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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30), EORTC QLQ-Multiple Myeloma Module (QLQ-MY20), and EuroQoL 5 dimensions 5 levels (EQ-5D-5L) were administered before treatment, on day 1 of each treatment cycle, and at end of treatment.
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PMC11585565
Western blot analysis of wild-type and mutant CNNM4 protein at 24- and 48-hours post-transfection.
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PMC9429973
After 12 and 24 weeks, all patients who continued in luspatercept had a significant decrease in transfusion blood needs, approximately -29.4% and -36.1 % compared to baseline.
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PMC11739696
The Co3O4NPs utilized in the current study were acquired in from Sigma Chemical Company (St. Louis, MO, USA) as s black powder with an average particles size of ≤ 50 nm (product No. 637025, CAS No. 1308-06-1).
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PMC11314247
Finally, samples were acquired via flow cytometry (FACS BD Canto II, Beckton Dickinson, Franklin Lakes, NJ, USA) using the FACS Diva V6.0 software.
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PMC11473843
Analysis of the TRRUST module of Metascape showing that the genes of cluster 5 are identified as transcription factor targets (colored, left) and STRING database analysis showing the possible interaction between the different transcription factors (right). (
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PMC11267830
Whole-cell lysates were harvested using RIPA buffer (Beyotime, P0013).
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PMC11319300
The consensus identity score is depicted, with yellow-green colours indicating conservation ranging from 50% to 100%. (
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PMC11638764
The gradient was composed of 6% solvent B (11 min), 6-25% B (124 min), 25-40% B (45 min), 40–98% B (1 min) and 98% B (15min); solvent A: 2% ACN and 0.2% FA in water; solvent B: 80% ACN and 0.2% FA.
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PMC6102174
Sophora tonkinensis (Yuenanhuai) is mainly present in Guangxi, Guizhou and Yunnan Provinces of China, whose roots and rhizomes are commonly used as the traditional Chinese medicine “Shandougen” for treating acute pharyngolaryngeal infections and sore throat.
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PMC5330095
CBD was found to exhibit a dose-dependent inhibition of the HCV virus in the dose-response assay [Table 2].
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PMC11087301
These properties and potential vulnerabilities have made CTCs an attractive landscape for cancer diagnosis, treatment and prognosis .
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PMC11768927
This reduction in antiviral defenses improved the susceptibility of PDA cells to VSV-induced cell death.
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PMC7338939
The expression pattern of important genes in Notch and Wnt pathways and intermediate genes between these two pathways in groups 1 and 2 (A) and groups 3 and 4 (B) were assessed by qRT-PCR.
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PMC9895440
Cells were then transferred to 24 well plates at 1 mio/ml in fresh medium with 50 U/ml IL-2, 1:4 bead to cell ratio of anti-CD3+ anti-CD28 stimulatory beads and if indicated additional NY-ESO-1 TCR virus at 1 MOI.
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PMC8073654
There have also been reports on the preparative purification of phenylbutenoids from Z. cassumunar by countercurrent chromatography (CCC) .
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PMC6114978
Immunofluorescence demonstrating constitutive nuclear localization of TAZ and YAP in A204 cells grown to confluence. (
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PMC11719944
It has been shown in some human or rat experiments to stimulate glucose-dependent insulin secretion, insulin gene transcription, and β-cell proliferation .
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PMC11394730
Maintaining cholesterol homeostasis involves liver-X-receptor (LXR) proteins, which sense cholesterol.
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PMC11092418
The cells were then washed once with PBS and lysed with 300 µL of preheated lysis buffer (Invitrogen; Thermo Fisher Scientific, Inc.) containing protease inhibitor cocktail (Sigma-Aldrich; Merck KgaA) and homogenized using 25 × 5/8′ gauge needles to reduce its viscosity.
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PMC10957991
Bar 200 um. (
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PMC10976516
In this section, we emphasize the arming of OVs with immune-stimulating molecules, such as cytokines, molecules that improve immune system cross-priming, and T cell co-stimulatory molecules, as a critical method to improve anti-tumoral responses after OV infection.
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PMC9429973
Additional studies are required to fully understand the mechanism of SYK-mediated antitumor immune responses in AML.
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PMC9712534
NS not significant.
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PMC11564405
Complex migratory activities are guided by dynamic interactions between chemokine receptors on effector T cells and their cognate chemokines, which is more like being able to determine the spatial navigation of immune effectors, directing them towards the center of the tumor environment.
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PMC11756907
In addition, the concentration (dose) impact on the anti-tumor activity of GO, rGO, and their derivatives as well have been also documented.
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PMC9118379
We implemented the above four different combinations of search types and FDR calculations, i.e., SSe-gFDR, SSe-cFDR, CMSe-gFDR, and CMSe-cFDR, using the Comet, MS-GF+, and X!Tandem search engines on the HEK293 cell line data set for protein and variant peptide identification.
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PMC11721064
MESCM consisted of DMEM/F12 (Gibco), supplemented with 10% knockout serum, insulin (5 μg/mL), transferrin (5 μg/mL), sodium selenite (5 ng/mL), basic fibroblast growth factor (4 ng/mL), human leukemia inhibitory factor (hLIF, 10 ng/mL), gentamicin (50 μg/mL), and amphotericin B (1.25 μg/mL).
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PMC11753435
All uAb plasmids were generated from the standard pcDNA3 vector, harboring a cytomegalovirus promoter and a C-terminal P2A-eGFP cassette.
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PMC8409415
Similar tumor sizes were observed between the control‐ADC and PBS groups (A2780cisR, P = .92; SKOV3cisR, P = .20) (Figure 6B,E).
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PMC11015054
I, J) HE staining of tissue from tumor sections of SMMC‐7721 and HepG2 cell line showing tumor necrosis area. (
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PMC6222726
yucatanensis Lundell) is commonly known as yala-guito .
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PMC3931643
Analogs of the allosteric mTOR inhibitor rapamycin are approved for mantle cell lymphoma but have limited efficacy in other blood cancers.
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PMC9429973
Methods: Tumor tissue biopsies (paraffin blocks) obtained from 66 patients with newly diagnosed DLBCL (median age - 58 years) were used as material for the study.
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PMC11686380
Interhemispheric cortical axon extension was also impaired, with axons failing to reach the contralateral hemisphere properly.
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PMC9429973
Further study of the combination without a 2-week window (of itacitinib alone) and with objective measurement of patient reported symptoms is planned.
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PMC10607604
PTPN13 KO/KD also led to increased expression of EMT master genes (SNAIL, SLUG, ZEB1, and 2), decreased expression and intercellular junction localization of cell junction markers such as desmoplakin, ZO-1, and PAR3, and a morphological shift towards a mesenchymal phenotype.
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PMC11599565
It is important to note that cisplatin only slightly enhances the neuronal characteristics that ovarian carcinoma cells naturally possess.
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PMC8041314
Reports were only considered when they either presented simultaneous testing at ABCB1, ABCC1, and ABCG2, or the respective compound has been evaluated regarding ABCB1, ABCC1, and ABCG2 in several individual reports.
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PMC11670407
First, we found that OTULIN knockdown significantly inhibited GPX4 expression (Fig. 5a).
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PMC9429973
Our results suggest the clear benefit of early administration of CP to avoid protracted COVID-19 disease in patients with B-cell lymphopenia.
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PMC11707832
However, in comparison, expression levels are comparatively lower in regions such as the cerebellum, cerebral cortex, frontal and temporal lobes .
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PMC11589157
The genome size of N. leucogenys (approx.
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PMC11684269
Similarly, in the context of insufficient optic atrophy 1 (OPA1), LKB1, as a sensor of mitochondrial perturbation, orchestrates mitochondrial membrane disruption, which hinders Th17 effector function.
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PMC9429973
Summary/Conclusion: A bio-inspired nanomedicine was constructed by integrating Mn2+ mediated STING pathway activation for synergized acute myeloid leukemia chemo- and immunotherapy.
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PMC6799808
All other antibodies and reagents were obtained as previously described.
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PMC11391695
The comprehensive primer specifications are detailed in Table S2.
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PMC10123657
This agrees with the representation of molecular functions such as oxidoreductase and protein disulfide isomerase enzymatic activities, binding to monosaccharides and ADP, or binding to phospholipids, Ca and actin (Figure 3B).
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PMC11657744
Cells were subjected to serum deprivation for 24 h to promote cilia development.
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PMC11351758
In diabetes mellitus, complications involving the vascular organs and multiple organ systems are strongly linked to the excessive production of reactive oxygen species (ROS) triggered by high blood sugar levels .
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PMC11638255
Vittorio, O. (2024).
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PMC9429973
FISH revealed -7 in 2/18 patients confirming their karyotypes, loss of one p53 allele in 3/18 patients at low frequencies (6,5%, 4,5%, 3,5%) all with hypocellular RCC and transfusion-dependency that underwent SCT, +8 in 2/18 (in 8% and 2,7% of cells) confirming trisomy 8 in their karyotypes and loss of one MLL allele and MLL rearrangement in a patient that was transformed to s-AML in 4,4% of cells.
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PMC11525293
B p63-null U-2 OS cells were transiently transfected with 10 and 25 ng of ΔNp63α expression vector.
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PMC10174970
For example, the commonly-used ovarian cell line SKOV3 has less genomic fidelity to patient tumors than the 2 less-described cell lines KURAMOCHI and OVSAHO (9).
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PMC9429973
During follow-up, JAK2V617F/TP53KO mice developed the same phenotype than JAK2V617F transgenic mice without leukemia.
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PMC11488203
Subconfluent MSC cultures (about 10 cells) at a density of 7 × 10 cells/cm were incubated either in appropriate dilution (1:700) of solvent (49.7% ethanol = final concentration of 0.07% ethanol) for control exosomes or in the presence of 10 µM taxol (paclitaxel in solvent, diluted 1:700 from a 7 mM stock solution) (Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany) for 24 h, washed three times with serumfree culture medium, and incubated with serumfree culture medium for further 24 h. Thereafter, the conditioned medium was removed and used for EV/exosome preparations by three different methods.
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PMC11463018
1 3 6 ∼ 137 °C.
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PMC9429973
Grade 3+ haemorrhage was observed in 60 patients (28%), of which the majority (48%) occurred within the first year of SVT diagnosis.
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PMC10719213
We applied next generation sequencing to study mutations in the mtDNA after cladribine exposure.
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PMC8992508
The modulating activities for P-gp and MRP1 were evaluated by calcein assay using Kb-V1 (P-gp) and MDCK II (MRP1) cell lines, respectively.
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PMC11515150
Cytotoxicity of 12 C CAR-NK, IL-15 CAR-NK and NT-NK cells against CD5 hematologic malignant cells was evaluated. (
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PMC3730428
SAHA also enhanced sensitivity of MPM cells to concentrations of AT-IAP as low as 10 nM and in cells cotreated with concentrations of TNFα as low as 0.1 ng/ml (Figure 6d).
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PMC11720808
Colony formation assay was applied to investigate proliferation of 143B and MG63 cells under SCU treatment.
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PMC11243198
While GANT61 was less effective than BAS 07019774 in U87MG, they had comparable effects in T98G cells.
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PMC11539788
Thus, our findings revealed that RNF19A could interact with ILK and promote its ubiquitination and degradation.
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PMC6948907
The data were obtained from three independent experiments and are presented as means ± SD (standard deviations).
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PMC9429973
Next, we addressed the role of HDAC3 in ERG’s transcriptional activity.
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PMC11286266
The samples were also blotted for actin as a loading control.
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PMC10940855
P < 0.01; ****, P < 0.0001; , P < 0.05; , P < 0.001. (
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PMC10421378
This parameter is a property of amorphous materials that are formed, e.g., by removing the dispersing medium.
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PMC11794588
Lab Solution software was used to obtain the data.
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PMC11507371
The response to single H2O2 treatment also revealed a strong inhibitory effect on respiration in both cells, although the curve was clearly different from that with CAP, which is also attributable to the presence of other RONS in CAP (Figure 4C).
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PMC9412887
Considering that chemotherapy resistance-related drug efflux proteins mainly reside in the nuclear membranes and blood, but not in the mitochondria , delivering chemotherapy agents into the mitochondria is an emerging strategy to surmount drug resistance to chemotherapy .
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PMC10969097
In the context of cancer, we searched only for the term “cancer” as a condition, and the result showed us that there are currently more than 23,700 studies in the Clinicaltrial.com database and more than 26,500 in ICTRP just in the recruitment phase.
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PMC11506670
In addition to the three NRAS mutants described in this study, other novel mutations in KRAS, NRAS, RRAS, BRAF, PIK3CA, PTEN, and MEK1 are still undergoing detailed characterization and analysis, and are currently unpublished.
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PMC11562028
New Re carbon nanodots with narrow size distribution, good water solubility and high cell membrane permeability were prepared from a herbal extract.
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PMC3203927
Human neural stem cells or neural progenitors (NP) were maintained in neural basal media (Invitrogen, PA) supplemented with penicillin/streptomycin, L-glutamine, recombinant human leukemia inhibitory factor (hLIF), bFGF and B-27, at 37°C in a 5% CO2 humidified incubator.
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PMC11750712
Note, one patient (14) who received 225 × 10 AUTO4 CAR T cells was in CMR following bridging at time of infusion and is marked NE.
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PMC11534377
Unrestricted access to autoclaved water and pelleted nourishment was facilitated.
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PMC11279598
After 24 h, cells were incubated in the presence of 0.6%, 2.5%, or 5.0% MH for 24 h in phenol-red free medium with 5% FBS.
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PMC9622879
Thereafter, a non-cooperative sharing game was used to determine the energy sharing profile and corresponding payments of each building.
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PMC11047729
This substance inhibits hTERT expression by invalidating the binding activity of RBFOX3 to the hTERT promoter, which ceases cell proliferation.
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PMC9429973
This could lead to potentially increased risk for the mother and the newborn.
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PMC9884169
The level of ROS of cells was evaluated with a fluorescence microscope (OLYMBUS IX83, Japan) after washing 3 times with PBS.
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PMC11701801
Recently, we devised the synthetic lethal target screening method based on “the simultaneous inhibition of a paralog pair as a synthetic lethal target” concept and showed that screening for paralog pairs is a viable approach to identifying innovative synthetic lethal targets (19).
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PMC11656657
In parallel, we also collected plasma from non-tumor-bearing mice, as negative control.
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PMC11770130
We confirmed that the serum abundance of ceramides C20–C24 was positively correlated to energy intake in both children and adults.
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PMC10747160
Within 1 min of pipetting out media, 15 μL of fresh 3t3 media was added to the wells to prevent the cells from desiccating.
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PMC10890307
We previously showed that mitochondria content varies when changing the carbon source , so we included mitochondrial staining for the conditions tested.
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PMC11726183
Triple Negative Breast Cancer (TNBC) is one of the most aggressive forms of Breast Cancer (BC), which is associated with a very poor prognosis.
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PMC7171147
Next, oligomycin (1 µM), FCCP (0.125 µM), and rotenone/antimycin (0.5 µM) were sequentially injected and OCR is measured over time.
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PMC11761919
It was subsequently treated with a 1:1 mixture of absolute ethanol and tert-butanol.
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PMC8357004
Besides maximal up-regulation was seen in the combined treatment groups after 24 and 48 h of treatment as indicated in Figure 8.
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PMC11343332
Treatment significantly inhibited Bcl-2 and p53 anti-apoptotic gene expression in breast cancer cells (Figure 4).
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PMC11583010
The generation of MDA-MB-231-N4+ cells was previously described (3).
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PMC11604015
Related donor-derived CAR-T cells are still dependent on HSCT-derived, HLA-matched, or haploidentical donors.
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PMC11363012
Anhydrovinblastine (14), the precursor for vinblastine (15), is much less abundant in leaves, and this compound was observed in a range of 300 μM to 10 mM in a smaller number of cells (ca.
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PMC10582049
Dendrograms are generated in accordance with hierarchical clustering.
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PMC11787355
Canonical markers were employed to identify and annotate the cell type.
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PMC11638255
To further explore the enriched pathways, network plots were created to highlight the top ten genes associated with each gene set.
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