR were performed to uncover a potential mechanism of tumor cell regulation of macrophages. | [
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PMC11594641 | Others described melanoma cell sEVs containing various signaling molecules from the MAPK family, HSP70, Tyrp2, and several microRNAs or pro-angiogenic factors (IL-8, VEGF, MMP-2, EGFR) that regulate the proliferation, migration, and invasion capabilities of neighboring cells . | [
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PMC11757131 | Immunoreactivity was visualized with chemiluminescent HRP substrate (Millipore, Billerica, MA) using the VersaDoc imaging system (Tanon, China). | [
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PMC11310713 | The increased serum levels of FSH and LH in OVX rats are suppressed by the ovarian hormones released from GTBs (Fig. 4). | [
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PMC11470381 | B. The cell ROIs across time frames (F0–F10) were fitted into an ellipse. | [
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PMC9429973 | We conducted a cross-sectional, multicenter, prospective study, based on the validation design of a survey offered to these patients, where demographic and social characteristics, tumor characteristics, management characteristics of the technologies of information and communication, as well as the patient portal and data on the COVID-19 pandemic were included. | [
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PMC10568263 | The particle size of the synthesized Au was calculated at about 16.8 nm. | [
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PMC10545062 | Moreover, testing different methods for determining fluid responsiveness will include machine learning algorithms and other measures (continuous oximetry, continuous thermistor, near-infrared spectroscopy, esophageal Doppler, etc.). | [
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PMC11696576 | An inhibitor of related structure, ZPL-5,212,372 (2, Fig. 1), demonstrated excellent efficacy in animal models of airway and skin inflammation and entered trials for topical application. | [
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PMC11697189 | However, our study proposes new prognostic genetic markers with potential clinical application value, which may improve the prognosis of ccRCC patients and even develop new therapeutic strategies. | [
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PMC11806818 | Adapted with permission from Aptasensors for the detection of MCF-7 CTCs. ( | [
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PMC11700340 | Cervical cancer has significant variation in prevalence throughout various areas of the world, with over 85% of cases concentrated in low-to-medium-resource countries. | [
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PMC11758416 | Incubate culture plate at 37°C for 5 min. | [
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PMC8526701 | In an AML mouse model, BI-9564-treated mice exhibited a significant decrease in tumor growth and improved survival . | [
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PMC11791264 | The proteins were separated by 10% SDS-PAGE and transferred to polyvinylidene fluoride (PVDF, Millipore) membranes. | [
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PMC7039683 | Focusing on ATAC-seq peaks that concorded among three replicates in each cell type, 31,296 NFRs present in HIOEC cells were absent in HEPM cells (Supplementary file 1j). | [
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PMC11648299 | The DD diagnoses were verified from the medical records, including clinical description, clinical images, and histopathology. | [
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PMC8345486 | Then, the tert-butyldimethylsilyl protection was removed by treatment with tetrabutylammonium fluoride to provide compounds 14–16. | [
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PMC11672881 | Both TQ and CU individually influence apoptotic pathways. | [
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PMC8916024 | The diversity of bacterial communities has been reported to contribute to biochemical reactions within the ecosystems of sediments (Gilbride et al., 2006). | [
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PMC11747949 | All mice were sacrificed once a single mouse reached a tumor volume of 1500 mm. | [
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PMC7171147 | Briefly, proteins were extracted from cell pellets using lysis buffer containing 80 mM Tris–HCl, 4% sodium dodecyl sulfate, 100 mM DTT, pH 7.4, alkylated with iodoacetamide and digested with trypsin using the filter-aided sample preparation method. | [
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PMC11387401 | Cycling conditions of the LightCycler 480 (Roche Applied Science, Germany) were 95 °C for 5 min, 45 amplification cycles of 95 °C for 10 s, 58 °C for 30 s, and 72 °C for 30 s. Assay specificity was assessed visually in the LightCycler 480 software, based on the 60 °C to 95 °C melting curve and all samples past quality control. | [
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PMC11731614 | PDN is characterized by neuropathic pain associated with dorsal root ganglion (DRG) nociceptor hyperexcitability and the degeneration with loss or retraction of the cutaneous DRG neuron axons that innervate the skin (small fiber neuropathy) (Lauria and Devigili, 2007, Sommer and Lauria, 2007). | [
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PMC10123657 | Our preliminary study is a proof of concept, and further research is needed to address the suitability and type of bias of the herein proposed methodology. | [
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PMC11482552 | The remaining cells were used for the cell-sorting procedure. | [
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PMC11264242 | Genomic analysis of FLAG-SS18-SSX2 in CRISPR-modified synovial sarcoma cells. ( | [
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PMC11367146 | The root of Vanda tessellata is reported to exhibit activity against bacterial infection, tuberculosis, abdominal diseases, tremors, and otitis . | [
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PMC11794588 | Prasad et al.reported that cedryl acetate has anti-cancer effects by inducing apoptosis in HeLa cells Cedryl acetate’s potential to induce apoptosis in cervical cancer cells further supports its use as a therapeutic agent. | [
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PMC10490530 | Whole-cell extracts were prepared using RIPA buffer with sodium vanadate, sodium fluoride, and a proteinase inhibitor cocktail. | [
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PMC9532503 | The Tangential flow filtration (TFF) output recovery was found to be 95%. | [
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PMC11754784 | Finally, the mica was rinsed three times with DPBS. | [
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PMC9927933 | Human embryonic kidney 293 (HEK293) cells, lung cancer A427 cells, and cervical carcinoma HeLa cells were purchased from American Type Culture Collection (ATCC) and maintained in Dulbecco’s modified Eagle’s medium (DMEM) containing 10% (v/v) FBS and 1% penicillin-streptomycin. | [
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PMC11036064 | The viability and stemness of the A172 cells were investigated using the colony formation assay. | [
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PMC11085211 | The Guava ViaCount™ distinguishes viable and non-viable cells based on the differential permeabilities of two DNA-binding dyes. | [
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PMC11640476 | FI data were expressed as mean ± SD, where SD represents the standard deviation. | [
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PMC9792775 | However, the effects of the combined use of LFU and PTX for sarcoma tumors remain unclear and warrant further investigation. | [
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PMC11695623 | The first five most relevant BP, CC, MF and KEGG were still selected to be displayed in the form of a bubble chart (Fig. 5D). | [
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PMC11248911 | The synthesized compounds were examined for their in vitro activity against MCF-7 human cancer cell line and human healthy cell line (BJ-1) using the LDH assay. | [
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PMC9429973 | We found that 110 unique circRNAs were significantly upregulated in MDS relative to healthy controls, whilst none were significantly downregulated (Figure B). | [
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PMC11541241 | Recently, they identified the corresponding genes of the TOR pathway in P. infestans and found that the PiSNF1 and PiAMPK kinase complex was targeted by StPR1 (S. tuberosum pathogenesis‐related protein 1), which played a vital role in plant defence against P. infestans (Luo et al., 2023). | [
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PMC11055323 | In brief, 6-week-old female NCG mice (Gempharmatech, T001475) were subcutaneously implanted with 5.0 × 10 SW 982 cells overexpressing SS18-SSX1-EGFP in 50% Matrigel (Corning, 354234)/Leibovitz's L-15 medium (Gibco, 11415064). | [
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PMC11064533 | Four functional classes contained significantly more genes that were expressed at a higher level and three classes at a lower level in clumps compared to planktonic cells. “ | [
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PMC9429973 | We found that BTM-3566 activates OMA1 in a manner unrelated to changes in mitochondrial ATP synthesis, reactive oxygen species generation or electron transport chain inhibition. | [
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PMC11765243 | Cells were washed and rested for 2 h at 37 °C before activation with anti-CD3 plus anti-CD28 as described above. | [
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PMC10969097 | The Ganoderma lucidum lipid fraction combined with chemotherapy (Epirubicin) in the MDA-MB-231 cell line transfected with miR-378 was subjected to treatment with Epirubicin (2.0 µg/mL), with or without the Ganoderma lucidum lipid fraction. | [
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PMC9046263 | Due to this association, further investigation into the oncogenic potential of HML-6 may be warranted. | [
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PMC8041314 | All compounds were screened for substructures present in pan-assay interference compounds (PAINS) and did not contain any of these motifs. | [
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PMC9596868 | No. 05-636; 1:3500), overnight at 4°C. | [
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PMC8913139 | no. ab181602) primary antibodies (Abcam, Shanghai, China). | [
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PMC9786247 | Specific virulence factors may also be deployed by C. burnetii to manipulate the host response to create a safe replicative niche in bovine udder cells. | [
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PMC10213179 | Agents that promote EphA2 activation can be useful for suppressing cancer cell malignancy. | [
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PMC10818573 | EBV is a DNA virus with a genome size of approximately 170 kb that contains more than 100 open reading frames. | [
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PMC11792888 | We utilized high-performance liquid chromatography with a C18 reverse-phase column to pinpoint the soluble venom components affecting cell viability. | [
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PMC11674146 | The CCK-8 assay was applied to determine the viability of BJAB and RA 1 cells, as seen in the reduced OD value at 12, 24 and 36 h (Figs. 2F and 2G, P < 0.01). ( | [
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PMC9599726 | Here, we established that VP cytotoxicity is mediated by ferroptosis and confirmed that VP behaves like a canonical YAP inhibitor in GIST882 and GIST48 cells, since VP decreased the expression level of several known YAP transcriptional targets, as reported in other cell lines . | [
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PMC11545737 | In BMDMs YopE and YopT can induce pyroptosis only in the absence of YopM, a virulence factor which inhibits pyrin inflammasome . | [
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PMC11806106 | I Calculated EC50 values for dynorphine A (H) were comparable between BRET (209 nM) and FRET-based sensor (219 nM) (P = 0.7294, unpaired t test with Welch’s correction). | [
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PMC11476837 | The expression of NRF2 and its main repressor, Kelch-like ECH-associated protein 1 (KEAP1), at mRNA and protein levels was examined. | [
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... |
PMC11279397 | Among numerous traditional Chinese medicine prescriptions, Perilla frutescens stands out due to its distinct antiviral efficacy and garners high comments from physicians throughout various dynasties. | [
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... |
PMC11786767 | C: The relative Ki-67 signals in Ki67-miR- and Ctrl-miR-expressing cells. | [
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PMC10560648 | According to the decreased expression of DNMT1, it seems that due to the decrease in DNMT1 expression, p15 INK4b and p53 methylation are also reduced, and by increasing their expression, C. Andromeda venom causes apoptosis of Jurkat cells. | [
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PMC10607604 | Inhibition of anti-apoptotic transduction pathways by PTPN13 also could explain this sensitizing effect. | [
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PMC11085211 | Regarding the possible bio-active compound characterizing FR2-A, we initially focused on β-arbutin. | [
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PMC6133382 | These results demonstrate that changing the glycosylation while leaving the amino acid sequence intact can significantly improve the antigenic structure of A244-rgp120 with respect to the binding of several bNAbs to glycan-dependent epitopes. | [
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PMC11802855 | 7CXCL7 activates the JAK/STAT3 pathway, resulting in the upregulation of MMP13 and C-myc, further promoting osteoclast signaling pathway activation and tumor proliferation. | [
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PMC11481779 | We have made a few changes to make it work with the Hi-C data. | [
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PMC11591052 | Furthermore, the functional consequences of the 20E-mediated effect on these cells included the up-regulation of glycolysis and respiration, enhanced glucose uptake, and ATP production. | [
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... |
PMC11756514 | TarS is the most common glycosyltransferase in S. aureus. | [
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PMC11782780 | Additionally, CSCs can differentiate into varying cell types. | [
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PMC11711345 | Cuminic acid and sodium cuminate showed a low ability to cross the BBB according to the ADMETlab server (Table S3). | [
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PMC11394730 | Genistein has proven its ability to restrain the formation of new blood vessels by inhibiting the expression of vascular endothelial growth factor (VEGF), which is a key regulator of angiogenesis. | [
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... |
PMC11637284 | A cell line shown in (C) induced for two days that also expresses mini-p166-HA was analyzed. | [
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PMC6889484 | Subtype B patient isolates were obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH from the panel of 60 international HIV-1 isolates (catalog #11412), contributor Dr. Robert Gallo for HIV-1 MN virus (catalog #317), and contributor Dr. Nelson Michael for HIV-1 BK132 (GS 009) virus (catalog #7691) and HIV-1 BZ167/GS 010 (89BZ_167) virus (catalog #7692). | [
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... |
PMC11777207 | Administration of PD-L1 43H12 antibodies in KikGR mice resulted in considerably less KikRedDCs in the dLN 24 hours after polyI:C injection (fig. S4A) where both cDC1 and cDC2 frequency and number were reduced in the dLN following αPD-L1 43H12 administration (Fig. 3, G to K). | [
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PMC7305184 | Nevertheless, no development of adaptive resistance to PEF was detected in permeabilization. | [
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"tokens": [
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PMC11719944 | Regarding serum PRL levels, in cases where prolactin levels are normal, serum PRL remains consistent regardless of the age at diagnosis. | [
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PMC11653533 | This approach not only updates the current scientific understanding of Ficus species but also highlights their relevance to modern medicinal research, enhancing the practical and clinical significance of this review compared to past works. | [
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... |
PMC11085211 | In view of this consideration, we performed a second step of fractionation, subjecting the FR2 fraction to a reverse-phase MPLC, which led to the identification of the FR2-A fraction as the most active one in imatinib-sensitive cellular models (GIST-882 and GIST-T1), regardless of primary KIT mutations. | [
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PMC10553757 | Reverse transcription-quantitative PCR (RT-qPCR) demonstrated that lactating human mammary epithelial cells (HMECs) isolated from breast milk express the GH receptor. | [
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... |
PMC11791264 | We next investigated the function of LC3B methylation in OC cells. | [
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PMC11568601 | B TGT inhibited the longitudinal migration of osteosarcoma cells according to the transwell assay. | [
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PMC7642379 | The overall comparison of genomic and transcriptomic profiles confirmed the picture of clonally diverged progeny cells as compared to the parental HEK293 (Fig. 1b,c). | [
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PMC10938336 | In addition to disease-associated pathways, the analysis illuminated the engagement of these genes in essential cellular processes. | [
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PMC11248911 | With respect to malignant tumor growth, APN is a vital target for anticancer therapy because it is associated with different cancer hallmarks such as cell proliferation, angiogenesis, metastasis and invasion. | [
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PMC9910796 | By contrast, under permissive conditions, vEP84Ri produced similar titers to those of parental BA71V virus. | [
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PMC11541409 | 40(16_suppl): p. 11513-11513.This reference is of importance because it reports that olverembatinib is a promising drug for SDH-deficient GIST patients. | [
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PMC6181431 | Similar results were obtained from SNU349 cells with stable downregulation of PBRM1 (S2 Fig). ( | [
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PMC11033180 | This shared activity of Sema5A between the gut and the brain supports the existence of gut-brain molecular interaction. | [
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PMC11783017 | Therefore, mouse monocyte macrophages (RAW264.7) and DCs were co-cultured with 143B and K7M2 cells treated with different groups in the transwell system for 24 h to assess macrophage polarization and dendritic cell maturation (Fig. 4A). | [
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PMC11678368 | These results support the conclusion that the 5ClL ligand provides enhanced stabilization and a strengthening of the M-L bonds in both Pd(II) and Pt(II) complexes. | [
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PMC4659567 | As in the case of DMF-d 7/D2O solution, the addition of D2O into the MeOD-d 4 solution of 8 resulted to the formation of white precipitate, which was centrifuged before the H NMR acquisition. | [
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PMC10898159 | Immunotherapy is a promising hotspot in the treatment of tumors , but the efficacy cannot be determined in the existing cases of GIST . | [
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PMC11594074 | ZINC15 has an interesting feature called “tranches”, which allows the users to download the ligands based on their physical properties. | [
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