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BioData-CellLine_annotated

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PMC11127909
The different states of ANTs are consistent with the mPTP opening state, and mPTP opening requires ANTs to be placed in the c-state; however, when ANTs are fixed in the m-state, mPTP opening is inhibited .
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PMC11705067
DLAT expression was positively correlated with infiltration levels of eosinophils (r = 0.310, P < 0.001), neutrophils (r = 0.224, P < 0.001), T helper cells (r = 0.205, P < 0.001), but negatively correlated with CD8 T cells (r = -0.266, P < 0.001), cytotoxic cells (r = -0.393, P < 0.001) and B cells (r = -0.135, P < 0.002) (Fig. S2).
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PMC6442998
Nuclear YAP-ir was observed in the KIT-positive region of five primary GIST samples as well as in basal cell carcinoma, used as positive control for nuclear YAP localization (Figure 3A).
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PMC11705862
For IRIS-1, the annealing temperature was 57 °C for 10 s. Samples were separated on 1.1% agarose gels and visualized using SybrSafe reagent.
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PMC9429973
Therapies used in hospitalised patients were administered according to institutional protocol and included sotrovimab, dexamethasone, remdesivir and baricitinib.
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PMC10932641
Transwell migration experiment for detecting the effect of silencing and overexpressing GPRC5D-AS1 on the invasion of 786-0 cells.
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PMC9429973
The highest 5-year OS (86%) was recorded in the group of patients with simultaneously low expression of markers (p16-/p53-; n=25).
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PMC11240052
First-strand complementary DNA (cDNA) synthesis was performed on 500ng of treated RNA using the Revert Aid First Strand cDNA Synthesis Kit (Thermo Scientific, Fermentas, Waltham, MA, USA).
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PMC11787381
It relies on distal cues to navigate in an open swimming arena with a hidden escape platform.
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PMC8557138
Angiogenic modulators vary in tumors compared to other tissues: the need for developing tumor-specific vascular modelsTo fulfill the nutritional demands of the tissues, including solid tumors a functional vasculature is essential.
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PMC9429973
All ten patients are survived at the time of report.
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PMC11082662
Meanwhile, some factors in the tumor microenvironment can also regulate the expression of SMPDL3B, forming an interactive cycle.
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PMC9776316
Mechanistically, the increased sensitivity to cisplatin upon XRCC4 knockdown was caused by accumulated DNA damage.
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PMC2944824
Viability was measured with the MTT assay and repeated in three independent experiments in triplicate (A).
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PMC9872547
This growth inhibitory effect of curcumin is much less than nano-curcumin.
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PMC10507284
Although the current results indicate no significant difference in the effect of immunosuppressants in STS patients with different TROAP expressions, this may be due to the lack of more cohort data on immunotherapy for STS, and a larger STS cohort in the future is needed for further validation.
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PMC9429973
FLT3::ITD mutation was detected in all of them.
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PMC10748106
Spinomannoside, which is structurally very similar to 5-deoxypulchelloside, contains a mannose at C1 instead of the glucose.
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PMC11790971
In passage 0, the four cell lines exhibited similar characteristics in morphology, SLAM intensities, redox ratio, and NAD(P)H mean lifetime.
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PMC11519567
Furthermore, we performed fluorescence recovery after photobleaching (FRAP) experiments to analyze the diffusion kinetics of these two condensates and show that the molecular exchange velocity of SS18-SSX onco-condensate is significantly lower than that of SS18 (Fig. 1H, I).
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PMC11753435
The strict training set consists of 7388 peptide-protein pairs, with a validation set and test set of 737 and 1002 pairs, respectively.
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PMC9429973
When in combination with HDACis, DAC induced a higher percentage of apoptotic cells comparing to combinations with AZA.
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PMC11786600
PED4 inhibits MMP9 expression and promotes macrophage polarization.
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PMC11637276
Secondary antibodies were then applied for 1 h at room temperature.
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PMC11718109
Fig. 8DA axonal varicosities show presence of small and large vesicles in situ.
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PMC11799978
Fibroblasts have diverse functions owing to their heterogeneous phenotypes shaped by the microenvironment.
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PMC11585565
Notably, these mutant CNNM4 proteins demonstrate a loss of Mg extrusion activity, with no detectable localization defects.
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PMC10243817
After that, cells were treated with 2 mL of BD Phosflow Perm Buffer I (BD Biosciences) on ice for 30 minutes in the dark and stained with PE-conjugated mouse monoclonal Ab against human p-SMAD2 (Supplemental Table 6) for 30 minutes at 37°C in the dark.
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PMC11397654
This work was based on the fact that betaine required high doses to show anticancer action.
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PMC11361748
Whole cell lysates were prepared in NP-40 lysis buffer [0.5% NP-40, 150 mM NaCl, 20 mM Tris (pH 7.5), EDTA 1 mM, 1× cOmplete protease inhibitor cocktail solution (Millipore #11836170001), 1× Pierce phosphatase inhibitor cocktail solution (Thermo Scientific #A32957), milliQ water].
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PMC11348300
It is widely believed that nearly all solid tumors have existing chronic hypoxia that comes from the tumor cell growth outstripping the blood supply (18–23).
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PMC11706491
C, E) Nuclear SynCut3 mean fluorescence and Pcn1 Std fluorescence of cells grown in EMM (C) or YE5S (E).
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PMC10734950
The impact of JAK-STAT signaling on cancer cell survival, proliferation, invasion of tumors, coupled with the hyperactivation of STAT3 and STAT5; has positioned the JAK-STAT pathway as a potential pathway for cancer therapy .
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PMC10605143
MDA-MB-468 cells, possessing the lowest HSF1 level and being positive for CDH1 expression, showed the mass phenotype (less invasive).
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PMC11763111
The CD161 expression levels on the NK cell surface were measured using peripheral blood samples from seven healthy persons (Fig. 5A and S7A), with the average expression exceeding 50% (Fig. 5B).
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PMC11787355
Doublets were identified and excluded with scDblFinder (1.14.0).
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PMC9429973
basis of this observation.
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PMC11657695
I Normalized cell coverage in SK-ES-1 cell line at 72 h after the beginning of treatment with κ-Conotoxin (N = 3).
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PMC11629143
Furthermore, there is potential to combine dCas9‐p300 with light‐inducible or chemically‐inducible control to allow dynamic regulation .
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PMC9429973
GFPLucNCI-H929 specifically located in the femur in nude mouse model, the model was a quite successful and ideal in vivo model for MM study since it has cluster of MM cells in injected femur and localized bone destruction.
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PMC11704834
Briefly, the number of metabolically active cells was measured using the PrestoBlue Cell Viability Reagent (Invitrogen; Thermo Fisher Scientific, Inc.) with fluorescence reading at 485 nm excitation wavelength and 520 nm emission wavelength in a microplate reader.
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PMC8481254
Scale bar, 500 mm.
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PMC11795610
The cell proliferation was measured on days 0, 2, 4, and 6.
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PMC8750422
We confirmed the downregulation of GPR87 in GPR87-silenced A549 cells.
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PMC9545474
HRMS‐ESI: calculated [M+H] 533.04106 m/z, found 533.04289 m/z. [(
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PMC11264242
To provide a direct molecular link between the SS18-SSX2 fusion and FYN gene expression, we conducted anti-FLAG ChIP experiments in SSX2-FLAG SYO-1 cells.
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PMC11725127
As shown in Fig. 2C, the biotin-GA probe effectively pulled down the USP2 protein in the cell lysates.
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PMC11718809
CircMYL1, as a molecular sponge for miR-2400, can eliminate its inhibitory effect on myoblast differentiation .
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PMC11075223
The surface of the root is generally black and cross-section owns many invaginated and round hole-shaped old stems .
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PMC11777207
Each experiment was completed two times with three to six technical replicates per treatment group.
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PMC11615828
≈58.1% and 60.3% of LAMP1‐ and TGN38‐vesicles move with random directions, respectively (defined as “Free”), which were not affected by nocodazole treatments, implying that these populations of vesicles move via MT‐independent mechanisms (Figure S10d,g, Supporting Information).
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PMC11389534
Further analysis has demonstrated that UFL1 achieves this by competitively binding to STING independent of UFMylation, preventing the interaction between STING and TRIM29, a E3 ubiquitin‐protein ligase, thereby suppressing the ubiquitination and proteasomal degradation of STING.
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PMC10654497
Patients in the cluster1 subtype had a better prognosis and higher immune cell infiltration ratios than those in the cluster2 subtype.
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PMC11502962
Among the three groups, CD8+ T cells were the most abundant in the LG (LG vs. MG vs. HG: 0.35 ± 0.15 vs. 0.27 ± 0.10 vs. 0.09 ± 0.02, P = 0.003), whereas CD68 macrophages were the most abundant in the HG (LG vs. MG vs. HG: 0.38 ± 0.09 vs. 0.64 ± 0.17 vs. 0.98 ± 0.19, P = 0.03) ( Figure 9A ).
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PMC9429973
Results: A total of 110 patients with RS-DLBCL (median age 72 years, range 43-89 years; 61% males) were selected, including 22 (20%) concurrent RS, 38 (35%) treated RS, and 50 (45%) untreated RS.
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PMC9429973
U266/MYC cells possess the ability to oxidize glutamine at a higher rate compared to U266/Ctrl.
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PMC8750422
Recently, several studies have been conducted to investigate the functional role of eNOS expressed in cancer.
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PMC10178190
Interestingly, CM derived from tumor-activated HS-5 was more effective in conferring chemoresistance than was CM derived from HS-5 cells.
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PMC11453018
Senescent cells were identified by β-Gal staining and quantified in at least three random fields.
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PMC10808409
A D-optimal design with three factors was used for the optimization of polymeric mixed micelles by studying the effects of each of total Pluronics mixture (mg), Pluronic P123 percentage (%w/w), and drug amount (mg) on both entrapment efficiency (EE%) and particle size.
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PMC11774747
The study observed minimal severe adverse effects, with only a few instances of reversible grade 4 cytopenia and mild CRS, which resolved without intervention.
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PMC9429973
Combination of VEN and the hypomethylating agent azacitidine (AZA) has deeply changed the paradigm of treatment of newly diagnosed (ND) AML patients ineligible for high dose chemotherapy because of older age or comorbidities.
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PMC11040965
Chart data are mean and SD for 7 independent experiments. *
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PMC11792888
Furthermore, cleaved caspase-3 levels in cells treated with venom did not differ significantly from those in untreated cells (Figures 5 B and 5G).
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PMC11792740
Depletion of canonical BAF complex members, such as Arid1a, maintained the effector program and the downregulation of exhaustion-related genes in tumor-infiltrating T cells.
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PMC6461034
INKA scoring implicates MAPK3 as the number one activated kinase.
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PMC8956657
Crystallization of IMPα2 in the presence of MERS ORF4b NLS wild-type and mutant peptides was achieved by mixing the peptide in a 2:1 molar ratio, and crystallization conditions were the same as the protein complex above.
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PMC11295144
Synaptic contacts were defined based on signal colocalization between the VGAT and GFP (green and blue channels in Figure 1A) and analyzed using Image J as described in the Methods and previously (Brown et al., 2014).
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PMC11629461
UVA (380 nm) light irradiation at power densities of 0.1, 0.3, 3.5, 6, and 12 mW/cm (1.5 min) (i.e., 9, 27, 315, 540, 1080 mJ/cm), however, elicited conspicuous Ca spikes in NOX5‐CHO‐K1 cells (Figure 1E–I), with very clear dose–response relationship (Figure 1J).
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PMC11783017
Through Hematoxylin-eosin (H&E) staining, Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick End Labeling (TUNEL) staining, and Ki-67 staining of the tumor tissue, we found that the Cis/Mn/NH@PGP group exhibited the strongest damage to the tumor tissue, with significant inhibition on tumor cell proliferation and significant enhancement on apoptosis (Fig. 5H–J).
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PMC11599565
Stathmin, also known as oncoprotein 18, plays a crucial role in cytoskeleton regulation specifically by modifying microtubule dynamics.
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PMC8662250
as well as the one used in our experimental conditions), we do not expect serious side effects at usually therapeutical CBD doses.
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PMC11543885
Of note is that one may detect more than 700 proteins to be determined as significantly enriched.
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PMC11551844
A humidified incubator with a temperature set at 37 °C and 5% of carbon dioxide (CO2) was used to maintain the cells.
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PMC11752740
This substantial reduction indicates a strong inhibition of the NF-κB pathway, which plays a critical role in cancer cell survival and the modulation of immune responses.
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PMC10253553
In this context, NDRG1 provides cancer cell resistance to apoptosis by stabilizing DNA repair proteins that counter the apoptotic-inducing activity of alkylating drugs in glioblastoma .
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PMC11720808
Here, the inhibitory role of SCU on OS has only been measured using a cell line-derived xenograft model.
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PMC11754432
Created with BioRender.com.
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PMC11547917
The beneficial effects of bioactive molecules are attributed to secondary compounds such as alkaloids, terpenoids and polyphenolic compounds , these compounds being powerful antioxidants that fight free radicals, which result from respiration and metabolic processes .
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PMC8540692
The subsequent analysis was performed on Muse™ Cell Analyzer (Merck, Germany).
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PMC7840816
In order to investigate the role of SOX9 in PTC, SOX9 was silenced by siRNA in the human TPC-1 and BCPAP cells, respectively.
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PMC11781181
Plasma exosomes were isolated and observed using ultra-centrifugation and transmission electron microscopy (TEM), respectively (Fig. S3A).
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PMC10723784
This increase leads to the reduction of mitochondrial membrane potential, which subsequently increases the release of cytochrome C into the cell cytoplasm leading to apoptosis. ,
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PMC11700247
Graphs show the mean ± SEM.
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PMC11723947
Altogether, these data support the conclusion that HP1α does not control Tconv activation and differentiation.
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PMC9429973
Median PFS was the primary endpoint, using a one-sided stratified log-rank test at a one-sided significance level of 0.1.
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PMC11172027
It can therefore be speculated that methionine alone may reduce cell growth and mitochondrial activity by other mechanisms.
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PMC3813807
The study further demonstrated that miR-373 induces the cell proliferation of gastric cancer cells in vitro, via the downregulation of TNFAIP1.
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PMC9856122
Synthetic derivatives of cepharanoline were investigated against HIV in U1 cells.
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PMC10747139
The succinimide complex 9 enhanced the viability of the PBMCs.
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PMC11700165
Although a similar loss-of-function mechanism was thought to operate also in the ITK-SYK activation, unexpectedly, ITK-SYK-R29C induced T cell lymphomas in a mouse model.
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PMC11402217
p < 0.0001 vs. Dkk1.
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PMC9429973
The median age was 40 years (range, 20-67 years), and 52% were men.
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PMC11659921
To investigate the effect of TNFSF11 on vessel formation.
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PMC3035438
ELISA experiments were performed as described (6).
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PMC8956657
Using recombinantly expressed IMPα isoforms spanning members from each of the three subfamilies (SF1: IMPα1/2; SF2: IMPα3; SF3: IMPα5/7), agarose gel mobility shift assays were performed in the absence and presence of a FITC-tagged MERS-CoV ORF4b peptide spanning residues 19–39 (henceforth simply referred to as “NLS”).
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PMC8345486
Differential interference contrast (DIC, Nomarski interference contrast) images were collected to visualize the spheroid morphology.
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PMC11711663
This discretization step assigns a new value to each voxel using the formula This discretization approach offers the advantage of noise suppression and improved robustness of radiomic features.
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PMC11577421
CD spectroscopy characterization of adsorbed BSA, BSA+, and BSA– compared to the free proteins.
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PMC11180402
Previous studies have shown that ISO elicits multiple anticancer activities, including the inhibition of cell invasion and proliferation , as well as the promotion of apoptosis and autophagy .
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