Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
 Community
1
PMCID
string
Sentences
string
ner
list
PMC9429973
Summary/Conclusion: Our results unraveled the dual role of TPO on HSC and Mk BM niche in a disease condition of chronically reduced TPO stimulation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11615101
Expression of LDHA mRNA level in the siTaxilin treated group compared to NS and recombinant pure α-Taxilin group. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "LDHA", "mRNA"...
PMC7802142
Recently, miR-100 activate Wnt signaling pathway by repressing multiple Wnt negative regulators, along with increased nuclear β-catenin expression .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "miR-100", ...
PMC11541241
Finally, more fieldwork is needed to demonstrate the efficacy of these fungicides and biopesticides.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "more", "fieldwork", "is", "needed", "to", ...
PMC9143157
In this regard, a drug delivery system that delivers drugs selectively to tumors is a useful and effective strategy, namely, tumor targeting.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5261804
See S1 Methods, where we demonstrate that this iterative update is guaranteed to converge and has a closed form answer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "S1", "Meth...
PMC11525293
Means ± SE of three replicates are shown.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Means", "±", "SE", "of", "three", "replicates", "are", "shown", "." ] } ]
PMC9429973
2005;3:692-4.
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "2005;3:692", "-", "4", "." ] } ]
PMC11650848
DNA variants were examined using pyrosequencing and Sanger sequencing, with results compared to published studies using bioinformatic approaches.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "variants", "were", "examin...
PMC8358006
c H3K27me3 difference for GSDs marked gene (mean values; x-axis) plotted against expression of the corresponding genes (y-axis; log2 values) in KYSE450 cells versus NE2 cells (along axes): red, selected H3K27me3 losses and upregulated genes; blue, H3K27me3 gains and downregulated genes; and black diagonal line, linear regression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534035
The control cells had an average size of 45.28±3.352 px, and all treatment groups were compared to this average in one-way ANOVA analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11279598
Thus, MH and TH may inhibit ER-positive tumor progression in part by reducing circulating estrogen levels and potentially acting as selective estrogen receptor modulators to disrupt estrogen signaling pathways .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223
Tanaka f. hispidula Hsiao. (
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tanaka", "f.", "hispidula", "Hsiao", ".", "(" ] } ]
PMC11723947
The analysis was performed on total Tconv from mice injected with Tconv only, or on anergic (A) or non-anergic (N-A) Tconv from mice injected with Tconv and Treg. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5716223
Analysis of viable, trypan blue negative (white) and nonviable, trypan blue positive (black) cells was performed after 48 h with or without NGF (10 and 100 ng/ml) and it is expressed as total number of counted cells (Viable cells: Ctrl, 8.8 ± 2.5 × 10; NGF 10 ng/ml, 10.1 ± 3.6 × 10; NGF 100 ng/ml, 9.2 ± 2.2 × 10; p > 0.05; Nonviable cells: Ctrl: 1.3 ± 0.6 × 10; NGF 10 ng/ml: 3.3 ± 1.9 × 10; NGF 100 ng/ml: 2.1 ± 2.6 × 10; p > 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Elimination of MRD in patients having reached complete remission (CR) could therefore improve their long-term outcomes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elimination", "of", "MRD", "in", "pati...
PMC8409415
The cells were washed twice with fluorescence‐activated cell sorting (FACS) buffer (PBS with 1% FBS and 0.1% sodium azide) and then incubated with mouse monoclonal antihuman CD70 antibody (1:50, clone Ki‐24; BD Biosciences) as the primary antibody.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929
Leveraging the longitudinal scRNA-seq and scCITE-seq data generated from the same COVID-19 cohort, we tracked SARS-CoV-2-specific CD8 T cells matched on patient ID and TCR sequences from acute to post-acute timepoints (Fig. 7a, Supplementary Data 11).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584666
These results indicated that GPI-80 expression augmented NF-κB activation in PC3 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", "results", "indicated", "that", "GPI-80", "expression", "augmented", ...
PMC11593713
These chemicals directly neutralize ROS, facilitate the recycling of defense enzymes, or modulate redox-sensitive transcription factors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "chemicals", "directly", "neutralize...
PMC9429973
Median OS was not achieved in both groups, 3-year OS was 97,8% and 96,5% respectively (p=0.356).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "OS", "w...
PMC11040965
Chart data are mean and SD for 7 independent experiments. *
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chart", "data", "are", "mean", "and", "SD", "for", "7", "independent", "experiments",...
PMC8623816
Most fungal viruses that infect their hosts are symptomless, which makes the exploration of novel viruses a great challenge; thus, a large number of mycoviruses in R. solani remain undiscovered.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496728
Electrophoresis detection was performed using fast electrophoresis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrophoresis", "detection", "was", "performed", "using", "fast", "electrophoresis", "." ] } ]
PMC10996034
Taxol is also used clinically in the treatment of patients with LUNG, HSSC and UCEC, as well as other types of cancer (35–37).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Rates of myelosuppression and infection are high and careful monitoring is required.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rates", "of", "myelosuppression", "and", "infection", "are", "high", "and", "car...
PMC10589262
The sections were deparaffinized and treated with BLOXALL endogenous blocking solution (Vector Laboratories, CA, USA) to inhibit endogenous peroxidase activity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11298021
The results showed a considerable decrease in mTOR expression (****P <0.0001) and a significant increase in PI3K and S6KB1 gene expression (**P <0.01) in the rapamycin-treated group (Fig. 7C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834
Importantly, the A549GR cells displayed reduced sensitivity to gefitinib-induced apoptosis relative to parental A549 cells (Fig. 4B).
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",...
PMC11760643
Then, 50 µL RPMI‐BSA, 50 µL of PBS, anti‐P2X7 or isotype control mAb (2 µg/mL), and 50 µL of rabbit complement (at a final dilution of 1:4) (Cedarlane Laboratories, Burlington, Canada) were added per well in triplicate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145
Indeed, some of the effects we observed in MPM cells after administration of TB resemble a phenotype commonly associated with the anti-cancer effects of mitochondrial uncouplers .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10777969
The Michael addition of 1-thio-1,3,4-thiadiazole (2) to levoglucosenone 1 produced crystalline adduct FCP23 in a good 65% yield.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Michael", ...
PMC11033180
Of note, the steady-state average I/V relationship was unaffected by Sema5A-Fc exposure (Table 1; Figure 9D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "the...
PMC11295144
NL2 was tagged with mCherry (red) while GABAergic terminals were labeled an anti-Bassoon-specific antibody (cyan).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NL2", "was", "tagged", "with", ...
PMC9429973
SARS-CoV-2 affected 8 (50.0%) low-risk patients, 5 (31.3%) intermediate-risk and 3 (18.7%) high-risk patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10170482
Afterward, cells were loaded with 0.5 μM MitoTracker red CM-H2XRos (Thermo Fisher Scientific, Waltham, MA, USA) for 15 min at 37 °C in the dark and imaged using the spinning disk confocal system IXplore SpinSR (Olympus, Tokyo, Japan).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Overexpression or overactivity of the two major PRMTs (1 and 5) have been previously identified in Acute Myeloid Leukemia (AML) patients and their biological or pharmacological inhibition leads to a decreased leukemia progression in mice (PRMT1, 4, 5).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240
To further explore the importance of residues presenting more than 50% occupancy in the stability of the complex, an in silico alanine scanning was performed (Fig. S8).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994
The dashed line stands for the normative limit of 70% metabolic activity of the control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dashed", "line", "stands", "for", "the", ...
PMC10729469
Single cell suspensions of splenocytes (10 cells), lymph nodes (10 cells), or whole blood (50 μL) were used for flow staining.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780
Next, we analyzed the hsa-miR-301b-3p level in BC tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "analyzed", "the", "hsa-miR-301b-3p", "level", "in", "BC", "tissues", "....
PMC7338939
Melanoma has been determined by its medical treatment failure, tumor recurrence, and rapid metastasis to distant organs (6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "...
PMC11787381
Results are expressed as mean ± SEM [(A): n = 6 except for bambuterol (n = 5), (B): n = 6 except for Aβ (n = 5)].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684269
In this context, undiminished GLUT1 compensates the glucose uptake for further effector functionality (21).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "context", ",", "undiminished", ...
PMC10940855
n = 5/group, analyzed with ANOVA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5/group", ",", "analyzed", "with", "ANOVA", "." ] } ]
PMC11204465
The STCs are a group of compounds with a bifuranic ring and an anthracenone skeleton, which are widely distributed in nature and are very diverse .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9910796
At the end of the transfection period, the transfected cells were fixed for immunofluorescence or EM analysis or dissociated for immunoprecipitation or immunoblotting, as indicated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8753818
Previously, it is reported that the caspase-7 deficiency in CHO cells reduces the cell proliferation rate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previously", ",", "it", "is", "reported"...
PMC7642379
Genome sequencing was performed at the National Genomics Infrastructure (Scilifelab, Solna, Sweden) using the Illumina HiSeq X platform.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genome", "se...
PMC11367146
The significant pathways and functions were determined based on the threshold limit of p-value <0.05, FDR (False Discovery Rate) < 0.01 and by selecting the species as “Human”.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786156
This study shows that cell-to-cell adhesion via CD54 enhances cell proliferation, and we propose a hypothesis that the TME influences adhesion-associated cell proliferation (Figure 5) both in vitro and in clinical tissue specimens of DLBCL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9473868
Snail induces EMT through the suppression of many epithelial markers, including E-cadherin and claudins .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Snail", "induces", "EMT", "through", "the", "suppression", ...
PMC9429973
Cases were randomly divided into a training (n=43) and a validation (n=35) set.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cases", "were", "randomly", "divided", "into", ...
PMC11457557
The most notable pathological hallmark of ESRD is kidney fibrosis, characterized by increasing tissue scarring that leads to glomerular and tubulointerstitial fibrosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11438317
Densitometry values of the myc blot on the top, expressed as percentage of the WT are indicated below.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Densitometry", "values", "of", "t...
PMC6948907
The apoptotic effects of GE in combination with VPA were more significant that of each compound alone.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apoptotic", "effects", "of", "GE", "...
PMC11612794
First, we examined the phosphorylation sites in the CENP-T aa 161–216 region using mitotic DT40 cell extracts by mass spectrometry and found that S175 and T184 were phosphorylated during mitosis (Figures 5A and S6A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393
A library of chemical probes targeting a spectrum of epigenetic regulators is screened using a panel of ccRCC models.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "library", "of", "chemical", ...
PMC10362265
Overall, these analyses suggested that the initial conformation of the surface epitope affects the flexibility of region I of IL18 and region III of IL18BP (Fig. 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132
Three days after transduction, the percentages of δ2 T cells expressing GFP were measured in GFP DNA-transduced cultures by flow cytometry to estimate transduction efficiency.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6133382
Sequences of the MGAT1 gene for 3.4F10 and 3.5D8 cell lines both had the same single-base insertion, shown in a black box. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11672881
The cells were treated for 24 h with 10 μM of TQ, 25 μM of CU, and their combination.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "w...
PMC11659921
Notably, we found that the mRNA levels of these genes exhibited a positive correlation with heterozygous amplified CNVs, while showing a negative correlation with heterozygous deleted CNVs (Figure 2D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676674
The findings from the two analysis methods were not different; indeed, a similar trend of results was obtained in both analyses, where the C. monspeliensis extracts in the absence of MMC showed no genotoxic effect and, in the presence of MMC, the lowest concentration produced a significantly lower genotoxic effect when compared to the cells treated with MMC alone.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Results: NK reached a mature immunophenotype faster in the case of haplo-HSCT with TCRαβ-depletion: by day +30 after HSCT, the median proportion of CD56dimCD16+ NK cells with TCRαβ-depletion was 57% versus 9% when using PT-Cy, p= 0.0045.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470999
A p‐value < 0.05 was considered statistically significant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "p‐value", "<", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC10154881
The expression of NECTIN4 conferred infectivity and susceptibility to rMV‐SLAMblind infection in mouse cancer cells (Figures 1 and 2A,B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11459296
The CB-MNC-humanized NSGS model exhibited rapid, sustained, and functional myeloid-lymphoid engraftment with a low risk of GvHD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CB-MNC-humanized", "NSGS", ...
PMC9412887
Therefore, inhibiting HIF-1 pathways during chemotherapy might be a promising method to circumvent chemo-resistance .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "inhibiting", "HIF-1", "pathways", "during", ...
PMC6461034
Phosphorylation of residues in the activation loop counteracts the positive charge of a critical arginine in the catalytic loop, eliciting conformational changes and consequent kinase activation (Nolen et al, 2004).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298
The loss of H2O generates the product ion at m/z 161 (Jaiswal, Halabi, Karar, & Kuhnert, 2014).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC4816271
Assays were carried out in triplicate at effector:target ratios of 32:1, 16:1, 8:1 and 4:1 in 96-well V-bottom plates.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Assays"...
PMC9429973
The study observations support the emerging trend toward reserving drug therapy for ITP patients with major bleeding manifestations or troublesome impairment of quality of life.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11291490
The pellets were lysed using 100 μL of radioimmunoprecipitation assay (RIPA) lysis buffer (Beyotime, China) containing 1% phenylmethanesulfonyl fluoride (PMSF, Beyotime, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
A meta-analysis of available clinical evidence may provide insights to help standardize clinical practice for combination chelation therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "meta-analysis", "of", "available", ...
PMC8633974
LTR-1/GagD was selected as a reference control because of its utility in sterilizing one-third of HIV-1 infected humanized mice, thereby establishing proof-of-concept for a CRISPR-based HIV cure in an animal model .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258
For this reason, drug combinations of such therapies are an important option to overcome resistance to single drug treatments and improve overall survival.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10748106
Derived from the ligand-based design, we observed that the presence of an aldehyde or a hydroxymethyl in C4, hydroxyls in C1, C6, and C8, and the lack of the double bond in C7–C8 increased the predicted biological activity of the iridoids.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474
P27 is a negative regulator of CDKs and is ubiquitinylated by S-phase kinase-associated protein 2 (SKP2), reducing its cellular concentration by proteasomal degradation .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5600151
Linking or conjugation of dendrimers with PEG chains has been shown as an important step in reducing the cytotoxicity of dendrimers .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Linking", "or", "...
PMC9429973
Summary/Conclusion: This study summarises the self-reported impacts of COVID on psychosocial health and care access during the early pandemic in vulnerable patient groups; MM patients are also highlighted as especially vulnerable.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490
However, due to the limited cross-presentation of antigens and the absence of an immune microenvironment that promotes cellular immune responses, such as Th1 cell assistance and the expression of related cytokines like IFNγ, the cellular immune responses induced by the inactivated vaccine are not prominent.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034
Store at −80°C.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Store", "at", "−80", "°", "C", "." ] } ]
PMC2191574
It is 18 kb long and comprises five exons.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "18", "kb", "long", "and", "comprises", "five", "exons", "." ] } ]
PMC11209164
Other HSV-1-based oncolytic viruses like G47Δ are showing promise in clinical trials.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "HSV-1-based", "oncolytic", "viruses", "like", "G47Δ", "are", "showing", ...
PMC10530622
Mechanistic data from experimental models provides evidence for the toxic effects of oxalate in vascular function .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanistic", "data", "from", "experimental", "models", ...
PMC11684821
Our catch-all strategy to generate cancer-specific MR1-restricted T cells is outlined in Figure 1A and involved T cell priming from the PBMC of 3 donors using C1R cells (MR1*01) overexpressing MR1*01.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
There are, however, remaining open questions, since clinical studies applied variable techniques, cutoff values and time points.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", ",...
PMC9429973
Total protein analysis from BM cells of Kank1 (n=3) compared to Kank1 mice (n=3) showed a significant reduction (FC >0.5, adj.p.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379
As expected, the gene expression of Large T and EBNA-1 was detected in 293T and 293E, respectively (Fig. 1e).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O"...
PMC11538390
Variants reaching P values less than 1.0 × 10 in these additional analyses are shown in Supplementary Data 5, 6, 7.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Variant...
PMC11711127
Interestingly, several works have also shown that nitric oxide (NO) generated by macrophages and fibroblasts when treated with IFN-γ, lead to the inhibition of T cell activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Methods: Currently, 17 hospitals contribute to the registry, and the collection and analysis of data from the Taiwan Blood and Marrow Transplantation Registry is approved by the institutional review board of each participating hospital.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503685
However, formulating CSA-131 in poloxamer micelles using Pluronic® F-127 eliminated cilia damage without changing the antimicrobial activity .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "formulating", "CS...
PMC10452486
They exposed the PMA-treated resting T cells and trypsin-treated PMA-activated cells to BFA, which arrests the exit of newly synthesized proteins from the ER.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10938377
The successful synthesis of the peptides, L1–L4, was confirmed via high-resolution ESI(+) spectrometry, with the [M + 2H] ion observed at m/z 1101.6240 (L1), 1101.6228 (L2), 1039.0308 (L3) and 1039.0299 (L4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377
Conversely, TBX21, which plays a role in immune system activation, exhibited a significant upregulation with a FC of 55.022327 (log FC = 5.781945, p = 7.47E-05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874
One potential regulatory mechanism for such a robust oscillation is a post-translational modification of DBP protein.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "potential", "regulatory", "mechanism", "for", "...
PMC2944824
Cells were plated into 100 mm dishes and treated as indicated in the figure legend.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "plated", "into", "100", "mm", "dishes", ...
PMC11745600
These results indicate that Ins1 NOG mice are valuable for long-term xenotransplantation experiments, providing an effective platform to assess both the efficacy and safety of long-term xenograft engraftment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...