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OTAR3088
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BioData-CellLine_annotated

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PMC9599726
Data were exported as CSV channel values.
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PMC11756937
Despite stringent quality control procedures, not all iPSCs pass quality control assessments to qualify for long-term distribution to the research community.
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PMC11754432
Next, expression of ALOX15B was analysed in non-lesional and lesional skin of psoriatic patients.
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PMC11321678
Cancer genomics has revealed four molecular subgroups of medulloblastoma: SHH, WNT, Group3, and Group4, which differ in their genetic, transcriptional, epigenomic, and clinical features. , , , , ,
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PMC9429973
We analysed rates of transfusion, number of red blood cells (RBC) units per transfusion, haemoglobin levels and the incidence of iron deficiency anaemia (IDA) prior to transfusion.
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PMC11473750
siRNA’s used were siRNF121-1: GAAAUGGUCCUCAUCCUCA (Dharmacon: J-007011-06) and siRNF121-4: CCAUAGGGUUCUACAGCGA (Dharmacon: J-007011-08) or non-targeting control siRNAs (ONTARGETplus siRNA, #D-001810-0X, Dharmacon).
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PMC2614416
Comparative proteomics and Gene Ontology analyses of the HepG2 Cells and normal human liver proteomes show that oxidoreductase enzymes are down-regulated in HepG2 cells by 57%.
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PMC9429973
Centrifugation was applied to separate the fatty layer containing BMAT from the BM cell suspension.
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PMC10900886
EV-D68 infects respiratory epithelial cells, which results in the production of infectious virus particles and the recruitment of immune cells, such as imDCs.
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PMC10999934
Then we conducted differentially expressed analysis for epithelial cells in these two groups.
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PMC11544771
Cdc25 phosphatases, including Cdc25A, Cdc25B and Cdc25C, and can dephosphorylate and activate G1-, S-, and G2/M-CDK, respectively, thus promoting cell cycle progression .
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PMC5716223
b, c Quantitative analysis of αB-Cry and Hsp27 expression during differentiation process (2, 5 and 9 days) of myogenic cells supplemented with or without NGF (αB-Cry: NGF 1.3 ± 0.08 vs Ctrl 2.0 ± 0.11, p < 0.05; Hsp27: NGF 1.0 ± 0.03 vs Ctrl 0.53 ± 0.04, p < 0.05).
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PMC10170482
Therefore, to visualize the 3D microstructure of the scaffold in a liquid environment, we labeled collagen fibers with the low-molecular-weight fluorescent probe Col-F (Figure 2A).
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PMC11473843
10 weeks after Cre delivery, mice were treated with XMD8-92 or Seliciclib or in combination for 2 weeks (Fig. 3A).
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PMC11719944
As seen in Figure 6, there was a difference in the expression of PD1 between the memory T cell subpopulations.
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PMC8193813
The two tested stacks are 14m above ground level and 7m apart.
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PMC9611901
The supernatant was drained off and small amounts of PBS buffer were added to the precipitate.
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PMC9444294
Positive cases with RT-PCR confirmation are also listed as containing either the SSX1 or the SSX2 variant.
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PMC8540611
Since we tried to induce tumor cells to die through apoptosis by blocking proteins of the bcl2 family, it was also necessary to analyze the types of cell death.
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PMC5261804
A context specific PPI network was created for each cell line by using mutational and CNV events to re-wire the topology of a prior-knowledge superpathway containing 2,186 proteins and 11,488 PPIs.
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PMC11172027
If this is reduced by substances, like 2-oxoglutarate and/or 5-hydroxy-methyl-furfurale, both cell lines appear to lead to apoptosis via mitochondrial pathways.
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PMC11748363
Results were expressed as MIC compared to standards amphotericin B (AMB) and voriconazole (VRC).
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PMC9878278
Recombinant TGF-β1 and Activin A proteins were purchased from the R&D System.
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PMC9429973
Grade 3/4 TEAEs >10% in resistant patients were thrombocytopenia (22.2%) and neutropenia (11.1%), and in intolerant patients were increased alanine aminotransferase (26.7%), diarrhea (23.3%), pleural effusion (13.3%), and rash (13.3%).
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PMC11727907
PKM2 exists in tetrameric and dimeric form, both composed of the same monomer, but with different biological actions : tetrameric PKM2 functions as a cytosolic enzyme, catalyzing the final step of glycolysis by converting phosphoenolpyruvate into pyruvate and producing ATP .
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PMC7294030
Statistical significance is indicated by *p<0.05, **p<0.01 or ***p<0.001.
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PMC11707832
Key members of this family include MAN2A1, MAN2A2, MAN2B1, MAN2B2 and MAN2C1 .
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PMC9693627
After centrifugation (25,000× g, 20 min), dissolved inclusion bodies were applied to 1 mL Ni-NTA column (HisTrap, GE Healthcare, Marlborough, MA, USA) connected to AKTA Purifier chromatography system (GE Healthcare, Marlborough, MA, USA) and pre-equilibrated with the same buffer.
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PMC9096373
Next, the tumor samples were collected, and the protein expression of VEGFR-2, CD31, Ki-67, andγ-H2AX levels were determined using immunohistochemistry (IHC).
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PMC9429973
The findings are summarised in Table 1.
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PMC9031474
Against A549-, SkMel-28-, U373-, MCF-7-, Hs683-, and B16F10 cell lines GI50 values between 4 and 14 μM were obtained for 74a.
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PMC11607321
The randomization was stratified by hematopoietic and lymphoid cell lines to ensure balanced representation across cell line types and distinct culture conditions, i.e. suspension vs adherent.
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PMC9429973
ISS stage 3 was present in 12 (24%) patients.
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PMC11525028
Data are presented as the mean ± SD.
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PMC9429973
Aims: For r/r T-cell lymphoma, a clinical trial using CD7 chimeric antigen receptor T-cell(CD7 CAR-T) has been registered, and the safety and efficacy will be evaluated.
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PMC11661024
Finally, although we employed HUVEC cells as a control for normal cells, evaluating the postbiotics on a broader array of normal and cancer cell lines would be beneficial to determine their specificity and potential off-target effects.
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PMC9429973
Results: Treatment of ALCL cell lines with increasing concentrations of CSN5i-3 resulted in decreased protein levels of CSN5/Jab1, which was associated with significantly decreased cell growth but slight increase in apoptosis (10-15%).
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PMC11748335
Similarly, in the D425 medulloblastoma cell line, PMDs covered by H3K27me3 are shorter than those covered by H3K9me3, implying a spatial correlation between PMDs and H3K27me3 or H3K9me3 blocks .
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PMC11530949
Among all tested agents, cisplatin exhibited the most pronounced cytotoxic effect, outperforming the biosynthesized and chemically synthesized NPs as well as the Ephedra intermedia extract.
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PMC11588085
To examine molecular features, we performed GSEA on the OVCAR3-KRAB transcriptome profiles to identify the mesenchymal-like cancer SC signature associated with XIST expression.
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PMC5916734
In particular, a significant percentage of FIX secreted in CHO cells is inactive at almost any level of specific productivity, since it contains an unprocessed propeptide that completely inhibits the functioning of the Gla domain.
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PMC11521786
The PC9 cell line and erlotinib-resistant PC9ER cell line were obtained from the Department of Biological Regulation at the Weizmann Institute of Sciences (Israel).
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PMC11705630
Knockdown of STAT2/or IRF9 alone as well as double knockdown of STAT2 and IRF9 in the GLDC depleted ACHN cells reversed earlier increase and longer lasting appearance of p-H2AX as observed in GLDC depleted cells treated with Dox/or CP (Fig. 6C and Fig. S2B).
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PMC11682172
In addition, a prominent role of coronin-1A in the formation of cerebral metastases in breast cancer patients is strongly suggestive by its upregulation in tissue samples of breast cancer patients with brain metastases.
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PMC11711871
Salt-sensitive hypertension is a common type of high blood pressure that is exacerbated by a high-salt diet and affects approximately 30% of healthy humans and 50% of individuals with hypertension .
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PMC10747160
The next day, Griffithsin protein sample was then resuspended in commercial PBS, as described above, and was serially diluted with PBS so that at least 500 μL of Griffithsin protein was present for each dilution concentration.
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PMC11585565
Individual data points are shown with means and standard errors.
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PMC10440586
The correlation between CD99 expression and hypoxia-related metabolic pathways in the TCGA datasets. (
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PMC8711270
Comparison of various rAAV production methods.
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PMC6617630
The B cell lymphoma cell lines OCILY10 (LY10), SUDHL2 (DHL2) OCILY1(LY1), OCILy3, and OCILy19 were a kind gift from Dr. Louis Staudt (NCI, Bethesda, MD, USA).
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PMC11682172
The comparison was based on t-test between two groups using Excel and Anova analysis among three groups using Scaffold software, and the p values of all proteins were considered differentially expressed if p < 0.05.
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PMC7868205
Later, the particles integrate to form a definite and final shape.7 Although the advantages of nanomedicine appear plenty, risk assessment and analysis of the exposure of these particles obtained using rapid synthesis procedures towards normal or cancer cells are critical at specific doses for enhanced applications in nanomedicine.8,9 The toxicity assessment for health hazards of AgNPs is still in its infancy although their role in nanomedicine is well known.10–12 Few reports indicate both local and systemic toxicity of AgNPs, with mechanisms that relate to toxicity at genome levels, induction of immune cells, and oxidative stress.
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PMC9429973
cycle 1: d 1, 8, 15, 22, 29; cycles 2-3: d 1, 15, 29.
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PMC9429973
Uncomplicated VOCs were defined as pain crises, whereas complicated VOCs were defined as acute chest syndrome, acute splenic sequestration, acute hepatic sequestration or priapism.
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PMC11607764
qRT-PCR revealed significant upregulation of PTBP1 mRNA in LUAD, COAD, and SKCM cell lines, as well as melanoma-forming mouse models.
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PMC10968586
Results in vitro underline the diverse sensitivity that cell lines exhibit against OLE- and HT-mediated effects on cell growth.
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PMC9429973
Methods: 35 children with Haplo-cord transplantation and 14 children with Haplo-SCT in our hospital were followed up between May 2017 and May 2021, the engraftment, immune reconstitution,Virus reactivation, incidence of GVHD and 3-year overall survival rate were observed.
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PMC11476106
The circularity of the small clusters was lower in HGs without added VN than in VN-added scaffolds at both timepoints, 2 weeks (p < 0.001) and 3 weeks (p < 0.001).
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PMC11291490
When dusCD40L was employed in conjunction with the TMUV prM-E DNA vaccine, it significantly enhanced both the humoral and cellular immune responses elicited by the vaccine.
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PMC11269933
NGi and NAn represent the C. gigas and C. angulata were reared at northern site.
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PMC9429973
Data of SCD, and related complications were collected from the patients’ records.
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PMC9429973
No serious AEs, Grade >= 2 AEs, and AEs leading to study withdrawal were reported.
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PMC9429973
Based on mutation data and multivariate selection models, patients were stratified into 3 groups: (1) pts with TET2 or SF3B1 (only available 81-gene panels) mutations, (2) pts with TP53 mutations or RAS pathway mutations, and (3) pts without TET2/SF3B1/TP53/RAS mutations.
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PMC11469524
For example, a recent study described an essential dependency to MAPK activity in Chronic Lymphocytic Leukemia progression suggesting that insights from this study could be valuable for treatment decisions in CLL .
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PMC11544122
It is also possible that it may not be a sequence determinant per se, but rather the location of CXCR4 at the plasma membrane that might define the SNX9 mode of endocytosis.
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PMC11637276
Primary antibodies Alexa-Fluor 488 Anti-human CD29 (ITGB1, Clone TS2/16; 303016), FITC anti-human CD49b (ITGA2; Clone P1E6-C5; 359306), Alexa-Fluor 488 anti-mouse CD49b (Clone HMα2; 103510), and mouse anti-human LAMP2 (354303) from BioLegend, primary antibodies mouse anti-human CD49b (611017) mouse anti-EEA1 (610457) from BD Bioscience.
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PMC11551844
The presence of β-sitosterol (31.97%), stigmasterol (16.16%) and campesterol (10.38%)—which have reported anticancer activity—contributed to the activity of JC-2.
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PMC11481779
We can see that the FID score is then 0.0 - because the distributions are precisely the same.
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PMC7519871
According to NIH statistics, 13,800 new cases of cervical cancer and 4,290 resulting deaths are expected in 2020.
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PMC10772747
Additionally, EBE was observed to disrupt the cell cycle, leading to a significant increase in the sub G1 and S phases, and a significant decrease in the G2-M and G1 phases.
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PMC9250505
All 6/6 vehicle-treated xenografts were categorized as PD, 2/6 Olaparib and 5/6 NPB-treated xenografts were categorized as PR and 3/6 Olaparib and 1/6 NPB-treated xenografts were categorized as SD.
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PMC4443654
This is expected since H3k9me3 is anticorrelated or uncorrelated with most other input features (Additional file 1: Figure S5), and is therefore a relatively information-rich variable.
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PMC10882807
Venn diagram analysis of the two databases (CircInteractome and CircFunBase) identified EIF4A3 as a candidate. (
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PMC11337594
Cyclin A2 can activate CDK2 and facilitate the transition between the G1/S and G2/M phases of the cell cycle (Fig. 4B).
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PMC11707577
Thiophene‐based nanoparticles (TNPs) are largely used in nanotechnology, particularly in electronics and optoelectronics, as active components of organic light‐emitting diode (OLED), field‐effect transistor (OFET), light‐emitting transistors (LET), lasers, biosensors, chemosensors, and electrochromic devices. , , ,
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PMC11711871
We found a large increase in oxidation products derived from linoleic acid (LA) and arachidonic acid (AA) and the docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and alpha-linolenic acid (ALA) pathways.
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PMC8345486
After treatment, the cells were collected by trypsinization and stained with annexin V-FITC and PI as described earlier .
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PMC11790971
Imperfections in artificial pool predictions highlight the complexity and heterogeneity within these pools, suggesting the need for further optimization of the single-cell analysis pipeline and ML classifiers to enhance accuracy in order to meet real-world production standards.
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PMC11682224
Studies have shown that CHD1L plays an important role in various cancers.
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PMC11144200
Since Nb36 was expressed, His-tag, an anti-His-tag mAb (Abcam, UK, Cat No. ab213204) could be utilized as a secondary antibody.
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PMC11658074
b The mRNA expression of Col1A1, MMP9, and CDKN1A in the four groups.
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PMC9429973
Cellular response to chemical stress is also upregulated, which demonstrates the reported sensitivity of ERCC6L2-deficient cells to some chemicals.
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PMC11218145
Data are expressed as mean ± standard error and the statistical significance (p<0.05) of the comparisons between controls and treatments is indicated by the asterisk (*) It has been hypothesized that TB could act at the mitochondrial level by affecting ATPase-ATP synthases and by activating the apoptotic cascade via BAX.
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PMC11040965
We filtered out probes with P > 0.01, SNP-related probes, multi-hit probes, probes for the X and Y chromosomes, probes with < 3 beads in at least 5% of samples, and non-CpG probes.
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PMC11487720
By co-immunoprecipitation, we determined the presence of the TRADD/TRAF2/WWOX/p53 complex.
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PMC10667689
For each treatment, the initial seeding number was 5 × 10 cells per mL medium with three replicates, cultured in a 24-well plate.
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PMC11725127
GA-induced cleavage PARP-1, a hallmark of apoptosis, can be partly rescued by overexpressing USP2 in RPMI 8226 cells (n = 3). (
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PMC11611077
Normalization was achieved by dividing Qmax by Clin, which is proportional to the membrane area of cells.
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PMC11754094
For ABEs, we observed that target sequences including a TC motif within the editing window, as in ABLIM3 and FANCF, had larger frequencies of both small indels and large deletions compared with target sequences without a TC motif, as in KLHL29 and BRD4 (Fig. 4b,d).
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PMC11562028
For all experimental data (n ≥ 3), p < 0.05 were considered statistically significant.
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PMC9727330
Like other amino acids, Asp plays a crucial role in cancer development as a building block required for protein synthesis (Jiang et al., 2021).
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PMC10936243
Because, sometimes, if there are animals that are thrashing against the cage and we put bedding, it will become more difficult for it, and may hinder and they can sometimes get caught up in the towel” [D062]. “
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PMC9884169
siRNAs used in the knockdown of the MCT4 group and the negative control group were synthesized by GenePharma (Suzhou, China) and transfected into 5637 cells using Lipofectamine 2000 (Thermo Fisher Scientific, USA) according to the manufacturer's protocol.
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PMC10777969
We chose the certain concentration range of FCPs because it fits the NCI recommendations for a potential anticancer drug and is also similar to the concentration array used in our previously published studies, and we expected similar bioactivity .
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PMC11519788
IHC staining on tissue microarray containing another 94 human UBC tissues from our own cohort further revealed that SPOP levels were markedly lower in high-grade tumors compared to low-grade tumors (Figure 1F-G, Table S1).
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PMC10999934
However, there are some limitations in our study.
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PMC11470381
To enhance transfection efficiencies, ensure that the cell line is healthy and has undergone no more than 10 passages.
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PMC11789597
As one of the adhesion‐related genes regulated by CAV1 (Figure S2D, Supporting Information), CDH2 has been reported to contribute to the adhesion of MM cells to bone marrow stromal cells (BMSCs).
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PMC11036064
.
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PMC11597167
In the RNA isolation protocol, cell pellets were homogenized using 1 mL of TRIzol reagent and incubated for 5 min at room temperature.
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