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PMC11486946
To consider the effect of fluorescence bleaching caused by repetitive irradiation by the laser, timelapse images of the cells without compound treatment were acquired and analyzed by the same method.
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PMC11679033
Combined exposure to CBD and CIT resulted in lower lymphocyte viability compared to the CBD-treated group but with no statistical significance.
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PMC9250505
Despite effective responses of the combinations of PARPis and PI3K/AKT/MEK-inhibitors, the ORR of <30% indicates that possible feedback or compensatory bypass mechanisms were activated.
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PMC10955424
In contrast, 75 % of cirrhotic ascites (3 out of 4) did not induce platinum chemoresistance in OC cells.
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PMC11763764
Therefore, new approaches to stratify patients and a better understanding of the dysregulation in the EGFR pathway will be critical for improving the efficacy of EGFR-targeted therapy in ovarian cancer.
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PMC11489275
This study was officially approved by the Ethics Committee of Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School (NO.:
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PMC10196713
Since a growing body of evidence has demonstrated that cisplatin induces ferroptosis in carcinoma cells (13), whether treatment with deferoxamine, an iron chelator, could inhibit cisplatin-induced death of OC cells was confirmed.
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PMC10024132
Both blinatumomab and CD19-CAR-T cells make use of T cell-mediated cytotoxicity and CD19 targeting to fight against ALL.
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PMC11756907
Table 4Combustion Elemental Analysis DataGOrGOCarbon [%]40.279.8Oxygen [%]51.415.3 Combustion Elemental Analysis Data According to the invention, GO-2-ME or rGO-2-ME can be used as a therapeutic system with the regulated bioavailability and controlled release of the active component, 2-ME.
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PMC3203927
Table 3 lists 13 genes (ANGTL7/CDT6, ARMET/MANF, BMP8B/OP2, CCL13/MCP-4, FGF5, GHRL, IL-11, IL-1B/IL-1F2, NOV/IBP-9, PDGFB, STC1, TGFA, and VEGF-A), whose transcripts were up-regulated in both 3D and NS culture conditions, and examples of their functions.
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PMC10900886
When BLCLs were co-cultured with EV-D68-inoculated imDCs, the percentage of infected BLCL increased from 2% ± 1 at 6 hpi to 6% ± 1 at 24 hpi (Fig. 5C).
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PMC11727145
Within our work, we have demonstrated the comparability of a new simplified medium to that of mGreen’s medium and could, therefore, standardize this major component of the DED model.
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PMC9429973
Seven-year PFS was improved with G-chemo (63.4%) versus R-chemo (55.7%; hazard ratio [HR], 0.77; 95% confidence interval [CI]: 0.64–0.93; p=0.006; Figure).
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PMC10582049
UMAP representation of CAF populations.
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PMC11743316
Accordingly, multiomics investigations have provided a novel method to generate tailored biomarkers for ovarian cancer therapies.
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PMC11443022
In Japan, preimplantation genetic testing for aneuploidy is suggested for repeated miscarriages, and preimplantation genetic testing for structural rearrangement is suggested for chromosomal structural abnormalities.
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PMC11188874
We hypothesized that proteasome activators represented a feasible approach to increase antigen presentation to enhance antitumor immunity.
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PMC6684588
The tetanic force-frequency relationship was generated with square-wave stimuli of 200 ms.
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PMC9429973
Optical Genome Mapping (OGM) is a novel non-sequencing-based technique for genome-wide high-resolution SVP for all types of SVs: copy number alterations, structural rearrangements, inversions and partial tandem duplications (PTD).
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PMC11748363
Fractions containing pure product were collected and combined, and solvents were evaporated under reduced pressure to yield oily liquids, which, after some time, solidified at room temperature.
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PMC11753435
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery.
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PMC10362265
Nine out of fourteen hIL18 structures in PDB have adopted a compact 310 helical conformation for the surface epitope encompassing residues 68–81 (PDB IDs: 3wo2, 3wo3, 3wo4, 2vxt, 4hjj, 4r6u, 4xfs, and 4xft), while it is either missing (7al7, 3f62, 4eee, 4ekx) or highly flexible (1j0s) in some structures .
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PMC11499955
The use of chemical tagging in mass spectrometry (MS) is a well-known approach to increase the sensitivity of the quantification.
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PMC11474209
A technique was created and verified, showing that it was accurate, reproducible, and sensitive.16-LFICATap water0.04 ng/mLThe molecular imprinting technique was combined with an enzyme-assisted colorimetric method to increase the sensitivity of conventional LFICA significantly.
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PMC11490153
The nanoparticle droplets exhibit a non-uniform yet spherical configuration.
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PMC6163708
This implies a very specific cell context in rhabdoid tumors and suggests the HH pathway as a target for their treatment.
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PMC11507371
The extracted RNA was measured with a NanoDrop OneC (ThermoFisher Scientific, Waltham, MA, USA) to determine its concentration and purity and then transcribed into cDNA using the SensiFAST cDNA Synthesis Kit (Bioline/Meridian Bioscience Inc., Cincinnati, OH, USA).
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PMC8358006
Expression was significantly higher for 112 transcripts (“upregulated abundance”) and significantly lower for 154 transcripts (“downregulated abundance”) in TBX20-depleted KYSE510 cells (Fig. 5f, Supplementary Table 5).
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PMC8873393
In CSB cells, on the contrary, 24 h chromatin extract is separated from other time points examined (Fig. S2D), suggesting a failure of transcription recovery due to the lacking of CSB protein.
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PMC9429973
Methods:: A total of 67 samples of patients (33% men and 34 % women) with an overt AML with >20% blast cells, excluding acute promyelocytic leukemia, were included in this study.
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PMC11732628
RT-qPCR was used to analyze miR-490-3p expression in osteosarcoma and hFOB1.19 cell lines; (B) RT-qPCR was used to analyze miR-490-3p mRNA expression; (C) CCK-8 assays were used to analyze cell proliferation; (D,E) wound-healing assays were used to analyze cell migration.
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PMC9856122
Both the alkaloids magnoflorine and lanuginosine represent potent cytotoxic activity also with IC50 values of 0.4 and 2.5 µg/mL .
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PMC10073922
The number of invading or migrating cells was determined by counting five fields (400×) of a light microscope on each membrane and was calculated as the mean number of cells per field .
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PMC11451940
Dark-red solid: 46 mg (yield 59%).
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PMC11770199
Western blot was performed as previously described.
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PMC9429973
We also examined the usefulness of FLIPI, POD24, and cell-free DNA concentration in a recent cohort.
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PMC11661040
Nude mice were randomly divided into two groups with 6 mice in each group, and 1 × 10 143B-shCGREF1 or 143B-shNC cells were injected subcutaneously (200µL PBS mixed).
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PMC11791264
Each bar represents the mean ± SD (n = 3).
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PMC11367146
The degree of a node indicates the number of interactions it has with the nodes.
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PMC11476222
The clear supernatant containing sphingolipids was carefully pipetted into a separate vial.
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PMC9684669
Four concentrations of compounds from the library of pharmacologically active compounds (LOPAC, Sigma-Aldrich) consists of 1,280 small molecules, the NIH Chemical Genomics Center Pharmaceutical (NPC) collection with 4,265 compounds (28), as well as the Mechanism Interrogation Plate (MIPE) with 1,920 compounds were added to assay plates at 23 nL/well using a pintool station (WAKO Scientific Solutions, San Diego, CA).
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PMC8777939
Moreover, etravirine diminished proliferation, migration, and invasion in vitro.
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PMC11657744
Membranes were blocked for 1 h in TBST containing 5% skim milk or BSA, followed by overnight at 4 °C with the following primary antibodies: mouse anti-Aurora A (MyBiosource, MBS212609, 1:1000), mouse anti-β-actin (Santa Cruz, sc-47778, 1:10000).
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PMC4485786
NHS-IL12/IL-2MAB602 tumors devoid of CD161 and RORC mRNA strongly suggest that IL-17-producing NK cell or T-cell phenotypes were suppressed in these mice by IL-2.
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PMC11718817
Furthermore, nine OT-I mice and seven Il18r OT-I mice were sacrificed to generate CTLs.
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PMC11701801
Next, 15 μg of protein was analyzed by immunoblotting.
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PMC11047729
Moreover, it increases the intracellular level of ROS .
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PMC11361748
The data is publicly available at the Gene Expression Omnibus (GSE245384).
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PMC9429973
IMG-7289-CTP-201 is an ongoing, global, open-label, Phase 2b study of bomedemstat taken QD for 24+ weeks in patients with ET who are resistant/intolerant to at least one standard treatment (NCT04254978).
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PMC11594641
Elevated levels of CD63 and TSG101 were also observed in the RAB27A KO A375 sEVs.
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PMC9599726
We assessed SLC7A11 and GPX4 protein expression.
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PMC9429973
For women, age was not a significant adverse factor.
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PMC11745600
Small rodents such as mice and rats have long served as the preferred species for animal models in biomedical research because of their anatomical, physiological, and genetic similarity to humans, ease of maintenance, and abundant genetic resources.
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PMC5833712
The standard of care for the management of advanced ovarian cancer has been unchanged for many years and includes maximum cytoreductive surgery followed by platinum-based chemotherapy (carboplatin or cisplatin) in combination with paclitaxel.
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PMC9429973
Results: Hematologic toxicity of different regimens (CLV, LEAM, BeEAC).
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PMC7987994
Metabolic activity of the medium without ZnCl2 was taken as 100%. (
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PMC11720808
The CCK-8 assay was carried out following the manufacturer’s instructions.
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PMC11618052
It was more effective than erlotinib against all four cancer cell lines and twice as effective against the MCF-7 breast cancer cell line.
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PMC11745823
RIT1 protein has a typical GTP‐binding domain and can exert its biological functions in a GTP‐binding state .
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PMC10788478
Hence, the development of new treatment strategies and biomarkers for lung cancer are urgently required.
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PMC11681005
BLCA incidence is 3–4 times higher in males , ; however, when diagnosed with BLCA, women tend to present with more advanced disease stages compared to men, resulting in poorer treatment outcomes and higher mortality rates. ,
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PMC5963610
This immune response depends on the immunogenic cell death induced by the mAb mediated inhibition of EGFR signaling, which likely stimulate tumor-antigen presentation by dendritic cells in vivo.
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PMC11684269
In this process, T cell act as a prominent pathogenic element, worsening the pre-existing kidney damage (147).
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PMC11787355
Each dot represents a technical replicate, n = 5.
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PMC11676169
Approximately 30 mg of cytoplasmic extracts were incubated overnight with EZview Red anti-FLAG M2 affinity gel beads (F2426; Sigma-Aldrich, Merck, Darmstadt, Germany).
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PMC9429973
On the other hand, the long intergenic noncoding RNAs (lincRNA) fraction was reduced in triple mutants.
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PMC9429973
Chemotherapy combined with G-CSF stimulation causes inflammation associated with intense angiogenesis and disruption of signaling pathways associated with HSC motility.
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PMC11442172
Indeed, microfluidic systems have been demonstrated to be able to mimic the in vivo tumor conditions better than traditional 2D systems (88).
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PMC11643361
The highest cytotoxic effect was shown by compound 40, which was two to three times higher than the one exhibited by cisplatin (Figure 5B).
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PMC10094712
Restriction was carried out using EcoR I and SalI restriction enzymes for 3 h at 37 °C, after which the cut PCR products were purified from restriction enzymes according to the Evrogen protocol.
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PMC11779605
Patterns of immune cell types and cytotoxicity scores were found to be similar, while the endothelial cells were higher, in the tumor and ascites specimens ( Figure 2B ).
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PMC11204465
Studies have shown that sterigmatocystins and aflatoxins have a wide range of biological activities such as antitumour, antibacterial, anti-inflammatory, antiplasmodial, etc.
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PMC11534035
The first goal of this study was to assess the VC cell behavior with respect to migration and invasion capabilities as well as clonogenicity at varying levels of PAI1 expression.
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PMC9429973
Therefore, soluble BCMA detection is one of the predictors of refractory disease.
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PMC11791203
Additionally, Kheyar et al. evaluated the antiproliferative effect of an Inula viscosa phenolic extract on HT29 cells (EC50 = 62.39 µg/ml).
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PMC11012012
Among the SLAMF receptors, the expression of SLAMF1/CD150 can be considered the best described in B-CLPD.
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PMC11337594
Drawing by Figdraw. (
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PMC11185260
The surface of liposome is decorated with TfRscFv, which allows the nanocomplex to target brain tumor cells that overexpress TfRs with exquisite specificity and actively ferry payloads across the BBB by virtue of the elevated expression of TfRs in the cerebral endothelium via TfR-mediated transcytosis.43 We have previously evaluated the in vivo distribution of scL nanocomplex carrying a fluorescence labeled oligonucleotide payload after a tail vein injection in tumor bearing mice.33 Ex vivo imaging of tumors and major organs revealed a selective tumor-targeting by scL nanocomplex and much lower delivery to other major organs.
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PMC11541241
Consistently, TOR inhibition by exposure to TOR inhibitor or using the virus‐induced gene silencing (VIGS) system increased tomato immune responses and disease resistance to B. cinerea (Marash et al., 2022).
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PMC10538569
To transduce human primary CD4 T cells, human primary CD4 T cells were enriched from CD14 monocyte-depleted PBMCs by negative selecting magnetic beads (see above).
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PMC9429973
Results: A total of 34 patients were included in the PEG arm, 125 patients in the RAV arm, and 121 patients in the ECU arm.
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PMC6835428
Peritoneal persistence can be also improved by using positively charged delivery systems that can easily interact with the negatively charged membrane of MS .
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PMC11680562
The gel's biocompatible properties guarantee its permanence, thereby enhancing vaginal health and providing continuous protection during cervical cancer treatment.
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PMC6337547
Phenolic acids have diverse structures (monomers, dimers, trimers, tetramers, and multimers) and are present in high concentrations, which has important taxonomic significance for Chinese Salvia species .
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PMC11763533
The larger spectral shifts at 37 and 45 °C in relation to 22 °C indicate that, although this luciferase bioluminescence spectrum is more stable and less sensitive to pH at lower temperatures under in vitro conditions, it is a much better pH indicator at the elevated temperatures of mammalian cells.
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PMC9065483
Fluorescence images were captured 24 hpi. (
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PMC11535726
Colonies circular, characterised by dense, flat, spreading and fluffy growth, with an entire margin.
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PMC11594641
To examine whether the vesicular composition was altered due to the loss of Rab27, we decided to study the expression of the tetraspanins CD63 and CD81, and the ESCRT proteins ALIX and TSG101, as they are considered some of the most universal markers of sEVs .
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PMC11442172
Chano et al. (55) showed a higher sensitivity of osteosarcoma cells to HDAC inhibitors at pH 6.5, suggesting that acidosis promotes metabolic profiles that contribute to epigenetic maintenance.
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PMC11216402
These findings establish a map of TF activity in GC and highlight the role of copy number driven alterations in shaping epigenomic regulatory programs as potential drivers of GC heterogeneity and progression.
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PMC11705862
The expression of both IRIS-1 and IRIS-2 significantly decreased in SH-SY5Y cells during all treatments.
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PMC11656380
Western blot analysis of protein expression of PTEN in various human leukemia cells.
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PMC9429973
Telomere length was shorter than first percentile in 81.5% of patients.
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PMC11739484
Thus, targeting MMPs may offer dual benefits by inhibiting tumor progression while enhancing the efficacy of immunotherapy approaches in melanoma treatment.
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PMC8540692
Numerous epidemiological studies demonstrated the relationship between diet and cancer and the potential of dietary components, particularly polyphenols as promising anticancer and chemopreventive agents .
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PMC10887351
Further studies are required to explain the underlying mechanisms and interactions between the TME and host immune system.
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PMC11470381
The protocol outlined below offers a comprehensive, step-by-step account of the experimental methodology and analytical approach employed to assess the polarity of Piezo1 mCherry and actin-GFP in chemokine-stimulated Jurkat cells.
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PMC11323699
Our findings revealed that TAX2 treatment demonstrated notable, albeit moderate, activity in PARPi-naive mice in this particularly aggressive model of metastatic OC, corroborating previous studies performed in different OC xenograft models , and other tumor indications [28–32].
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PMC11350568
d–f) Comparison of the internalization rate of AptG-1, AptG-2 and Sgc8c∼lib at different time points, CCRF-CEM cells were incubated with 500 nM AptG-1, AptG-2, and Sgc8c∼lib for 3, 5, or 10 min in cell culture medium at 37 °C.
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PMC9429973
Results: Group 1 included 49.2% with de novo AML 20.3% patients with secondary AML and 30.5% with HR MDS.
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