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PMC11155445
Similarly, among the three, compound (154) was found a more potent inhibitor of elastase enzyme with an inhibition zone of 86.5% and IC50 value of 1.48 μM. Newly synthesized amantadine linked acyl thiourea derivatives also exhibit potent anticancer activity against malignant glioma MG-U87 cells (Fig. 81).
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PMC9895440
For surface staining, cells were washed and resuspended in FACS buffer (PBS supplemented with 2 mM EDTA, 0.1% Na-Azide, 2% FCS), and stained with the appropriate antibodies for 30 min at 4 °C.
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PMC9786247
Modern pasteurization protocols for high-temperature, short-time pasteurization of milk are effective in inactivating C. burnetii , reassuring the high safety level of off-the-shelf dairy products.
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PMC11661452
The online and PDF versions of the article and the Supplementary Materials PDF have been updated.
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PMC11012012
They identified four immune-related genes (SLAMF2/CD48, IL1RL, PSDM3, and RXFP3) significantly associated with overall survival.
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PMC11172027
Media: RPMI 1640, FBS, DMEM, antibiotic–antimycotic solution (Thermofisher, Vienna, Austria); reagents: Cytofix–Cytoperm permeabilization Kit (Thermofisher, Vienna, Austria), FITC Active Caspase-3 Apoptosis Kit (BD Biosciences Kit; Allschwil, Germany), WST-1 Cell Proliferation Reagent (Abcam; Cambridge, UK); chemicals: NALM and NASeLM (Sigma), guanidine-HCl, butyl-hydroxy-toluene (BHT; Sigma Aldrich, St. Louis, MO, USA), di-nitro-phenyl-hydrazine (DNPH) (Altmann Analytics, Munich, Germany); and flasks (Falco Cell Culture; Corning Incorporated, New York, NY, USA) were used.
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PMC8751435
Cell apoptosis was analyzed using the Annexin V‐FITC Apoptosis Detection Kit (Beyotime) according to the manufacturer's instructions.
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PMC5963610
Statistical differences are indicated: p<0.001, p<0.05.
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PMC8633974
These cell lines are latently infected cell models where each cell has at least one copy of HIV genome.
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PMC11792888
IC50 values were determined as above.
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PMC11371627
There were no signs of formal or content-related cognitive abnormalities and a neuropsychological screening revealed unsuspicious results regarding common screening instruments (Bayer Activities of Daily Living Scale B-ADL (1,16), Hospital Anxiety and Depression Scale HADS-D (anxiety: 7, depression: 1), Montreal Cognitive Assessment MoCa (29/30), Symbol Digit Modalities test SDMT (58).
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PMC9429973
Subgroup analyses for effectiveness and safety may be performed, on the basis of gender, age, or baseline Eastern Cooperative Oncology Group performance status.
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PMC8973085
Some new pyridinethione and thienopyridine derivatives have been synthesized and evaluated for their antiproliferative activity using the MTT assay.
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PMC9429973
There is therefore a great urgency to identify biomarkers correlated with the different stages of the disease and to treat patients with a more tailored treatment.
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PMC11661024
On the other hand, treated HUVEC cells with two postbiotics of L. fermentum CH and L. fermentum KH at IC50 concentrations indicated 2% and 3.3% of total cell death, respectively.
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PMC11434983
The stability was evaluated by incubating HPLC-purified samples in PBS (pH 7.4) at room temperature for 6 h. To challenge the stability, 0.5 mL of an aqueous solution of 2 × 10 M cysteine or histidine was added to 0.5 mL (3.7 MBq) of Tc-complex solution and incubated at 37 °C for 6 h. Aliquots of these solutions were analyzed using HPLC at 1, 3, and 6 h .
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PMC6114978
Increase in expression was defined as a two-fold or greater increase in expression after treatment with 10 μM 5-azacytidine. (
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PMC11155445
N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives (92aa–ae, 93aa–ae, 92ba–b and 93ba–bb) were synthesized by Poyraz et al. and characterized using IR, NMR, MS and Single Crystal X-ray diffraction, and DFT studies.
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PMC11635087
Our top-down synthetic biology-based approach may serve as a foundation for creating artificially photosynthetic animal cells.
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PMC9429973
Despite this remarkable success, long term studies on patients treated with CD19 or CD22 CAR T-cells revealed the emergence of relapses that can be due to antigen loss.
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PMC9429973
M.-W. Lee, S.-H. Yeon, H. Ryu, I.-C. Song, H.-J. Lee, H.-J. Yun, S. Y. Kim, J. E. Lee, K. S. Shin, D.-Y. Jo Department of Internal Medicine; Department of Laboratory Medicine; Department of Radiology, Chungnam National University College of Medicine, Daejeon, South Korea Background: At present, palpable splenomegaly is relatively uncommon in patients with polycythemia vera (PV), possibly because of early diagnosis facilitated by a lowering of the diagnostic thresholds for hemoglobin and hematocrit levels as well as the wide application of driver gene mutation tests.
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PMC11672881
Mass spectrometry was performed in both positive and negative ion modes, using a resolution of 70,000 at m/z 200, an automatic gain control target of 3 × 10, and a scan range of m/z 72–1000.
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PMC11462673
D Relevant bioluminescence imaging of D12, D26 and D32 days in MBZ group and control group.
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PMC9429973
An annual discount rate of 1.5% to both quality-adjusted life-expectancies (QALEs) was utilised.
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PMC11576293
Yield 87%; m. p. 239–241°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.09 (d., 2H, Ar-H, J = 8.7 Hz), 7.7 (m, 3H, Ar-H and pyrimidine–C5-H), 7.51 (m., 4H, Ar-H), 7.31 (m., 3H, Ar-H), 6.99 (d., 1H, Ar-H, J = 8.4 Hz), 4.61 (s., 2H, SCH2C6H5), 3.99 (2 overlap singlets, 6H, 2 OCH3); C NMR (75 MHz, CDCl3) δ (ppm) = 171.9, 164.5, 163.3, 151.8, 149.3, 138, 137.1, 135.4, 129.4, 129.1, 128.8, 128.5, 127.1, 120.4, 110.9, 110, 107.2, 56.1, 35.5; HRMS (ESI+) calcd.
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PMC11188874
Pharmacologics were prioritized based upon arbitrary cutoffs of >30% increase in proteasome activity and 75% cell viability.
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PMC9444294
Cells were then blocked with 1% BSA and incubated overnight at 4°C with SS18-SSX antibody (dilution 1:1000).
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PMC11395280
Induction of Leukemia R26PR mice were crossed with B6.Cg-Tg(Mx-1-Cre)1Cgn/J mice to produce R26PR/Mx-1 Cre mice.
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PMC11518702
In BCR-stimulated *U2932 cells, HGAL-Y107->F (vs. mock and WT-HGAL) expression yielded greater increases in calcium flux, NF-kB transcriptional reporter activity, and phosphorylation of SYK, BLNK, and BTK (8).
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PMC11013014
In our case, all compounds show synthetic accessibility values below 10, which meet the criteria of a fairly easy access.
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PMC10440586
The accumulation of lactic acid in the TME due to hypoxia can activate the function of Tregs, thereby further suppressing the anti-tumor immune response.
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PMC10094992
Consistently, we observed a significant reduction in NADH levels resulting in an increased NAD/NADH ratio in MPM MCSs treated with NR6.
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PMC10040136
Cell proliferation was evaluated by utilizing the CCK-8 (Cat No. CK04, Dojindo, Japan) assay, following the manufacturer's guidelines.
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PMC5673060
Drug response profiling rediscovers several previously reported vulnerabilities associated with pazopanib and dasatinib resistance and identifies a new dependency to the second generation HSP90 inhibitor NVP-AUY-922.
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PMC11471176
Additionally, ACE2 manifested robust correlations with genes associated with breast cancer resistance, with heightened ACE2 expression serving as a preceptive marker for unfavorable prognosis among patients undergoing chemotherapy .
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PMC11747885
To identify molecules that combine high enzymatic activity with low cytotoxicity against living cells, all bioactive compounds were tested for their cytotoxic properties using the HEK293 cell line, which has been previously utilized in Rlig1 investigations.
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PMC11527437
Thus, there is opportunity for improvement, and a multitude of innovative strategies are being investigated to enhance TCR-T efficacy.
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PMC11746948
After that, the sections were incubated with primary antibodies at 4 °C overnight.
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PMC11750161
In the inactivating mutants, many studies have reported in equine LH/CGR-D405N, -R464H, and Y546F (Byambaragchaa et al., 2021a), hLH/CGR-V144F (Richter-Unruh et al., 2005), hLH/CGR-F194V (Gromoll et al., 2002), rat LH/CGR-D383N, -R442H, and -Y524F (Dhanwada et al., 1996; Min et al., 1998), indicating that any mutants were completely impaired or not impaired.
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PMC11574029
C, D Assessment of proliferation capacity of stable transfected T24 and 5637 cells using the CCK8 assay.
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PMC9429973
However, many pts relapse and studies suggest that each subsequent relapse is associated with shorter durations of response to the next treatment.
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PMC11777207
Instead, we found that the most notable decrease in DC migration was caused by the antibody with the highest Kd (lower affinity), atezolizumab, when compared to durvalumab and avelumab at the lowest dose tested (2 μg) (Fig. 1C).
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PMC10297204
Anti-tumor effects of ethanol on various types of cancers have been described, and the ethanol concentration was likely to be a determining factor of these cancer treatments.
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PMC9429973
Image: Summary/Conclusion: Prior to HSCT most CH-associated mut remain detectable in pts in CR/CRi.
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PMC8873393
It is broadly studied about the mechanisms and factors responsible for the dramatic shutdown of transcription genome wide after UV irradiation .
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PMC11765243
Thymocytes suffer various processes of selection (see Figure S1B), the first of them, at the DN3 stage, is named β-selection as only DN3 cells with functionally recombined TCRβ develop further to express a pre-TCR (composed of TCRβ, pre-TCRα, and CD3 subunits).
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PMC11754784
2 × 10 CEM cells were pre-stained with Hoechst (Beyotime Biotechnology, Shanghai, China) for fluorescence confocal microscopy imaging.
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PMC5443223
A-204 cells were seeded onto glass slides.
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PMC11638255
No other immune subsets or erythrocyte measurements were significantly affected (Supp.
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PMC9611901
The latter test in its “cytome” version can provide a range of useful information valuable for further risk assessments.
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PMC6835762
At higher substitutions particles tended to be ellipsoidal or spherical with an increased particle size, reflecting either an increase in the space taken up by the acyl groups or an increase in aggregation number (Figure 2).
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PMC3019555
The percentage of translated versus untranslated mRNA is displayed as mean ± SEM (n = 2).
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PMC10506676
Cervical carcinoma (CC) is the fourth most common cancer among women after breast, lung, and colon cancers, which accounts for 1.6% of cancer deaths in women (2).
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PMC7189327
Ling et al. analyzed p53 mutations in sporadic and hereditary BCC tumors, and genetic alterations of p53 were responsible for BCC progression .
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PMC9275501
A summary of the studies of natural active components as drug carriers in NDCDS is shown in Table 3.
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PMC9429973
In the pivotal Phase 2 PACE (Ponatinib Ph+ ALL and CML Evaluation) trial (NCT01207440), patients with resistant/intolerant CP-CML demonstrated deep, lasting responses to ponatinib 45 mg once daily.
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PMC8711270
Protein production in producer cell lines can be increased by the use of gene amplification technology (Lai et al., 2013).
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PMC11486946
The other hit compounds exhibit effects on the clustering, internalization, and expression level of EGFR without strong inhibition of the tyrosine kinase activity upon EGF stimulation.
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PMC11406030
We have recently reported the expression and dimerization of integrin αV and β1 subunits in ovarian cancer tissues and cells.
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PMC11535726
Based on our phylogenetic analyses, K.dendryphioides strains (KUNCC 10431 and KUNCC 10499) form a subclade sister to the strains of Kirschsteiniotheliaatra (CBS 109.53, DEN, MFLUCC 15-0424, MFLUCC 16-1104 and S-783) with 83% ML and 0.99 PP support (Fig. 1).
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PMC11623887
Previous studies have been shown that GATA1 is an important transcription factor in supporting B19V infection in erythroid cells lineage, and the inhibitory effect of NS1 on GATA-1 can lead to decrease in the proliferation and differentiation of the erythroid lineage.
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PMC9429973
The mean age was 15 (SD 16.03) years and 58% of the patients were female.
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PMC9429973
Five (26%) patients had Karnofsky performance status < 90%.
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PMC11687663
Activating PPAR-δ has been associated with inhibiting cell proliferation and inducing apoptosis in certain instances, suggesting potential anti-tumorigenic effects .
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PMC11515150
CD5 CCRF-CEM cells and CD5 CAR-T cells or NT-T cells were cocultured overnight at the indicated E: T ratio (n = 3; two-way ANOVA; ***p < 0.001) (top panel).
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PMC11770130
In addition, we tried to normalize the serum concentration of GDF15 by enhancing its endogenous production by treating the mice with PERK agonist (PERKa).
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PMC11412721
We next performed bulk RNA-seq and differential expression analyses comparing the spleens from 4- to 6-week-old Trp53 Eμ-Myc males to spleens from age-matched Trp53 Eμ-Myc males.
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PMC11612315
c Effects of intraplantar injection of exendin 9–39 (Exe 9–39) (5 and 10 μg) on mechanical allodynia in a CFA-induced inflammatory chronic pain mouse model via the von Frey test (mean ± S.E.M., n = 7 each).
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PMC11185260
A densitometric analysis of Western blot results presented (right panel).
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PMC9412887
As more nanomedicines are developed and optimized, the advantages of nanomedicines over current treatment strategies will continue to be exploited.
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PMC9429973
Co-occurrence of these three mutations is associated to a unique AML subset characterized by high peripheral blood and bone marrow blast counts, normal cytogenetic and very poor EFS and OS.
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PMC9429973
Additionally, Case Report Forms (CRFs) were filled.
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PMC10196713
To identify genes associated with enhanced cisplatin resistance in OC, gene expression profiles were compared between cisplatin-sensitive and cisplatin-resistant OC cell lines.
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PMC8973085
Dose dependent antiproliferative data of the 19 compounds against MCF-7 cancer cells according to the MTT assay after 48 h of exposure.
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PMC8389560
There is a wide range of biological molecules with pro and antioxidant properties, among which selenium compounds play an important role.
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PMC11803149
Since GzmB primarily exerts cytotoxic functions in a perforin-dependent manner (48), age-related increase in GzmB expression alone is not likely sufficient to enhance cytotoxic activity of aged CD8 TCR-T cells.
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PMC9429973
106 pts (88%) had ≥ one grade 3/4 non-hematological treatment-emergent adverse events (TEAE) with the most frequent grade 3/4 TEAEs being neutropenic infections in 92 pts (77%) and elevated liver enzymes in 25 pts (21%).
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PMC10958426
Dot plot of normalized expression level and expression percentage of cell-type-specific genes in 9 cell types. (
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PMC3675084
Cells were incubated with 20 nM BPR0L075 for 6 hours, then cells were washed, harvested, and lysed for LC/MS/MS measurement.
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PMC9429973
An important drop in hemoglobin was observed in 3 patients: 2 had cancer and one presented hemorrhagic shock with acute renal failure secondary to cave vein haematoma which needed intensive care.
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PMC11509309
Human prion diseases (Creutzfeldt–Jakob Disease (CJD), variant Creutzfeldt–Jakob Disease (vCJD), Gerstmann–Sträussler–Scheinker Disease (GSS) and Fatal Familial Insomnia (FFI) ) are rare, with annual incidence between 1.5 and 2 cases per million worldwide according to the National Public Health Agency.
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PMC11597167
The H-bonding interactions between hydroxyl groups and the G23, P70, Y198, and G230 residues were present in the oleuropein:BACE1 complex.
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PMC9429973
The primary endpoint is the number of patients who achieve measurable residual disease negative (Euroflow NGF 10) complete response during and/or after 18 cycles of study treatment.
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PMC5600151
Li and co-workers interestingly showed that a size transition from 80 nm pH-sensitive nanoparticles comprised of dendrimer building blocks improved tumor penetration in vitro (spheroids) and in vivo after they were dissociated into 10 nm dendrimers in a slightly acidic environment .
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PMC10237474
Small-scale expression cultures can be set up during expansion.
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PMC9479186
After inoculation, the nude mice were raised in cages, fed with water, and feed regularly, and padded materials were changed regularly.
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PMC11098378
One prediction of our approach is that the host substrates of effector proteins secreted by mammalian and plant pathogens are key regulators of viral restriction in the moth.
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PMC11741577
Here, we found that treatment with CM from HMC-1 enhanced HaCaT cell migration in vitro.
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PMC7519871
The combination of BA with cisplatin, however, showed a synergistic trend when administered as bolus (both drugs applied at same time) while moderately antagonistic effect was observed on application of one drug (either) 4 hours before the other (Supplementary Table).
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PMC11763764
As shown in the representative data in Figure 1B, the surviving cancer cells had an increased expression of KLF9 and SORL1, which are statistically significant.
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PMC10213179
Cells were washed twice, and bound aptamers were analyzed using a Gallios flow cytometer and Kaluza Analysis 2.1 software (Beckman Coulter, Brea, CA).
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PMC9031474
Best results were obtained for derivative 64 against MCF-7 cancer (GI50 = 7.0 µM) being 10-fold more active than polygodial (2).
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PMC3675084
In conclusion, BPR0L075 displays potent cytotoxic effects in ovarian cancer cells with a potential to overcome paclitaxel resistance by bypassing efflux transporters and inducing mitotic catastrophe.
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PMC10568263
The optimal HSP70 incubation time was found to be 60 min, as the binding efficiency of the antibody to HSP70 tended to be stable after this time.
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PMC10965680
Remarkably, goats not only survive but efficiently reproduce under extreme conditions, making them a top choice for farmers with limited resources.
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PMC11711935
KGF/FGF7 is a member of the fibroblast growth factor (FGF) family and a key regulatory factor for epithelial growth and differentiation.
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PMC11206502
Patented as a prevention and therapeutic agent for various skin changes , HB has been submitted to numerous in vitro studies .
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PMC11583690
Tan Le Hoang Doan: Writing – review & editing, Resources, Methodology, Data curation, Conceptualization.
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PMC11486946
Next, we carried out the screening using a library of 1134 FDA-approved compounds whose target proteins are responsible for broad functions such as receptors, channels, kinases, enzymes, transporters, and so on (Fig. 2b, Supplementary Table 2, and Supplementary Data 1).
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PMC10729469
The arms of the maze had 39.5*8.5*13 cm dimensions with 120° angle between the arms.
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