Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC10870498
We used the volcanic map to show the differentially expressed genes in ATC and normal samples (Fig. 1A).
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PMC10114490
mRNA level for senescence markers CDKN1A and CDKN2A was several fold lower than in diHLC with similar PD (Additional file 1: Fig. S1E).
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PMC9429973
Secondary endpoint was achieving transfusion-free status (no transfusions in FDP).
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PMC10362265
Surrounding hydrophobic amino acids were shown by white stick models.
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PMC8992508
Therefore, selective inhibition of one efflux transporter could be compensated by the remaining transporters, and in the last years many studies were devoted to evaluating the inhibitory activity of new derivatives on cells overexpressing different transporters.
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PMC11533140
Reagents and conditions: (a) NH2OH.HCl, AcOH/H2O, r.t.∼60°C; (b) SOCl2, reflux; (c) morpholine, THF, −20°C ∼ r.t.;
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PMC10877303
In MERS-CoV, the S protein, containing 1353 amino acids, is a type I transmembrane glycoprotein comprising two subunits: S1 and S2.
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PMC8140214
Consistent to our study, Alam et al. showed that CAT, SOD, glutathione-S-transferase and GSH levels were significantly increased in type-2 diabetic mice treated with quercetin for three weeks compared to normal controls (Alam et al., 2014).
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PMC11799978
160 μg/mL NaHCO3 (pH = 9.0) equates to 280 μg/mL [99% Na2HPO4 (S818100, Macklin) + 1% NaH2PO4 (S817780, Macklin)] (pH = 9.1).
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PMC5673060
The inner and outer nodes are PazR and A204 parental datasets, respectively.
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PMC11740207
However, unlike VSELSCs, LT-HSCs do not express some ESC markers, such as SSEA4 and OCT4, suggesting pluripotency.
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PMC11802855
B Results of weighted gene co-expression network analysis of RNA-seq data in the TT2 set.
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PMC11638288
Multiple studies have indicated that elevated expression of NKp46 is associated with various forms of infertility, such as recurrent pregnancy loss (RPL) and repeated implantation failure (RIF).
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PMC11736898
We previously showed that the gene expression profile of keloid keratinocytes resembles the process of EMT, including decreased expression of proteins involved in cell adhesion and increased expression of mesenchymal genes and genes involved in migration, compared with normal keratinocytes .
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PMC11805741
As shown in Fig. 1S, the pigment accumulation pattern of the isolate followed its growth pattern, where the pigment yield increased gradually from the onset of the log phase until it reached its maximum value at the beginning of the stationary phase.
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PMC9429973
FB23-2 represents a promising strategy to novel treatment optimum in CLL.
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PMC11786767
Figure 5Ki-67 knockdown alters chromosome structure and delays mitotic progression.
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PMC10213199
In vivo treatments were performed using Canton-S Drosophila corresponding to three groups: control, low-concentration (low-conc.),
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PMC8973725
UALCAN (http://ualcan.path.uab.edu/) is an online, open-access platform that contains TCGA data, including gene expression, protein expression (CPTAC dataset), promoter methylation, miRNA expression, and clinicopathological data.
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PMC9429973
Previously we showed that RBC pyruvate kinase (PKR), the key regulatory enzyme of glycolysis, is impaired in SCD and that ex vivo treatment with mitapivat, an allosteric activator of PKR, increased enzymatic activity and thermostability, reduced 2,3-DPG levels, decreased p50, and subsequently reduced sickling (Rab et al, Blood 2021).
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PMC11429241
Thus, mechanical quality and shape fidelity were considered sufficient for the biological experiments.
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PMC9429973
No new safety signals were observed.
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PMC9822769
As shown in Figure 9, Ctr1, OCT1, and OCT2 were lower in A2780cisR than in A2780, whereas OCT3 was significantly higher.
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PMC11397654
Calixpyrroles have a wide range of applications, including ion recognition and biomedical applications , and their cytotoxic activity against certain cancer cell lines has also been reported in the past.
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PMC11530949
The enhanced cytotoxic activity of the bimetallic NPs, both chemically and biosynthesized, can be attributed to their unique physicochemical properties.
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PMC11628904
Liquid treatments (sterile water and saline) were both kept at room temperature prior to topical application to ensure that any change in burn wound temperature would be consistent across treatment groups.
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PMC7724160
The mass accuracy for the positive and negative electrospray ionization data was within 5 ppm at 35,000 resolution.
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PMC9429973
Besides we observed rarely such complications as pain, numbness, paresthesia of the upper limb in 50 patients (1.7%).
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PMC11756907
Data were analyzed with GraphPad Prism Software version 8.0.1 using bidirectional ANOVA with Tukey’s multiple comparison tests; The results for the ANOVA test were: p < 0.0001, n=3.
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PMC5941560
SnpEff annotated one of these mutations as a frameshift variant and the other as a stop-gained variant, predicting that both of these variants would result in loss of function.
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PMC9024365
Scale bar = 20 μm. (
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PMC10671321
They identified the D-CTD as the domain of interaction with LRP4 through two approaches.
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PMC11705862
All statistical analyses were performed using GraphPad Prism 10, or R 4.3.3.
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PMC11657744
Scale bars, 20 μm.
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PMC11047729
The lowered telomerase level was connected with silymarin-induced apoptosis .
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PMC11791203
The bioactive chloroform extract of H. malabarica was subjected to GC-MS analysis to delineate the organic constituents present.
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PMC11701801
In this study, we show that simultaneous inhibition of a paralog pair (CBP and p300) causes synthetic lethality in SMARCA4/SMARCA2-deficient cancer cells and SS18–SSX fusion cancer cells; these results are similar to those obtained for SMARCB1-deficient cancer cells (19).
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PMC9429973
Summary/Conclusion: There is a very fragile balance between disease-specific survival and treatment-specific survival with the current doublet protocols, due to their high intrinsic toxicity; decreases in disease-related death through the addition of a third non-targeted drug are often accompanied by increases in treatment-related death secondary to cumulative toxicity.
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PMC9031474
Additionally, the bis-acetalization and dimerization of polygodial (2) are strategies to increase its cytotoxic effects .
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PMC11791264
The methylation of proteins mediated by SETD7 has a wide range of outcomes.
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PMC9429973
We classified patients into different groups according to their predicted immune system configuration and showed that one class of patients required complete CML eradication to achieve TFR, while other patients were able to control residual leukemia levels after treatment cessation.
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PMC11752740
Carfilzomib (CFZ) is a second-generation proteasome inhibitor currently utilized in treating patients with multiple myeloma .
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PMC9429973
Methods: Data was collected on a 71-year-old female with HFXD receiving prophylactic treatment with pdFX.
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PMC11760643
Gating strategies for these and the flow cytometric studies below were based on journal guidelines .
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PMC11476106
Both cell lines secreted VN, and cross-linking VN in HGs appeared to have a positive effect on cell growth in the PDX73 cell line.
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PMC5941560
We identified the same two variants, rs398122841 and rs398122840, each of which were found in approximately half of the mapped reads.
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PMC11488203
Thus, exposure of MSC to taxol increased the expression of several tetraspanins in the EVs/exosomes.
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PMC10898159
The emerging PI3K or P55PIK inhibitors, including Copanlisib, showed high efficacy and low toxicity in IM-resistant GIST .
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PMC11770130
The peptides for LFQ analysis were eluted using the following gradients: 2%–5% B in 2 min, 5%–35% B in 100 min, 35%–44% B in 6 min, 44%–100% B in 2 min, 100% B for 10 min, at a flow rate of 200 nL/min.
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PMC10729469
Scale bar = 100 µm.
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PMC4839679
A designation of *** indicates p < 0.001 (Fisher’s exact t-test).
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PMC10956161
The sections were stained with 0.01% 3,3′-diaminobenzidine at room temperature for 5 min and then rinsed with 0.01 M PBS (pH 7.5) three times at room temperature for 3 min each time.
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PMC11727306
It was shown by others that Macrophage Galactose-type Lectin (MGL)-binding glycans are expressed in high levels on the cell surface of activated T-cells .
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PMC6450504
The results fully demonstrate the advantages of bPEI-coating as a responsive alternative to conventional PEGylation.
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PMC11746948
Scale bar, 100 μm.
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PMC11597167
Van der Waals (vdW) radius scaling factor 0.80, partial charge cutoff 0.15, and optimized potentials for liquid simulations (OPLS4) force field were used for receptor grid generation.
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PMC11674441
The results of IFN-γ ELISpot assays for each neoantigen peptide using peripheral blood lymphocytes isolated before and after the six vaccine doses are shown in Figure 2a.
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PMC11052306
At the concentration of 3 µM, all SF188 cells were killed by 9-G0-Cu5, whereas no SF188 cells were killed by 9-G0-[Au5][AuCl4]5, and only about 30% of the SF188 cells were killed by temozolomide.
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PMC11686380
Loss of GAP43 disrupts the neuronal polarity in cerebellar granule neurons, and GAP43 mice die in the early postnatal period with abnormal extension of retinal axons.
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PMC9429973
For targeted sequencing of structural aberrations, we developed a CRISPR-Cas9 based tiling approach using sgRNA pools (Integrated DNA Technologies, IDT).
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PMC9429973
However, HSC-niche interactions are still underexplored in disease condition associated to chronic stress.
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PMC11799978
A culture medium for cultured cells was collected and calibrated using a standard buffer solution with a known pH, ranging from 4.00 to 7.00, prior to application.
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PMC8875242
Although grazoprevir is a substrate for ABCB1 , it was reported not to inhibit ABCB1 in vitro , contradicting the results obtained with both of our experimental models.
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PMC11049548
A. 20016 Pero (MI), Italy.
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PMC11185260
MRI-based measurement of tumor volume.
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PMC9429973
The ORR was 61.5%, and 4 patients achieved complete remission (CR), 1 CRu, and 3 PR.
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PMC10125312
Data showed a higher susceptibility for the normal hepatic cell line L02 compared to cancer HepG2 cells.
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PMC11757230
Microscopic morphology of naïve CLC cells (left panel) and CLC/fLuc cells transduced with lentiviral vectors (right panel).
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PMC10154097
100 tissues including 50 normal and 50 HCC were obtained.
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PMC11271278
In LNCaP cells, HAPI genes are more likely to interact with super-enhancers compared to non-HAPI enhancer-connected genes as expected (Fig. S1C), but there are additional highly interactive HAPI genes that do not utilize super-enhancers (Figure S1C).
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PMC11467964
Differences in clinicopathologic characteristics and expression levels of BMRGs between the two distinct subtypes.
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PMC9622879
We describe a prosumer-centric CEMS for a community for comparison with our proposed CEMS in this section.
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PMC9429973
In vitro addition of human antithrombin resulted in thrombin generation inhibition in a dose-dependent manner (p<0.001 for trend), with a slight effect on fibrin clot properties.
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PMC11435360
NaHS (H2S donor) was purchased from Thermo Fisher Scientific (Burlington, ON, Canada).
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PMC11721064
Cell counts were determined using a hemocytometer, and cells were seeded into a six-well coated dish.
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PMC11574029
The results showed that SPP1 expression paralleled NOTCH3 expression, with high levels of SPP1 observed in NOTCH3 overexpressing cells and downregulated levels of SPP1 observed in NOTCH3 knockdown cells (Fig. 3H, I, K, L) (Supplementary Fig. S2A, B, D, E).
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PMC9429973
Although the difference was not statistically significant (P = 0.214, P = 0.476).
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PMC11122631
Accordingly, the structure of 2 was then determined.
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PMC8073654
Particularly, 11 showed greater enhancement of [H]-DNM accumulation and the attenuation of the [H]-DNM efflux compared to those of verapamil.
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PMC9436459
The other MDAAs with potent inhibitory effects on α-glucosidase were listed in Table 7 .Table 7Inhibitory activities of MDAAs against α-glucosidaseCompdActivity (IC50 in μM); Ki value; Inhibition typePositive control (acarbose, IC50 in μM)Chalcomoracin (5)6.00 0.02Albasin B (8)2.90; Ki = 0.42 μM; Competitive 203.97Mulberrofuran E (9)5.22 1428Wittiorumin F (18)1.89 1428Macrourin I (21)1.70 1428Macrourin J (22)1.58 1428Mongolicin C (24)4.79 203.97Macrourin G (26)3.61; Ki = 2.42 μM; Competitive 203.97Morusalbin A (27)4.53 203.97Mulberrofuran G (31)2.29 203.971.07 293.502.48 85.29 (1-DNJ)1.67; Ki = 1.2 μM; Mixed-competitive 119.16Mulberrofuran F (32)2.13 1428Mulberrofuran K (40)5.91 203.971.25 1428Morusalbin B (42)5.07 203.97Yunanensin A (44)3.64; Ki = 1.19 μM; Competitive 203.97Albanol B (46)4.34 203.971.31; Ki = 0.9; Mixed-competitive 119.16Morusalbin C (49)5.40 203.97Albafuran C (50)2.52 1428Sorocein I (65)1.47 1428Morusalbin D (67)3.55; Ki = 0.64 μM; Competitive 203.97Kuwanon J (81)30.3 3322.17 1428Kuwanon R (86)48.3 332Kuwanon G (92)2.35; Ki = 2.51; Mixed-competitive 119.162.80 293.50Kuwanon H (93)0.82 293.50Deoxyartonin I (102)7.80 332Kuwanon L (118)11.03 293.50Sanggenon G (124)2.97 293.5011.96 55.40 (LUT)Sanggenon O (131)3.06 55.40 (LUT)Kuwanon M (151)0.60 293.50Mulberrofuran H (162)12.51 203.971-DNJ 1-Deoxynojirimycin, LUT Lutenolin Inhibitory activities of MDAAs against α-glucosidase 1-DNJ 1-Deoxynojirimycin, LUT Lutenolin Tyrosinase is a rate-limiting enzyme in the formation of melanin pigments in mammals and the key enzyme for enzymatic browning of many plant-derived food products .
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PMC8414691
Overall, SRCAP appears to be a multifaceted protein implicated in several cellular processes, including chromatin regulation, transcription, and DNA repair [10, 18–22, 24, 27].
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PMC11694625
All chemical raw materials used were obtained from Beijing Inno Chem Science &Technology Co., Ltd (Beijing, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "chemi...
PMC11732635
Research on CAR T-cell therapy in treating a variety of viral infections is ongoing.
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PMC10854447
Refer to Appendix A (Supp.
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PMC11736898
ANOVA: Analysis of variance; CAMP: Cathelicidin antimicrobial peptide; CYP24A1: Cytochrome P450 family 24 subfamily A member 1; CYP27A1: Cytochrome P450 family 27 subfamily B member 1; CYP27B1: Cytochrome P450 family 27 subfamily B member 1; ECM: extracellular matrix; EMT: epithelial-mesenchymal transition; FZD7: Frizzled 7; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; HAS2,: Hyaluronan synthase 2; IRB: Institutional review board; MMP1: Matrix metalloproteinase 1; MMP3: Matrix metalloproteinase 3; POSTN: Periostin; UC: University of Cincinnati; VDR: Vitamin D receptor; WNT5A: Wnt family member 5A.
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PMC10006224
In the center of the matrix (boxed) a long loop decreases and a shorter one within slightly increases in the NIPBL KD condition (dashed arrows below the matrix).
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PMC9429973
Aims: In this study, the anti-leukemia activities of the dual BCL-2 and BCL-XL inhibitor AZD4320 and of MCL-1-selective AZD5991 were evaluated and compared to the effects of other BH3-mimetics (BCL-2-selective venetoclax, BCL-XL-selective A-1331852 and MCL-1-selective S63845).
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PMC11572213
It was found that in 50 µM glutamine-containing medium, TET2 mRNA expression was nearly doubled compared with that in 2 mM glutamine-containing normal medium (*p<0.05) (Figure 1).
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PMC11593031
Most of these cell lines were established decades ago.
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PMC6267596
We hypothesized that during the absence of treatment (off-therapy period) DIAP cells could undergo reductive cell divisions.
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PMC8753818
:> 0.05, **:> 0.01, ***:> 0.001, ****:> 0.0001) Proliferation in mammalian cells is regulated by a group of checkpoints which together form the cell cycle.
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PMC11699465
Combined with the results of the Cut&Tag assay, we proposed that TMEM199 regulates PD-L1 expression by mediating transcription factors such as IFNGR1, IRF1, c-Jun, KAT8, and Trim28.
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PMC11502962
Clinicopathological characteristics of 80 patients for immunohistochemistry.
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PMC11269792
Therefore, exploring the regulatory mechanism of the Warburg effect is likely to develop new strategies for GIST treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "exploring", "th...
PMC11496728
Results indicated that the expression level of target proteins with the addition of regulatory elements was significantly increased compared with the control group.
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PMC11755624
The introduction of si-NORAD reduced keratinocyte proliferation and cell viability.
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PMC11575040
Over the preceding 3 decades, the incidence of melanoma has considerably increased worldwide.
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PMC11750712
Additionally, regions of interest were acquired at a ×20 magnification.
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PMC7602170
On the other hand, inactivated 4E-BP1 enhances the release of eukaryotic translation initiation factor 4E (eIF4E), considering 4E-BP1 as an inhibitor mediator in the initiation of translation .
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PMC10858941
Conversely, cell death in the peripheral normoxic zones was not significantly affected by NNC treatment, further supporting the specificity of the drug’s action under restricted oxygen conditions.
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