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OTAR3088
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BioData-CellLine_annotated

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PMC11764090
CBL2, CBL3, CIPK9, and CIPK27 negatively regulate the ABA signal pathway in A. thaliana .
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PMC11521786
The preimmune (PI) sera (dotted red line) served as an additional specificity control. (
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PMC10988555
Control solutions of CT-DNA, CT-DNA + DMSO, and DMSO were also prepared.
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PMC11687663
Worldwide and in Nepal, the death rates from cancer, cirrhosis, fatty liver, and chronic hepatitis are high.
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PMC11206502
Further molecular studies are needed to confirm these findings and investigate their applicative potential.
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PMC11470381
This approach can be extended to live-cell imaging and polarity assessment of other fluorescently labeled proteins.
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PMC9429973
E. Khan, J. Nourse, S. Tokalov, S. Khokhar, D. Arnold-Schild, L. Schott, L. Eder, S. Danckwardt Center for Thrombosis and Hemostasis; Johannes Gutenberg-University Medical Center Mainz, Mainz, Germany Background: Thrombin is the central protease involved in blood coagulation.
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PMC11547917
The Aristolochia species were already screened for their chemical composition; therefore, secondary metabolites, classified according to chemical structure, including aristolochic acids and esters, aristolactams, aporphines, protoberberines, isoquinolines, benzylisoquinolines, amides, flavonoids, lignans, biphenyl ethe...
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PMC11407042
Set the wavelength to 490 nm or 492 nm.•Researchers may add antibiotics in DMEM during the culture of A549 cells to prevent bacterial contamination.
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PMC7887261
Specifically, the risk MLNR p.Q334V fs*3del interacted with pack-years (P-value 0.0035); the protective-effect associated with the MOB3A p.F69_I75del is substantial and significant among males (10/11 control carriers were male, whereas 0/2 LCs carriers were male; P-value 0.042), smokers (6/11 control carriers were smok...
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PMC11244823
In this study, 60 horse sera from Switzerland (No. 1–60), 50 horse sera from Iceland (No. 61–110) and one serum from Germany (PosC2) were analysed.
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PMC11295144
Furthermore, to assess if the ICL of γ2 subunit mediates this interaction, α2β3γ2-, or α2β3δγ2ICL- or α2β3δ-GABAARs were co-expressed with HA-tagged NL2 in HEK293 cells, and subjected to co-immunoprecipitation with the Myc-antibody followed by immunoblotting with the NL2-antibody or β3-subunit antibody.
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PMC8358006
Blue dots indicate the top 5% broadest H3K27me3 domains which we defined “grand H3K27me3 silencer domains.”
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PMC11489175
The mechanism of USP1 inhibitor-induced killing involved RAD18, an E3 ligase for PCNA ubiquitination that upon USP1 inhibition is trapped at replication forks and is likely to block the refilling of ssDNA gaps mediated by translesion synthesis polymerase.
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PMC9436459
Yunanensin C (23) was another typical representative, which possessed a 6-membered oxygen ring with the same orientation of CH3-7" as H-5" formed by the intramolecular nucleophilic addition of 16″-OH with C-1" .
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PMC11513571
Briefly, the PBMCs were resuspended in PBS containing 2% FBS and 1 mm EDTA, and the enrichment cocktail was added and incubated at room temperature (RT) for 10 min.
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PMC11697065
As such, several studies have identified metabolic signatures associated with improved antibody titre including yeast cytosolic pyruvate carboxylase (PYC2) , , mitochondrial malate dehydrogenase II (MDH II) and the fructose transporter gene, Slc2a5 , .
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PMC11269933
All data reported in this paper will be shared by the lead contact upon request.
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PMC11594588
The mtDNA copy number is considered an indirect measure of mitochondrial function, and its quantification in peripheral blood primarily reflects the mtDNA copy number in leukocytes and platelets.
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PMC3765139
Expression of regulatory core transcription factors in melanoma cell lines NANOG = Nanog homeobox; OCT4 = POU-domain transcription factor; SOX2 = SRY (sex determining region Y)-box2; (-) = no expression (<10); (+) = moderate expression (≥10<10); (+ +) = strong expression (≥10).
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PMC11612794
The cell cycle distribution was analyzed according to a previous report.
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PMC11707832
In another study by Paula Juricic et al. , chronic rapamycin treatment in female Drosophila and mice elicited a geroprotective response.
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PMC9429973
On the other hand, genetic alterations, such as SNVs and CNVs, driving AML evolution are early identified by single cell analysis despite being undetectable by bulk sequencing.
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PMC11772585
The initial glucose level was subtracted from the subsequent measurement to determine the amount of glucose taken up by the cells.
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PMC10158546
Prion inocula included human clinical isolates of Scjd-MM1 and Scjd-VV2, the RML strain of mouse-adapted scrapie, and the 263K strain of hamster-adapted scrapie.
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PMC11463018
H NMR (500 MHz, Chloroform-d) δ: 8.08 − 8.06 (m, 1H), 8.02 − 7.99 (m, 2H), 7.75 − 7.71 (m, 1H), 7.57 − 7.53 (m, 1H), 7.48 − 7.38 (m, 4H), 6.91 − 6.88 (m, 1H), 5.15 − 5.10 (m, 1H), 4.66 (d, J = 6.3 Hz, 2H), 3.90 (s, 3H).
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PMC11721064
1The molecular expression patterns in the skin and cornea.
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PMC11768281
Thus, blocking this pathway in individuals with acute malaria may lead to immunopathology .
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PMC11657695
Ewing sarcoma cell lines (Table S1) and A-673/TR/shEF/ cell line, stably transduced with a doxycycline-inducible shRNA targeting EWS::FLI1 , were kindly provided by Olivier Delattre (Curie Institute, France).
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PMC8427838
7High TMIGD1, moesin and Ezrin expression in renal cancer correlate with better survival.
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PMC9874064
Fig. 2Preparation, characterization and the intracellular uptake of NP-Pt-USP1i.
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PMC9844987
Interestingly, ETS factors, here associated with low variable promoters, can interact with transcriptional co-activators and chromatin modifying complexes (Curina et al., 2017; Göös et al., 2022).
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PMC11549062
Proteins were extracted using RIPA lysis Buffer (Abcam, Ab156034, UK), followed by centrifugation at 12,000 g for 15 min at 4°C.
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PMC11267830
The study used indisulam-dependent splicing as a pharmacodynamic marker for treatment efficacy, a hypothesis that was validated in primary patient cells.
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PMC11261875
While sunitinib and regorafenib are considered effective for treating imatinib-resistant GIST, the median progression-free survival is 8.5 months for sunitinib and 4.8 months for regorafenib [, , ].
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PMC9429973
Median age was 67 years, there were 64% males.
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PMC10956161
Bioinformatics methods were used to determine the diagnostic value and impact on survival of the PRDX6 gene in patients with lung adenocarcinoma.
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PMC11700165
Along with ITK-SYK-R29C, we also generated its counterpart BTK-SYK-R28C.
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PMC10530622
Moreover, oxalate induced ROS formation in isolated kidney mitochondria .
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PMC11618052
C NMR (100 MHz, δ ppm CDCl3): 161.71, 156.87, 147.68, 135.52, 135.19, 134.89, 130.18, 129.80, 129.78, 129.44, 129.16, 128.81, 128.44, 127.50, 126.12, 126.01, 120.59, 120.01, 27.25.
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PMC9429973
One third of patients was still untreated during the follow-up (median 86 months, range 21-271), and the time to first treatment among 68 patients was 38 months (range 11-141).
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PMC11406030
Both nuclear and cytoplasmic LMTK3 expression correlates with tumor grade and patient survival.
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PMC11401350
It is therefore very challenging to evaluate new therapies for AITL, for which patient biopsies are very scarce and only a few AITL or Tfh-like PTCL patients can be enrolled in clinical trials.
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PMC11612794
Asterisk indicates nonspecific bands.
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PMC9118379
Of these, 111 PSMs passed all of the five-aspect examinations at the PSM level, where each aspect examination results from at least one tool supporting the reliability of variant PSMs.
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PMC11635519
Finally, the production NPT runs were performed for 300 ns for each system.
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PMC11768281
Both experimental and non-experimental studies were considered, encompassing in vivo and in vitro research, provided they were published in English and available in full-text.
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PMC9429973
POMP maintenance was given for up to 3 years.
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PMC10823017
The reduced expression of N-cadherin was also observed with declines in the activated vimentin level in both the 786-0 and Caki-1 cells.
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PMC9429973
Imaging flow cytometry experiments were performed to study the role of MRC2 in gelatin uptake.
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PMC9429973
In a previous propensity score matching (PSM) analysis (Bachy et al., ASH 2021) allowing for balanced comparison between axi-cel and tisa-cel outcomes, we reported on a prolonged progression-free survival (PFS) but a higher toxicity associated with axi-cel compared with tisa-cel.
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PMC9509578
Their results showed that the 2D nanomaterials interfered with total glutathione (GSH/GSSG) levels, expression of glutamylcysteine synthetase and glutathione peroxidase in both resistant cell lines and a murine model.
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PMC11747467
ERBB2 expression values were extracted from these datasets to compare the expression differences among subtypes.
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PMC9429973
Dose delay or dose reduction have occurred in 17 patients (65%).
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PMC11779960
Since normal TCRαβ T cells comprise of a mixture of either TRBC1 or TRBC2 T cells, this allows for selective targeting of TRBC isoform expressed by the lymphoma, with preservation of normal T cells which express the alternate isoform.
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PMC10589262
Since there are no commercial antibodies for ICC analysis of P85 and GRB2, HA-tagged P85 and GRB2 expression vectors were constructed.
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PMC11411131
Sensor vectors facilitate the quantitative detection of intracellular stress responses that are otherwise difficult to observe.
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PMC11591794
For this reason, every natural herbal product has become the focus of attention in cancer treatment and is seen as a way to overcome these problems.
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PMC10956161
All patient details were de-identified and patients were required to provide verbal informed consent.
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PMC11591030
This indicates that PDTC inhibited AOP’s activation of NF-κB and its target genes through the TLR4 signaling pathway, leading to reduced ROS generation and, consequently, diminished antioxidant enzyme activities in the PBLs.
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PMC8956657
Pymol software was used to generate images.
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PMC11786600
The control group received no treatment; the remaining groups changed their corresponding dressing every three days.
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PMC11525028
We further performed RNA-seq and acRIP-seq with NAT10-KO and control 143B and HOS cells, respectively.
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PMC9545474
H NMR spectra (400 MHz, CDCl3 or D2O) of complexes 3–8.
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PMC9856122
The in vitro study of alkaloids against anti-HSV and anti-PI3 activity using Vero and madine-darby bovine kidney (MDBK) cell lines represents effective results .
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PMC11290772
On the contrary, it is important to acknowledge the limitations inherent to PBMC-derived CAR-NK cells, which extend beyond the scope of our own research.
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PMC11633763
In the present study, USP22 knockdown markedly reduced the protein levels of HK2 and β‐catenin and strongly suppressed the proliferation and glycolytic rate of osteosarcoma cells.
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PMC11787355
The supernatant was collected 24 h and 48 h post-transfection, filtered, and concentrated with PEG-it Virus Precipitation Solution (#LV810A-1, Systems Bioscience).
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PMC9545714
We are also excited to report, for the first time, the existence of olfactory receptors in human dermal fibroblasts and their significant up regulation by GTE.
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PMC11371747
In pancreatic cancer, FOLFIRINOX (a combination of FOLFOX and FOLFIRI) is an active regimen, although at the expense of increased toxicity (Conroy et al., 2011; Caparello et al., 2016).
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PMC7723249
In addition, we have to highlight that HAZV has a much faster replication process in Caco-2 compared to CCHFV.
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PMC4485648
Changes in the activity of each signaling pathway were determined by comparing the normalized luciferase activities of the reporter in treated vs. untreated transfected cells.
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PMC10772747
Therefore, further scientific evidence is needed through in vivo testing on animal models and clinical trials in humans to prove the potential of Dayak onion as a candidate breast cancer drug.
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PMC11732635
EBV not only infects B cells, but also T and NK cells.
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PMC11707832
Gene expression analysis unveiled a close relationship between heightened enzyme activity and transcriptional upregulation.
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PMC11291490
Additionally, our findings unveiled that dusCD40L could simultaneously enhance the expression of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.
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PMC11655536
This study may provide a new treatment strategy for clinical treatment of MM.
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PMC9429973
Current guidelines suggest aiming for a TKI treatment duration >6 years to increase TFR success rate.
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PMC9031474
Because of its amphiphilic nature, polygodial (2) is supposed to act as a non-ionic detergent on the mitochondrial membrane (MM), leading to the distortion of the mitochondrial membrane potential (MMP).
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PMC9429973
The baseline characteristics of the patients are listed in Table 1.
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PMC11750712
Multispectral imaging was performed using the PhenoImager HT and exported from the inForm software (Akoya Biosciences).
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PMC9429973
Baseline characteristics were: median age 22 years (range 16-59 years), 6/9 (67%) female, and 6/9 (67%) used hydroxyurea.
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PMC11699465
Data are represented as mean ± SEM.
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PMC9545714
Linoleic acid from the circulation is taken up by the epidermis and is initially incorporated into a small pool of triglycerides.
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PMC11638255
Media alone or containing 0.2 × 10 SK-N-BE(2)-C cells were seeded in 2% FBS/DMEM before overnight treatment with 1 mM TEPA.
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PMC11701801
The gating of live cells was based on side scatter (SCC) and forward scatter (FSC) area parameters.
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PMC11656657
Using Oncogenomics pediatric sarcoma database, we characterize B4GALNT1 gene expression also in pediatric subpopulation.
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PMC9599726
Here, we studied the impact of the class II ferroptosis inducer (FIN), RSL3, a direct GPX4 inhibitor, on the viability and lipid peroxidation of GIST882 and GIST48 cells.
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PMC11544122
FLAG-SNX9, and GST-CXCR4-CT, and pGlo BiosensorFLAG-SNX9, and GST-CXCR4-Ctail, and pGlo Biosensor have been previously described.
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PMC11389534
On the other hand, the IRE1α/XBP1 pathway was shown to stimulate the expression of UFBP1 and UFMylation system genes.
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PMC11484188
ATG7 mRNA levels were downregulated in U266 and RPMI-8226 cells post-transfection with miR-1343-3p mimic.
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PMC11737091
However, its significance in ccRCC has not yet been explored.
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PMC9429973
Aims: Preclinical data shows JAK/STAT pathway may mediate the pathogenesis of PTCL, making it a promising target.
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PMC11703992
The two-step structure endows Slingshot with high robustness to noisy single-cell datasets, allowing it to infer trajectories and stages of cell differentiation in multiple branching lineages from complex single-cell data.
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PMC5330095
Autoimmune hepatitis is an inflammatory liver condition elicited by activated T-cells and macrophages.
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PMC7053076
The c-Rel plays an essential role in the regulation of T-cell-mediated immunity .
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PMC9220170
Thus, SELENOM-KD and SELENOT-KD contributed to functional disorders of the ER, reducing its capacity for storing Ca ions, with the most pronounced effect being shown for SELENOM-KD when the ER was practically empty and the application of TG led to a mild increase in [Ca]i.
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PMC10421378
Next, the stream of filtered and heated air was introduced through the bottom perforated plate to keep the matrix in the fluid phase and to ensure even drying.
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PMC11320834
OLL was used in the same 12.5–400 μM concentration range to treat all six studied ovarian cancer cell samples.
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PMC11781181
Ferroptosis is indeed associated with severe damage to mitochondrial biogenesis 5.
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