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OTAR3088
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BioData-CellLine_annotated

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PMC11792090
Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of DEGs. (
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PMC8540611
The control value was 90.5% for all registered events.
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PMC11754784
c Flow cytometry result of DNP enhanced phagocytosis of CEM cells by macrophages.
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PMC11509224
Seven formamido-diterpenes—cavernenes A–D, kalihinenes E–F, and kalihipyran C (1–7, Figure 3)—were isolated from the South China Sea sponge Acanthella cavernosa .
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PMC11225860
Apoptosis analysis was performed on U2932 cells treated with DMSO, Alisertib, Aurkin A, or a combination of Alisertib and Aurkin A for five days (D).
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PMC10758402
Additionally, DMF hinders the activation of signal transducer and activator of transcription 1 (STAT1) following IFN stimulation.
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PMC9398137
In such cells, S63845 displaces the pro-apoptotic activator BIM or effector protein BAK1 from MCL1 thereby triggering apoptosis.
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PMC11711345
However, p-cymene has not been shown to induce antiproliferation in several HCCLs, such as HT-1080 (≤ 800 µM) , A549 (lung adenocarcinoma), DLD-1 (colon adenocarcinoma) (≤ 100 µM), Hep3B (≤ 10 µM) , and HepG2 (hepatic carcinomas) (≤ 25 µg/ml) .
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PMC3734024
These data therefore suggest that, rather than enhancing the effects of IL-5, IL-4 instead strongly inhibited the killing function induced by IL-5 in B cells.
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PMC9429973
Patient chracteristics, treatment and outcomes Image: Summary/Conclusion: SF3B1 mutation is an uncommon event in MF and does not substantially affect the disease phenotype and outcomes.
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PMC9817179
Figure 1—figure supplement 3.Fixation at various paraformaldehyde (PFA) concentrations can change the apparent liquid–liquid phase separation (LLPS) behaviors of EGFP-EWS(IDR).We show the percentage change of LLPS parameters after 10 min of fixation.
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PMC9429973
Mutation analysis identified at least one somatic non-synonymous mutation in 92.2% (71/77) of patients in the LN biopsy and in 87.0% (67/77) in the ctDNA.
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PMC10907726
Fig. 3The overview of RNA-seq. (
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PMC10978090
Heparin-induced platelet activation assay (HIPA) was performed as previously reported.
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PMC11791432
Then, the t-distributed Stochastic Neighbor Embedding (tSNE) algorithm and the Umap method were applied to reduce the dimensionality of the initial PC , and cluster classification analysis was performed in all cells, with Resolution chosen as 0.5.
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PMC11727638
The central cells in the Cell Dome were hypoxic, with an oxygen concentration gradient within the Cell Dome.
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PMC11350568
Comparison of the binding ability of aptamers against that of A549 cells.
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PMC11078693
Alternatives: Any confocal microscope can be used for imaging.b.
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PMC11633763
Therefore, to investigate the molecular mechanism by which USP22 activates HK2 in osteosarcoma cells, we verified whether endogenous USP22 and HK2 directly bind to 143B cells.
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PMC8839885
Measurements of platinum intracellular concentration: To monitor the platinum intracellular concentration of cisplatin (IV) prodrugs into OC cell lines, the experiment was carried out as previously described .
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PMC9429973
Of 13 with >5% blasts, 12 (92%; 90% confidence interval 68-100%) achieved CR/CRi, 10 (77%) after 1 cycle.
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PMC8193046
The best alignment was selected and the pharmacophore model was generated using the consensus method implemented in the Pharmacophore Query Editor with a threshold value of 50.0% and a tolerance distance of 1.2 Å. The conformers of the most potent multitarget ABCB1, ABCC1, and ABCG2 inhibitor in this work, compound 23, were generated using the conformational search tool by selecting the stochastic search method implemented in MOE 2019.01.
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PMC11612508
Magnetic microspheres can also be easily moved and collected with an external magnetic field, making them a desirable choice for drug delivery using a remote magnetic field.
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PMC11583010
MaxiSorp wells were coated overnight at +4°C with 10 nmol/L of recombinant soluble nectin-1VCC-Fc, nectin-4V-Fc, and nectin-4VCC-Fc in PBS buffer (3).
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PMC11655498
EBV-encoded BALF3 is involved not only in viral DNA synthesis but also in the packaging and release of mature virus particles (Chiu et al., 2014).
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PMC11656657
Figure created using Biorender—https://biorender.com.
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PMC10955424
Pharmaceutical inhibitors targeting the IL −6/ JAK signalling pathway, such as ruxolitinib and tofacitinib, were mildly effective in overcoming platinum chemoresistance induced by malignant ascites.
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PMC10222971
They were centrifuged, and the supernatant was discarded.
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PMC8382973
At autopsy, rectal and vaginal irritation was assessed by the Eckstein method, which reflects the collective histopathological grading of four parameters within the vagina, including epithelial morphology, leucocyte infiltration, congestion, and edema.
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PMC6450504
n = 4) Each point represents a mean ± S.D., two-way ANOVA with Dunnett’s multiple comparisons. ****
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PMC11687167
In recent years, SREBPs were found to be upregulated in a variety of tumors, to promote tumor growth, and to provide a mechanistic link between altered lipid metabolism and malignancy [105–107].
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PMC5035325
4T1-model showed a similar result (25 %) (Fig. 4e).
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PMC11283030
After ORO (Solarbio, China) staining, the LDs in the cytoplasm were observed under microscopy and quantified with ImageJ software.
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PMC11730000
In contrast, EGCG alone or in combination with RA did not reduce ROS formation compared with the DOX-treated group (Figure 5).
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PMC11269933
The results showed that, except for the known vertebrates (human and mouse), the PK genes in the genomes of the remaining species were single-copy genes (Figure 1A).
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PMC10222971
Regarding the analogues investigated, cytotoxic properties for derivatives 4, 6 and 10, are described for the first time.
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PMC6190245
After 24, 48 and 72 hr of treatment, media were changed and one of the two similar plates was exposed to 2 Gy γ-rays.
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PMC11764090
The normal functions and structures of cells are disrupted by the destruction of the plasma membrane and organelle membrane systems under cold stress.
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PMC11740573
Such modulatory activity is related to the fact that liposoluble compounds increase the bacterial cell membrane permeability for various substances, including antibiotics, to enter inside .
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PMC6487404
The Caco-2 cell model is generally considered as a standard method to determine preliminarily whether a compound is a P-gp substrate or not.
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PMC8633974
Gel extracted PCR amplicons, and total PCR contents were sequenced and subjected to Synthego Inference of CRISPR Edits (ICE) Analysis v2.0 (https://ice.synthego.com/#/).
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PMC6312945
HBV is a type of hepadnavirus that has a very high mutation rate; although it can be controlled, it cannot be completely eliminated, and it is one of viruses which is the most difficult to cure under present medical technology (1).
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PMC7685376
A and B) Pie diagram of GO enrichment of differential proteins.
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PMC11026382
Round the Horn’ or inverse PCR (iPCR) with mutagenic NNS primers (N = A/T/G/C, S = G/C) was used to introduce all 20 amino acid substitutions at a single amino acid position as described in Thompson et al. (see Appendix 1 of Thompson et al for a complete list of primers).
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PMC5811757
The results showed that CRISPR/Cas9 system could significantly reduce the expression of P-gp.
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PMC9444294
Middle column: single-channel immunofluorescence staining of BRG1 protein.
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PMC9878278
BMP6 and activins control SC differentiation via the SMAD transcription factors and are vital for maintaining spermatogenesis and immune homeostasis (Wang et al., 2017).
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PMC11577421
However, the CD spectrum of BSA– displayed visible structural alterations, consistent with previous reports indicating partial denaturation of BSA upon succinylation.
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PMC9429973
Results: A total of 18 patients met inclusion criteria for the PK deficiency cohort (mean [SD] age: 56.8 [13.6] years, 94.4% male, mean [SD] duration of follow-up: 7.3 [5.2] years) and were matched to 90 individuals in the general population who became the non-PK deficiency cohort (mean [SD] age: 56.8 [13.1] years, 94.4% male, mean [SD] duration of follow-up: 9.2 [5.8] years).
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PMC8316344
Membrane fractions were extracted by a Fatty Acid Extraction Kit, while AA and AdA were measured by ELISA-based kits.
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PMC11703992
Combined with the low mTOR protein activity of the highly active subpopulation of DDIT4 mentioned above (Fig. 6C), we suggest that DDIT4 causes only a limited increase in T-cell activity after antigen stimulation.
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PMC6024716
It is also possible that the effect of metabolic load is cell line dependent .
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PMC11634794
Notably, none of the included patients exhibited lymph node metastasis; hence N stage assessment was not applicable.
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PMC9786247
In contrast, bovine mammary gland epithelial cells showed no immune response after infection with the reference strains NMI and NMII during the first 24 h p.i. .
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PMC10873328
Six hub genes (TGFBI, CDKN1B, AKAP12, GPC1, TGM2 and ANGPTL4) were selected to create a HRGs prognosis classifier and four genes (TGFBI, AKAP12, GPC1 and TGM2) were selected to construct diagnosis classifiers.
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PMC11672142
A recent study exploring Fe(II/III) complexation by Trp and Trp analogues revealed that complexes that exhibited a reversible redox couple less than E1/2 = 0.2 V vs NHE and not greater than E1/2 = 0.5 V vs NHE could effectively redox cycle in the cellular environment and reduce the tyrosyl radical of RNR R2.
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PMC11707832
in vitro experiments further confirmed that exposing alveolar macrophages to morpholine induced a time-dependent elevation in α-mannosidase activity.
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PMC11476004
The analyses in the present study identifying chromosomal instabilities provide new scientific information about the genome of these animals.
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PMC11352666
Approximately 1 million cells were cultured in a 6-well plate and allowed to adhere overnight, then treated with MRX-2843 or an equivalent volume of DMSO vehicle for 1 h. Cells were treated with pervanadate phosphatase inhibitor, and MERTK was immunoprecipitated as previously described .
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PMC10932641
The abnormal activation of this signaling pathway is closely related to the increase of tumor incidence, malignant progression, poor prognosis, and even the increase of related mortality (37,38).
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PMC9596868
Given the synergism observed by us in the current study, we also propose further investigations to explore the co-treatment as a cancer preventive and post-treatment supportive therapy to prevent cancer recurrence.
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PMC10938336
Of note, the Venn diagram revealed 263 potential anticancer genes specifically associated with curcumin.
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PMC11536589
We also observed that CTNNB1 or TCF4 knockdown decreased the viability of AsPC1-MR and KPC210-MR cells treated with Erastin or MRTX1133 (Fig. 5J and S3E).
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PMC10969097
With regard to the health benefits of mushrooms, in one study, an ethanolic extract of Pleurotus pulmonarius proved effective in reducing the negative effects of a high-fat diet in hyperlipidaemic rats, showing hypolipidaemic, antioxidant and anti-inflammatory properties, inhibiting the levels of NF-κB2, STAT3 and CREB1 .
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PMC11024707
The solution was mixed by pipetting up and down several times.
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PMC11604830
In vitro H‐CSI of PEG‐LIPO, PEG‐MIC, and PFCE‐NE.
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PMC11635519
PepA3 is derived from the FZ domain of the human CPZ, a zinc-containing metallocarboxypeptidase that cleaves C-terminal amino acids from proteins and peptides.
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PMC11248911
The compound was created using Marvin sketch.
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PMC11612315
Therefore, our study indicated that GLP-1-derived peptides offer effective pain relief without these significant adverse effects, suggesting their potential as safer alternatives for chronic pain management.
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PMC8992508
Compound 94 showed a concentration dependent cytostatic effect on proliferating MCF-7/Topo cells that could be ascribed to the reactive α−β-unsaturated ketone core.
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PMC11765243
Intriguingly, the level of ICOS expression in p110αKD-T CD4 cells from immunized mice was increased (Figure 9A, left panel).
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PMC9429973
A greater proportion of RUX vs BAT responders had severe disease (56.3% [71/126] vs 44.4% [44/99]).
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PMC11704834
Importantly, high TLE1 expression strongly associated with shorter overall survival (OS) and disease-free survival in patients with LUAD (Fig. 1B).
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PMC11742047
The PCA plot, a non-supervised multivariate analysis, displayed a tight clustering of the QC, revealing low instrumental variation (Figure Supporting information 1).
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PMC9812014
A comprehensive study reported that cyclopamine (CPM) alkaloid and its chemical analogue A3E have potent anti-RSV activities.
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PMC9325715
Nearly 1.5 mg of the complex was suspended in 0.5 mL of the buffer and incubated for 2 h. Subsequently, mixtures were filtrated with Amicon Ultra Centrifugal Filtres cut-off 3 kDa.
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PMC11769516
During treatment with the discussed mycotoxin, the researchers observed chromatin aggregation and condensation, the lack of nuclei and severe cytoplasmic edema and the lack of nuclear and subcellular organelles and mitochondrial edema with increased DON concentration .
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PMC11756514
Data are presented normalized to CP- and depicted as the mean +/- sd, Langerin; five independent experiments, Mannan-binding lectin; four independent experiments, ****p < 0.0001, two-way ANOVA followed by Dunnett’s multiple comparison test.
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PMC11248911
HNMR (DMSO-d6, δ ppm): 2.19 (s, 3H, CH3), 2.95–3.01 (dd, 1H, pyrazoline, J = 4.00, 18.64 Hz), 3.74–3.82 (dd, 1H, pyrazoline), 3.82 (s, 3H, OCH3), 3.83 (s, 3H, OCH3), 5.70–5.74 (dd, 1H, pyrazoline, J = 4.00, 11.04 Hz), 7.16–7.58 (m, 9H, Ar–H and CH-benzylidene).
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PMC3813807
Gastric cancer is a heterogeneous disease with various subtypes.
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PMC8345486
It is known that OVCAR-3 loses its resistance in adhesive cultures in vitro.
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PMC7840816
Then 500 μl of DMEM containing 10% FBS was added to the bottom chamber.
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PMC7081114
KIF21B expression level (P < 0.01) and age were independent risk factors for DFS (Table 3).
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PMC9429973
Three patients in SB12 and 2 patients in ECU had serious TEAEs.
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PMC9429973
F. Efficace, F. Cottone, B. Yanez, F. Castagnetti, G. Caocci, M. Bonifacio, A. Patriarca, I. Capodanno, M. C. Miggiano, M. Tiribelli, M. Breccia, L. Luciano, V. Giai, A. Iurlo, E. Abruzzese, C. Fava, G. Rosti, J. Cortes, V. Kota, M. Vignetti, D. Cella Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Italy; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States of America; Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna; Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari; Section of Hematology, Department of Medicine, University of Verona, Verona; Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara; Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia; Hematology Department, San Bortolo Hospital, Vicenza; Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine; Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome; Haematology Unit “Federico II”, University of Naples, Naples; Hematology Unit, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, Torino; Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano; Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Rome; Department of Clinical and Biological Sciences, University of Turin, Turin; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori”, Meldola, Italy; Georgia Cancer Center, Augusta University Medical Center, Augusta, United States of America Background: Adherence to tyrosine kinase inhibitors (TKIs) is critical to maximize clinical effectiveness of drugs in patients with chronic myeloid leukemia (CML).
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PMC9250505
In a clinical trial (NCT00753545) a patient population with EOC containing TP53 mutations attained a significant OS benefit from Olaparib treatment regardless of BRCA mutant status.
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PMC10578720
The differences in metabolic patterns within the macrophages between higher HBV titers (10 IU/mL) and lower titers (0, 10 IU/mL) were visualized in heatmaps (Figure 2F).
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PMC9964654
The advantages of polymeric micelles include, among others: (i) an ability to solubilize hydrophobic or poorly water-soluble drugs within their cores, thus enhancing bioavailability; (ii) hydrophilic coronas that allow for longer durations in blood circulation, prevent quick uptake by the reticuloendothelial system (RES), and give steric stability; (iii) biocompatibility; and (iv) low toxicity .
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PMC11019355
Mechanisms underlying phenotypic divergence across species remain unresolved.
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PMC10988808
Scar bar, 100 μm We collected tumor tissues and corresponding adjacent non-tumor tissues from ccRCC (clear cell renal cell carcinoma) patients.
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PMC9429973
There is a decrease in the amount of RBC units transfused per patient.
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PMC11648299
The results support previously proposed molecular links between Darier disease and skin cancer, but further investigations are needed.
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PMC11604768
The investigators were not blinded to allocation during experiments and outcome assessment.
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PMC10898159
HDAC inhibitors, SAHA and LBH589, attenuate the activity of HSP90 by acetylating on HSP90 gene.
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PMC11502962
The results showed that macrophages were increased and CD8 T cells were exhausted with tumor progression, which is similar to other studies (11, 18).
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PMC10568263
This study establishes HSP70 as a potential biomarker for monitoring therapeutic response during anticancer therapy.
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PMC9429973
The subgroups were formed as follows: Responder: Complete response (CR); non-responder: Incomplete or failure.
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PMC11783017
The peaks corresponding to the C-H, C=O and N-H vibrations were enhanced in Lipo-IL11 as compared to Lipo. (
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PMC9429973
The age-adjusted VTE incidence rates for females and males with newly diagnosed MBL/CLL were 1275 and 1228 per 100,000 person-years, respectively.
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PMC11361748
We next applied a Triton X-100-based fractionation protocol to monitor the partitioning of K17, RACK1, and PKCα proteins in parental A431 keratinocytes after Tx with TPA.
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