OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11774112	The mouse weights did not differ between the groups that received different therapeutic regimens and the control group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mouse", "weights", "did", ...
PMC11782508	Cells were cultured in a production medium at 150 rpm and 32 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "in", "a", "production", "medium", "...
PMC8097906	F-actin filaments in the processed images are shown as colored lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F-actin", "filaments", "in", "the", "processed", "images", "are", "shown", "as", "col...
PMC11763111	Peripheral blood was collected weekly to monitor HuCD45 CAR-T cell counts via flow cytometry and tumor progression was tracked using bioluminescence imaging (Fig. 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7841189	Experiments were performed in triplicate. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "performed", "in", "triplicate", ".", "*" ] } ]
PMC9429973	Results: The results indicated that ZnO NPs could significantly inhibit human MM cell proliferation and cell death in a time- and dose-dependent manner in vitro, and this outcome can be confirmed by cell morphology and apoptosis assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544771	For this, A549 and A427 cells were treated with CPX (0–10 μM) with or without PRE (0–20 nM) for 72 h, followed by the MTS assay.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11700165	Cells were treated overnight with the proteasome inhibitor MG = MG132 (10 μM) or DMSO (control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "treated", ...
PMC11711871	Recently, angiotensin II infusion of wild-type C57BL/6J mice increased the levels of proinflammatory oxylipins, including hydroxyeicosatetraenoic acids (HETEs) and dihydroxyoctadecenoic acids (DiHOMEs), which are implicated in immune responses and cytotoxic processes and thus contribute to senescence and oxidative stress .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584319	These results were obtained under conditions wherein AZD8055 treatment did not affect cell viability (Figure 2c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "were", "obtained", ...
PMC11683240	Cells were left untreated as further control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "left", "untreated", "as", "further", "control", "." ] } ]
PMC9509578	In addition to carcinogenesis, CYP2 and CYP3 enzymes also contribute to MDR by activation or degradation of chemotherapeutic agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", ...
PMC9429973	This increase was above the upper normal limit in the majority of patients (16/22), although 13/22 had normal baseline levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11507371	For treatment, the distance from the tip of the plasma jet to the surface of the medium was set to 1 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11529598	These data showed that miR-3154 promotes glioblastoma cells metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "showed", "that", "miR-3154", "promotes", "glioblastoma", "cells", "metastasis", "." ] ...
PMC11476004	In addition, Rossner et al. tested the frequency of chromosomal instability in peripheral blood lymphocytes in non-melanoma skin cancer to confirm the hypothesis of a positive correlation between the frequency of instability in lymphocytes and cancer risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8609870	Subsequently, we measured the RNA concentration and purity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "measured", "the", "RNA", "concentration", "and", "purity", "." ] } ]
PMC11599565	The cells were then washed with cold PBS, trypsinised, resuspended in DMEM containing 10% FCS and centrifuged at 300×g for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	n = 14 mice per genotype, two-way ANOVA, Bonferroni’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "14", "mice", "per", "genotype", ",", "two-way", ...
PMC11188874	To determine whether the effect was specific to SIINFEKL or more broadly applicable, multiple myeloma cells with an anti-HLA-ABC antibody and then cocultured with autologous T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11089031	For the wound healing assay, 1.5 × 10 cells were seeded into a 24-well plate and cultured for 12–18 h. A wound was made using a white Corning pipette tip, and the wells were washed with PBS to remove cell debris and maintained with DMEM without FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	The membranes were incubated overnight at 4 °C with primary antibodies against GAPDH (Trevigen, Gaithersburg, MD, USA), KIT (Dako or Cell Signaling Technology, Beverly, MA, USA), HA (Cell Signaling Technology), phospho-KIT (Cell Signaling Technology), AKT (Cell Signaling Technology), phospho-AKT (Cell Signaling Technology), ERK (Santa Cruz Biotechnology, Santa Cruz, CA, USA), phospho-ERK (Santa Cruz Biotechnology), P85 (Cell Signaling Technology), GRB2 (Cell Signaling Technology), GBF1 (BD Biosciences; NJ, USA), GM130 (BD Biosciences), Golgin97 (MyBioSource, San Diego, CA, USA), TGN38 (Bio-Rad Laboratories, Hercules, CA, USA), GRASP55 (Abcam), GRASP65 (Invitrogen, Carlsbad, CA, USA), BLZF1 (Novus Biologicals, Littleton, CO, USA), STX3 (Abcam), STX6 (Cell Signaling Technology), GOLPH3 (LifeSpan Biosciences, Seattle, WA, USA), ATF6 (Abcam), IRE1α (Cell Signaling Technology), phospho-IRE1α (Novus Biologicals), PERK (Cell Signaling Technology), phospho-PERK (Cell Signaling Technology), CHOP (Cell Signaling Technology), BIP (Cell Signaling Technology), GRP94 (Cell Signaling Technology), HSP70 (Abcam) and HSP90 (Cell Signaling Technology).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The results were obtained from a representative real-world evidence dataset analyzed over a 12-year period, which was sufficient to observe EOD events, and are generalizable to the UK and similar populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761218	Approximately 29% of all malignancies are lung cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "29", "%", "of", "all", "malignancies", "are", "lung", "cancers", "." ] } ]
PMC8735881	LTR, long terminal repeat; RRE, Rev response element; cPPT, central polypurine track; PGK, human PGK promoter; DAF, delay-accelerating factor; WPRE, woodchuck hepatitits virus posttranscription regulatory element. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7570809	Statistical analysis was performed using a t-test where p < 0.05 was considered to indicate a statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", ...
PMC9429973	Thirteen patients (28.8%) were followed up in the intensive care unit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thirteen", "patients", "(", "28.8", "%", ")", "were", "followed"...
PMC11633763	As a member of the DUB family, USP22 exerts its function by binding to its substrate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "member", "of", "the", "DUB", ...
PMC7057940	In addition, it was also clear that the EWS and FLI1 genes were present in this sample (patient 2), leading to the conclusion that the proportion of cells with the fusion gene in this case could be significantly smaller than that without the translocation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	Although each of the above approaches has its specific advantages, the method presented here is unique in that the microfluidic device is disconnected from flow control for most of the experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	Six FOVs were imaged per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Six", "FOVs", "were", "imaged", "per", "well", "." ] } ]
PMC11627060	Prior studies have also indicated that Baicalin-loaded folic acid-modified albumin NPs can trigger apoptosis and oxidative stress in MCF-7 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Prior", "studies", ...
PMC9532503	Supplementary Figure S1 shows the chromatogram for affinity chromatography.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supplementary", "Figure", "S1", "shows", "the", "chromatogram", "for", "affinity", "chromatography", "." ...
PMC9429973	Romiplostim (ROM), a thrombopoietin receptor agonist (TPO-RA), has shown safety and clinical efficacy in prospective trials in LR-MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11634027	The ds allele may thus prove useful for future investigations of this question.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ds", "allele", "may", "thus", "prove", "useful", "for", "futur...
PMC10335954	Cells were seeded into 6-well plates at a density of 500 cells/well, incubated at 37 °C in a 5% CO2 incubator, and observed for 10 days with half of the medium changed every 3 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	The wells were exposed to different concentrations of extract (1.5 mg/mL, 2.0 mg/mL, and 2.5 mg/mL) prepared in complete media, and incubated for 24 h. After 24 h the media were removed and wells were washed twice with sterile distilled water, then different concentrations of t-BHP (0, 100 µM, 150 µM, 200 µM), were dissolved in complete media and were added to all groups, except control and incubated for 24 h .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11349530	In addition, there is a big variability in patient responses, and in most cases, patients do not respond to immune checkpoint immunotherapy (92).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strategies", "to", "control", "HIV-1", "replication", "without", ...
PMC10470467	The above results have shown that there may exist differences in response to immunotherapy for patients in distinct subgroups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "results", "have",...
PMC6461034	Erlotinib‐resistant HCC827‐ER3 NSCLC cells with mutant EGFR.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Erlotinib‐resistant", "HCC827‐ER3", "NSCLC", "cells", "with", "mutant", "EGFR", "." ] } ]
PMC11506827	Although surgery is the standard treatment for localized RCC, the recurrence rate is high .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "surgery", "is", "the", "standard", "treatment", ...
PMC11045125	EBV-infected BLs support restricted forms of viral latency that do not transform B cells in vitro and lack expression of the major EBV oncoproteins, EBNA2 and LMP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	Immunosuppression also plays a role in the pathogenesis, but to a smaller extent than in NHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunosuppression", "also", "plays", "a", "role",...
PMC11754436	The preliminary qualitative analysis by immunohistochemical staining indicated that the expression levels of Bcl2 in the shDHRS4-AS1 group were higher than those in the control group, while the expression levels of Bax and caspase 3 in the shDHRS4-AS1 group were lower than those in the control group (Fig. 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11464982	However, the likelihood of such reactions will not exceed the likelihood of allergic reactions to Penicillium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "likelihood", "of", "...
PMC9429973	Interestingly, this observation was correlated with the fact that synapse capability was only partially recovered in CD4 T-cells but not in CD8 T-cells (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No surgical history or medication were reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "surgical", "history", "or", "medication", "were", "reported", "." ] } ]
PMC11098378	Following incubation, 300 μL TBS buffer (25 mM Tris-HCl pH 7.4, 150 mM NaCl, 1 mM DTT) and 30 μL of washed GST beads were added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792090	Survival curves of mice in each treatment group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "curves", "of", "mice", "in", "each", "treatment", "group", ".", "(" ] } ]
PMC11402217	ns = no significance.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ns", "=", "no", "significance", "." ] } ]
PMC10698968	Currently, the gold standard treatment of localized MFS is surgery with free margins from neoplastic infiltration, alone or in combination with (neo) adjuvant radio- or chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11482552	Jurkat cell line samples at three different concentrations were subsequently evaluated using the OncoPredict HPV Quality Control (QC) real-time PCR assay, employing CCR5 for molecular cellularity quantification.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761218	The collected plant material was thoroughly washed three times with running water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "collected", "plant", "material", "was", "thoroughly", "washed", "three", ...
PMC11352311	Isomeric SMILES: C1=CC(=O)OC2=CC(=C(C=C21)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O. RCC targets were obtained from GeneCards (https://www.genecards.org) (accessed on 11 August 2024) by searching for “Renal cell carcinoma” and saving the relevant disease genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8343815	The optical density (OD) of dissolved formazan is equivalent to the number of viable cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optical", "density", "(", "OD", ")",...
PMC9429973	Cox regression models were used to analyse prognosis factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cox", "regression", "models", "were", "used", "to", "analyse", "prognosis", "factors", "." ] } ]
PMC3122064	Our results show that combining non-toxic concentrations of Nutlin-3 with cisplatin sensitises both intrinsic as well as acquired cisplatin-resistant TC cells to low concentrations of cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11144200	Next, these tumor sections were subjected to immuno-staining with anti-Ki-67 mAb (Biolegend, China, Cat No. 328605), and the results were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	The PAE also shows that the aa 187–216 region of CENP-T binds to Mis12C with high reliability (Figure S3C; rank_1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC8913139	Then, the luciferase vector was transfected into A-172 MG cells containing miR-448 mimics for 48 h. Luciferase activity was measured by dual luciferase assay system (Promega, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11047729	Vitamin A is a vital nutrient that serves several purposes in the human body .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vitamin", "A", "is", "a", "vital", "nutrient", "that", "serves",...
PMC11453018	Initial results showed that iP300w treatment reduced cell viability in EWS::ERG cells, though this effect was less pronounced compared to EWS::FLI1 cell lines at 48 h, as measured by the ATP assay (Supplementary Fig. 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	Additionally, GLPT not only inhibited mTORC1-mediated S6K1 and 4E-BP1 phosphorylation but also repressed mTORC2-mediated Akt phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "GLPT", "not", "only", ...
PMC10940855	Among patients in the CoMMpass trial, those with the highest decile of EFNB2 expression demonstrated decreased progression-free survival and decreased overall survival compared with all other patients (Fig. 6F and G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	The pLEX-JRed vector was obtained from the Royan Institute in Tehran.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pLEX-JRed", "vector", "was", "obtained", "from", "the", "Royan", "Institute", ...
PMC11482552	The Thoma chamber slide was observed using an inverted microscope (Olympus) with a 10× objective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Thoma", "chamber", "slide", "wa...
PMC6617630	Fig. 6Effect of I-BET and JQ1 on cell surface expression of CD47 and PD-L1 on WT, DHL and THL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Effect", ...
PMC10969097	After 24 h of treatment, the IC50 values were 39.917 μM in SKOV3 cells and 207.191 μM in SKOV3/DDP cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "After", ...
PMC11694625	MTT results showed that they all displayed broad-spectrum antiproliferative activity against selected cancer cell lines (BGC-823, BEL-7402, MCF-7 and A549).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", ...
PMC11765243	In contrast, in the CD4 T cell population the percentages of naïve and memory lymphocytes were not altered in p110αKD-T spleens (Figure S5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9221284	All Burkitt lymphoma cell lines that were studied exhibited doublet bands (Figure 2B): c-Myc2 (64 kDa) and probably its phosphorylated form (65 kDa).	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	Duplicate reads were removed using SAMtools rmdup and peaks called with MACS2 callpeak on the usegalaxy.eu platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Duplicate", "reads", "were", "removed", "using", ...
PMC11703896	However, despite its therapeutic potential, the clinical application of rapamycin faces several limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "despite", "its", "therapeutic", "potential", ...
PMC11754784	Data are represented as mean ± s.d. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "represented", "as", "mean", "±", "s.d", ".", "(" ] } ]
PMC10114490	Genes significantly enriched (p < 0.05) in diHLC-T are highlighted in a red box, while those genes significantly enriched (p < 0.05) in HepG2 are highlighted in a green box (only ABCB6, top).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Although KU70 and KU80 subunits are predominantly localized in the nucleus, they are also present in the cytoplasm and at the cytoplasmic membrane, where they have been implicated in numerous cellular processes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590870	Therefore, natural antioxidants have been suggested as an alternative to prevent this disorder.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "natural", "antioxidants", "have", "been", "suggested...
PMC11407042	A high concentration of serum may lead to a high background absorbance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "high", "concentration", "of", "serum", "may", "lead", "to", "a", "hig...
PMC9429973	Methods: 27 adult MM patients who underwent ASCT at The Stem Cell Transplant Center of Dokuz Eylul University Hospital between October 2011 and August 2021 and who relapsed within 18 months of transplantation were included in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. Sadovskaya, N. Petinati, N. Kapranov, N. Drize, A. Vasilieva, O. Gavrilina, E. Parovichnikova Faculty of biology, Department of Immunology, Lomonosov Moscow State University; NATIONAL MEDICAL RESEARCH CENTER FOR HEMATOLOGY, Moscow, Russia Background: The stromal microenvironment plays a key role in both maintaining normal hematopoiesis and assisting malignant cells during leukemia development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7612475	Coverslips were mounted with Cytoseal and imaged and exchanges counted using a Nikon Eclipse Ti-S microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coverslips", "were", "mounted", "with", "Cytoseal", "a...
PMC11371747	Relative protection by l-LV from antifolate (PMX, PLX and RTX) -induced growth inhibition of NSCLC and MPM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "protection"...
PMC11357960	In conclusion, our research developed a predictive method, based on the gene expression of three SUMO machinery components (SUMO1, SUMO3 and UBE2I), to distinguish the resistance to anti-PD-1 immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	Results of the correlation between TFRC-ir and histopathological GIST characteristics are summarized in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "of", "the", "correlation", "between", "TFRC-ir", ...
PMC9856122	Viral infections have become a serious global concern for health workers due to their uncontrollable morbidity and death rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viral", "infections", "have", "be...
PMC8557138	Ex vivo assays enable the spatial organization of various cell types and extracellular matrices along with spatial–temporal gradients of angiogenic factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ex", ...
PMC11705862	The following model specifications were used: Imer (IRIS-1/ 2 ∼ ptau + (1\| case), REML = FALSE, control = lmerControl (‘bobyqa’), data = MixedModel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	This ATF6α∆ clone was re-targeted with a unique sgRNA/Cas9, alongside ATF6α_LD, ATF6α_LD, or ATF6α_LD repair templates (Figure 5B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11767793	The colloidal stability of the Au-PEI@NIST in physiologically relevant conditions was studied previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colloidal", "stability", "of", "the", "Au-PEI@NIST", "in", "physiolo...
PMC11143482	To examine the ability of tumour formation and pulmonary metastases development, cancer cell lines were inoculated at two locations: lower hind leg (primary) and back (metastasis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10440586	The scRNA-seq profiles of GBM samples conducted by Neftel et al. was obtained from the Single Cell Portal (https://singlecell.broadinstitute.org/single_cell) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scRNA-seq", ...
PMC11701801	Before all downstream analyses, duplicate reads were removed using the MarkDuplicates command in Picard version 2.26.11 (RRID: SCR_006525; http://broadinstitute.github.io/picard).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9454178	Interestingly, we found that c-KIT transcription and protein expression were significantly inhibited after CDK7 knockdown or THZ1 treatment in both GIST T1 and 882 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "B-CellLine"...
PMC5330095	Lamivudine and interferon alpha were used as positive controls against HBV and HCV, respectively, and they significantly inhibited viral replication at the single-dose assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11703896	The hexahedron cells were found to have change to round and shrunken morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hexahedron", "cells", "were", "found", "to", "have", "change", ...
PMC11723947	HP1α-deficiency therefore enables donor-specific murine Tconv to maintain their effector functions in a Treg-mediated immunosuppressive environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HP1α-deficiency", "therefore", "enables", "donor-specific", ...
PMC9429973	were significantly associated with a shorter OS in the univariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "were", "significantly", "associated", "with", "a", "shorter", "OS", "in", "the", "uni...
PMC9792775	Cell samples were randomly allocated to four groups with three parallel samples per group (Group I, control group containing untreated A-204 and HT-1080 tumor cells; Group II, A-204 and HT-1080 tumor cells treated with PTX; Group III, A-204 and HT-1080 tumor cells treated with LFU, 100 mW, 5 min; Group IV, A-204 and HT-1080 tumor cells treated with LFU, 100 mW, 5 min, Plus PTX).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC11541409	Ripretinib, a fourth-line therapy, has shown broad efficacy against most mutant types of KIT/PDGFRA, with moderate inhibition of JM domain and ATP-binding site mutations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11774112

The mouse weights did not differ between the groups that received different therapeutic regimens and the control group. (

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PMC11782508

Cells were cultured in a production medium at 150 rpm and 32 °C.

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PMC8097906

F-actin filaments in the processed images are shown as colored lines.

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PMC11763111

Peripheral blood was collected weekly to monitor HuCD45 CAR-T cell counts via flow cytometry and tumor progression was tracked using bioluminescence imaging (Fig. 7B).

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PMC7841189

Experiments were performed in triplicate. *

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PMC9429973

Results: The results indicated that ZnO NPs could significantly inhibit human MM cell proliferation and cell death in a time- and dose-dependent manner in vitro, and this outcome can be confirmed by cell morphology and apoptosis assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11544771

For this, A549 and A427 cells were treated with CPX (0–10 μM) with or without PRE (0–20 nM) for 72 h, followed by the MTS assay.

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PMC11700165

Cells were treated overnight with the proteasome inhibitor MG = MG132 (10 μM) or DMSO (control).

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PMC11711871

Recently, angiotensin II infusion of wild-type C57BL/6J mice increased the levels of proinflammatory oxylipins, including hydroxyeicosatetraenoic acids (HETEs) and dihydroxyoctadecenoic acids (DiHOMEs), which are implicated in immune responses and cytotoxic processes and thus contribute to senescence and oxidative stress .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8584319

These results were obtained under conditions wherein AZD8055 treatment did not affect cell viability (Figure 2c).

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PMC11683240

Cells were left untreated as further control.

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PMC9509578

In addition to carcinogenesis, CYP2 and CYP3 enzymes also contribute to MDR by activation or degradation of chemotherapeutic agents.

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PMC9429973

This increase was above the upper normal limit in the majority of patients (16/22), although 13/22 had normal baseline levels.

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PMC11507371

For treatment, the distance from the tip of the plasma jet to the surface of the medium was set to 1 cm.

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PMC11529598

These data showed that miR-3154 promotes glioblastoma cells metastasis.

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PMC11476004

In addition, Rossner et al. tested the frequency of chromosomal instability in peripheral blood lymphocytes in non-melanoma skin cancer to confirm the hypothesis of a positive correlation between the frequency of instability in lymphocytes and cancer risk.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8609870

Subsequently, we measured the RNA concentration and purity.

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PMC11599565

The cells were then washed with cold PBS, trypsinised, resuspended in DMEM containing 10% FCS and centrifuged at 300×g for 5 min.

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PMC11001582

n = 14 mice per genotype, two-way ANOVA, Bonferroni’s multiple comparison.

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PMC11188874

To determine whether the effect was specific to SIINFEKL or more broadly applicable, multiple myeloma cells with an anti-HLA-ABC antibody and then cocultured with autologous T cells.

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PMC11089031

For the wound healing assay, 1.5 × 10 cells were seeded into a 24-well plate and cultured for 12–18 h. A wound was made using a white Corning pipette tip, and the wells were washed with PBS to remove cell debris and maintained with DMEM without FBS.

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PMC10589262

The membranes were incubated overnight at 4 °C with primary antibodies against GAPDH (Trevigen, Gaithersburg, MD, USA), KIT (Dako or Cell Signaling Technology, Beverly, MA, USA), HA (Cell Signaling Technology), phospho-KIT (Cell Signaling Technology), AKT (Cell Signaling Technology), phospho-AKT (Cell Signaling Technology), ERK (Santa Cruz Biotechnology, Santa Cruz, CA, USA), phospho-ERK (Santa Cruz Biotechnology), P85 (Cell Signaling Technology), GRB2 (Cell Signaling Technology), GBF1 (BD Biosciences; NJ, USA), GM130 (BD Biosciences), Golgin97 (MyBioSource, San Diego, CA, USA), TGN38 (Bio-Rad Laboratories, Hercules, CA, USA), GRASP55 (Abcam), GRASP65 (Invitrogen, Carlsbad, CA, USA), BLZF1 (Novus Biologicals, Littleton, CO, USA), STX3 (Abcam), STX6 (Cell Signaling Technology), GOLPH3 (LifeSpan Biosciences, Seattle, WA, USA), ATF6 (Abcam), IRE1α (Cell Signaling Technology), phospho-IRE1α (Novus Biologicals), PERK (Cell Signaling Technology), phospho-PERK (Cell Signaling Technology), CHOP (Cell Signaling Technology), BIP (Cell Signaling Technology), GRP94 (Cell Signaling Technology), HSP70 (Abcam) and HSP90 (Cell Signaling Technology).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The results were obtained from a representative real-world evidence dataset analyzed over a 12-year period, which was sufficient to observe EOD events, and are generalizable to the UK and similar populations.

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PMC10761218

Approximately 29% of all malignancies are lung cancers .

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PMC8735881

LTR, long terminal repeat; RRE, Rev response element; cPPT, central polypurine track; PGK, human PGK promoter; DAF, delay-accelerating factor; WPRE, woodchuck hepatitits virus posttranscription regulatory element. (

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PMC7570809

Statistical analysis was performed using a t-test where p < 0.05 was considered to indicate a statistically significant difference.

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PMC9429973

Thirteen patients (28.8%) were followed up in the intensive care unit.

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PMC11633763

As a member of the DUB family, USP22 exerts its function by binding to its substrate.

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PMC7057940

In addition, it was also clear that the EWS and FLI1 genes were present in this sample (patient 2), leading to the conclusion that the proportion of cells with the fusion gene in this case could be significantly smaller than that without the translocation.

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PMC10165258

Although each of the above approaches has its specific advantages, the method presented here is unique in that the microfluidic device is disconnected from flow control for most of the experiment.

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PMC11790971

Six FOVs were imaged per well.

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PMC11627060

Prior studies have also indicated that Baicalin-loaded folic acid-modified albumin NPs can trigger apoptosis and oxidative stress in MCF-7 cells .

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PMC9532503

Supplementary Figure S1 shows the chromatogram for affinity chromatography.

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PMC9429973

Romiplostim (ROM), a thrombopoietin receptor agonist (TPO-RA), has shown safety and clinical efficacy in prospective trials in LR-MDS.

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PMC11634027

The ds allele may thus prove useful for future investigations of this question.

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PMC10335954

Cells were seeded into 6-well plates at a density of 500 cells/well, incubated at 37 °C in a 5% CO2 incubator, and observed for 10 days with half of the medium changed every 3 days.

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PMC8336407

The wells were exposed to different concentrations of extract (1.5 mg/mL, 2.0 mg/mL, and 2.5 mg/mL) prepared in complete media, and incubated for 24 h. After 24 h the media were removed and wells were washed twice with sterile distilled water, then different concentrations of t-BHP (0, 100 µM, 150 µM, 200 µM), were dissolved in complete media and were added to all groups, except control and incubated for 24 h .

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PMC11349530

In addition, there is a big variability in patient responses, and in most cases, patients do not respond to immune checkpoint immunotherapy (92).

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PMC6889484

Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure.

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PMC10470467

The above results have shown that there may exist differences in response to immunotherapy for patients in distinct subgroups.

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PMC6461034

Erlotinib‐resistant HCC827‐ER3 NSCLC cells with mutant EGFR.

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PMC11506827

Although surgery is the standard treatment for localized RCC, the recurrence rate is high .

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PMC11045125

EBV-infected BLs support restricted forms of viral latency that do not transform B cells in vitro and lack expression of the major EBV oncoproteins, EBNA2 and LMP1.

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PMC11765988

Immunosuppression also plays a role in the pathogenesis, but to a smaller extent than in NHL.

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PMC11754436

The preliminary qualitative analysis by immunohistochemical staining indicated that the expression levels of Bcl2 in the shDHRS4-AS1 group were higher than those in the control group, while the expression levels of Bax and caspase 3 in the shDHRS4-AS1 group were lower than those in the control group (Fig. 2D).

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PMC11464982

However, the likelihood of such reactions will not exceed the likelihood of allergic reactions to Penicillium.

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PMC9429973

Interestingly, this observation was correlated with the fact that synapse capability was only partially recovered in CD4 T-cells but not in CD8 T-cells (Figure 1B).

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PMC9429973

No surgical history or medication were reported.

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PMC11098378

Following incubation, 300 μL TBS buffer (25 mM Tris-HCl pH 7.4, 150 mM NaCl, 1 mM DTT) and 30 μL of washed GST beads were added.

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PMC11792090

Survival curves of mice in each treatment group. (

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PMC11402217

ns = no significance.

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PMC10698968

Currently, the gold standard treatment of localized MFS is surgery with free margins from neoplastic infiltration, alone or in combination with (neo) adjuvant radio- or chemotherapy .

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PMC11482552

Jurkat cell line samples at three different concentrations were subsequently evaluated using the OncoPredict HPV Quality Control (QC) real-time PCR assay, employing CCR5 for molecular cellularity quantification.

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PMC10761218

The collected plant material was thoroughly washed three times with running water.

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PMC11352311

Isomeric SMILES: C1=CC(=O)OC2=CC(=C(C=C21)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O. RCC targets were obtained from GeneCards (https://www.genecards.org) (accessed on 11 August 2024) by searching for “Renal cell carcinoma” and saving the relevant disease genes.

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PMC8343815

The optical density (OD) of dissolved formazan is equivalent to the number of viable cells.

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PMC9429973

Cox regression models were used to analyse prognosis factors.

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PMC3122064

Our results show that combining non-toxic concentrations of Nutlin-3 with cisplatin sensitises both intrinsic as well as acquired cisplatin-resistant TC cells to low concentrations of cisplatin.

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PMC11144200

Next, these tumor sections were subjected to immuno-staining with anti-Ki-67 mAb (Biolegend, China, Cat No. 328605), and the results were analyzed.

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PMC11612794

The PAE also shows that the aa 187–216 region of CENP-T binds to Mis12C with high reliability (Figure S3C; rank_1).

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PMC8913139

Then, the luciferase vector was transfected into A-172 MG cells containing miR-448 mimics for 48 h. Luciferase activity was measured by dual luciferase assay system (Promega, USA).

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PMC11047729

Vitamin A is a vital nutrient that serves several purposes in the human body .

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PMC11453018

Initial results showed that iP300w treatment reduced cell viability in EWS::ERG cells, though this effect was less pronounced compared to EWS::FLI1 cell lines at 48 h, as measured by the ATP assay (Supplementary Fig. 6A).

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PMC6799808

Additionally, GLPT not only inhibited mTORC1-mediated S6K1 and 4E-BP1 phosphorylation but also repressed mTORC2-mediated Akt phosphorylation.

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PMC10940855

Among patients in the CoMMpass trial, those with the highest decile of EFNB2 expression demonstrated decreased progression-free survival and decreased overall survival compared with all other patients (Fig. 6F and G).

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PMC11139449

The pLEX-JRed vector was obtained from the Royan Institute in Tehran.

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PMC11482552

The Thoma chamber slide was observed using an inverted microscope (Olympus) with a 10× objective.

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PMC6617630

Fig. 6Effect of I-BET and JQ1 on cell surface expression of CD47 and PD-L1 on WT, DHL and THL cells.

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PMC10969097

After 24 h of treatment, the IC50 values were 39.917 μM in SKOV3 cells and 207.191 μM in SKOV3/DDP cells.

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PMC11694625

MTT results showed that they all displayed broad-spectrum antiproliferative activity against selected cancer cell lines (BGC-823, BEL-7402, MCF-7 and A549).

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PMC11765243

In contrast, in the CD4 T cell population the percentages of naïve and memory lymphocytes were not altered in p110αKD-T spleens (Figure S5).

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PMC9221284

All Burkitt lymphoma cell lines that were studied exhibited doublet bands (Figure 2B): c-Myc2 (64 kDa) and probably its phosphorylated form (65 kDa).

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PMC9429973

Duplicate reads were removed using SAMtools rmdup and peaks called with MACS2 callpeak on the usegalaxy.eu platform.

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PMC11703896

However, despite its therapeutic potential, the clinical application of rapamycin faces several limitations.

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PMC11754784

Data are represented as mean ± s.d. (

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PMC10114490

Genes significantly enriched (p < 0.05) in diHLC-T are highlighted in a red box, while those genes significantly enriched (p < 0.05) in HepG2 are highlighted in a green box (only ABCB6, top).

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PMC11676169

Although KU70 and KU80 subunits are predominantly localized in the nucleus, they are also present in the cytoplasm and at the cytoplasmic membrane, where they have been implicated in numerous cellular processes .

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PMC11590870

Therefore, natural antioxidants have been suggested as an alternative to prevent this disorder.

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PMC11407042

A high concentration of serum may lead to a high background absorbance.

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PMC9429973

Methods: 27 adult MM patients who underwent ASCT at The Stem Cell Transplant Center of Dokuz Eylul University Hospital between October 2011 and August 2021 and who relapsed within 18 months of transplantation were included in this study.

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PMC9429973

A. Sadovskaya, N. Petinati, N. Kapranov, N. Drize, A. Vasilieva, O. Gavrilina, E. Parovichnikova Faculty of biology, Department of Immunology, Lomonosov Moscow State University; NATIONAL MEDICAL RESEARCH CENTER FOR HEMATOLOGY, Moscow, Russia Background: The stromal microenvironment plays a key role in both maintaining normal hematopoiesis and assisting malignant cells during leukemia development.

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PMC7612475

Coverslips were mounted with Cytoseal and imaged and exchanges counted using a Nikon Eclipse Ti-S microscope.

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PMC11371747

Relative protection by l-LV from antifolate (PMX, PLX and RTX) -induced growth inhibition of NSCLC and MPM cells.

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PMC11357960

In conclusion, our research developed a predictive method, based on the gene expression of three SUMO machinery components (SUMO1, SUMO3 and UBE2I), to distinguish the resistance to anti-PD-1 immunotherapy.

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PMC9599726

Results of the correlation between TFRC-ir and histopathological GIST characteristics are summarized in Table 1.

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PMC9856122

Viral infections have become a serious global concern for health workers due to their uncontrollable morbidity and death rate.

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PMC8557138

Ex vivo assays enable the spatial organization of various cell types and extracellular matrices along with spatial–temporal gradients of angiogenic factors.

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PMC11705862

The following model specifications were used: Imer (IRIS-1/ 2 ∼ ptau + (1| case), REML = FALSE, control = lmerControl (‘bobyqa’), data = MixedModel).

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PMC11286266

This ATF6α∆ clone was re-targeted with a unique sgRNA/Cas9, alongside ATF6α_LD, ATF6α_LD, or ATF6α_LD repair templates (Figure 5B). (

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PMC11767793

The colloidal stability of the Au-PEI@NIST in physiologically relevant conditions was studied previously .

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PMC11143482

To examine the ability of tumour formation and pulmonary metastases development, cancer cell lines were inoculated at two locations: lower hind leg (primary) and back (metastasis).

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PMC10440586

The scRNA-seq profiles of GBM samples conducted by Neftel et al. was obtained from the Single Cell Portal (https://singlecell.broadinstitute.org/single_cell) .

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PMC11701801

Before all downstream analyses, duplicate reads were removed using the MarkDuplicates command in Picard version 2.26.11 (RRID: SCR_006525; http://broadinstitute.github.io/picard).

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PMC9454178

Interestingly, we found that c-KIT transcription and protein expression were significantly inhibited after CDK7 knockdown or THZ1 treatment in both GIST T1 and 882 cells.

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PMC5330095

Lamivudine and interferon alpha were used as positive controls against HBV and HCV, respectively, and they significantly inhibited viral replication at the single-dose assay.

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PMC11703896

The hexahedron cells were found to have change to round and shrunken morphology.

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PMC11723947

HP1α-deficiency therefore enables donor-specific murine Tconv to maintain their effector functions in a Treg-mediated immunosuppressive environment.

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PMC9429973

were significantly associated with a shorter OS in the univariate analysis.

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PMC9792775

Cell samples were randomly allocated to four groups with three parallel samples per group (Group I, control group containing untreated A-204 and HT-1080 tumor cells; Group II, A-204 and HT-1080 tumor cells treated with PTX; Group III, A-204 and HT-1080 tumor cells treated with LFU, 100 mW, 5 min; Group IV, A-204 and HT-1080 tumor cells treated with LFU, 100 mW, 5 min, Plus PTX).

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PMC11541409

Ripretinib, a fourth-line therapy, has shown broad efficacy against most mutant types of KIT/PDGFRA, with moderate inhibition of JM domain and ATP-binding site mutations .

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