PMCID string | Sentences string | ner list |
|---|---|---|
PMC11543853 | a, b Endosomes with segments of their surface covered with protein coats. | [
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PMC10243817 | RBPs may possess different functions depending on their intracellular localization. | [
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PMC11535726 | This was later supported by Hawksworth (1985). | [
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PMC11721587 | After 10,000g centrifugation for 10 min, the supernatant was collected and dialyzed against the stocking buffer [20 mM Hepes (pH 7.9), 100 mM KCl, 1 mM DTT, 0.1 mM EDTA, 20% glycerol, and 1× Complete protease inhibitor cocktail] for 2 hours at 4°C. | [
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PMC8358006 | e Metagenes of H3K27me3, H3K4me3, H3K4me1, and H3K27ac ChIP-seq density (reads per kilobase per million mapped reads). | [
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PMC11490153 | Specifically, the expression levels of the pro-apoptotic gene Bax and the anti-apoptotic gene BCL-2 using qPCR were examined to assess how these treatments modulate these critical genes. | [
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PMC11773391 | Levels of p‐ERK1/2 were detected in A375 cells treated with TMZ (0.1, 0.25, 0.5 and 0.75 μM) for 24 h using Western blot analysis. ( | [
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PMC9000591 | As shown in Figure 2, the fraction SE1 inhibited KMS11 from a concentration of 62.5 μg/mL. However, until reaching a concentration of 500 μg/mL, mild cytotoxicity to LCL was recorded. | [
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PMC11252033 | In this step, clean data (clean reads) were obtained by removing reads containing adapter, reads containing ploy-N and low-quality reads from raw data. | [
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PMC11791264 | The proteins (30 μg) were equally resolved using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and then immunoblotted with the specified antibodies. | [
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PMC11711127 | This comprehensive understanding sets the stage for future advancements that may revolutionize the landscape of immunotherapy and improve patient outcomes. | [
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PMC10253553 | Cell viability data are indicated as the means with SD of four replicates. | [
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PMC6379402 | The stickiness-index based model (STICKY). | [
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PMC11400680 | Initially, CellSAM gets the prompts from a CellFinder which is a transformer-based object detector (DETR). | [
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PMC5025404 | On the other hand, the second strategy was not as effective to attain high HC expression, LC was in excess, and no stress emerged. | [
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PMC11412721 | Means ± SEM from 100 lymph nodes from Trp53 Eμ-Myc males, 96 from Trp53 Eμ-Myc females, 148 from Trp53 Eμ-Myc males, and 124 from Trp53 Eμ-Myc females. ( | [
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PMC11680391 | R-project.org/, accessed on 15 June 2022) The first analysis aimed to establish the level of agreement for each construct regarding the perception of communication between the dairy farmer and the herd veterinarian during udder health consulting. | [
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PMC6102174 | Swertiakoside B is a new secoiridoid glycoside in which the glycosyl is attached to the aglycon by the OH-1′ and OH-2′ simultaneously. | [
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PMC11730311 | An overview of the primary structures of the hαCGRP8-37 analogues with associated half-lives is presented in Fig. 5. | [
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PMC11594806 | This effect is attributed to the accumulation of hypophosphorylated retinoblastoma protein, which decreases the kinase activities of cyclin-dependent kinases (CDKs) 2 and 4. | [
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PMC10723784 | However, further contact time induced cytotoxicity with measurable IC50s. | [
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PMC8916024 | To obtain high-quality clean reads, raw reads containing more than 10% of unknown nucleotides (N), or containing less than 50% of bases with a quality (Q-value) >20, were removed using FASTP (Chen et al., 2018a). | [
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PMC10607604 | Conversely, DPK expression was decreased by 1.2 to 4 times (Figure 3A). | [
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PMC10713411 | After the transfection of si-TRIB3 and si-NC, A498 cells were plated into the confocal dishes, 6-cm cell culture dishes and chambers of cell culture inserts. | [
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PMC11525293 | Extensive information available on Thal’s mechanisms of action and its efficacy and safety in hemophagocytic syndrome–induced cytokine storm, idiopathic pulmonary fibrosis (IPF), or severe H1N1 and paraquat poisoning lung injury argues for the possible action of Thal on COVID-19-induced lung effects and cytokine storm [9–12]. | [
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PMC11682172 | Type I coronins (1A, 1B and 1C) localize to actin-rich cellular structures serving a wide variety of cellular processes, among which cell motility. | [
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PMC6684588 | In the present study, we evaluated the potential of ACE-083 – a locally acting, follistatin-based fusion protein – as a novel therapeutic agent for focal or asymmetric myopathies. | [
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PMC10955424 | Thus, metabolites in malignant ascites as well as in cirrhosis ascites were monitored using LC/MS-MS. | [
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PMC5574817 | 2Gel electrophoresis of restriction enzyme digestion products of the plasmid map. | [
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PMC9429973 | Belamaf monotherapy at 2.5mg/kg is administered by intravenous infusion every 6 weeks for a maximum of 8 cycles; dosing can be reduced to 1.92mg/kg for toxicity. | [
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PMC7802142 | In previous studies, miR-100 plays a critical role in tissue regeneration. | [
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PMC11216402 | Similar TF activation is detected when training on a primary GC tumor (TCGA-STAD) versus normal stomach. | [
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PMC11723947 | b–d Percentage of WT or HP1α KO TCR Vβ6CD4 T cells producing IFN-γ (b), IL-17A (c) or both (d) 21 days after engraftment. | [
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PMC6182045 | This is particularly true for Sub-Saharan Africa and South Asia, where the majority of new infections are predicted to occur over the next decade (1). | [
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PMC9429973 | Image: Summary/Conclusion: We generated AML MRD PDX mouse models, and identified transcriptional and epigenetic characteristics of AML MRD that might guide the design of “targeted” combination treatment strategies potentially eliminating relapse-initiating cells. | [
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PMC8414691 | Total RNA was extracted from DOM-A-depleted Drosophila S2 cells and control, using Trizol reagent and retro-transcribed with Sensi-FAST cDNA synthesis kit (BioLine), according to manufacturer instructions. | [
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PMC9429973 | Responses were assessed with the cumulative incidence competing risk (CICR) method considering the competing event of TKI discontinuation for any cause. | [
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PMC11683240 | Among these residues can be highlighted GLN44, SER45, GLU175, ASP177, ARG178, ASP179, SER313, and ASN314 for interaction with S3 and residues GLU75 and GLU78 for the interaction with S4_2. | [
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PMC11186948 | Then 1/30 of Triton X100 10% was rapidly added to the solution which was left on ice for 5 min and centrifuged at maximum speed for one minute at 4 °C. | [
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PMC9429973 | The 61% survival rate without MMR loss in CML pts having the 1 TKI discontinuation after the dose reduction phase is encouraging. | [
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PMC11026382 | b DHFR and TYMS in folate metabolism. | [
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PMC11769516 | It was also found that MON is characterized by the same rate of BBB penetration as DON and morphine, which has a strong effect on the CNS, but both MON and DON penetrate the BBB only to a small extent. | [
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PMC11697189 | The annotations below the waterfall chart indicate different mutation types represented by different colors (B) The CNV variation frequency of gain and lost for HSP genes in TCGA cohort. | [
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PMC11569208 | B–D) 786-0 cells were infected with either VSV∆51-non targeting control (NTC) or VSV∆51-shACP2 (with indicated multiplicity of infection, MOI). ( | [
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PMC11742047 | The color indicates fold change between the two conditions. | [
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PMC7351993 | The insets show representative SRS images of cells in the sort (n = 108) and unsort regions (n = 11,068). | [
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PMC3730428 | An inflammatory microenvironment makes a major contribution to cancer progression and drug resistance by promoting tumor cell survival. | [
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PMC11740207 | In suitable experimental models, VSELSCs have exhibited pluripotent or multipotent capabilities (Bhartiya et al., 2012; Vojnits et al., 2014; Bhartiya, 2015), differentiating into various cell types, including skeletal cells (Havens et al., 2012), vascular endothelial cells, cardiomyocytes (Wu et al., 2011), lung epithelial cells (Jin et al., 2013), and male or female gametes (Virant-Klun et al., 2008, 2013; Bhartiya et al., 2012; Bhartiya, 2015). | [
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PMC9429973 | In particular, essential thrombocythemia (ET) and CALR mutation seem to be related to an increased efficiency of both classical coagulation pathways, with significantly more contracted clot formation times (CFT). | [
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PMC11657744 | Cilia were visualized by immunofluorescence staining using anti-Arl13b antibody. | [
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PMC11594588 | The main cause of the disruption of mitochondrial platelet metabolism is hypoxia or hyperoxia. | [
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PMC10495912 | However, TQ (75 µM) along with hydrogen peroxide can increase LDH activity in the culture medium compared to the control (p < 0.01), TQ (75 µM; p < 0.001) and hydrogen peroxide groups (p < 0.01). | [
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PMC11013014 | IR (neat): ν = 3392 (NH), 1666 (C=O Ketone), 1655 (C=O Amide) cm. | [
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PMC11201989 | Studies have demonstrated a role for known cilia regulators in immune synapse formation. | [
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PMC11732628 | After different treatments, the harvested cells were suspended in serum-free DMEM. | [
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PMC11694625 | Three independent experiments were conducted with similar results. | [
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PMC11078693 | Most approaches involve cytocentrifugation, whereby some degree of deformation is tolerated to promote strong attachment of suspension cells to a glass slide. | [
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PMC9429973 | Aims: Triplications are considered rare because the de novo crossover events that generate them occur infrequently. | [
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PMC4685407 | Guide RNA hybridizes to a target integration site and induces Cas9 protein expression, leading to DSB. | [
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PMC10847511 | Among the compounds in the CTRP1/2, those with clinical application or FDA approval were retained. | [
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PMC11765988 | Previous studies have successfully utilized MRI, particularly diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurements, to differentiate between malignant and benign lymph node pathologies. | [
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PMC10926885 | Using the UALCAN web portal, the methylation status of the NDE1 promoter region may be examined. | [
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PMC9844987 | p-values were determined using the Wilcoxon rank-sum test (*: p<0.05; **: p<0.01; ***: p<0.001; NS.: | [
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PMC11790599 | When for experimental purposes, to accurately assess the effects of treatments or to avoid any confounding influence of continuous lapatinib exposure, the growth medium is switched to complete RPMI 1640 devoid of lapatinib at least 48 h before conducting the experiments. | [
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PMC11610461 | In addition, a certain concentration of metformin was found to inhibit the proliferation, migration and invasion of KIRC cells, in which PSENEN down-regulation, AMPK up-regulation and mTOR down-regulation were also observed. | [
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PMC4360730 | Metadata integrity using facets in the curation interface. | [
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PMC10958426 | The tissues were digested with Human Tumor Dissociation Kit (Miltenyi Biotec) according to manufacturer's manual. | [
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PMC11629461 | Quantification of the calcium peak area above baseline (per 10 min) showed the statistical data from the above experiments performed multiple times (Figure 6L). | [
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PMC9684669 | In this study, we reported that the CAMK2/CREB pathway, particularly CAMK2D, is a promising target for reversing ABCB1-mediated drug resistance in ovarian cancer ( Figure 7 ). | [
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PMC11698348 | Using immunohistochemistry, we observed Elf5 protein was expressed in the basal layer (Elf5/Krt14, Fig 1d) and in the differentiated suprabasal layer of the epidermis (Elf5/Krt14). | [
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PMC11422497 | n = 3. * | [
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PMC9429973 | For discordant NGS/LC-MS cases, 9/12 (75%) were NGS/LC-MS. | [
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PMC11463018 | We ran experiments in duplicate, SD <15%. | [
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PMC7504302 | Their work showed that activin A was highly expressed in epithelioid phenotype and silencing of activin βA expression by siRNA attenuated cell viability and clonogenicity of MPM cell lines. | [
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PMC10919056 | Flow cytometry showed that knockdown of GJA5 or GJB1 inhibited cells apoptosis (Figure 12C). | [
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PMC11697065 | Stably transfected CHO cell pools and clones were routinely maintained in AstraZeneca proprietary medium. | [
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PMC8143558 | Numerous studies show evidence that saponins possess potent antiviral, , antibacterial, and antifungal activities . | [
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PMC9503541 | The bioactive metabolites from the antitrypanosomal active fractions were predicted using the OPLS-DA loading S-plot. | [
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PMC11357960 | Recently, epigenetic drugs have been shown to reduce the resistance of certain cancer patients to PD-1 inhibitors (16). | [
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PMC9429973 | Median follow-up from the index date until death or censoring was 13.8 mo (IQR: 6.2–25.3). | [
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PMC10999934 | FBXO2-dominated interaction network. | [
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PMC11513571 | Sera were measured by ELISA for the TSLP concentration (pg/mL) in both groups; MERS-CoV-infected patients (n=4) and HC; healthy noninfected group (n=5). | [
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PMC11621493 | Imaging data were processed using the LasX and ImageJ software (15). | [
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PMC11411131 | Dissociated CGCs were cultured in basal medium eagle (Thermo Fisher Scientific) supplemented with 25 mM KCl and 10% fetal bovine serum from 1 to 3 days in vitro (DIV) and subsequently cultured in minimum essential media (Thermo Fisher Scientific) containing ITS and Ara C from 4 DIV onward. | [
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PMC11206251 | Whether the PEIM inhibited HepG2 cells through apoptosis was further determined by flow cytometry. | [
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PMC11754094 | For sequences that were difficult to amplify, primers were replaced or gDNA was re-extracted. | [
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PMC9429973 | To mitigate CRS, step-up epcoritamab dosing and prophylactic corticosteroids were required in C1. | [
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PMC9429973 | DNA isolated from lymph node biopsies with reactive polyclonal B-cell proliferation (n=11) was used to control the tumor-specificity of the detected methylation. | [
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PMC10729469 | The TCRAβ-Tregs that received 0.50 μL of TCRAβ plasmid showed higher suppressive function compared to those that received 0.25 μL of the plasmid. | [
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PMC9429973 | The trial is ongoing at clinical sites in the United States and Australia. | [
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PMC11243198 | Probes specific for murine Gli1 (Mm00494654_m1) and murine β-actin (Mmo2619580_g1) were obtained from Applied Biosystems (Thermo Fisher Scientific). | [
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
... |
PMC11707577 | In vivo biodistribution of M13EGFR(TNP) in Hydra by fluorescence imaging. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"vivo",
"biodistribution",
"of",
"M13EGFR(TNP",
")",
"in",
"Hydra",
"by",
"fluor... |
PMC9429973 | For the patient relapsing without prior CH MRD positivity, the last available sample was taken 169 days before relapse & was CH MRD. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
... |
PMC6901583 | Mice were treated with IgG or αCCL2 antibody. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Mice",
"were",
"treated",
"with",
"IgG",
"or",
"αCCL2",
"antibody",
"."
]
}
] |
PMC8193813 | To our knowledge, determination of emission factors from a stack plume using a UAS-borne sampling system has not been previously demonstrated. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"To",
"our",
... |
PMC9352806 | The medium was changed every two days. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"medium",
"was",
"changed",
"every",
"two",
"days",
"."
]
}
] |
PMC9065483 | All viral titers were determined by standard plaque assay according to published protocol. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"All",
"viral",
"titers",
"were",
"determined",
"by",
"standard",
"plaque",
... |
PMC11782780 | We will increase animal experiments to provide a better theoretical basis for BC-targeted therapeutic strategies. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"We",
"will",
"increase",
"animal",
"experiments",
"to",
"pr... |
PMC11787381 | For each condition, 30 pictures (representative of the whole well area) per well were taken using ImageXpress (Molecular Devices) at 20x magnification. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9412887 | In addition, the disfunction of PTEN also promotes the aggregation of suppressive immune cells, such as bone marrow-derived suppressive immune cells (MDSCs) and regulatory T cells (Tregs) . | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
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