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OTAR3088
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PMC11350568
To address these issues, this study presents a highly efficient TMPD system (TMPDS) that integrates an optimized bivalent aptamer glue with a potent protein transport shuttle.
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PMC10212663
The KEGG enrichment analysis suggested that advanced KRAS‐mt LUAD are enriched for adhesion‐related pathways, especially for the cell adhesion molecules, whereas the KRAS‐wt ones are not (Figure 6(a)–(c)).
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PMC11540664
For example, the Keynote524 studies showed that the objective response rate to lenvatinib in combination with PD1 reached 46% (8).
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PMC9429973
1258 patients were treated by an intensive therapy.
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PMC10040136
GIST-882 cells (1 × 10) were seeded in each well of a 6-well plate and grown in MSC-CM for 48 h to conduct a Transwell invasion assay.
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PMC7823217
Despite substantial advances in early diagnosis and improved interventions, the 5-year survival rate is only 15% .
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PMC10652261
Mp 187–188 °C.
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PMC11705547
In addition, cisplatin resistance can lead to upregulation of PD-1 to inhibit T cell activation and thus promote tumor cell proliferation.
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PMC10919056
To further explore the prognostic significance of the GRPS in ccRCC, a computation was performed based on the coefficients derived from the multivariate Cox regression model, along with the corresponding gene expression levels.
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PMC9429973
Dendron-based dendriplexes (DG2, DG3) had pro-apoptotic effect on leukemia cells.
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PMC11695546
Comparing between impact of crude coconut oil and after exposing to O3 on viability % of A431- cells at different concentrations of oils Ozonized oils are gaining more attention from scientists and being used in medical centers as a result of the ongoing search for potent biomedical therapies that can treat illnesses with manageable negative consequences (Pietrocola et al. 2018).
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PMC11194678
Upper: Representative sedimentation assay images showing the distribution of various STAU1 fragments at 10 μM. Lower: Statistic data for the sedimentation assay. (
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PMC3122064
These results prove that the observed upregulation of Fas membrane expression after Nutlin-3 treatment in TC cells is wild-type p53 dependent as well.
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PMC10218459
The fluorescence signals of the cells treated with the cytostatic drugs were then normalized to the signals of cells treated with DMSO (control) to determine their respective cell viability.
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PMC6889484
NL4-3 shows wild-type kinetics with peak virus at day 11, with no detectable virus in CEMSS/D128K cells.
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PMC11640115
The primary site was diverse with the most common being the oropharynx at 27.8%.
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PMC10654497
P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC9429973
SAEs were reported in 41.5% I+V and 38.2% I pts.
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PMC11541409
Blocking the complex formation of SCF/KIT and PDGF/PDGFRA has limited efficacy, as approximately 85% of GIST patients have KIT or PDGFRA mutants, which is independent of ligands.
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PMC9856122
However, the main precursor for the BBI alkaloids is tyrosine.
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PMC9429973
Á. Díaz González, G. Avetisyán, E. Mora, M. Santiago, A. Liquori, S. Furió, S. García, A. Villalba, Á. López, J. V. Gil, C. García, E. González, C. Martínez, B. Fernández, M. Guaita, B. Martín, L. Cordon, E. Barragán, J. de la Rubia, J. Cervera, E. Such Hematology; Genetics Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain Background: The prognosis of myelofibrosis patients is highly variable.
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PMC11701801
By contrast, the IC50 values for CP-C27 in the SMARCA4-deficient cell line group [A549, H1299, H1819, and H1650 (point mutant type: SMARCA4N1164Y)], the ARID1A-deficient cell line group (OVTOKO, OVISE, TOV-21G, and RMG-V), and the PBRM1-deficient cell line group [KMRC-1, Caki-2, RCC-FG2, and OS-RC-2 (point mutant type: PBRM1I233T)] were comparable with those in the SWI/SNF-proficient cell line group (Fig. 1E and F).
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PMC11787381
Anxiety was assessed by studying the average time that the animals spent at the center of the open field arena (Fig. 5B).
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PMC9856122
For example, twelve compounds were isolated from the plant Dasymaschalon rostratum Merr.
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PMC5415764
The ROS levels in the different cell treatment groups were shown in Fig. 5B.
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PMC11515150
To avert the fratricide of CD5 CAR-T attributing to surface marker profile largely overlapped with surface antigen of malignant T cells, the same VHH sequence was joined to the sequences encoding endoplasmic reticulum (ER) retention peptides, coupled with the second-generation CD5 CAR mentioned above.
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PMC11632064
Schematic depicting the strategy to identify transcripts associated with resistance to PLK1 targeting using the indicated publicly available datasets. (
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PMC10362265
The viral tetramer from YLDV (4eee) and the symmetry-related human tetramer were also modeled in the presence (S-S) and absence of (-SH) the intermolecular disulfide bonds.
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PMC3019555
The 40, 60, and 80S ribosomal subunits and polysomes were fractionated and monitored with continuous A254 measurements.
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PMC10237474
Untreated control cells with growth media only were included.
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PMC9429973
Although there have been some improvements in outcomes over the past few decades, only ∼50% of children with first relapse of ALL survive long term, and outcomes are much worse with second or later relapses.
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PMC11201989
Primary cilia are critical for normal development and homeostasis .
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PMC11335267
In wild type mice, expression of Alx3 was not found in organs directly involved in peripheral metabolic regulation such as vWAT, BAT, muscle, or liver (Fig. 6B).
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PMC3274243
Briefly, MTT solution was added to the cultures to a final concentration of 0.5 mg mL and incubated for 2 hours.
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PMC9429973
The detection of SARS-COV2 in this cohort of patients made it possible to analyze the course of COVID-19, as well as to develop a strategy for the disease management of these patients.
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PMC11594641
In summary, Rab27A controlled the migration and invasion of low-invasive SkMel28 and DMBC12 cells, which corresponded to decreased levels of N-cadherin, while the behavior of the RAB27A KO A375 (highly invasive) cell line was not affected in any capacity.
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PMC11607321
Specifically, feature selection was conducted in a data-type-specific manner before the encoding process.
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PMC11402217
Wt.
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PMC11252033
Immunoprecipitation assay of CryZ in extracts of A375 cells treated with ASA or with the DMSO alone; β-actin was used as control. (
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PMC10728200
IM upregulates STUB1 expression.
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PMC11024707
This might suggest that mi-RNA-151a, which plays a role in cochlear development, has a role in the pathogenesis of hypo/hypersensitivity to certain sounds in autism; it could also represent a new treatment option in treating symptoms such as hyperacusis, which significantly impair the quality of life in autism.
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PMC11347429
VENN diagrams were generated with the function vennPlot (http://faculty.ucr.edu/~tgirke/Documents/R_BioCond/My_R_Scripts/overLapper.
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PMC10212663
The risk distribution plot showed that as risk‐score increased, survival time decreased, whereas death or recurrence rates increased (c).
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PMC11257988
The impact of KRAS mutations remains controversial, with inconsistent findings in various studies .
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PMC11666785
Scale bar = 1μm.
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PMC10142392
Polymeric nanoparticles are a key tool to improve the bioavailability of drugs or produce site-specific effects .
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PMC11746942
Psoriasis is characterized by hyperproliferation and aberrant differentiation of keratinocytes in the epidermis, accompanied by the expression of K16 and K17 cytoskeletal proteins .
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PMC11049294
In the case of female patients, the heterogeneous and not always clear initial symptoms may delay the establishment of the diagnosis.
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PMC10142392
This section provides a brief overview of efforts in this direction, specifically focusing on the concept of PCL-based nanovectors.
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PMC11730320
Laboratory evaluations ND not done.
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PMC11588008
In conclusion, this study used PM to act on human granulosa cells to analyze the effects of HUC-MSCs on injured granulosa cells.
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PMC11634027
Sequence of the D motif, with regions I, II, and III in green, red, and blue letters, respectively. (
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PMC11046454
Groups ii–iv received intravenous (i.v.)
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PMC11471157
Arrows indicate small spheroids.
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PMC11531735
Common toxicities associated with TKIs in breast cancer include gastrointestinal disturbances, rash, and hepatotoxicity.14–16 As research continues to refine next-generation TKIs, the goal is to develop potent dual tyrosine kinase inhibitor (DTKI) to mitigate these toxicities while optimizing the therapeutic benefits for HER2-positive breast cancer patients.
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PMC11424574
Knockdown of MTA2 protein and mRNA expression in human HOS and 143B cells was confirmed by western blot and RT-qPCR assay, respectively (Figure 2A, 2B).
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PMC8409415
JMP 13 (SAS Institute) was used for statistical analysis.
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PMC7553912
Mulay et al. reported that in tubular epithelial cells, tumor necrosis factor receptor (TNFR) signaling induces the expression of crystal adhesion molecules, CD44 and annexin (ANX) II.
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PMC11700523
After 24 hours, the medium was changed to DMEM with IS (Cayman Chemical Company, MI, USA), aldosterone (Sigma-Aldrich, MO, USA) or α-lipoic acid (FUJIFILM).
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PMC5963610
We assessed the changes in the intracellular Src and FAK status in 3LL-metastases removed from treated mice.
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PMC11792766
No. 20102.292), ethanol (Merck, Cat.
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PMC11786704
Additionally, PC capsules could alleviate the inhibitory effect of H2O2 on NIH3T3 cell migration, highlighting the potential protective role of PC capsules under oxidative stress conditions (Fig. S3).Fig.
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PMC8759873
pVHL30 and pVHL 19 have different localizations in cells, and their functions have not yet been fully clarified.
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PMC10582049
Further exploration showed that 663 CAFs (62.8%) were obtained from indolent group and 393 CAFs (37.2%) were obtained from aggressive group.
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PMC11381192
Decision curve analysis (DCA) was employed to facilitate the clinical applicability of the nomogram by demonstrating its potential net benefits.
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PMC11521786
These are currently in advanced clinical trials, but only a few objective responses have been observed, suggesting limited activity as single agents (1, 22–24).
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PMC10495912
After 24 h, the culture medium was removed.
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PMC11514418
A total of 97 patients who were diagnosed with pancreatic cancer and received GS chemotherapy at The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) from March 2021 to December 2021 were included in the retrospective analysis.
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PMC9429973
Secondary endpoints include progression free survival, overall survival, overall response rate (ORR), safety evaluations and patient-reported outcome.
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PMC11676169
After washing with PBS, DAPI staining was performed to visualize nuclear DNA.
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PMC9325715
The amount of iron in the complex was determined by ICP-MS analysis.
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PMC9429973
Collecting real-world clinical data from TAG is important to increase understanding of clinical outcomes, especially in pts commonly underrepresented in clinical trials.
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PMC11711127
Yet, Yu et al. (2) argue this may be by evolutionary design: a perfectly efficient culling of auto-reactive cells leaves too many ‘holes’ in the T cell repertoire, lending itself to invasion by opportunistic pathogens.
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PMC6617630
p < 0.05 value was significant for both the concentrations in all the cell lines tested Anti-lymphoma activity of BET bromodomain inhibitors on the DHL/THL cells.
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PMC11098378
For determining the electrostatic potential of Ceg10 and Ceg10 the APBS plugin for PyMOL (PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC) was used.
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PMC11377827
These findings were consistent with the anti-14-3-3 pan siRNA predominantly targeting 14-3-3ζ and 14-3-3ε (Figs. 7G EV5E,F).
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PMC11307990
Furthermore, DNA nanotapes-SUN treatment significantly increased the number of TUNEL-positive cells compared with the SUN group, which was consistent with the CCK8 assay results (Figure 5C).
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PMC11792740
For instance, reduced phosphorylation levels of the TCR-CD3 complex obstruct the activation of downstream signaling molecules, such as ZAP70, LAT, PLCγ1, and PKCθ .
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PMC11518994
To investigate a possible impairment of PAX5 function in the development of the B cell lineage, we examined the B-cell repertoire on fresh peripheral blood mononuclear cells by FACS analysis in both healthy carriers (n = 2), compared to healthy controls (n = 4); interestingly, both healthy carriers had a moderate reduction in memory B cells IgD− CD27+ (healthy carriers 9% vs 27% healthy donor) (Fig. 2), while no difference was observed in the amount of B cells (CD19+ B cells) and naive B cells (IgD + CD27−).
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PMC10452486
Similarly, when HLA-G was immunoprecipitated from surface-biotinylated HLA-G transfectants, HLA-G dimers were detected under nonreducing conditions even in the presence of IAM, suggesting that they were preexisting dimers and not an artifact.
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PMC9105697
Comprehensive mutation profiling with an SS-specific panel and additional exome sequencing comes at some cost.
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PMC11089031
Then, the inserts were photographed with a CCD camera connected to an inverted microscope, and the cells were counted using ImageJ. Statistical analysis of tumor gene expression levels across clinicopathological feature subgroups was carried out using the UALCAN web tool.
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PMC7917457
For the MAGE-A3 assay, CD8 T cells were presensitized with tumor antigen-containing peptide MAGE-A3(168−176).
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PMC11314247
However, the activities of caspase-8 and -9, the Bid/Bax balance, ROS production, and alterations at the checkpoints between the S and G2 phases of the cell cycle must be determined to elucidate HO-AAVPA’s mechanism of action in BC cell lines.
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PMC11574271
For the T24 cell model, athymic BALB/c-nu mice (male, aged at 5 weeks) were from China Vital River Co (City, country) and randomly divided into 3 groups (5 animals per group).
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PMC11721295
Briefly, the KPL-86 line was generated from lung tissues of 9-month-old Kras; Trp53 mice treated with ad-Cre recombinase.
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PMC11798926
The following day, transfected cells were fixed and stained; however, prior to fixation, the following procedures were used: for live surface labeling experiments, cells were rinsed twice with ice cold PBS (containing 1 mM CaCl2, 0.5 mM MgCl2) and then blocked for 20 min with prechilled 0.2% bovine serum albumin (BSA) in PBS at 4°C.
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PMC5261804
Clustering of these 360 PPIs across the 165 cell lines identified 12 major PPI clusters.
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PMC3164356
CHO-K1 cells were grown in F12 medium exponentially.
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PMC11804588
The positive cooperativity between TFs support concentration-dependent DNA binding by multiple factors, whereas the negative cooperativity assures fast bidirectional gene regulation with short response time when TF concentrations in the nuclei suddenly change.
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PMC9611901
This is the main difference between the exposure of the cells used in our experimental conditions and the real exposure of skin cells.
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PMC11332076
Fig. 2Immunocytochemical analysis of ERK and AKT activation by F-iIR and F-iIGF1R in the absence of insulin.
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PMC7642379
SNVs and indels have been called using the GATK HaplotypeCaller.
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PMC11754432
siRNA-mediated silencing of ALOX15B revealed increased cytokine secretion of CCL2, CCL5, and CXCL10.
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PMC9985266
Finally, the PCR products were detected by agarose gel electrophoresis, stained with ethidium bromide and analyzed by an image analysis system.
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PMC11366496
It has been associated with various cellular processes, encompassing apoptosis (programmed cell death) and cell proliferation. ,
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PMC11310713
Scale bars, 200 μm. (
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PMC11650848
Top, overview of human chromosome 6 (genome release hg19), with ZFP57 alternative isoforms (dark blue) starting at a differentially methylated region (green) and a CTCF binding site (grey) with insulator activity (light blue).
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PMC9577200
Furthermore, CS treatment increased the activity of the P53 protein, which serves as a tumor suppressor.
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PMC11592837
While ETP showed no marked effect, the mean DII of DOX-treated samples steadily declined, starting from 0.57 at 1 h and reaching a minimum (0.35) after 8 h without statistical significance in pairwise comparison to the control.
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